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S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC 5 AC via extracellular signal‐regulated kinase and nuclear factor‐κB pathways

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcb.21639openalex-snapshot
S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes
inferredcites →https://doi.org/10.1002/jcb.22575openalex-snapshot
Carboxylated N‐glycans on RAGE promote S100A12 binding and signaling
inferredcites →https://doi.org/10.1016/j.anai.2013.06.028openalex-snapshot
Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma
inferredcites →https://doi.org/10.1016/j.bbrc.2004.09.157openalex-snapshot
Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2–TAK1-dependent p38 MAPK-AP1 and IKKβ-IκBα-NF-κB signaling pathways
inferredcites →https://doi.org/10.1016/j.bbrc.2012.03.131openalex-snapshot
High-mobility group box-1 protein induces mucin 8 expression through the activation of the JNK and PI3K/Akt signal pathways in human airway epithelial cells
inferredcites →https://doi.org/10.1016/j.jaci.2006.08.021openalex-snapshot
S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity
inferredcites →https://doi.org/10.1016/j.jmb.2004.09.059openalex-snapshot
PMA Induces the MUC5AC Respiratory Mucin in Human Bronchial Epithelial Cells, via PKC, EGF/TGF-α, Ras/Raf, MEK, ERK and Sp1-dependent Mechanisms
inferredcites →https://doi.org/10.1016/j.yexcr.2005.10.013openalex-snapshot
S100A8 and S100A9 activate MAP kinase and NF-κB signaling pathways and trigger translocation of RAGE in human prostate cancer cells
inferredcites →https://doi.org/10.1016/s0021-9258(20)89506-4openalex-snapshot
Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells.
inferredcites →https://doi.org/10.1016/s0092-8674(00)80801-6openalex-snapshot
RAGE Mediates a Novel Proinflammatory Axis
inferredcites →https://doi.org/10.1034/j.1399-3003.1999.13a35.xopenalex-snapshot
Role of neutrophil elastase in hypersecretion in asthma
inferredcites →https://doi.org/10.1038/emboj.2012.309openalex-snapshot
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis
inferredcites →https://doi.org/10.1038/modpathol.3800661openalex-snapshot
The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?
inferredcites →https://doi.org/10.1038/nm.2150openalex-snapshot
The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
inferredcites →https://doi.org/10.1038/nm1638openalex-snapshot
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
inferredcites →https://doi.org/10.1038/sj.cdd.4401850openalex-snapshot
TLR signaling
inferredcites →https://doi.org/10.1074/jbc.273.12.6812openalex-snapshot
Cloning of the Amino-terminal and 5′-Flanking Region of the Human MUC5AC Mucin Gene and Transcriptional Up-regulation by Bacterial Exoproducts
inferredcites →https://doi.org/10.1074/jbc.m006993200openalex-snapshot
Coregulation of Neurite Outgrowth and Cell Survival by Amphoterin and S100 Proteins through Receptor for Advanced Glycation End Products (RAGE) Activation
inferredcites →https://doi.org/10.1074/jbc.m204862200openalex-snapshot
Induction of MUC2 and MUC5AC Mucins by Factors of the Epidermal Growth Factor (EGF) Family Is Mediated by EGF Receptor/Ras/Raf/Extracellular Signal-regulated Kinase Cascade and Sp1*
inferredcites →https://doi.org/10.1074/jbc.m300096200openalex-snapshot
Interleukin-1β and Tumor Necrosis Factor-α Induce MUC5AC Overexpression through a Mechanism Involving ERK/p38 Mitogen-activated Protein Kinases-MSK1-CREB Activation in Human Airway Epithelial Cells
inferredcites →https://doi.org/10.1074/jbc.m305790200openalex-snapshot
Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways
inferredcites →https://doi.org/10.1074/jbc.m507977200openalex-snapshot
Tumor Necrosis Factor-α Triggers Mucus Production in Airway Epithelium through an IκB Kinase β-dependent Mechanism
inferredcites →https://doi.org/10.1074/jbc.m803732200openalex-snapshot
Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway
inferredcites →https://doi.org/10.1097/shk.0b013e318186262dopenalex-snapshot
ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO
inferredcites →https://doi.org/10.1111/cei.12139openalex-snapshot
S100A9 promotes human lung fibroblast cells activation through receptor for advanced glycation end-product-mediated extracellular-regulated kinase 1/2, mitogen-activated protein-kinase and nuclear factor-κB-dependent pathways
inferredcites →https://doi.org/10.1111/j.1365-2222.2008.03186.xopenalex-snapshot
Expression profiling of genes related to asthma exacerbations
inferredcites →https://doi.org/10.1111/j.1365-2249.2009.03986.xopenalex-snapshot
Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages
inferredcites →https://doi.org/10.1111/j.1365-2567.2012.03619.xopenalex-snapshot
Induction of nuclear factor‐κ B responses by the S 100 A 9 protein is Toll‐like receptor‐4‐dependent
inferredcites →https://doi.org/10.1139/y09-054openalex-snapshot
S100A8/A9: a mediator of severe asthma pathogenesis and morbidity?This article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.
