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IL ‐33: biological properties, functions, and roles in airway disease

https://doi.org/10.1111/imr.12552
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inferredcites →https://doi.org/10.1002/eji.201041033openalex-snapshot
IL‐33‐activated dendritic cells are critical for allergic airway inflammation
inferredcites →https://doi.org/10.1002/eji.201242863openalex-snapshot
IL‐33 citrine reporter mice reveal the temporal and spatial expression of IL‐33 during allergic lung inflammation
inferredcites →https://doi.org/10.1016/0014-5793(89)81679-5openalex-snapshot
A putative protein of a growth specific cDNA from BALB/C‐3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor
inferredcites →https://doi.org/10.1016/j.ajpath.2011.03.032openalex-snapshot
Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model
inferredcites →https://doi.org/10.1016/j.anai.2016.06.006openalex-snapshot
Chronic rhinosinusitis phenotypes
inferredcites →https://doi.org/10.1016/j.cell.2015.08.021openalex-snapshot
A Distinct Function of Regulatory T Cells in Tissue Protection
inferredcites →https://doi.org/10.1016/j.clim.2014.09.007openalex-snapshot
Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness
inferredcites →https://doi.org/10.1016/j.coi.2014.09.004openalex-snapshot
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy
inferredcites →https://doi.org/10.1016/j.imbio.2015.02.005openalex-snapshot
IL-33/ST2 axis controls Th2/IL-31 and Th17 immune response in allergic airway diseases
inferredcites →https://doi.org/10.1016/j.immuni.2005.09.015openalex-snapshot
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
inferredcites →https://doi.org/10.1016/j.immuni.2009.05.007openalex-snapshot
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
inferredcites →https://doi.org/10.1016/j.immuni.2012.06.012openalex-snapshot
Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation
inferredcites →https://doi.org/10.1016/j.immuni.2014.01.011openalex-snapshot
Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation
inferredcites →https://doi.org/10.1016/j.immuni.2015.01.016openalex-snapshot
The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway
inferredcites →https://doi.org/10.1016/j.immuni.2015.02.011openalex-snapshot
Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection
inferredcites →https://doi.org/10.1016/j.immuni.2015.05.019openalex-snapshot
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation
inferredcites →https://doi.org/10.1016/j.immuni.2015.06.006openalex-snapshot
Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation
inferredcites →https://doi.org/10.1016/j.immuni.2015.06.021openalex-snapshot
An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers
inferredcites →https://doi.org/10.1016/j.immuni.2015.07.007openalex-snapshot
Barrier Epithelial Cells and the Control of Type 2 Immunity
inferredcites →https://doi.org/10.1016/j.immuni.2016.01.009openalex-snapshot
Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells
inferredcites →https://doi.org/10.1016/j.immuni.2016.06.017openalex-snapshot
Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation
inferredcites →https://doi.org/10.1016/j.jaci.2005.07.011openalex-snapshot
Airway remodeling contributes to the progressive loss of lung function in asthma: An overview
inferredcites →https://doi.org/10.1016/j.jaci.2008.04.005openalex-snapshot
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
inferredcites →https://doi.org/10.1016/j.jaci.2009.02.026openalex-snapshot
IL-33–activated dendritic cells induce an atypical TH2-type response
inferredcites →https://doi.org/10.1016/j.jaci.2009.09.048openalex-snapshot
Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5− TH2 responses
inferredcites →https://doi.org/10.1016/j.jaci.2009.12.935openalex-snapshot
Increased IL-33 expression by epithelial cells in bronchial asthma
inferredcites →https://doi.org/10.1016/j.jaci.2010.03.003openalex-snapshot
Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma
inferredcites →https://doi.org/10.1016/j.jaci.2012.02.013openalex-snapshot
A critical role of IL-33 in experimental allergic rhinitis
inferredcites →https://doi.org/10.1016/j.jaci.2013.04.012openalex-snapshot
IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma
inferredcites →https://doi.org/10.1016/j.jaci.2013.05.012openalex-snapshot
IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction
inferredcites →https://doi.org/10.1016/j.jaci.2013.12.1080openalex-snapshot
Association of IL33–IL-1 receptor–like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood
inferredcites →https://doi.org/10.1016/j.jaci.2013.12.1086openalex-snapshot
Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84
inferredcites →https://doi.org/10.1016/j.jaci.2014.02.002openalex-snapshot
Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations
inferredcites →https://doi.org/10.1016/j.jaci.2014.05.011openalex-snapshot
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice
inferredcites →https://doi.org/10.1016/j.jaci.2014.06.024openalex-snapshot
Enhanced innate type 2 immune response in peripheral blood from patients with asthma
inferredcites →https://doi.org/10.1016/j.jaci.2014.06.036openalex-snapshot
Allergens and the airway epithelium response: Gateway to allergic sensitization
inferredcites →https://doi.org/10.1016/j.jaci.2014.07.029openalex-snapshot
Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy
inferredcites →https://doi.org/10.1016/j.jaci.2014.11.037openalex-snapshot
Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33
inferredcites →https://doi.org/10.1016/j.jaci.2015.01.016openalex-snapshot
Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33
inferredcites →https://doi.org/10.1016/j.jaci.2015.10.003openalex-snapshot
Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses
inferredcites →https://doi.org/10.1016/j.jaci.2015.12.1324openalex-snapshot
Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers
inferredcites →https://doi.org/10.1016/j.jaci.2016.01.032openalex-snapshot
Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation
inferredcites →https://doi.org/10.1016/j.jaci.2016.04.021openalex-snapshot
Follicular helper T cells mediate IgE antibody response to airborne allergens
inferredcites →https://doi.org/10.1016/j.jaci.2017.01.015openalex-snapshot
IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs
inferredcites →https://doi.org/10.1016/j.jaut.2014.02.012openalex-snapshot
Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation
inferredcites →https://doi.org/10.1016/j.rmed.2015.09.016openalex-snapshot
Type 2 innate lymphoid cells: A novel biomarker of eosinophilic airway inflammation in patients with mild to moderate asthma
inferredcites →https://doi.org/10.1016/j.str.2009.08.009openalex-snapshot
Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes
inferredcites →https://doi.org/10.1016/s0002-9440(10)63631-0openalex-snapshot
Molecular Characterization of NF-HEV, a Nuclear Factor Preferentially Expressed in Human High Endothelial Venules
inferredcites →https://doi.org/10.1031/ni.2131openalex-snapshot
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
inferredcites →https://doi.org/10.1038/35037014openalex-snapshot
Induction and regulation of the IgE response
inferredcites →https://doi.org/10.1038/90667openalex-snapshot
Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
inferredcites →https://doi.org/10.1038/embor.2008.145openalex-snapshot
Molecular mimicry between IL‐33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket
inferredcites →https://doi.org/10.1038/jid.2012.180openalex-snapshot
Novel Splice Variants of IL-33: Differential Expression in Normal and Transformed Cells
inferredcites →https://doi.org/10.1038/mi.2015.59openalex-snapshot
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis
inferredcites →https://doi.org/10.1038/nature08636openalex-snapshot
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
inferredcites →https://doi.org/10.1038/nature08900openalex-snapshot
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
inferredcites →https://doi.org/10.1038/nature10772openalex-snapshot
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
inferredcites →https://doi.org/10.1038/nature13577openalex-snapshot
The alarmin IL-33 promotes regulatory T-cell function in the intestine
inferredcites →https://doi.org/10.1038/ncomms3990openalex-snapshot
Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation
inferredcites →https://doi.org/10.1038/ncomms9327openalex-snapshot
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
inferredcites →https://doi.org/10.1038/ng.2830openalex-snapshot
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
inferredcites →https://doi.org/10.1038/ng.323openalex-snapshot
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
inferredcites →https://doi.org/10.1038/ng.888openalex-snapshot
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
inferredcites →https://doi.org/10.1038/ni.2045openalex-snapshot
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
inferredcites →https://doi.org/10.1038/ni.2104openalex-snapshot
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
inferredcites →https://doi.org/10.1038/ni.2131openalex-snapshot
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
inferredcites →https://doi.org/10.1038/ni.3085openalex-snapshot
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells
inferredcites →https://doi.org/10.1038/ni.3370openalex-snapshot
Interleukin 33 is a guardian of barriers and a local alarmin
inferredcites →https://doi.org/10.1038/ni1050openalex-snapshot
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
inferredcites →https://doi.org/10.1038/nm.2754openalex-snapshot
Therapies for allergic inflammation: refining strategies to induce tolerance
inferredcites →https://doi.org/10.1038/nri.2016.95openalex-snapshot
Interleukin-33 in health and disease
inferredcites →https://doi.org/10.1038/nri1500openalex-snapshot
The immunogenetics of asthma and eczema: a new focus on the epithelium
inferredcites →https://doi.org/10.1038/nri2644openalex-snapshot
New insights into the differentiation and function of T follicular helper cells
inferredcites →https://doi.org/10.1038/nri2873openalex-snapshot
Sterile inflammation: sensing and reacting to damage
inferredcites →https://doi.org/10.1038/srep34255openalex-snapshot
Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells
inferredcites →https://doi.org/10.1056/nejmoa0906312openalex-snapshot
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
inferredcites →https://doi.org/10.1073/pnas.0606854104openalex-snapshot
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
inferredcites →https://doi.org/10.1073/pnas.0906988106openalex-snapshot
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
inferredcites →https://doi.org/10.1073/pnas.1003059107openalex-snapshot
IL-33 is a crucial amplifier of innate rather than acquired immunity
inferredcites →https://doi.org/10.1073/pnas.1003988107openalex-snapshot
Systemically dispersed innate IL-13–expressing cells in type 2 immunity
inferredcites →https://doi.org/10.1073/pnas.1115884109openalex-snapshot
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
inferredcites →https://doi.org/10.1073/pnas.1201042109openalex-snapshot
Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
inferredcites →https://doi.org/10.1073/pnas.1206587110openalex-snapshot
IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms
inferredcites →https://doi.org/10.1073/pnas.1410700111openalex-snapshot
Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
inferredcites →https://doi.org/10.1073/pnas.1512600113openalex-snapshot
Thy1 + IL-7 + lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation
inferredcites →https://doi.org/10.1073/pnas.1601914113openalex-snapshot
