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Hallmarks of the aging T‐cell system

https://doi.org/10.1111/febs.15770
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CD4+,CD28? T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems
inferredcites →https://doi.org/10.1002/art.1780380912openalex-snapshot
Emergence of oligoclonal t cell populations following therapeutic t cell depletion in rheumatoid arthritis
inferredcites →https://doi.org/10.1002/emmm.201000096openalex-snapshot
DNA‐dependent protein kinase catalytic subunit mediates T‐cell loss in rheumatoid arthritis
inferredcites →https://doi.org/10.1007/s00018-012-0970-0openalex-snapshot
Immune aging and autoimmunity
inferredcites →https://doi.org/10.1016/j.ccr.2011.06.003openalex-snapshot
TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis
inferredcites →https://doi.org/10.1016/j.cell.2013.05.039openalex-snapshot
The Hallmarks of Aging
inferredcites →https://doi.org/10.1016/j.cell.2016.07.050openalex-snapshot
Epigenetic Mechanisms of Longevity and Aging
inferredcites →https://doi.org/10.1016/j.cell.2018.03.079openalex-snapshot
Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging
inferredcites →https://doi.org/10.1016/j.celrep.2016.01.002openalex-snapshot
Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals
inferredcites →https://doi.org/10.1016/j.celrep.2018.05.057openalex-snapshot
Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells
inferredcites →https://doi.org/10.1016/j.celrep.2018.10.074openalex-snapshot
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells
inferredcites →https://doi.org/10.1016/j.celrep.2019.10.044openalex-snapshot
Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency
inferredcites →https://doi.org/10.1016/j.celrep.2021.109981openalex-snapshot
The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age
inferredcites →https://doi.org/10.1016/j.cels.2016.09.009openalex-snapshot
Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans
inferredcites →https://doi.org/10.1016/j.clim.2007.12.002openalex-snapshot
T cell subset-specific susceptibility to aging
inferredcites →https://doi.org/10.1016/j.clim.2016.11.018openalex-snapshot
A novel class of somatic mutations in blood detected preferentially in CD8 + cells
inferredcites →https://doi.org/10.1016/j.clim.2019.07.003openalex-snapshot
Metabolic reprogramming in memory CD4 T cell responses of old adults
inferredcites →https://doi.org/10.1016/j.cmet.2020.04.015openalex-snapshot
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
inferredcites →https://doi.org/10.1016/j.coi.2010.02.007openalex-snapshot
Epigenomics of T cell activation, differentiation, and memory
inferredcites →https://doi.org/10.1016/j.immuni.2009.11.007openalex-snapshot
Diversity in T Cell Memory: An Embarrassment of Riches
inferredcites →https://doi.org/10.1016/j.immuni.2012.02.006openalex-snapshot
Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans
inferredcites →https://doi.org/10.1016/j.immuni.2014.12.007openalex-snapshot
Tissue-Resident Memory T Cells
inferredcites →https://doi.org/10.1016/j.immuni.2016.09.013openalex-snapshot
Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis
inferredcites →https://doi.org/10.1016/j.immuni.2017.03.010openalex-snapshot
Successful and Maladaptive T Cell Aging
inferredcites →https://doi.org/10.1016/j.immuni.2018.02.010openalex-snapshot
Understanding Subset Diversity in T Cell Memory
inferredcites →https://doi.org/10.1016/j.it.2009.03.013openalex-snapshot
CD28− T cells: their role in the age-associated decline of immune function
inferredcites →https://doi.org/10.1016/j.it.2009.04.007openalex-snapshot
T-cell immunosenescence: lessons learned from mouse models of aging
inferredcites →https://doi.org/10.1016/j.jaci.2020.03.017openalex-snapshot
Influence of immune aging on vaccine responses
inferredcites →https://doi.org/10.1016/j.molcel.2012.10.016openalex-snapshot
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
inferredcites →https://doi.org/10.1016/j.smim.2004.02.008openalex-snapshot
Immunological memory in humans
inferredcites →https://doi.org/10.1016/j.smim.2005.01.005openalex-snapshot
DNA methylation and the expanding epigenetics of T cell lineage commitment
inferredcites →https://doi.org/10.1016/j.smim.2012.04.001openalex-snapshot
Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects
inferredcites →https://doi.org/10.1016/j.tibs.2017.11.008openalex-snapshot
TCR Signaling: Mechanisms of Initiation and Propagation
inferredcites →https://doi.org/10.1016/j.xcrm.2020.100054openalex-snapshot
Single-Cell Analyses Identify Dysfunctional CD16+ CD8 T Cells in Smokers
inferredcites →https://doi.org/10.1016/j.xphs.2017.04.078openalex-snapshot
Transporters Involved in Metformin Pharmacokinetics and Treatment Response
inferredcites →https://doi.org/10.1016/s0065-2776(08)60789-0openalex-snapshot
T Cell Dynamics in HIV-1 Infection
inferredcites →https://doi.org/10.1016/s0167-5699(98)01299-7openalex-snapshot
A very high level of crossreactivity is an essential feature of the T-cell receptor
inferredcites →https://doi.org/10.1016/s1074-7613(00)80092-8openalex-snapshot
The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery
inferredcites →https://doi.org/10.1016/s1074-7613(01)00244-8openalex-snapshot
CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities
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Aging as war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair
inferredcites →https://doi.org/10.1038/cr.2007.111openalex-snapshot
Regulation of DNA double-strand break repair pathway choice
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The coronavirus is most deadly if you are older and male — new data reveal the risks
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Asymmetric and symmetric stem-cell divisions in development and cancer
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mTOR regulates memory CD8 T-cell differentiation
inferredcites →https://doi.org/10.1038/nature19768openalex-snapshot
Tissue-specific mutation accumulation in human adult stem cells during life
inferredcites →https://doi.org/10.1038/nature24633openalex-snapshot
Origin and differentiation of human memory CD8 T cells after vaccination
inferredcites →https://doi.org/10.1038/ncomms12484openalex-snapshot
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
inferredcites →https://doi.org/10.1038/ncomms14617openalex-snapshot
DNA methylation signatures in peripheral blood strongly predict all-cause mortality
inferredcites →https://doi.org/10.1038/ncomms15869openalex-snapshot
Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
inferredcites →https://doi.org/10.1038/ncomms6366openalex-snapshot
Age-related variations in the methylome associated with gene expression in human monocytes and T cells
inferredcites →https://doi.org/10.1038/ni.2018openalex-snapshot
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
inferredcites →https://doi.org/10.1038/ni.3665openalex-snapshot
A sestrin-dependent Erk–Jnk–p38 MAPK activation complex inhibits immunity during aging
inferredcites →https://doi.org/10.1038/ni1513openalex-snapshot
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
inferredcites →https://doi.org/10.1038/nm.2963openalex-snapshot
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
inferredcites →https://doi.org/10.1038/nm1006-1133openalex-snapshot
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
inferredcites →https://doi.org/10.1038/nm917openalex-snapshot
Duration of antiviral immunity after smallpox vaccination
inferredcites →https://doi.org/10.1038/nri.2015.3openalex-snapshot
Tissue-resident memory T cells: local specialists in immune defence
inferredcites →https://doi.org/10.1038/nri1292openalex-snapshot
The many important facets of T-cell repertoire diversity
inferredcites →https://doi.org/10.1038/nri1440openalex-snapshot
Will telomere erosion lead to a loss of T-cell memory?