inferredcites →https://doi.org/10.1146/annurev-immunol-020711-074942openalex-snapshot
Neutrophil Function: From Mechanisms to Disease
inferredcites →https://doi.org/10.1146/annurev.physiol.70.113006.100441openalex-snapshot
Regulation of Airway Mucin Gene Expression
inferredcites →https://doi.org/10.1152/ajplung.1999.276.5.l835openalex-snapshot
Neutrophil elastase increasesMUC5ACmRNA and protein expression in respiratory epithelial cells
inferredcites →https://doi.org/10.1164/ajrccm.160.3.9812110openalex-snapshot
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
inferredcites →https://doi.org/10.1164/ajrccm.160.5.9806170openalex-snapshot
Neutrophilic Inflammation in Severe Persistent Asthma
inferredcites →https://doi.org/10.1164/ajrccm.163.2.2004039openalex-snapshot
Mild and Moderate Asthma Is Associated with Airway Goblet Cell Hyperplasia and Abnormalities in Mucin Gene Expression
inferredcites →https://doi.org/10.1164/rccm.200304-505soopenalex-snapshot
Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
inferredcites →https://doi.org/10.1164/rccm.201209-1602ocopenalex-snapshot
Proinflammatory S100A12 Can Activate Human Monocytes via Toll-like Receptor 4
inferredcites →https://doi.org/10.1165/ajrcmb.22.3.3768openalex-snapshot
Muc-5/5ac Mucin Messenger RNA and Protein Expression Is a Marker of Goblet Cell Metaplasia in Murine Airways
inferredcites →https://doi.org/10.1165/rcmb.2012-0492tropenalex-snapshot
The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon?
inferredcites →https://doi.org/10.1182/blood-2004-07-2520openalex-snapshot
Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells
inferredcites →https://doi.org/10.1186/1465-9921-6-116openalex-snapshot
Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide
inferredcites →https://doi.org/10.1186/ar1939openalex-snapshot
The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis
inferredcites →https://doi.org/10.1189/jlb.0306170openalex-snapshot
S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
inferredcites →https://doi.org/10.1189/jlb.0607397openalex-snapshot
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
inferredcites →https://doi.org/10.1189/jlb.1008647openalex-snapshot
The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
inferredcites →https://doi.org/10.1189/jlb.1009676openalex-snapshot
Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism
inferredcites →https://doi.org/10.1371/journal.pbio.1000097openalex-snapshot
Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides
inferredcites →https://doi.org/10.1371/journal.pone.0038629openalex-snapshot
Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity
inferredcites →https://doi.org/10.1378/chest.08-0422openalex-snapshot
Advances in Neutrophil Biology
inferredcites →https://doi.org/10.3904/kjim.2005.20.4.275openalex-snapshot
Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
inferredcites →https://doi.org/10.4049/jimmunol.1003606openalex-snapshot
MUC5AC Expression through Bidirectional Communication of Notch and Epidermal Growth Factor Receptor Pathways
inferredcites →https://doi.org/10.4049/jimmunol.170.6.3233openalex-snapshot
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
inferredcites →https://doi.org/10.4049/jimmunol.171.5.2602openalex-snapshot
Blockade of S100A8 and S100A9 Suppresses Neutrophil Migration in Response to Lipopolysaccharide
inferredcites →https://doi.org/10.4049/jimmunol.175.6.4009openalex-snapshot
Neutrophil Elastase Induces MUC5AC Mucin Production in Human Airway Epithelial Cells via a Cascade Involving Protein Kinase C, Reactive Oxygen Species, and TNF-α-Converting Enzyme

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4656875openalex-extracted
inferred← citeshttps://doi.org/10.1002/2211-5463.12719openalex-snapshot
Identification of differentially expressed genes and signaling pathways in chronic obstructive pulmonary disease via bioinformatic analysis
inferred← citeshttps://doi.org/10.1002/cbin.10840openalex-snapshot
Blocking the ERK1/2 signal pathway can inhibit S100A12 induced human aortic smooth muscle cells damage
inferred← citeshttps://doi.org/10.1002/ctm2.1771openalex-snapshot
Endotypes of severe neutrophilic and eosinophilic asthma from multi‐omics integration of U‐BIOPRED sputum samples
inferred← citeshttps://doi.org/10.1002/jcb.26568openalex-snapshot
Retracted: Effects of S100A12 gene silencing on serum levels of anti‐inflammatory/pro‐inflammatory cytokines in septic rats through the ERK signaling pathway