Alternative splicing of interleukin-33 and type 2 inflammation in asthma
inferredcites →https://doi.org/10.1074/jbc.m111.298703openalex-snapshot
Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells
inferredcites →https://doi.org/10.1084/jem.187.5.787openalex-snapshot
Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells
inferredcites →https://doi.org/10.1084/jem.20112691openalex-snapshot
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
inferredcites →https://doi.org/10.1084/jem.20121849openalex-snapshot
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
inferredcites →https://doi.org/10.1093/intimm/dxn037openalex-snapshot
Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system
inferredcites →https://doi.org/10.1093/intimm/dxn060openalex-snapshot
IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells
inferredcites →https://doi.org/10.1097/00004647-199911000-00013openalex-snapshot
Identification of Genes Differentially Expressed in Canine Vasospastic Cerebral Arteries after Subarachnoid Hemorrhage
inferredcites →https://doi.org/10.1111/all.12440openalex-snapshot
Association between Group 2 Innate Lymphoid Cells enrichment, nasal polyps and allergy in Chronic Rhinosinusitis
inferredcites →https://doi.org/10.1111/all.12446openalex-snapshot
Group 2 innate lymphoid cells and CD 4 + T cells cooperate to mediate type 2 immune response in mice
inferredcites →https://doi.org/10.1111/all.12667openalex-snapshot
Interaction of thymic stromal lymphopoietin, IL ‐33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps
inferredcites →https://doi.org/10.1111/cea.12283openalex-snapshot
IL ‐33 stimulates CXCL 8/ IL ‐8 secretion in goblet cells but not normally differentiated airway cells
inferredcites →https://doi.org/10.1111/cea.12462openalex-snapshot
Group 2 innate lymphoid cells ( ILC 2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia
inferredcites →https://doi.org/10.1111/j.1365-2222.2008.03114.xopenalex-snapshot
Association of serum interleukin‐33 level and the interleukin‐33 genetic variant with Japanese cedar pollinosis
inferredcites →https://doi.org/10.1111/j.1365-2222.2011.03867.xopenalex-snapshot
The role of IL ‐33 and its receptor ST 2 in human nasal epithelium with allergic rhinitis
inferredcites →https://doi.org/10.1111/j.1365-2567.2007.02774.xopenalex-snapshot
Special regulatory T‐cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression
inferredcites →https://doi.org/10.1111/j.1365-2567.2009.03221.xopenalex-snapshot
Expression and regulation of interleukin‐33 in human monocytes
inferredcites →https://doi.org/10.1111/j.1398-9995.2012.02825.xopenalex-snapshot
Interleukin‐33 induces interleukin‐17 F in bronchial epithelial cells
inferredcites →https://doi.org/10.1111/j.1600-065x.2008.00713.xopenalex-snapshot
Welcome to the neighborhood: epithelial cell‐derived cytokines license innate and adaptive immune responses at mucosal sites
inferredcites →https://doi.org/10.1126/science.1215418openalex-snapshot
The Alarmin Interleukin-33 Drives Protective Antiviral CD8 + T Cell Responses
inferredcites →https://doi.org/10.1136/thoraxjnl-2016-208772openalex-snapshot
The role of interleukin-33 in chronic rhinosinusitis
inferredcites →https://doi.org/10.1136/thoraxjnl-2016-209655openalex-snapshot
Role of interleukin 33 in chronic rhinosinusitis
inferredcites →https://doi.org/10.1146/annurev-immunol-020711-075053openalex-snapshot
Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function
inferredcites →https://doi.org/10.1146/annurev-immunol-031210-101400openalex-snapshot
Follicular Helper CD4 T Cells (T FH )
inferredcites →https://doi.org/10.1146/annurev.immunol.22.012703.104716openalex-snapshot
A sthma : Mechanisms of Disease Persistence and Progression
inferredcites →https://doi.org/10.1146/annurev.iy.12.040194.005015openalex-snapshot
Tolerance, Danger, and the Extended Family
inferredcites →https://doi.org/10.1152/ajplung.00174.2012openalex-snapshot
STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria
inferredcites →https://doi.org/10.1152/ajplung.00252.2011openalex-snapshot
IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice
inferredcites →https://doi.org/10.1152/physiol.00035.2004openalex-snapshot
Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms
inferredcites →https://doi.org/10.1164/ajrccm.164.2.2008120openalex-snapshot
Elevated Soluble ST2 Protein Levels in Sera of Patients with Asthma with an Acute Exacerbation
inferredcites →https://doi.org/10.1164/rccm.200907-1101ocopenalex-snapshot
Beyond Atopy: Multiple Patterns of Sensitization in Relation to Asthma in a Birth Cohort Study
inferredcites →https://doi.org/10.1164/rccm.201212-2227ocopenalex-snapshot
IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps
inferredcites →https://doi.org/10.1164/rccm.201406-1039ocopenalex-snapshot
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
inferredcites →https://doi.org/10.1165/rcmb.2012-0444ocopenalex-snapshot
IL-1 Family Cytokines Drive Th2 and Th17 Cells to Innocuous Airborne Antigens
inferredcites →https://doi.org/10.1165/rcmb.2016-0099ocopenalex-snapshot
IL-13+ Type 2 Innate Lymphoid Cells Correlate with Asthma Control Status and Treatment Response
inferredcites →https://doi.org/10.1172/jci65570openalex-snapshot
Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
inferredcites →https://doi.org/10.1177/0194599810391852openalex-snapshot
Cost Burden of Chronic Rhinosinusitis
inferredcites →https://doi.org/10.1182/blood-2008-05-157818openalex-snapshot
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33
inferredcites →https://doi.org/10.1189/jlb.0811425openalex-snapshot
The mouse interleukin (Il)33 gene is expressed in a cell type- and stimulus-dependent manner from two alternative promoters
inferredcites →https://doi.org/10.1371/journal.pone.0003331openalex-snapshot
The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?