inferredcites →https://doi.org/10.1038/nri3198openalex-snapshot
Regulation and function of mTOR signalling in T cell fate decisions
inferredcites →https://doi.org/10.1038/nri3279openalex-snapshot
Why must T cells be cross-reactive?
inferredcites →https://doi.org/10.1038/nri3433openalex-snapshot
The ageing haematopoietic stem cell compartment
inferredcites →https://doi.org/10.1038/nri3846openalex-snapshot
Lymph node fibroblastic reticular cells in health and disease
inferredcites →https://doi.org/10.1038/s41419-019-1744-5openalex-snapshot
Roles of circular RNAs in immune regulation and autoimmune diseases
inferredcites →https://doi.org/10.1038/s41467-017-02088-wopenalex-snapshot
Structural absorption by barbule microstructures of super black bird of paradise feathers
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Exceptional increase in the creep life of magnesium rare-earth alloys due to localized bond stiffening
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Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
inferredcites →https://doi.org/10.1038/s41467-018-05552-3openalex-snapshot
Regulation of miR-181a expression in T cell aging
inferredcites →https://doi.org/10.1038/s41514-021-00056-9openalex-snapshot
The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a
inferredcites →https://doi.org/10.1038/s41577-018-0001-yopenalex-snapshot
The full spectrum of human naive T cells
inferredcites →https://doi.org/10.1038/s41577-018-0037-zopenalex-snapshot
Histone deacetylase function in CD4+ T cells
inferredcites →https://doi.org/10.1038/s41577-019-0180-1openalex-snapshot
Mechanisms underlying T cell ageing
inferredcites →https://doi.org/10.1038/s41577-020-0332-3openalex-snapshot
Building a T cell compartment: how immune cell development shapes function
inferredcites →https://doi.org/10.1038/s41586-018-0178-zopenalex-snapshot
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
inferredcites →https://doi.org/10.1038/s41586-018-0497-0openalex-snapshot
Population dynamics of normal human blood inferred from somatic mutations
inferredcites →https://doi.org/10.1038/s41586-019-1362-5openalex-snapshot
Single-cell analysis reveals T cell infiltration in old neurogenic niches
inferredcites →https://doi.org/10.1038/s41588-020-0595-4openalex-snapshot
DNA methylation disruption reshapes the hematopoietic differentiation landscape
inferredcites →https://doi.org/10.1038/s41590-018-0296-7openalex-snapshot
N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation
inferredcites →https://doi.org/10.1038/s41590-020-00816-xopenalex-snapshot
The immunology of rheumatoid arthritis
inferredcites →https://doi.org/10.1038/s41590-020-0643-3openalex-snapshot
Sestrins induce natural killer function in senescent-like CD8+ T cells
inferredcites →https://doi.org/10.1038/s41591-018-0290-5openalex-snapshot
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency
inferredcites →https://doi.org/10.1038/s41591-019-0381-yopenalex-snapshot
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
inferredcites →https://doi.org/10.1038/srep30842openalex-snapshot
The aged lymphoid tissue environment fails to support naïve T cell homeostasis
inferredcites →https://doi.org/10.1038/srep32053openalex-snapshot
Correction: Corrigendum: Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos
inferredcites →https://doi.org/10.1056/nejmc1111708openalex-snapshot
TET2 and DNMT3A Mutations in Human T-Cell Lymphoma
inferredcites →https://doi.org/10.1056/nejmoa1114885openalex-snapshot
Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
inferredcites →https://doi.org/10.1056/nejmoa1408617openalex-snapshot
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
inferredcites →https://doi.org/10.1073/pnas.0705905104openalex-snapshot
Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates
inferredcites →https://doi.org/10.1073/pnas.0811332106openalex-snapshot
Telomerase insufficiency in rheumatoid arthritis
inferredcites →https://doi.org/10.1073/pnas.1109797109openalex-snapshot
Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
inferredcites →https://doi.org/10.1073/pnas.1209283110openalex-snapshot
Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age
inferredcites →https://doi.org/10.1073/pnas.1409155111openalex-snapshot
Diversity and clonal selection in the human T-cell repertoire
inferredcites →https://doi.org/10.1073/pnas.1607794113openalex-snapshot
Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing
inferredcites →https://doi.org/10.1073/pnas.1804149115openalex-snapshot
Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice
inferredcites →https://doi.org/10.1073/pnas.1902510116openalex-snapshot
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
inferredcites →https://doi.org/10.1073/pnas.1915008117openalex-snapshot
Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins
inferredcites →https://doi.org/10.1073/pnas.92.24.11091openalex-snapshot
Human naive and memory T lymphocytes differ in telomeric length and replicative potential.