inferred← citeshttps://doi.org/10.1002/jgm.70107openalex-snapshot
S100A8 Mediating TLR4/NF‐κB Axis Activation to Inhibit Diabetic Foot Healing in Bacterial Colonization
inferred← citeshttps://doi.org/10.1002/kjm2.12651openalex-snapshot
S100A9 promotes tumor‐associated macrophage for M2 macrophage polarization to drive human liver cancer progression: An in vitro study
inferred← citeshttps://doi.org/10.1002/oto2.91openalex-snapshot
Cell Type Catalog of Middle Turbinate Epithelium (Cell Catalog of Turbinate Epithelium)
inferred← citeshttps://doi.org/10.1002/pmic.201400169openalex-snapshot
Investigation of phosphoproteome in RAGE signaling
inferred← citeshttps://doi.org/10.1002/rai2.12046openalex-snapshot
Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases
inferred← citeshttps://doi.org/10.1007/978-3-319-28486-6_5openalex-snapshot
Chronic Obstructive Pulmonary Disease Following Bronchopulmonary Dysplasia
inferred← citeshttps://doi.org/10.1007/978-981-13-8413-4_11openalex-snapshot
Immunological Basis of Oxidative Stress-Induced Lung Inflammation in Asthma and COPD
inferred← citeshttps://doi.org/10.1007/s00005-016-0405-yopenalex-snapshot
Transcription Factor NF-κB: An Update on Intervention Strategies
inferred← citeshttps://doi.org/10.1007/s00011-018-1173-4openalex-snapshot
Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer
inferred← citeshttps://doi.org/10.1007/s00408-020-00376-9openalex-snapshot
Association Between Serum S100A8/S100A9 Heterodimer and Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.1007/s10571-019-00731-2openalex-snapshot
Genetic and Molecular Biology of Multiple Sclerosis Among Iranian Patients: An Overview
inferred← citeshttps://doi.org/10.1007/s11596-022-2559-7openalex-snapshot
Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness
inferred← citeshttps://doi.org/10.1007/s12016-020-08815-4openalex-snapshot
The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.1007/s13402-018-0392-6openalex-snapshot
TLR4 and RAGE conversely mediate pro-inflammatory S100A8/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms
inferred← citeshttps://doi.org/10.1016/b978-0-323-82763-8.00025-xopenalex-snapshot
Cystic Fibrosis
inferred← citeshttps://doi.org/10.1016/bs.acc.2020.02.006openalex-snapshot
S100 family proteins in inflammation and beyond
inferred← citeshttps://doi.org/10.1016/j.alit.2022.08.005openalex-snapshot
S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.06.057openalex-snapshot
Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.153426openalex-snapshot
Unveiling the therapeutic potential of Resveratrol against neutrophil-mediated hyperinflammation in sepsis: An in-silico, molecular docking, and ex-vivo approach
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122546openalex-snapshot
A functional 3D full-thickness model for comprehending the interaction between airway epithelium and connective tissue in cystic fibrosis
inferred← citeshttps://doi.org/10.1016/j.cbi.2016.06.024openalex-snapshot
Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.111929openalex-snapshot
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112525openalex-snapshot
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
inferred← citeshttps://doi.org/10.1016/j.chest.2017.11.008openalex-snapshot
Mucins, Mucus, and Goblet Cells
inferred← citeshttps://doi.org/10.1016/j.cyto.2023.156387openalex-snapshot
Prognostic significance of peripheral blood S100A12, S100A8, and S100A9 concentrations in idiopathic pulmonary fibrosis
inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.12.025openalex-snapshot
Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115173openalex-snapshot
Protective effects and mechanisms of N-acetylcysteine on indomethacin-induced intestinal injury in a porcine model
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174467openalex-snapshot
Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation
inferred← citeshttps://doi.org/10.1016/j.fsi.2022.10.011openalex-snapshot
Characterization of S100A12 from nile tilapia (Oreochromis niloticus) and its roles on inflammatory responses
inferred← citeshttps://doi.org/10.1016/j.ijporl.2017.07.025openalex-snapshot
Expression of calcium-binding proteins S100A8, S100A9 and S100A12 in otitis media
inferred← citeshttps://doi.org/10.1016/j.intimp.2016.07.007openalex-snapshot