inferredcites →https://doi.org/10.1371/journal.pone.0011944openalex-snapshot
IL-33 Is Produced by Mast Cells and Regulates IgE-Dependent Inflammation
inferredcites →https://doi.org/10.1371/journal.pone.0059441openalex-snapshot
Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity
inferredcites →https://doi.org/10.1371/journal.pone.0078099openalex-snapshot
IL-33, but Not IL-25, Is Crucial for the Development of House Dust Mite Antigen-Induced Allergic Rhinitis
inferredcites →https://doi.org/10.2500/ajra.2010.24.3446openalex-snapshot
Treatment-Recalcitrant Chronic Rhinosinusitis with Polyps is Associated with Altered Epithelial Cell Expression of Interleukin-33
inferredcites →https://doi.org/10.2500/ajra.2015.29.4176openalex-snapshot
Interleukin-25 and Interleukin-33 as Mediators of Eosinophilic Inflammation in Chronic Rhinosinusitis
inferredcites →https://doi.org/10.3109/02770903.2013.816317openalex-snapshot
Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children
inferredcites →https://doi.org/10.4049/jimmunol.0901575openalex-snapshot
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation
inferredcites →https://doi.org/10.4049/jimmunol.0903818openalex-snapshot
IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells
inferredcites →https://doi.org/10.4049/jimmunol.1003020openalex-snapshot
The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses
inferredcites →https://doi.org/10.4049/jimmunol.1003080openalex-snapshot
The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-κB To Dampen NF-κB–Stimulated Gene Transcription
inferredcites →https://doi.org/10.4049/jimmunol.1003554openalex-snapshot
Transcriptional Regulation of Murine IL-33 by TLR and Non-TLR Agonists
inferredcites →https://doi.org/10.4049/jimmunol.1101977openalex-snapshot
Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33–LacZ Gene Trap Reporter Strain
inferredcites →https://doi.org/10.4049/jimmunol.1102832openalex-snapshot
IL-33–Responsive Lineage−CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs
inferredcites →https://doi.org/10.4049/jimmunol.1201212openalex-snapshot
IL-33–Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen–Induced Allergic Airway Inflammation
inferredcites →https://doi.org/10.4049/jimmunol.1201224openalex-snapshot
Inducible IL-33 Expression by Mast Cells Is Regulated by a Calcium-Dependent Pathway
inferredcites →https://doi.org/10.4049/jimmunol.1300974openalex-snapshot
Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses
inferredcites →https://doi.org/10.4049/jimmunol.1302984openalex-snapshot
IL-33 and Thymic Stromal Lymphopoietin Mediate Immune Pathology in Response to Chronic Airborne Allergen Exposure
inferredcites →https://doi.org/10.4049/jimmunol.1400110openalex-snapshot
Airway Uric Acid Is a Sensor of Inhaled Protease Allergens and Initiates Type 2 Immune Responses in Respiratory Mucosa
inferredcites →https://doi.org/10.4049/jimmunol.1400481openalex-snapshot
IL-33 Is an Unconventional Alarmin That Stimulates IL-2 Secretion by Dendritic Cells To Selectively Expand IL-33R/ST2+ Regulatory T Cells
inferredcites →https://doi.org/10.4049/jimmunol.1502669openalex-snapshot
Group 2 Innate Lymphoid Cells Promote an Early Antibody Response to a Respiratory Antigen in Mice
inferredcites →https://doi.org/10.4049/jimmunol.1502702openalex-snapshot
TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1–Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells
inferredcites →https://doi.org/10.4049/jimmunol.161.9.4866openalex-snapshot
The IL-1 Receptor-Related T1 Antigen Is Expressed on Immature and Mature Mast Cells and on Fetal Blood Mast Cell Progenitors
inferredcites →https://doi.org/10.4049/jimmunol.179.4.2051openalex-snapshot
Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells
inferredcites →https://doi.org/10.4049/jimmunol.181.1.17openalex-snapshot
Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3
inferredcites →https://doi.org/10.4049/jimmunol.181.12.8650openalex-snapshot
Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells
inferredcites →https://doi.org/10.4049/jimmunol.181.7.4780openalex-snapshot
IL-33 Induces Antigen-Specific IL-5+ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4
inferredcites →https://doi.org/10.4049/jimmunol.181.9.5981openalex-snapshot
An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor
inferredcites →https://doi.org/10.4168/aair.2016.8.3.216openalex-snapshot
Allergen-Dependent Differences in ILC2s Frequencies in Patients With Allergic Rhinitis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/2211-5463.13268openalex-snapshot
Fasting impairs type 2 helper T cell infiltration in the lung of an eosinophilic asthma mouse model
inferred← citeshttps://doi.org/10.1002/alr.23308openalex-snapshot
Nasal instillation of povidone‐iodine ameliorates ongoing mucosal inflammation in a pre‐sensitized murine model of Der p1‐induced allergic rhinitis
inferred← citeshttps://doi.org/10.1002/cpt.3147openalex-snapshot