inferredcites →https://doi.org/10.1080/21645515.2018.1560918openalex-snapshot
Immune responses to zoster vaccines
inferredcites →https://doi.org/10.1084/jem.179.3.951openalex-snapshot
Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes.
inferredcites →https://doi.org/10.1084/jem.20020066openalex-snapshot
Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells
inferredcites →https://doi.org/10.1084/jem.20020383openalex-snapshot
Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells
inferredcites →https://doi.org/10.1084/jem.20082251openalex-snapshot
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis
inferredcites →https://doi.org/10.1084/jem.20161066openalex-snapshot
Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
inferredcites →https://doi.org/10.1084/jem.20161760openalex-snapshot
Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis
inferredcites →https://doi.org/10.1084/jem.20170416openalex-snapshot
The chromatin accessibility signature of human immune aging stems from CD8+ T cells
inferredcites →https://doi.org/10.1084/jem.20170521openalex-snapshot
Reduced generation of lung tissue–resident memory T cells during infancy
inferredcites →https://doi.org/10.1093/gerona/glz029openalex-snapshot
Assessment of Lymph Node Stromal Cells as an Underlying Factor in Age-Related Immune Impairment
inferredcites →https://doi.org/10.1101/sqb.2008.73.008openalex-snapshot
Asymmetric Division and Stem Cell Renewal without a Permanent Niche: Lessons from Lymphocytes
inferredcites →https://doi.org/10.1111/acel.12311openalex-snapshot
Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover
inferredcites →https://doi.org/10.1111/acel.12865openalex-snapshot
Lymph nodes as barriers to T‐cell rejuvenation in aging mice and nonhuman primates
inferredcites →https://doi.org/10.1111/acel.12879openalex-snapshot
Functional pathways regulated by microRNA networks in CD8 T‐cell aging
inferredcites →https://doi.org/10.1111/acel.12956openalex-snapshot
Are skin senescence and immunosenescence linked within individuals?
inferredcites →https://doi.org/10.1111/acel.12957openalex-snapshot
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation
inferredcites →https://doi.org/10.1111/cei.12851openalex-snapshot
Immune senescence: significance of the stromal microenvironment
inferredcites →https://doi.org/10.1111/imm.12367openalex-snapshot
Immuno‐miRs: critical regulators of T‐cell development, function and ageing
inferredcites →https://doi.org/10.1111/imr.12693openalex-snapshot
Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium‐labeling experiments
inferredcites →https://doi.org/10.1111/imr.12694openalex-snapshot
The natural history of naive T cells from birth to maturity
inferredcites →https://doi.org/10.1111/imr.12838openalex-snapshot
Immunometabolism in the development of rheumatoid arthritis
inferredcites →https://doi.org/10.1111/j.1474-9726.2010.00549.xopenalex-snapshot
miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging
inferredcites →https://doi.org/10.1111/j.1474-9726.2012.00819.xopenalex-snapshot
Upregulation of miR‐24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death
inferredcites →https://doi.org/10.1126/sciadv.aba1808openalex-snapshot
FOXO1 deficiency impairs proteostasis in aged T cells
inferredcites →https://doi.org/10.1126/science.1139393openalex-snapshot
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
inferredcites →https://doi.org/10.1126/science.286.5441.958openalex-snapshot
A Direct Estimate of the Human αβ T Cell Receptor Diversity
inferredcites →https://doi.org/10.1126/science.aan4673openalex-snapshot
Clonal hematopoiesis in human aging and disease
inferredcites →https://doi.org/10.1126/sciimmunol.aaf6628openalex-snapshot
VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites
inferredcites →https://doi.org/10.1126/sciimmunol.aag0192openalex-snapshot
Epigenomics of human CD8 T cell differentiation and aging
inferredcites →https://doi.org/10.1126/sciimmunol.aah6506openalex-snapshot
Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites
inferredcites →https://doi.org/10.1126/sciimmunol.aao4013openalex-snapshot
Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
inferredcites →https://doi.org/10.1126/sciimmunol.aas9103openalex-snapshot
TCR signal strength controls the differentiation of CD4 + effector and memory T cells
inferredcites →https://doi.org/10.1146/annurev-immunol-042617-053019openalex-snapshot
Unraveling the Complex Interplay Between T Cell Metabolism and Function
inferredcites →https://doi.org/10.1146/annurev-immunol-042617-053352openalex-snapshot
Signaling and Function of Interleukin-2 in T Lymphocytes
inferredcites →https://doi.org/10.1146/annurev.immunol.22.012703.104702openalex-snapshot
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
inferredcites →https://doi.org/10.1172/jci.insight.134569openalex-snapshot
Immune cell repertoires in breast cancer patients after adjuvant chemotherapy
inferredcites →https://doi.org/10.1172/jci120216openalex-snapshot
Short telomere syndromes cause a primary T cell immunodeficiency
inferredcites →https://doi.org/10.1172/jci132417openalex-snapshot
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation
inferredcites →https://doi.org/10.1172/jci97377openalex-snapshot
Lymphoid tissue fibrosis is associated with impaired vaccine responses
inferredcites →https://doi.org/10.1182/blood-2002-07-2103openalex-snapshot
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
inferredcites →https://doi.org/10.1182/blood-2008-02-139154openalex-snapshot
Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets
inferredcites →https://doi.org/10.1182/blood-2008-10-184184openalex-snapshot
Quantifying the development of the peripheral naive CD4+ T-cell pool in humans
inferredcites →https://doi.org/10.1182/blood-2009-04-217604openalex-snapshot
Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells
inferredcites →https://doi.org/10.1182/blood-2015-10-672345openalex-snapshot
Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD
inferredcites →https://doi.org/10.1182/blood-2017-02-769869openalex-snapshot
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
inferredcites →https://doi.org/10.1186/1742-4933-5-6openalex-snapshot
Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people
inferredcites →https://doi.org/10.1186/gb-2013-14-10-r115openalex-snapshot
DNA methylation age of human tissues and cell types
inferredcites →https://doi.org/10.1186/s12979-020-00195-9openalex-snapshot
Genetic and environmental determinants of human TCR repertoire diversity
inferredcites →https://doi.org/10.1189/jlb.4a0316-112ropenalex-snapshot
CMV induces expansion of highly polyfunctional CD4+ T cell subset coexpressing CD57 and CD154
inferredcites →https://doi.org/10.1371/journal.pbio.2005523openalex-snapshot
Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness
inferredcites →https://doi.org/10.1371/journal.pone.0076217openalex-snapshot
Dual Role of miR-21 in CD4+ T-Cells: Activation-Induced miR-21 Supports Survival of Memory T-Cells and Regulates CCR7 Expression in Naive T-Cells
inferredcites →https://doi.org/10.1371/journal.pone.0076618openalex-snapshot
A Community Study of the Psychological Effects of the Omagh Car Bomb on Adults
inferredcites →https://doi.org/10.1371/journal.pone.0133627openalex-snapshot
Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging
inferredcites →https://doi.org/10.1371/journal.ppat.1003572openalex-snapshot
Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses
inferredcites →https://doi.org/10.1371/journal.ppat.1005892openalex-snapshot
Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals
inferredcites →https://doi.org/10.18632/aging.100705openalex-snapshot
Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase
inferredcites →https://doi.org/10.18632/aging.101414openalex-snapshot
An epigenetic biomarker of aging for lifespan and healthspan
inferredcites →https://doi.org/10.18632/aging.102438openalex-snapshot
Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy
inferredcites →https://doi.org/10.2217/epi-2016-0143openalex-snapshot
Age-Associated DNA Methylation Changes in Naive CD4 + T Cells Suggest an Evolving Autoimmune Epigenotype in Aging T Cells
inferredcites →https://doi.org/10.3324/haematol.2019.220889openalex-snapshot
Somatic mutations and T-cell clonality in patients with immunodeficiency
inferredcites →https://doi.org/10.3389/fimmu.2020.585168openalex-snapshot
Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells
inferredcites →https://doi.org/10.3390/cells9051181openalex-snapshot
The Aging of γδ T Cells
inferredcites →https://doi.org/10.3390/ijms21186497openalex-snapshot
The Transcription Factor TCF1 in T Cell Differentiation and Aging
inferredcites →https://doi.org/10.3390/ijms21238903openalex-snapshot
A Cell for the Ages: Human γδ T Cells across the Lifespan
inferredcites →https://doi.org/10.4049/jimmunol.0901784openalex-snapshot
ERK-Dependent T Cell Receptor Threshold Calibration in Rheumatoid Arthritis
inferredcites →https://doi.org/10.4049/jimmunol.1102514openalex-snapshot
Single-Cell Network Profiling of Peripheral Blood Mononuclear Cells from Healthy Donors Reveals Age- and Race-Associated Differences in Immune Signaling Pathway Activation
inferredcites →https://doi.org/10.4049/jimmunol.1201235openalex-snapshot
Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults
inferredcites →https://doi.org/10.4049/jimmunol.1202534openalex-snapshot
Human Neonatal Naive CD4+ T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a
inferredcites →https://doi.org/10.4049/jimmunol.1202914openalex-snapshot
Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors
inferredcites →https://doi.org/10.4049/jimmunol.1301721openalex-snapshot
Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans
inferredcites →https://doi.org/10.4049/jimmunol.1302509openalex-snapshot
Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells
inferredcites →https://doi.org/10.4049/jimmunol.1400553openalex-snapshot
Rapid Proliferation and Differentiation Impairs the Development of Memory CD8+ T Cells in Early Life
inferredcites →https://doi.org/10.4049/jimmunol.1401162openalex-snapshot
Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation
inferredcites →https://doi.org/10.4049/jimmunol.1402389openalex-snapshot
Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation
inferredcites →https://doi.org/10.4049/jimmunol.1600005openalex-snapshot
Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians
inferredcites →https://doi.org/10.4049/jimmunol.173.6.3725openalex-snapshot
Stimulatory Killer Ig-Like Receptors Modulate T Cell Activation through DAP12-Dependent and DAP12-Independent Mechanisms
inferredcites →https://doi.org/10.4049/jimmunol.174.11.7446openalex-snapshot
The Influence of Age on T Cell Generation and TCR Diversity
inferredcites →https://doi.org/10.4049/jimmunol.182.2.1138openalex-snapshot
Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA
inferredcites →https://doi.org/10.7554/elife.49900openalex-snapshot
The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes
inferredcites →https://doi.org/10.7554/elife.61639openalex-snapshot
Early life imprints the hierarchy of T cell clone sizes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Changes in Immune Cell Subtypes During Ageingchanges in Immune Cell Subtypes During Ageing
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Differential Diagnosis of Suspected Multiple Sclerosis in Pediatric and Late-Onset Populations
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Cellular senescence and the tumour microenvironment
inferred← citeshttps://doi.org/10.1002/cnr2.70648openalex-snapshot
TP53 Mutation and Tumor‐Infiltrating Lymphocytes as Predictors of PD ‐1/ PD ‐ L1 Inhibitor Efficacy in PD ‐ L1 ‐High Advanced NSCLC
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Biological Sex Influences Human Bystander CD8+ T Cell Activation
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Immune Aging, Immunosenescence, and Inflammaging: Implications for Vaccine Response in Older Adults
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High Versus Low Radiographic Burden Odontogenic Sinusitis: Culture, Histopathology, and Patient‐Reported Outcomes
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Polyphenol Treatment of Peripheral Blood Mononuclear Cells from Individuals of Different Ages
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Immunological Changes