Cold-inducible RNA-binding protein mediates cold air inducible airway mucin production through TLR4/NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2016.07.010openalex-snapshot
Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke
inferred← citeshttps://doi.org/10.1016/j.intimp.2018.01.001openalex-snapshot
Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways
inferred← citeshttps://doi.org/10.1016/j.intimp.2018.04.009openalex-snapshot
Myeloid related proteins are up-regulated in autoimmune thyroid diseases and activate toll-like receptor 4 and pro-inflammatory cytokines in vitro
inferred← citeshttps://doi.org/10.1016/j.isci.2026.117452openalex-snapshot
The persulfidome of alveolar epithelial cells reveals persulfidation of calprotectin as critical to preserve its antifungal activity
inferred← citeshttps://doi.org/10.1016/j.jaci.2021.12.761openalex-snapshot
Refractory neutrophilic asthma and ciliary genes
inferred← citeshttps://doi.org/10.1016/j.jcf.2015.03.003openalex-snapshot
Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
inferred← citeshttps://doi.org/10.1016/j.jep.2016.08.044openalex-snapshot
Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2016.10.029openalex-snapshot
A standardized bark extract of Pinus pinaster Aiton (Pycnogenol®) attenuated chronic obstructive pulmonary disease via Erk-sp1 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jid.2016.10.040openalex-snapshot
S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis
inferred← citeshttps://doi.org/10.1016/j.jid.2018.10.021openalex-snapshot
Phosphatidylglycerol Inhibits Toll-Like Receptor–Mediated Inflammation by Danger-Associated Molecular Patterns
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2026.110286openalex-snapshot
Maternal fructose consumption differentially programs the allergic airway response in male and female mouse offspring
inferred← citeshttps://doi.org/10.1016/j.mam.2021.100995openalex-snapshot
Cellular and molecular mechanisms of allergic asthma
inferred← citeshttps://doi.org/10.1016/j.micinf.2024.105421openalex-snapshot
S100A12 inhibits Streptococcus pneumoniae and aids in wound healing of corneal epithelial cells both in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2016.07.015openalex-snapshot
S100A8/A9: From basic science to clinical application
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107442openalex-snapshot
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with human cells
inferred← citeshttps://doi.org/10.1016/j.prrv.2017.03.012openalex-snapshot
All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses
inferred← citeshttps://doi.org/10.1016/j.pupt.2020.101896openalex-snapshot
Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury
inferred← citeshttps://doi.org/10.1016/j.toxlet.2018.09.010openalex-snapshot
RAGE mediates β-catenin stabilization via activation of the Src/p-Cav-1 axis in a chemical-induced asthma model
inferred← citeshttps://doi.org/10.1016/j.tvjl.2026.106606openalex-snapshot
In vivo transcriptomic profiling of colonic mucosa during Brachyspira hyodysenteriae infection in pigs
inferred← citeshttps://doi.org/10.1016/s2213-2600(24)00176-0openalex-snapshot
Rethinking bronchiectasis as an inflammatory disease
inferred← citeshttps://doi.org/10.1038/ni.3045openalex-snapshot
Respiratory epithelial cells orchestrate pulmonary innate immunity
inferred← citeshttps://doi.org/10.1038/onc.2015.478openalex-snapshot
MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling
inferred← citeshttps://doi.org/10.1038/s41380-024-02574-wopenalex-snapshot
Integration of multi-omics summary data reveals the role of N6-methyladenosine in neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1038/s41392-023-01344-4openalex-snapshot
Pathogenesis of allergic diseases and implications for therapeutic interventions
inferred← citeshttps://doi.org/10.1038/s41467-025-64302-4openalex-snapshot
Eosinophil-derived interleukin-24 compromises epithelial integrity and aggravates airway remodeling in mouse models of allergic asthma
inferred← citeshttps://doi.org/10.1038/s41598-019-54292-xopenalex-snapshot
Altered generation of ciliated cells in chronic obstructive pulmonary disease
inferred← citeshttps://doi.org/10.1038/s41598-020-58534-1openalex-snapshot
S100A12 is a promising biomarker in papillary thyroid cancer
inferred← citeshttps://doi.org/10.1038/s42003-021-02769-9openalex-snapshot
Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology
inferred← citeshttps://doi.org/10.1074/mcp.m115.050773openalex-snapshot
Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein–Protein Interaction Data*
inferred← citeshttps://doi.org/10.1080/02770903.2022.2051544openalex-snapshot
Identification of hub genes and potential biomarkers of neutrophilic asthma: evidence from a bioinformatics analysis
inferred← citeshttps://doi.org/10.1080/08820139.2021.1928183openalex-snapshot
sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma
inferred← citeshttps://doi.org/10.1080/08958378.2018.1561769openalex-snapshot
Involvement of PM2.5-bound protein and metals in PM2.5-induced allergic airway inflammation in mice
inferred← citeshttps://doi.org/10.1080/09273948.2018.1547835openalex-snapshot
Proinflammatory Effects of Calprotectin in Graves’ Orbitopathy
inferred← citeshttps://doi.org/10.1080/19336918.2024.2434209openalex-snapshot
Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer
inferred← citeshttps://doi.org/10.1080/2162402x.2016.1260213openalex-snapshot
S100A8+stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma
inferred← citeshttps://doi.org/10.1093/biolre/ioab188openalex-snapshot
The alarmin S100A12 causes sterile inflammation of the human chorioamniotic membranes as well as preterm birth and neonatal mortality in mice
inferred← citeshttps://doi.org/10.1093/biolre/ioac039openalex-snapshot
Calcium-binding proteins S100A8, S100A9, and S100A12: expression and regulation at the maternal-conceptus interface in pigs
inferred← citeshttps://doi.org/10.1093/cei/uxac019openalex-snapshot
Clinical features and nasal inflammation in asthma and allergic rhinitis
inferred← citeshttps://doi.org/10.1093/jimmun/vkaf298openalex-snapshot
Maternal proteome profiling reveals dynamic gestational age-specific responses to de novo vaccination
inferred← citeshttps://doi.org/10.1097/aci.0000000000000507openalex-snapshot
Neutrophil activation in occupational asthma
inferred← citeshttps://doi.org/10.1101/2022.10.09.511503openalex-snapshot
Cell type catalog of middle turbinate epithelium
inferred← citeshttps://doi.org/10.1111/all.14600openalex-snapshot
The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease
inferred← citeshttps://doi.org/10.1111/cea.12712openalex-snapshot
Chronic inflammatory airway diseases: the central role of the epithelium revisited
inferred← citeshttps://doi.org/10.1111/cea.13986openalex-snapshot
Transcriptomics of biopsies identifies novel genes and pathways linked to neutrophilic inflammation in severe asthma
inferred← citeshttps://doi.org/10.1111/cea.14229openalex-snapshot
Exploring proteomic plasma biomarkers in eosinophilic and neutrophilic asthma
inferred← citeshttps://doi.org/10.1111/iej.13966openalex-snapshot
Effects of glycation end‐products on the dental pulp in patients with type 2 diabetes
inferred← citeshttps://doi.org/10.1111/jicd.12290openalex-snapshot
Association of S100 calcium‐binding protein A12, receptor for advanced glycation endproducts, and nuclear factor‐κB expression with inflammation in pulp tissues from tooth caries
inferred← citeshttps://doi.org/10.1111/resp.13302openalex-snapshot
S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension
inferred← citeshttps://doi.org/10.1111/resp.14111openalex-snapshot
Time‐resolved proteomic profiling of cigarette smoke‐induced experimental chronic obstructive pulmonary disease
inferred← citeshttps://doi.org/10.1126/scitranslmed.adf3843openalex-snapshot
Neutrophil extracellular trap production and CCL4L2 expression influence corticosteroid response in asthma
inferred← citeshttps://doi.org/10.1128/iai.00544-15openalex-snapshot
The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence
inferred← citeshttps://doi.org/10.1146/annurev-physiol-061121-035838openalex-snapshot
Extracellular Vesicles as Central Mediators of COPD Pathophysiology
inferred← citeshttps://doi.org/10.1155/2016/1462563openalex-snapshot
Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK
inferred← citeshttps://doi.org/10.1155/2019/3515026openalex-snapshot
Role of Calprotectin as a Biomarker in Periodontal Disease
inferred← citeshttps://doi.org/10.1155/2020/2868373openalex-snapshot
S100A12 in Digestive Diseases and Health: A Scoping Review
inferred← citeshttps://doi.org/10.1155/2021/8896108openalex-snapshot
Inhibitory Effect of Paquinimod on a Murine Model of Neutrophilic Asthma Induced by Ovalbumin with Complete Freund’s Adjuvant