A Randomized Phase I Study of the Anti‐Interleukin‐33 Antibody Tozorakimab in Healthy Adults and Patients With Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.1002/cti2.70026openalex-snapshot
Decreased levels and function of dendritic cells in blood and airways predict COVID ‐19 severity
inferred← citeshttps://doi.org/10.1002/iid3.70043openalex-snapshot
Clinical Significance of Combined Detection of CCL22 and IL‐1 as Potential New Bronchial Inflammatory Mediators in Children's Asthma
inferred← citeshttps://doi.org/10.1002/iid3.788openalex-snapshot
Melatonin reduces IL‐33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly
inferred← citeshttps://doi.org/10.1002/iid3.842openalex-snapshot
Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis
inferred← citeshttps://doi.org/10.1002/jcph.2360openalex-snapshot
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF‐06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study
inferred← citeshttps://doi.org/10.1002/jmv.70432openalex-snapshot
Respiratory Syncytial Virus Infection Disrupts Airway Epithelial Barriers via IL‐33/ST2/MyD88 Signaling Axis
inferred← citeshttps://doi.org/10.1007/978-3-030-20812-7_8openalex-snapshot
Biomarkers, Targeted Therapies, Biologics, and Bronchial Thermoplasty
inferred← citeshttps://doi.org/10.1007/s00281-018-0677-xopenalex-snapshot
ILC2s in infectious diseases and organ-specific fibrosis
inferred← citeshttps://doi.org/10.1007/s00408-024-00682-6openalex-snapshot
Activated Leukocyte Cell Adhesion Molecule Regulates the Expression of Interleukin-33 in RSV Induced Airway Inflammation by Regulating MAPK Signaling Pathways
inferred← citeshttps://doi.org/10.1007/s10067-023-06575-yopenalex-snapshot
Association of interleukin 33 gene polymorphisms with susceptibility and regulation of inflammatory mediators in Systemic lupus erythematosus patients
inferred← citeshttps://doi.org/10.1007/s10571-018-0601-xopenalex-snapshot
Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage
inferred← citeshttps://doi.org/10.1007/s11302-022-09859-1openalex-snapshot
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma
inferred← citeshttps://doi.org/10.1007/s11481-026-10302-0openalex-snapshot
Targeting IL-33 in Precision Neuroimmunology: Cellular Mechanisms and Therapeutic Strategies for CNS Disorders
inferred← citeshttps://doi.org/10.1007/s12011-021-02859-zopenalex-snapshot
Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation
inferred← citeshttps://doi.org/10.1007/s13555-022-00737-7openalex-snapshot
Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis
inferred← citeshttps://doi.org/10.1016/b978-0-12-820589-1.00016-6openalex-snapshot
Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain
inferred← citeshttps://doi.org/10.1016/b978-0-443-34172-4.00024-0openalex-snapshot
Atopic dermatitis
inferred← citeshttps://doi.org/10.1016/bs.ai.2019.05.001openalex-snapshot
The airway epithelium in asthma
inferred← citeshttps://doi.org/10.1016/bs.ai.2025.09.001openalex-snapshot
The roles and diversity of alarmins in the mucosae
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165950openalex-snapshot
Characterization of immune responses and the lung transcriptome in a murine model of IL-33 challenge
inferred← citeshttps://doi.org/10.1016/j.bj.2024.100727openalex-snapshot
Doxycycline cotherapy with albendazole relieves neural function damage in C57BL/6 and BALB/c mice infected with Angiostrongylus cantonensis
inferred← citeshttps://doi.org/10.1016/j.cbi.2022.109915openalex-snapshot
IL-33 regulates M1/M2 chemokine expression via mitochondrial redox-related mitophagy in human monocytes
inferred← citeshttps://doi.org/10.1016/j.ccm.2018.10.014openalex-snapshot
Proinflammatory Pathways in the Pathogenesis of Asthma
inferred← citeshttps://doi.org/10.1016/j.cell.2026.06.004openalex-snapshot
Iron drives protease-independent cleavage of gasdermin D in allergic airway diseases
inferred← citeshttps://doi.org/10.1016/j.cellimm.2019.103928openalex-snapshot
Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet
inferred← citeshttps://doi.org/10.1016/j.cellimm.2020.104098openalex-snapshot
IL-33 induced airways inflammation is partially dependent on IL-9
inferred← citeshttps://doi.org/10.1016/j.cellsig.2022.110552openalex-snapshot
Targeting epithelial cell-derived TWIST1 alleviates allergic asthma
inferred← citeshttps://doi.org/10.1016/j.cyto.2020.155349openalex-snapshot
Respiratory syncytial virus upregulates IL-33 expression in mouse model of virus-induced inflammation exacerbation in OVA-sensitized mice and in asthmatic subjects
inferred← citeshttps://doi.org/10.1016/j.cyto.2022.155890openalex-snapshot
The IL-1 cytokine family as custodians of barrier immunity
inferred← citeshttps://doi.org/10.1016/j.cyto.2022.156015openalex-snapshot
IL-33/ST2 axis in autoimmune disease
inferred← citeshttps://doi.org/10.1016/j.cyto.2025.157080openalex-snapshot
Adding pieces to the puzzle: IL-33 contribution to fibrogenesis in chronic lung allograft dysfunction
inferred← citeshttps://doi.org/10.1016/j.healun.2024.02.1459openalex-snapshot
IL-33: Friend or foe in transplantation?