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Inflammaging and Immunosenescence
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Real-world single-center experience with pixantrone in DLBCL prior to its withdrawal: clinical outcomes and exploratory immunologic observations
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Age as a risk factor in vasculitis
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Revealing endogenous conditions for Peto’s paradox via an ordinary differential equation model
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Age-associated polyamines in peripheral blood cells and plasma in 20 to 70 years of age subjects
inferred← citeshttps://doi.org/10.1007/s10522-022-09995-6openalex-snapshot
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components
inferred← citeshttps://doi.org/10.1007/s11427-023-2305-0openalex-snapshot
Biomarkers of aging
inferred← citeshttps://doi.org/10.1007/s11904-023-00674-wopenalex-snapshot
Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure
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On frailty and accelerated aging during SARS-Cov-2: senescence
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Aging-related neoplasia
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Introducing immunology: Types of immunity, immune responses, deficiencies, and disorders
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Effect of mitochondrial oxidative stress on regulatory T cell manufacturing for clinical application in transplantation: Results from a pilot study
inferred← citeshttps://doi.org/10.1016/j.anai.2025.10.026openalex-snapshot
2025 Inborn errors of immunity practice parameter
inferred← citeshttps://doi.org/10.1016/j.archger.2024.105376openalex-snapshot
Changes in immune cell subtypes during ageing
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102783openalex-snapshot
Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103109openalex-snapshot
Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging
inferred← citeshttps://doi.org/10.1016/j.asjsur.2024.03.145openalex-snapshot
Efficacy of immune checkpoint inhibitors for NSCLC in patients with different age: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.bbadis.2022.166393openalex-snapshot
Oxidative stress and endogenous DNA damage in blood mononuclear cells may predict anti-SARS-CoV-2 antibody titers after vaccination in older adults
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112195openalex-snapshot
TRIB2 safeguards naive T cell homeostasis during aging
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117728openalex-snapshot
CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging
inferred← citeshttps://doi.org/10.1016/j.cels.2024.11.009openalex-snapshot
Cracking the code of adaptive immunity: The role of computational tools
inferred← citeshttps://doi.org/10.1016/j.coviro.2021.09.017openalex-snapshot
Understanding T cell aging to improve anti-viral immunity
inferred← citeshttps://doi.org/10.1016/j.exger.2024.112646openalex-snapshot
Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure
inferred← citeshttps://doi.org/10.1016/j.humimm.2022.01.016openalex-snapshot
T cell senescence and impaired CMV-specific response are associated with infection risk in kidney transplant recipients
inferred← citeshttps://doi.org/10.1016/j.immuni.2023.10.013openalex-snapshot
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells
inferred← citeshttps://doi.org/10.1016/j.it.2025.04.006openalex-snapshot
Causes and consequences of T cell DNA damage
inferred← citeshttps://doi.org/10.1016/j.it.2025.04.008openalex-snapshot
Restraining the killers: regulation of T cell quiescence
inferred← citeshttps://doi.org/10.1016/j.it.2026.01.001openalex-snapshot
Postpandemic adjuvants to tailor vaccine-induced immunity
inferred← citeshttps://doi.org/10.1016/j.jaci.2023.04.010openalex-snapshot
Generation and durability of immune memory in older adults
inferred← citeshttps://doi.org/10.1016/j.jaip.2026.05.022openalex-snapshot
Risk Factors for Secondary Immunodeficiency in the Aged
inferred← citeshttps://doi.org/10.1016/j.jaut.2022.102947openalex-snapshot
T cell aging as a risk factor for autoimmunity
inferred← citeshttps://doi.org/10.1016/j.jhlto.2024.100199openalex-snapshot
T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates
inferred← citeshttps://doi.org/10.1016/j.jiph.2024.04.002openalex-snapshot
Age-related antibody response to Orthopoxviruses and implications for public health measures: Insights from a South Korean study
inferred← citeshttps://doi.org/10.1016/j.jtct.2024.05.001openalex-snapshot
Comparison of Older Related versus Younger Unrelated Donors for Older Recipients of Allogeneic Hematopoietic Cell Transplantation with Acute Myeloid Leukemia or Myelodysplastic Syndrome: A Large Single-Center Analysis
inferred← citeshttps://doi.org/10.1016/j.mad.2025.112144openalex-snapshot
Blood aging: From definition and mechanisms to clinical practice
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107323openalex-snapshot
The brain-protective mechanism of fecal microbiota transplantation from young donor mice in the natural aging process via exosome, gut microbiota, and metabolomics analyses
inferred← citeshttps://doi.org/10.1016/j.semarthrit.2025.152757openalex-snapshot
Is T-cell senescence associated with inflammatory arthritis and disease burden? A systematic review
inferred← citeshttps://doi.org/10.1016/j.smim.2023.101814openalex-snapshot
Immune aging – A mechanism in autoimmune disease
inferred← citeshttps://doi.org/10.1016/j.smim.2023.101839openalex-snapshot
Better safe than sorry: Naive T-cell dynamics in healthy ageing
inferred← citeshttps://doi.org/10.1016/j.vetimm.2024.110725openalex-snapshot
Canine T zone lymphoma is a tumor of mature, previously activated αβ T cells
inferred← citeshttps://doi.org/10.1016/j.virol.2026.111054openalex-snapshot
Immunopathogenesis of TB-HIV Co-Infection: Mechanisms of Dual Immune Suppression and Viral–Bacterial Synergy
inferred← citeshttps://doi.org/10.1016/s2665-9913(21)00253-8openalex-snapshot
New insights into the pathogenesis of giant cell arteritis: are they relevant for precision medicine?