inferred← citeshttps://doi.org/10.1155/2021/9998697openalex-snapshot
Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID‐19
inferred← citeshttps://doi.org/10.1159/000441678openalex-snapshot
Serum S100A8 and S100A9 Enhance Innate Immune Responses in the Pathogenesis of Baker's Asthma
inferred← citeshttps://doi.org/10.1159/000464136openalex-snapshot
Interferon-β 1a Modulates Expression of RAGE but Not S100A12 and Nuclear Factor-κB in Multiple Sclerosis Patients
inferred← citeshttps://doi.org/10.11606/t.17.2023.tde-10042023-164825openalex-snapshot
S100A9 induz a cronificação da inflamação psoriasiforme pelo aumento da imunidade do tipo 3 dependente de IL-23
inferred← citeshttps://doi.org/10.1161/atvbaha.120.315527openalex-snapshot
Journey to a Receptor for Advanced Glycation End Products Connection in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
inferred← citeshttps://doi.org/10.1165/rcmb.2014-0356ocopenalex-snapshot
The Effects of In Utero Vitamin D Deficiency on Airway Smooth Muscle Mass and Lung Function
inferred← citeshttps://doi.org/10.1165/rcmb.2020-0302ocopenalex-snapshot
Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells
inferred← citeshttps://doi.org/10.1177/0194599817691258openalex-snapshot
Do Aging Factors Influence the Clinical Presentation and Management of Chronic Rhinosinusitis?
inferred← citeshttps://doi.org/10.1177/0300060519887841openalex-snapshot
Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease
inferred← citeshttps://doi.org/10.1183/13993003.01569-2016openalex-snapshot
Proteomic profile of cystic fibrosis sputum cells in adults chronically infected withPseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1186/s12864-017-4107-6openalex-snapshot
Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma
inferred← citeshttps://doi.org/10.1186/s12931-017-0657-zopenalex-snapshot
IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells
inferred← citeshttps://doi.org/10.1186/s12931-019-0973-6openalex-snapshot
Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells
inferred← citeshttps://doi.org/10.1186/s12931-020-1317-2openalex-snapshot
Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells
inferred← citeshttps://doi.org/10.1186/s12931-023-02604-1openalex-snapshot
S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.12659/msm.905509openalex-snapshot
Effects of 1,25-Dihydroxyvitamin D3 on the Prevention of Chronic Obstructive Pulmonary Disease (COPD) in Rats Exposed to Air Pollutant Particles Less than 2.5 Micrometers in Diameter (PM2.5)
inferred← citeshttps://doi.org/10.12677/hjbm.2025.151023openalex-snapshot
The Research Progress of S100A9 in Fibrotic Diseases
inferred← citeshttps://doi.org/10.1371/journal.pone.0162000openalex-snapshot
Blocking the Interactions between Calcium-Bound S100A12 Protein and the V Domain of RAGE Using Tranilast
inferred← citeshttps://doi.org/10.1371/journal.pone.0324007openalex-snapshot
Uncovering common disease mechanisms and critical biomarkers in Crohn’s disease with concurrent psoriasis and exploring potential therapeutic agents
inferred← citeshttps://doi.org/10.1371/journal.pone.0331325openalex-snapshot
Global transcriptional analysis of human FHs 74 Int intestinal epithelial cells after exposure to advanced glycation end products
inferred← citeshttps://doi.org/10.15616/bsl.2016.22.2.60openalex-snapshot
S100A8 Induces Secretion of MCP-1, IL-6, and IL-8 via TLR4 in Jurkat T Cells
inferred← citeshttps://doi.org/10.15616/bsl.2020.26.3.226openalex-snapshot
Inhibitory Effect of S100A8 on Neutrophil Apoptosis by Cytokine Release of Normal and Allergic Monocytes
inferred← citeshttps://doi.org/10.15789/2220-7619-pas-1253openalex-snapshot
Pseudomonas aeruginosa significantly increases expression of receptor for advanced glycation endproducts (RAGE) in the septicemia suffering patients
inferred← citeshttps://doi.org/10.18632/oncotarget.24022openalex-snapshot
Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3122211/v1openalex-snapshot
Prognostic significance of peripheral blood S100A12, S100A8, S100A9 concentrations in idiopathic pulmonary fibrosis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-7901738/v1openalex-snapshot
Proteomic and Crotonylomic Integration of a Self-Established IgA Nephropathy Cohort Reveals Dysregulated Secretory Proteins and Immune Cell Regulators
inferred← citeshttps://doi.org/10.2147/jmdh.s495121openalex-snapshot