inferred← citeshttps://doi.org/10.1016/j.iac.2024.07.005openalex-snapshot
Biologics in Chronic Rhinosinusitis
inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106243openalex-snapshot
Salidroside suppresses group 2 innate lymphoid cell-mediated allergic airway inflammation by targeting IL-33/ST2 axis
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109840openalex-snapshot
Quantitative live-cell imaging of secretion activity reveals dynamic immune responses
inferred← citeshttps://doi.org/10.1016/j.isci.2024.110117openalex-snapshot
The alarmin IL-33 exacerbates pulmonary inflammation and immune dysfunction in SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1016/j.jaci.2021.03.044openalex-snapshot
Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial
inferred← citeshttps://doi.org/10.1016/j.jaci.2023.03.023openalex-snapshot
Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice
inferred← citeshttps://doi.org/10.1016/j.jaci.2024.01.017openalex-snapshot
Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13
inferred← citeshttps://doi.org/10.1016/j.jaci.2024.08.026openalex-snapshot
Tissue-specific inducible IL-33 expression elicits features of eosinophilic esophagitis
inferred← citeshttps://doi.org/10.1016/j.jaci.2025.02.018openalex-snapshot
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders
inferred← citeshttps://doi.org/10.1016/j.jaci.2026.08.025openalex-snapshot
Staphylococcus aureus serine protease-like protein B is a potent allergen in a murine asthma model
inferred← citeshttps://doi.org/10.1016/j.jep.2020.113492openalex-snapshot
Baicalin suppresses type 2 immunity through breaking off the interplay between mast cell and airway epithelial cell
inferred← citeshttps://doi.org/10.1016/j.jped.2023.08.004openalex-snapshot
Serum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children
inferred← citeshttps://doi.org/10.1016/j.mehy.2023.111254openalex-snapshot
Piezo1 mediates abnormal type 2 immune response to aggravate ischemia–reperfusion acute lung injury which by regulating alveolar macrophages derived IL-33: A hypothesis
inferred← citeshttps://doi.org/10.1016/j.mucimm.2025.03.003openalex-snapshot
Airway epithelial cells as drivers of severe asthma pathogenesis
inferred← citeshttps://doi.org/10.1016/j.pupt.2020.101963openalex-snapshot
ORMDL3 modulates airway epithelial cell repair in children with asthma under glucocorticoid treatment via regulating IL-33
inferred← citeshttps://doi.org/10.1016/j.rmed.2024.107580openalex-snapshot
Advances in co-pathogenesis of the united airway diseases
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.163181openalex-snapshot
Inhalation of subway fine particles induces murine extrapulmonary organs damage
inferred← citeshttps://doi.org/10.1016/j.smim.2019.101346openalex-snapshot
Immune induction of airway remodeling
inferred← citeshttps://doi.org/10.1016/j.str.2026.08.012openalex-snapshot
Structural basis of QX007N neutralizing interleukin-33 for asthma and COPD treatment
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c01524openalex-snapshot
Discovery of Long-Acting Bifunctional Compounds with Muscarinic M3 and Histamine H1 Receptor Antagonism for the Treatment of Rhinitis
inferred← citeshttps://doi.org/10.1021/acsinfecdis.5c00859openalex-snapshot
IL-33/ST2 Signaling Protects the Heart by Restraining Inflammation and Parasite Burden during Trypanosoma cruzi Experimental Infection
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6c00349openalex-snapshot
Development of 2-Methyl-5-phenylpyrrolidine-Based ST2 Inhibitors for Neuroinflammatory Conditions
inferred← citeshttps://doi.org/10.1038/s41392-026-02842-xopenalex-snapshot
Neuro-immune interactions in tumors, immune-related disorders, and infections
inferred← citeshttps://doi.org/10.1038/s41419-020-02845-8openalex-snapshot
Costello syndrome model mice with a Hras G12S mutation are susceptible to develop house dust mite-induced atopic dermatitis
inferred← citeshttps://doi.org/10.1038/s41419-023-05766-4openalex-snapshot
IL-33 promotes double negative T cell survival via the NF-κB pathway
inferred← citeshttps://doi.org/10.1038/s41423-023-01029-6openalex-snapshot
Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation
inferred← citeshttps://doi.org/10.1038/s41423-023-01035-8openalex-snapshot
Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils
inferred← citeshttps://doi.org/10.1038/s41467-018-06468-8openalex-snapshot
DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
inferred← citeshttps://doi.org/10.1038/s41598-023-36642-yopenalex-snapshot
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
inferred← citeshttps://doi.org/10.1038/s41598-023-45678-zopenalex-snapshot
Exploring the significance of interleukin-33/ST2 axis in minimal change disease
inferred← citeshttps://doi.org/10.1051/medsci/2019078openalex-snapshot
L’interleukine 33
inferred← citeshttps://doi.org/10.1073/pnas.1714731115openalex-snapshot
CXCR6 + ST2 + memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth
inferred← citeshttps://doi.org/10.1080/01902148.2019.1611972openalex-snapshot
IL33/ST2 contributes to airway remodeling via p-JNK MAPK/STAT3 signaling pathway in OVA-induced allergic airway inflammation in mice
inferred← citeshttps://doi.org/10.1080/02770903.2024.2330063openalex-snapshot
Bacterial antigens and asthma: a comparative study of common respiratory pathogenic bacteria
inferred← citeshttps://doi.org/10.1080/08820139.2022.2130075openalex-snapshot
The Interleukin-33/ST2 Axis Enhances Lung-Resident CD14+ Monocyte Function in Patients with Non-Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.1080/08923973.2022.2055565openalex-snapshot
LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling
inferred← citeshttps://doi.org/10.1080/13543784.2019.1672657openalex-snapshot
Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma
inferred← citeshttps://doi.org/10.1080/13543784.2023.2273502openalex-snapshot
Current and emerging biological therapies for Chronic rhinosinusitis with nasal polyps with type 2 inflammation
inferred← citeshttps://doi.org/10.1080/13543784.2026.2619605openalex-snapshot
Investigational agents targeting alarmins for asthma treatment: insights and progress from phase I and II trials
inferred← citeshttps://doi.org/10.1080/15287394.2021.1945985openalex-snapshot
Exposure to lead on expression levels of brain immunoglobulins, inflammatory cytokines, and brain-derived neurotropic factor in fetal and postnatal mice with autism-like characteristics
inferred← citeshttps://doi.org/10.1084/jem.20231244openalex-snapshot
Treg–tissue cell interactions in repair and regeneration
