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A simple digital image analysis system for automated Ki67 assessment in primary breast cancer

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s10549-013-2560-8openalex-snapshot
Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry
inferredcites →https://doi.org/10.1007/s10549-015-3559-0openalex-snapshot
Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta-analysis of 64,196 patients
inferredcites →https://doi.org/10.1007/s10549-019-05163-6openalex-snapshot
Comparison of protein expression between formalin-fixed core-cut biopsies and surgical excision specimens using a novel multiplex approach
inferredcites →https://doi.org/10.1016/j.breast.2013.11.007openalex-snapshot
High Ki-67 score is indicative of a greater benefit from adjuvant chemotherapy when added to endocrine therapy in Luminal B HER2 negative and node-positive breast cancer
inferredcites →https://doi.org/10.1016/j.breast.2015.07.017openalex-snapshot
Strategies for developing Ki67 as a useful biomarker in breast cancer
inferredcites →https://doi.org/10.1016/j.breast.2016.11.016openalex-snapshot
POWERPIINC (PreOperative Window of Endocrine TheRapy Provides Information to Increase Compliance) trial: Changes in tumor proliferation index and quality of life with 7 days of preoperative tamoxifen
inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot
Hallmarks of Cancer: The Next Generation
inferredcites →https://doi.org/10.1016/s1470-2045(09)70262-1openalex-snapshot
Ki67 in breast cancer: prognostic and predictive potential
inferredcites →https://doi.org/10.1016/s1470-2045(20)30458-7openalex-snapshot
Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial
inferredcites →https://doi.org/10.1038/bjc.2011.569openalex-snapshot
Comparison of Visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer
inferredcites →https://doi.org/10.1038/labinvest.2014.7openalex-snapshot
A tissue quality index: an intrinsic control for measurement of effects of preanalytical variables on FFPE tissue
inferredcites →https://doi.org/10.1038/modpathol.2015.38openalex-snapshot
An international study to increase concordance in Ki67 scoring
inferredcites →https://doi.org/10.1038/npjbcancer.2016.14openalex-snapshot
Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration
inferredcites →https://doi.org/10.1038/s41379-018-0109-4openalex-snapshot
An international multicenter study to evaluate reproducibility of automated scoring for assessment of Ki67 in breast cancer
inferredcites →https://doi.org/10.1038/s41523-020-0168-9openalex-snapshot
Evidence-based guidelines for managing patients with primary ER+ HER2− breast cancer deferred from surgery due to the COVID-19 pandemic
inferredcites →https://doi.org/10.1038/sj.bjc.6603756openalex-snapshot
Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patients
inferredcites →https://doi.org/10.1038/srep00503openalex-snapshot
Detection and Segmentation of Cell Nuclei in Virtual Microscopy Images: A Minimum-Model Approach
inferredcites →https://doi.org/10.1093/annonc/mdp234openalex-snapshot
Discordance between core needle biopsy (CNB) and excisional biopsy (EB) for estrogen receptor (ER), progesterone receptor (PgR) and HER2 status in early breast cancer (EBC)
inferredcites →https://doi.org/10.1093/annonc/mdq738openalex-snapshot
Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial
inferredcites →https://doi.org/10.1093/jnci/djr393openalex-snapshot
Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group
inferredcites →https://doi.org/10.1093/jncimonographs/lgr034openalex-snapshot
Endocrine Therapy, New Biologicals, and New Study Designs for Presurgical Studies in Breast Cancer
inferredcites →https://doi.org/10.1097/pai.0b013e31817af2cfopenalex-snapshot
MIB-1 Cell Membrane Reactivity: A Finding That Should be Interpreted Carefully
inferredcites →https://doi.org/10.1111/his.13880openalex-snapshot
Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration
inferredcites →https://doi.org/10.1111/j.1365-2559.2006.02514.xopenalex-snapshot
Quantification of immunohistochemistry—issues concerning methods, utility and semiquantitative assessment I
inferredcites →https://doi.org/10.1136/jcp.2010.077578openalex-snapshot
Comparative validation of the SP6 antibody to Ki67 in breast cancer
inferredcites →https://doi.org/10.1155/2014/390618openalex-snapshot
Endocrine Resistance in Breast Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-1283openalex-snapshot
Standardized Ki67 Diagnostics Using Automated Scoring—Clinical Validation in the GeparTrio Breast Cancer Study
inferredcites →https://doi.org/10.1158/1538-7445.sabcs17-gs1-03openalex-snapshot
Abstract GS1-03: Peri-operative aromatase inhibitor treatment in determining or predicting longterm outcome in early breast cancer – The POETIC* Trial (CRUK/07/015)
inferredcites →https://doi.org/10.1186/1472-6890-11-3openalex-snapshot
Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer
inferredcites →https://doi.org/10.1186/1745-6215-14-261openalex-snapshot
WSG ADAPT – adjuvant dynamic marker-adjusted personalized therapy trial optimizing risk assessment and therapy response prediction in early breast cancer: study protocol for a prospective, multi-center, controlled, non-blinded, randomized, investigator initiated phase II/III trial
inferredcites →https://doi.org/10.1186/1746-1596-8-34openalex-snapshot
CognitionMaster: an object-based image analysis framework
inferredcites →https://doi.org/10.1186/bcr2719openalex-snapshot
Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer
inferredcites →https://doi.org/10.1186/s13058-019-1223-zopenalex-snapshot
Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients
inferredcites →https://doi.org/10.1186/s13058-020-01264-zopenalex-snapshot
MiR-7 reduces the BCSC subset by inhibiting XIST to modulate the miR-92b/Slug/ESA axis and inhibit tumor growth
inferredcites →https://doi.org/10.1200/jco.2006.09.6578openalex-snapshot
A Phase II Placebo-Controlled Trial of Neoadjuvant Anastrozole Alone or With Gefitinib in Early Breast Cancer
inferredcites →https://doi.org/10.1200/jco.2007.11.9453openalex-snapshot
Prognostic and Predictive Value of Centrally Reviewed Expression of Estrogen and Progesterone Receptors in a Randomized Trial Comparing Letrozole and Tamoxifen Adjuvant Therapy for Postmenopausal Early Breast Cancer: BIG 1-98
inferredcites →https://doi.org/10.1200/jco.2016.69.4406openalex-snapshot
Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance)
inferredcites →https://doi.org/10.1309/qphd-rb00-qxgm-uq9nopenalex-snapshot
Minimum Formalin Fixation Time for Consistent Estrogen Receptor Immunohistochemical Staining of Invasive Breast Carcinoma
inferredcites →https://doi.org/10.1371/journal.pone.0037379openalex-snapshot
How Reliable Is Ki-67 Immunohistochemistry in Grade 2 Breast Carcinomas? A QA Study of the Swiss Working Group of Breast- and Gynecopathologists
inferredcites →https://doi.org/10.1371/journal.pone.0188983openalex-snapshot
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer
inferredcites →https://doi.org/10.3390/cancers4030725openalex-snapshot
Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/hsr2.70412openalex-snapshot
Potential of Proliferative Markers in Pancreatic Cancer Management: A Systematic Review
inferred← citeshttps://doi.org/10.1002/path.6163openalex-snapshot
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects
inferred← citeshttps://doi.org/10.1007/s00428-026-04500-7openalex-snapshot
Optimization of Ki67 digital image analysis in breast cancer by automated tumor area identification
inferred← citeshttps://doi.org/10.1007/s12672-025-02233-8openalex-snapshot
Ki-67 and 21-gene recurrence score assay in decision making for adjuvant chemotherapy in breast cancer patients
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2026.140813openalex-snapshot
Sodium alginate hydrogel‑mediated local chemotherapy: A synergistic strategy for breast cancer therapy and postoperative wound repair
inferred← citeshttps://doi.org/10.1016/j.jpi.2022.100100openalex-snapshot
A digital method to interpret the C-MYC stain in diffuse large B cell lymphoma
inferred← citeshttps://doi.org/10.1016/j.mpdhp.2022.08.001openalex-snapshot
Bench to bedside: research influencing clinical practice in breast cancer
inferred← citeshttps://doi.org/10.1016/j.sciaf.2024.e02308openalex-snapshot
Protein biomarkers for diagnosis of breast cancer
inferred← citeshttps://doi.org/10.1016/j.vetpar.2025.110548openalex-snapshot
Dopaminergic neuropathology in calves naturally infected with Neospora caninum
inferred← citeshttps://doi.org/10.1038/s41379-022-01055-1openalex-snapshot
Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring
inferred← citeshttps://doi.org/10.1038/s41523-025-00745-8openalex-snapshot
Window-of-opportunity trials to screen effective agents and optimize dose in breast cancer prevention
inferred← citeshttps://doi.org/10.1038/s41698-026-01414-0openalex-snapshot
Validation of QuANTUM-derived tumor cell fraction for molecular testing in high-grade serous tubo-ovarian carcinoma
inferred← citeshttps://doi.org/10.1109/bibm55620.2022.9995030openalex-snapshot
MVSF: Multi-View Signature Fusion Network for Noninvasively Predicting Ki67 Status
inferred← citeshttps://doi.org/10.1111/his.70235openalex-snapshot
UK recommendations for Ki‐67 immunohistochemical staining and interpretation in breast cancer
inferred← citeshttps://doi.org/10.1177/17588359221122725openalex-snapshot
Clinical validity and clinical utility of Ki67 in early breast cancer
inferred← citeshttps://doi.org/10.1186/s12915-024-01980-4openalex-snapshot
Flow cytometric analysis for Ki67 assessment in formalin-fixed paraffin-embedded breast cancer tissue
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1222719openalex-snapshot
Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy
inferred← citeshttps://doi.org/10.3390/biom11111612openalex-snapshot
Independent Clinical Validation of the Automated Ki67 Scoring Guideline from the International Ki67 in Breast Cancer Working Group
inferred← citeshttps://doi.org/10.3390/diagnostics13193105openalex-snapshot
Use of a Novel Deep Learning Open-Source Model for Quantification of Ki-67 in Breast Cancer Patients in Pakistan: A Comparative Study between the Manual and Automated Methods
inferred← citeshttps://doi.org/10.3390/diagnostics14151584openalex-snapshot
Assessment of Ki-67 Proliferative Index in Cytological Samples of Nodal B-Cell Lymphomas
inferred← citeshttps://doi.org/10.3390/math13030417openalex-snapshot
RMD-Net: A Deep Learning Framework for Automated IHC Scoring of Lung Cancer IL-24
inferred← citeshttps://doi.org/10.6084/m9.figshare.26829014openalex-snapshot
Additional file 1 of Flow cytometric analysis for Ki67 assessment in formalin-fixed paraffin-embedded breast cancer tissue
inferred← citeshttps://doi.org/10.6084/m9.figshare.26829077openalex-snapshot
Additional file 2 of Flow cytometric analysis for Ki67 assessment in formalin-fixed paraffin-embedded breast cancer tissue
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