Unveiling Ventilator-Associated Pneumonia: S100A8 as a Promising Biomarker Through Integrated RNA-Seq Analysis
inferred← citeshttps://doi.org/10.2174/0929867327999200819145327openalex-snapshot
Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD
inferred← citeshttps://doi.org/10.29296/24999490-2024-04-01openalex-snapshot
FUNCTIONAL CHARACTERISTICS OF THE RAGE MOLECULE IN INTERCELLULAR INTERACTIONS IN NORMAL AND LUNG PATHOLOGY
inferred← citeshttps://doi.org/10.30782/jrvm.878763openalex-snapshot
Investigation of Calprotectin Positive Leukocytes in Canine Soft Tissue Tumors
inferred← citeshttps://doi.org/10.3389/fimmu.2017.01908openalex-snapshot
S100 Proteins As an Important Regulator of Macrophage Inflammation
inferred← citeshttps://doi.org/10.3389/fimmu.2018.00304openalex-snapshot
Coevolution of the Toll-Like Receptor 4 Complex with Calgranulins and Lipopolysaccharide
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01445openalex-snapshot
Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00761openalex-snapshot
More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis
inferred← citeshttps://doi.org/10.3389/fimmu.2021.714026openalex-snapshot
Associations of Serum S100A12 With Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Prospective Cohort Study
inferred← citeshttps://doi.org/10.3389/fimmu.2022.810338openalex-snapshot
S100A12 as Biomarker of Disease Severity and Prognosis in Patients With Idiopathic Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1191645openalex-snapshot
Pathogenic role of S100 proteins in psoriasis
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1745853openalex-snapshot
Modulation of host inflammatory pathways by Pseudomonas aeruginosa extracellular vesicles in cystic fibrosis: impact of pulmonary exacerbation and elexacaftor-tezacaftor-ivacaftor treatment
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1768140openalex-snapshot
Klebsiella pneumoniae infection induces an S100A8/A9-mediated autocrine loop in human airway epithelium to amplify inflammation
inferred← citeshttps://doi.org/10.3389/fneur.2021.807646openalex-snapshot
Single-Cell Transcriptome Profiling Unravels Distinct Peripheral Blood Immune Cell Signatures of RRMS and MOG Antibody-Associated Disease
inferred← citeshttps://doi.org/10.3390/biom14121550openalex-snapshot
Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses
inferred← citeshttps://doi.org/10.3390/biom5031266openalex-snapshot
NF-kappaB Signaling in Chronic Inflammatory Airway Disease
inferred← citeshttps://doi.org/10.3390/biomedicines13112829openalex-snapshot
Factors Released by Polarized Neutrophil-like Cells Modulate Cardiac Fibroblast Phenotype and Limit the Inflammatory Response After Myocardial Infarction
inferred← citeshttps://doi.org/10.3390/cells12182208openalex-snapshot
The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation
inferred← citeshttps://doi.org/10.3390/diagnostics11020207openalex-snapshot
A Review of Selected IBD Biomarkers: From Animal Models to Bedside
inferred← citeshttps://doi.org/10.3390/ijms19082456openalex-snapshot
Toll-Like Receptor Agonists Modulate Wound Regeneration in Airway Epithelial Cells
inferred← citeshttps://doi.org/10.3390/ijms22041706openalex-snapshot
Calprotectin in Lung Diseases
inferred← citeshttps://doi.org/10.3390/ijms22094295openalex-snapshot
Salivary Proteome Changes in Response to Acute Psychological Stress Due to an Oral Exam Simulation in University Students: Effect of an Olfactory Stimulus
inferred← citeshttps://doi.org/10.3390/ijms22179394openalex-snapshot
Links between Infections, Lung Cancer, and the Immune System
inferred← citeshttps://doi.org/10.3390/ijms23073866openalex-snapshot
Lysophosphatidylserine Induces MUC5AC Production via the Feedforward Regulation of the TACE-EGFR-ERK Pathway in Airway Epithelial Cells in a Receptor-Independent Manner
inferred← citeshttps://doi.org/10.3390/jcm12103366openalex-snapshot
The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD
inferred← citeshttps://doi.org/10.3390/v12080808openalex-snapshot
The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis
inferred← citeshttps://doi.org/10.3390/v15071406openalex-snapshot
Host Cell Response to Rotavirus Infection with Emphasis on Virus–Glycan Interactions, Cholesterol Metabolism, and Innate Immunity
inferred← citeshttps://doi.org/10.3779/j.issn.1009-3419.2018.09.03openalex-snapshot
Helicobacter Pylori Infection and Lung Cancer: New Insights and Future Challenges.