inferred← citeshttps://doi.org/10.1038/s12276-025-01527-9openalex-snapshot
Targeting immunosenescence and inflammaging: advancing longevity research
inferred← citeshttps://doi.org/10.1038/s41467-026-75681-7openalex-snapshot
Fast, flexible analysis of differences in cellular composition with crumblr
inferred← citeshttps://doi.org/10.1038/s41556-024-01424-9openalex-snapshot
Three-dimensional chromatin reorganization regulates B cell development during ageing
inferred← citeshttps://doi.org/10.1038/s41568-025-00868-xopenalex-snapshot
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
inferred← citeshttps://doi.org/10.1038/s41581-023-00778-xopenalex-snapshot
Clonal haematopoiesis, ageing and kidney disease
inferred← citeshttps://doi.org/10.1038/s41590-022-01369-xopenalex-snapshot
Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses
inferred← citeshttps://doi.org/10.1038/s41590-024-01828-7openalex-snapshot
The aged tumor microenvironment limits T cell control of cancer
inferred← citeshttps://doi.org/10.1038/s41598-023-46637-4openalex-snapshot
Multi-variate model of T cell clonotype competition and homeostasis
inferred← citeshttps://doi.org/10.1038/s41598-025-04736-4openalex-snapshot
Immune age is correlated with decreased TCR clonal diversity and antibody response to SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41598-025-98194-7openalex-snapshot
Construction and evaluation of a prognostic model for breast cancer based on aging related genes
inferred← citeshttps://doi.org/10.1038/s43587-022-00343-4openalex-snapshot
Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination
inferred← citeshttps://doi.org/10.1038/s43587-025-00966-3openalex-snapshot
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression
inferred← citeshttps://doi.org/10.1073/pnas.2207516120openalex-snapshot
Inferring the T cell repertoire dynamics of healthy individuals
inferred← citeshttps://doi.org/10.1073/pnas.2322929121openalex-snapshot
Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function
inferred← citeshttps://doi.org/10.1080/1744666x.2022.2106217openalex-snapshot
An immunologist’s guide to immunosenescence and its treatment
inferred← citeshttps://doi.org/10.1080/21505594.2026.2679815openalex-snapshot
Do BKPyV genomic features underlie clinical divergence between kidney and hematopoietic transplant recipients?
inferred← citeshttps://doi.org/10.1093/biomtc/ujaf005openalex-snapshot
A regularized Bayesian Dirichlet-multinomial regression model for integrating single-cell-level omics and patient-level clinical study data
inferred← citeshttps://doi.org/10.1093/gerona/glae236openalex-snapshot
The Fourth Annual Symposium of the Midwest Aging Consortium
inferred← citeshttps://doi.org/10.1093/immhor/vlag036openalex-snapshot
The language of the immune system: Part 1: Cytokine conversations and conversationalists
inferred← citeshttps://doi.org/10.1093/ofid/ofac585openalex-snapshot
Immune Senescence Markers Predict the Cellular Immune Response to BNT162b2 Vaccination in Hemodialysis Patients
inferred← citeshttps://doi.org/10.1096/fj.202300515ropenalex-snapshot
Cholesterol metabolism in T‐cell aging: Accomplices or victims
inferred← citeshttps://doi.org/10.1101/2021.08.27.457205openalex-snapshot
The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4 + T cell responses of older adults
inferred← citeshttps://doi.org/10.1101/2022.05.01.490247openalex-snapshot
Inferring the T-cells repertoire dynamics of healthy individuals
inferred← citeshttps://doi.org/10.1101/2022.05.10.490700openalex-snapshot
Delayed antigen-specific CD4 + T-cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderly
inferred← citeshttps://doi.org/10.1101/2023.02.24.529806openalex-snapshot
Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian aging
inferred← citeshttps://doi.org/10.1101/2023.10.20.563147openalex-snapshot
Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer
inferred← citeshttps://doi.org/10.1101/2024.11.13.623449openalex-snapshot
IMMClock reveals immune aging and T cell function at single-cell resolution
inferred← citeshttps://doi.org/10.1101/2025.06.05.658069openalex-snapshot
Antigen-specific Th17 T cells offset the age-related decline in durable T cell immunity
inferred← citeshttps://doi.org/10.1101/2025.06.10.658841openalex-snapshot
Accumulation of SA-βGal–High Cells in Human Naïve T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State
inferred← citeshttps://doi.org/10.1101/2025.06.16.659752openalex-snapshot
Characterisation of distinct senescent-like T cell populations during healthy and unhealthy ageing
inferred← citeshttps://doi.org/10.1111/acel.13582openalex-snapshot
Quantitative restoration of immune defense in old animals determined by naive antigen‐specific CD8 T‐cell numbers
inferred← citeshttps://doi.org/10.1111/acel.13792openalex-snapshot
Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging
inferred← citeshttps://doi.org/10.1111/acel.70109openalex-snapshot
Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8 + T Cells Responding to Coronavirus Infection
inferred← citeshttps://doi.org/10.1111/cei.13606openalex-snapshot
Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender
inferred← citeshttps://doi.org/10.1111/imcb.12645openalex-snapshot
ChAdOx1 nCoV‐19 vaccination generates spike‐specific CD8+ T cells in aged mice
inferred← citeshttps://doi.org/10.1111/imr.13206openalex-snapshot
Senescent T cells: Beneficial and detrimental roles
inferred← citeshttps://doi.org/10.1111/joim.20080openalex-snapshot
Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases
inferred← citeshttps://doi.org/10.1111/tid.14051openalex-snapshot
Cowpox to COVID: History of vaccination in the immunocompromised host
inferred← citeshttps://doi.org/10.1126/sciadv.aea7131openalex-snapshot
Antigen-specific T H 17 cells offset the age-related decline in durable T cell immunity
inferred← citeshttps://doi.org/10.1126/sciadv.aeg1622openalex-snapshot
Aging-associated SATB1 deficiency remodels 3D genome architecture and transcriptional programs in naive CD4 + T cells
inferred← citeshttps://doi.org/10.1128/spectrum.02419-23openalex-snapshot
Integrating SARS-CoV-2-specific interferon-γ release assay testing in the evaluation of patients hospitalized with COVID-19
inferred← citeshttps://doi.org/10.1136/jitc-2024-009462openalex-snapshot
Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma
inferred← citeshttps://doi.org/10.1152/ajpheart.00570.2024openalex-snapshot
The role of T cells in vascular aging, hypertension, and atherosclerosis