inferred← citeshttps://doi.org/10.1084/jem.20241830openalex-snapshot
Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production
inferred← citeshttps://doi.org/10.1093/cei/uxac083openalex-snapshot
Identification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections
inferred← citeshttps://doi.org/10.1093/discim/kyac006openalex-snapshot
The role of interleukin-33 in organ fibrosis
inferred← citeshttps://doi.org/10.1093/eep/dvaf007openalex-snapshot
Silencing TET1 expression alters the epigenomic landscape and amplifies transcriptomic responses to allergen in airway epithelial cells
inferred← citeshttps://doi.org/10.1093/jleuko/qiad092openalex-snapshot
ILC2 influence the differentiation of alveolar type II epithelial cells in bronchopulmonary dysplasia mice
inferred← citeshttps://doi.org/10.1093/jleuko/qiae232openalex-snapshot
Eosinophil-airway epithelial cell crosstalk reveals the eosinophil-mediated DUOX1 upregulation in a murine allergic inflammation setting
inferred← citeshttps://doi.org/10.1093/rheumatology/kead535openalex-snapshot
Serum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1093/toxsci/kfz114openalex-snapshot
Interleukin 33 Expression Induced by Aryl Hydrocarbon Receptor in Macrophages
inferred← citeshttps://doi.org/10.1096/fba.2025-00227openalex-snapshot
Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes
inferred← citeshttps://doi.org/10.1097/aci.0000000000000712openalex-snapshot
Cellular interactions in aspirin-exacerbated respiratory disease
inferred← citeshttps://doi.org/10.1097/nrl.0000000000000570openalex-snapshot
Predictive Value of Serum Inflammatory Factors and FT3 for Stroke-Associated Pneumonia in Patients With Acute Ischemic Stroke
inferred← citeshttps://doi.org/10.1101/2022.11.03.515050openalex-snapshot
IL-17A promotes epithelial cell IL-33 production during nematode lung migration
inferred← citeshttps://doi.org/10.1101/2022.12.21.521419openalex-snapshot
Molecular anatomy of eosinophil activation by IL5 and IL33
inferred← citeshttps://doi.org/10.1101/2023.01.26.525578openalex-snapshot
The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense
inferred← citeshttps://doi.org/10.1101/2023.09.23.559152openalex-snapshot
Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation
inferred← citeshttps://doi.org/10.1101/2024.09.29.615684openalex-snapshot
Treatment with carnosic acid attenuates the secretion of pro-inflammatory mast cell mediators following IL-33 activation
inferred← citeshttps://doi.org/10.1101/2025.11.14.25340263openalex-snapshot
Interactions with polygenic background impact quantitative traits in the UK Biobank
inferred← citeshttps://doi.org/10.1111/all.14491openalex-snapshot
Estrogen receptor‐α signaling increases allergen‐induced IL‐33 release and airway inflammation
inferred← citeshttps://doi.org/10.1111/all.14526openalex-snapshot
Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation
inferred← citeshttps://doi.org/10.1111/all.15609openalex-snapshot
Sounding the alarmins—The role of alarmin cytokines in asthma
inferred← citeshttps://doi.org/10.1111/all.15918openalex-snapshot
Tezepelumab decreases airway epithelial IL‐33 and T2‐inflammation in response to viral stimulation in patients with asthma
inferred← citeshttps://doi.org/10.1111/all.16092openalex-snapshot
Skin, gut, and lung barrier: Physiological interface and target of intervention for preventing and treating allergic diseases
inferred← citeshttps://doi.org/10.1111/all.16430openalex-snapshot
The Presence and Pathogenic Roles of M( IL ‐33 + IL ‐2) Macrophages in Allergic Airway Inflammation
inferred← citeshttps://doi.org/10.1111/all.70313openalex-snapshot
IL ‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways
inferred← citeshttps://doi.org/10.1111/apa.15175openalex-snapshot
IL33 rs1342326 gene variation is associated with allergic rhinitis at school age after infant bronchiolitis
inferred← citeshttps://doi.org/10.1111/bcp.16195openalex-snapshot
Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease
inferred← citeshttps://doi.org/10.1111/cea.13261openalex-snapshot
IL ‐33 signalling contributes to pollutant‐induced allergic airway inflammation
inferred← citeshttps://doi.org/10.1111/cea.13819openalex-snapshot
Increased expression of IL‐33 is found in the lower airways of patients with seasonal allergic rhinitis and is not related to natural allergen exposure
inferred← citeshttps://doi.org/10.1111/imcb.70126openalex-snapshot
Highlights of 2025: epithelial‐immune circuitry in allergic airway inflammation
inferred← citeshttps://doi.org/10.1111/imm.12911openalex-snapshot
The effects of interleukin‐33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma
inferred← citeshttps://doi.org/10.1111/imm.12931openalex-snapshot
Antigen‐specific airway IL ‐33 production depends on FcγR‐mediated incorporation of the antigen by alveolar macrophages in sensitized mice
inferred← citeshttps://doi.org/10.1111/imm.13054openalex-snapshot
IL ‐33 induces production of autoantibody against autologous respiratory epithelial cells: a potential mechanism for the pathogenesis of COPD
inferred← citeshttps://doi.org/10.1111/imm.13528openalex-snapshot
Suppression of airway allergic eosinophilia by Hp‐TGM , a helminth mimic of TGF ‐β
inferred← citeshttps://doi.org/10.1111/imr.12566openalex-snapshot
Introduction to “allergic inflammation”
inferred← citeshttps://doi.org/10.1111/sji.12724openalex-snapshot
Elevated levels of interleukin‐33 are associated with allergic and eosinophilic asthma
inferred← citeshttps://doi.org/10.1113/jp279379openalex-snapshot
Fungal allergen‐induced IL‐33 secretion involves cholesterol‐dependent, VDAC‐1‐mediated ATP release from the airway epithelium
inferred← citeshttps://doi.org/10.1124/jpet.120.000080openalex-snapshot
The Phosphodiesterase Inhibitor Ensifentrine Reduces Production of Proinflammatory Mediators in Well Differentiated Bronchial Epithelial Cells by Inhibiting PDE4
inferred← citeshttps://doi.org/10.1126/sciadv.adn5409openalex-snapshot
Functional tendon regeneration is driven by regulatory T cells and IL-33 signaling
inferred← citeshttps://doi.org/10.1126/science.add5327openalex-snapshot
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
inferred← citeshttps://doi.org/10.1126/sciimmunol.adk1673openalex-snapshot
Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen
inferred← citeshttps://doi.org/10.1128/mmbr.00180-25openalex-snapshot
Revisiting cattle respiratory health: key roles of the gut-lung axis in the dynamics of respiratory tract pathobiome
inferred← citeshttps://doi.org/10.1134/s0026893319050066openalex-snapshot
Interleukin-33: Friend or Enemy in the Fight against Tumors?