inferred← citeshttps://doi.org/10.3892/mmr.2017.7516openalex-snapshot
Cerebral ischemia/reperfusion injury induces airway mucus hypersecretion in rats and activates IL-13-associated inflammatory mechanisms
inferred← citeshttps://doi.org/10.3899/jrheum.160270openalex-snapshot
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium
inferred← citeshttps://doi.org/10.3969/j.issn.1673-4254.2017.10.04openalex-snapshot
[Receptor for advanced glycation end products upregulates MUC5AC expression and promotes mucus overproduction in mice with toluene diisocyanate-induced asthma].
inferred← citeshttps://doi.org/10.4103/jopp.jopp_23_23openalex-snapshot
Allergy symptoms and clinical pathophysiology
inferred← citeshttps://doi.org/10.4168/aair.2026.18.2.204openalex-snapshot
Butyrate Silences MUC5AC in Airway Epithelial Cells Through Histone Deacetylation at Its Promoter Region
inferred← citeshttps://doi.org/10.4236/wjcd.2018.81006openalex-snapshot
Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12, and VCAM-1 Levels with Further Post-Coronary Angiogram Endothelial Injury in Elderly and Younger Patients
inferred← citeshttps://doi.org/10.5415/apallergy.2014.4.4.187openalex-snapshot
Role of inflammasome activation in development and exacerbation of asthma
inferred← citeshttps://doi.org/10.5847/wjem.j.1920-8642.2023.099openalex-snapshot
Uncovering the potential pathological mechanism of acute pancreatitis in patients with COVID-19 by bioinformatics methods
inferred← citeshttps://doi.org/10.6084/m9.figshare.11978685openalex-snapshot
Additional file 1 of Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.11978694openalex-snapshot
Additional file 2 of Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.11978697openalex-snapshot
Additional file 3 of Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.11978700openalex-snapshot
Additional file 4 of Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.24630277openalex-snapshot
Additional file 1 of S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.6084/m9.figshare.24630477openalex-snapshot
Additional file 2 of S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.6084/m9.figshare.26644561openalex-snapshot
Additional file 3 of S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.6084/m9.figshare.26644564openalex-snapshot
Additional file 4 of S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.6084/m9.figshare.26644567openalex-snapshot
Additional file 5 of S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.6084/m9.figshare.26644570openalex-snapshot
Additional file 6 of S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.6084/m9.figshare.26644576openalex-snapshot
Additional file 7 of S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
inferred← citeshttps://doi.org/10.62347/uhjt1937openalex-snapshot
Effects of S100A12 reduction on H2O2-induced injury of human vascular smooth muscle cells (HVSMCs)
inferred← citeshttps://doi.org/10.70675/2a87d73ezf5a7z4b20z9e0az8975d81f6ab2openalex-snapshot
Modélisation de l’épithélium bronchique par les cellules souches pluripotentes induites humaines dans la bronchopneumopathie chronique obstructive (BPCO)
inferred← citeshttps://doi.org/10.70675/c1c07994zd14fz4b3cz94a4z1144865acf65openalex-snapshot
Caractérisation d’un agent anti-inflammatoire et approches pharmacologiques pour contrôler l’inflammation pulmonaire dans le contexte de la mucoviscidose
inferred← citeshttps://doi.org/10.70675/df28d166zb847z4bdbz979az3c6afebed201openalex-snapshot
Inflammation pulmonaire et rôle des microARN dans la mucoviscidose
inferred← citeshttps://doi.org/10.7150/ijms.37833openalex-snapshot
Suppressive effects of S100A8 and S100A9 on neutrophil apoptosis by cytokine release of human bronchial epithelial cells in asthma
inferred← citeshttps://doi.org/10.7554/elife.54100openalex-snapshot
Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9
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