inferred← citeshttps://doi.org/10.1152/ajpregu.00267.2023openalex-snapshot
CD8+ T-cell metabolism is related to cerebrovascular reactivity in middle-aged adults
inferred← citeshttps://doi.org/10.1158/2643-3230.bcd-25-0107openalex-snapshot
Rethinking Multiple Myeloma Treatment: The Biological and Clinical Insights Guiding Immune-Based Combinations
inferred← citeshttps://doi.org/10.1158/2767-9764.crc-26-0496openalex-snapshot
Impact of Proton versus Photon (Chemo)radiation on Circulating Immune Cells in Head and Neck Cancer
inferred← citeshttps://doi.org/10.1172/jci.insight.172848openalex-snapshot
PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age
inferred← citeshttps://doi.org/10.1183/16000617.0266-2023openalex-snapshot
Diverging patterns in innate immunity against respiratory viruses during a lifetime: lessons from the young and the old
inferred← citeshttps://doi.org/10.1186/s12964-025-02525-0openalex-snapshot
The cellular senescence–metabolism axis: emerging insights into T cell dynamics in the context of biological aging
inferred← citeshttps://doi.org/10.1186/s12974-026-03918-9openalex-snapshot
Antigen-specific adaptive immunity in Parkinson’s disease: peripheral priming, brain-border reactivation and parenchymal injury
inferred← citeshttps://doi.org/10.1186/s12979-021-00240-1openalex-snapshot
miR-181a-regulated pathways in T-cell differentiation and aging
inferred← citeshttps://doi.org/10.1186/s12979-022-00291-yopenalex-snapshot
Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
inferred← citeshttps://doi.org/10.1186/s12979-023-00369-1openalex-snapshot
Systemic immune response in young and elderly patients after traumatic brain injury
inferred← citeshttps://doi.org/10.1186/s12979-023-00399-9openalex-snapshot
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.1186/s40364-026-00968-2openalex-snapshot
Immunological decoding of adult T cell leukemia – its cell of origin and oncogenesis
inferred← citeshttps://doi.org/10.12677/acm.2026.1641554openalex-snapshot
Molecular Characteristics of CD57, Differential Expression and Functional Profiles across T-Cell and NK-Cell Subsets, Implications in Physiological Immune Aging, and Clinical Correlations in Diverse Disease Contexts
inferred← citeshttps://doi.org/10.1371/journal.ppat.1013866openalex-snapshot
Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity
inferred← citeshttps://doi.org/10.14336/ad.2023.0923openalex-snapshot
Immune Remodeling during Aging and the Clinical Significance of Immunonutrition in Healthy Aging
inferred← citeshttps://doi.org/10.15252/embr.202357925openalex-snapshot
Excessive apoptosis of Rip1‐deficient T cells leads to premature aging
inferred← citeshttps://doi.org/10.1667/rade-23-00065.1openalex-snapshot
Naive CD4 T Cells Highly Expressing the Inflammatory Chemokine Receptor CXCR3 Increase with Age and Radiation Exposure in Atomic Bomb Survivors
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1401703/v1openalex-snapshot
Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
inferred← citeshttps://doi.org/10.2147/ptt.s604199openalex-snapshot
Immunosenescence in Older Patients with Psoriasis: Mechanistic Insights and Opportunities for Biologic Therapy
inferred← citeshttps://doi.org/10.22625/2072-6732-2024-16-2-63-74openalex-snapshot
The impact of interferon receptor gene polymorphisms on humoral immunity to influenza and frequency of acute respiratory viral infections; taking into account vaccination status
inferred← citeshttps://doi.org/10.26599/agr.2023.9340007openalex-snapshot
Aging-related alternative splicing landscapes across human T cells
inferred← citeshttps://doi.org/10.26599/nr.2025.94907609openalex-snapshot
Nanomedicine strategies for ameliorating cancer by targeting immunosenescence: From challenge to opportunity
inferred← citeshttps://doi.org/10.31491/apt.2023.09.119openalex-snapshot
The role of immune aging in Giant Cell Arteritis
inferred← citeshttps://doi.org/10.31631/2073-3046-2023-22-6-183-200openalex-snapshot
Problems and Collisions of Vaccinology
inferred← citeshttps://doi.org/10.3389/fcimb.2026.1887322openalex-snapshot
Application of artificial intelligence in geriatric infection: recent advances and prospects
inferred← citeshttps://doi.org/10.3389/fcvm.2024.1384996openalex-snapshot
Inflammaging, immunosenescence, and cardiovascular aging: insights into long COVID implications
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1006941openalex-snapshot
Analysis of T cell repertoires of CD45RO CD4 T cells in cohorts of patients with bullous pemphigoid: A pilot study
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1298004openalex-snapshot
From aging to long COVID: exploring the convergence of immunosenescence, inflammaging, and autoimmunity
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1285798openalex-snapshot
Cytotoxic CD8+ Temra cells show loss of chromatin accessibility at genes associated with T cell activation
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1393324openalex-snapshot
Aging brain: exploring the interplay between bone marrow aging, immunosenescence, and neuroinflammation
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1455334openalex-snapshot
Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1585446openalex-snapshot
Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1621759openalex-snapshot
Mitochondrial unfolded protein response in regulatory T cell function: a protective mechanism in immune aging
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1742817openalex-snapshot
Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1895434openalex-snapshot
Beyond exhaustion: T cell fitness for next generation of immunotherapy for hematological cancer
inferred← citeshttps://doi.org/10.3389/fmed.2026.1775886openalex-snapshot
TREC dynamics as a biomarker of naive T-cell homeostasis in traumatic brain injury: a longitudinal analysis
inferred← citeshttps://doi.org/10.3389/fragi.2021.719342openalex-snapshot
Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals
inferred← citeshttps://doi.org/10.3389/fragi.2024.1490302openalex-snapshot
The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
inferred← citeshttps://doi.org/10.3389/fragi.2025.1568034openalex-snapshot
Multivariate analysis of immunosenescence data in healthy humans and diverse diseases
inferred← citeshttps://doi.org/10.3390/biom14101217openalex-snapshot
T Cell Peptide Prediction, Immune Response, and Host–Pathogen Relationship in Vaccinated and Recovered from Mild COVID-19 Subjects
inferred← citeshttps://doi.org/10.3390/cancers18091343openalex-snapshot
Immune Aging Within the Tumor Microenvironment Predicts Survival in Lung Adenocarcinoma
inferred← citeshttps://doi.org/10.3390/cancers18162542openalex-snapshot
Somatic Stem Cells: Control of Quiescence Versus Activation in Aging and Cancer
inferred← citeshttps://doi.org/10.3390/cells12232689openalex-snapshot
Sex and Age Impact CD4+ T Cell Susceptibility to HIV In Vitro through Cell Activation Dynamics
inferred← citeshttps://doi.org/10.3390/cells15080657openalex-snapshot
Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications
inferred← citeshttps://doi.org/10.3390/ijms222212539openalex-snapshot
How Immunosenescence and Inflammaging May Contribute to Hyperinflammatory Syndrome in COVID-19
inferred← citeshttps://doi.org/10.3390/ijms24032743openalex-snapshot
Natural Killer T-like Cells: Immunobiology and Role in Disease
inferred← citeshttps://doi.org/10.3390/ijms24108647openalex-snapshot
Melatonin and Cytokines Modulate Daily Instrumental Activities of Elderly People with SARS-CoV-2 Infection
inferred← citeshttps://doi.org/10.3390/ijms241713186openalex-snapshot
From Immunosenescence to Aging Types—Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation
inferred← citeshttps://doi.org/10.3390/ijms25020753openalex-snapshot
Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease
inferred← citeshttps://doi.org/10.3390/immuno4040023openalex-snapshot
Dynamics of Peripheral Lymphocyte Subsets from Birth until Old Age
inferred← citeshttps://doi.org/10.3390/jcm14186350openalex-snapshot
Uncovering the New Biology of Giant Cell Arteritis to Guide Therapeutic Strategies
inferred← citeshttps://doi.org/10.3390/jpm16060278openalex-snapshot
Genetic Determinants of T-Cell Homeostasis in Critical Illness: An Exploratory Analysis of Immune Gene Variants and TREC Dynamics
inferred← citeshttps://doi.org/10.3390/vaccines10040607openalex-snapshot
Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
inferred← citeshttps://doi.org/10.3390/vetsci10090541openalex-snapshot
Negative Influence of Aging on Differentiation and Proliferation of CD8+ T-Cells in Dogs
inferred← citeshttps://doi.org/10.37349/etat.2023.00186openalex-snapshot
A decade of CD4+ chimeric antigen receptor T-cell evolution in two chronic lymphocytic leukemia patients: were chronic lymphocytic leukemia cells present?
inferred← citeshttps://doi.org/10.4103/regenmed.regenmed-d-25-00012openalex-snapshot
Optimization of mononuclear cell collection material for chimeric antigen receptor T-cell therapy manufacturing: a narrative review
inferred← citeshttps://doi.org/10.47183/mes.2022-02openalex-snapshot
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Subpopulation composition of T-helpers in the peripheral blood of persons chronically exposed to radiation in the long term
inferred← citeshttps://doi.org/10.5217/ir.2024.00063openalex-snapshot
Factors affecting 1-year persistence with vedolizumab for ulcerative colitis: a multicenter, retrospective real-world study
inferred← citeshttps://doi.org/10.5312/wjo.v16.i4.103388openalex-snapshot
Senility, defecation disorders, sleep disorders, and non-operative spinal infections: A single-center retrospective analysis
inferred← citeshttps://doi.org/10.5772/intechopen.1015636openalex-snapshot
T Cells in Disease: From Dysregulation to Therapeutic Innovation
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Senescent white blood cells in colorectal carcinoma patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.20438160openalex-snapshot
Additional file 1 of Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
inferred← citeshttps://doi.org/10.6084/m9.figshare.20438163openalex-snapshot
Additional file 2 of Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
inferred← citeshttps://doi.org/10.6084/m9.figshare.20438166openalex-snapshot
Additional file 3 of Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
inferred← citeshttps://doi.org/10.6084/m9.figshare.23937245openalex-snapshot
Additional file 1 of Systemic immune response in young and elderly patients after traumatic brain injury
inferred← citeshttps://doi.org/10.6084/m9.figshare.23937248openalex-snapshot
Additional file 2 of Systemic immune response in young and elderly patients after traumatic brain injury
inferred← citeshttps://doi.org/10.6084/m9.figshare.23937251openalex-snapshot
Additional file 3 of Systemic immune response in young and elderly patients after traumatic brain injury
inferred← citeshttps://doi.org/10.6084/m9.figshare.24844603openalex-snapshot
Additional file 1 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.24844701openalex-snapshot
Additional file 2 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26654461openalex-snapshot
Additional file 3 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26654464openalex-snapshot
Additional file 4 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26654467openalex-snapshot
Additional file 5 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26654470openalex-snapshot
Additional file 6 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26654479openalex-snapshot
Additional file 7 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26654482openalex-snapshot
Additional file 8 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26654485openalex-snapshot
Additional file 9 of The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
inferred← citeshttps://doi.org/10.64898/2025.12.10.693494openalex-snapshot
High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the Brain
inferred← citeshttps://doi.org/10.64898/2026.07.02.26357118openalex-snapshot
Post-vaccination expansion of extrafollicular Th10 and regulatory Tfr cells distinguishes strong from weak influenza vaccine responses in older adults
inferred← citeshttps://doi.org/10.70675/211e0c0bzbf05z4531z8800z05b9b1a3a3aeopenalex-snapshot
Transcriptional and epigenetic responses of blood leukocytes in sows : towards new indicators of positive affective states
inferred← citeshttps://doi.org/10.70675/46537244ze125z43e1z9c39z92cf9f645f78openalex-snapshot
Efficacité et évolution de la réponse lymphocytaire T CD8 au cours de l'infection par VIH-1
inferred← citeshttps://doi.org/10.70675/625cdda6zca1dz443dzb6f4z3637549945b7openalex-snapshot
Statistical biophysics models of immune repertoire dynamics
inferred← citeshttps://doi.org/10.7554/elife.81464openalex-snapshot
Applying causal discovery to single-cell analyses using CausalCell
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