inferred← citeshttps://doi.org/10.1134/s0026898419050069openalex-snapshot
Интерлейкин-33: друг или враг в борьбе против опухоли?
inferred← citeshttps://doi.org/10.1136/bmjresp-2026-004145openalex-snapshot
Phase III LUNA clinical programme: design of four randomised, double-blind, placebo-controlled studies assessing the efficacy and safety of tozorakimab in patients with symptomatic COPD and a high risk of exacerbations
inferred← citeshttps://doi.org/10.1146/annurev-immunol-093019-125918openalex-snapshot
Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies
inferred← citeshttps://doi.org/10.1152/ajpcell.00308.2025openalex-snapshot
NADPH oxidase 1-PKCδ-dependent ZO-1 phosphorylation mediates IL-33-induced inner blood-retinal barrier disruption in proliferative retinopathies
inferred← citeshttps://doi.org/10.1152/ajpcell.00370.2023openalex-snapshot
ATP functions as a primary alarmin in allergen-induced type 2 immunity
inferred← citeshttps://doi.org/10.1155/2018/3858032openalex-snapshot
IL-33/IL-31 Axis: A Potential Inflammatory Pathway
inferred← citeshttps://doi.org/10.1155/2022/9155080openalex-snapshot
Predictive Values of Serum IL-33 and sST2 in Endotypes and Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps
inferred← citeshttps://doi.org/10.1155/carj/7341588openalex-snapshot
KAST Improves Airway Inflammation in Allergic Asthma via GATA3/ILC2
inferred← citeshttps://doi.org/10.1155/jimr/3274290openalex-snapshot
Impact of Transport Media on IL‐33 Levels in Samples From Patients With Viral Respiratory Infections
inferred← citeshttps://doi.org/10.1155/jimr/7715676openalex-snapshot
P2 Receptors as Therapeutic Targets in Allergic Rhinitis: Insights From the Use of Natural Products and Preclinical Studies
inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-2116openalex-snapshot
Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity
inferred← citeshttps://doi.org/10.1159/000497072openalex-snapshot
Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus
inferred← citeshttps://doi.org/10.1159/000498857openalex-snapshot
IL-33/ST2 Axis Regulates Vasculogenic Mimicry via ERK1/2-MMP-2/9 Pathway in Melanoma
inferred← citeshttps://doi.org/10.1159/000519575openalex-snapshot
High Mobility Group Box-1 Protein and Interleukin 33 Expression in Allergic Rhinitis
inferred← citeshttps://doi.org/10.1159/000525315openalex-snapshot
Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways
inferred← citeshttps://doi.org/10.1159/000540407openalex-snapshot
Control of Asthma and Allergy by Regulatory T Cells
inferred← citeshttps://doi.org/10.1159/000545439openalex-snapshot
TTC4 Overexpression Attenuates Allergic Rhinitis via Inhibiting AMPK-Mediated Autophagy
inferred← citeshttps://doi.org/10.1164/rccm.202111-2571edopenalex-snapshot
An Alarmin Role for P2Y13 Receptor during Viral-driven Asthma Exacerbations
inferred← citeshttps://doi.org/10.1172/jci.insight.174786openalex-snapshot
Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease
inferred← citeshttps://doi.org/10.1172/jci.insight.178381openalex-snapshot
Type 2 innate immunity promotes the development of pulmonary fibrosis in Hermansky-Pudlak syndrome
inferred← citeshttps://doi.org/10.1172/jci169583openalex-snapshot
Phospholipid scramblase-1 regulates innate type 2 inflammation in mouse lungs via CRTH2-dependent mechanisms
inferred← citeshttps://doi.org/10.1177/0192623318816295openalex-snapshot
The Endothelin-A Receptor Antagonist Zibotentan Induces Damage to the Nasal Olfactory Epithelium Possibly Mediated in Part through Type 2 Innate Lymphoid Cells
inferred← citeshttps://doi.org/10.1177/09603271221121320openalex-snapshot
Androgen receptor suppresses inflammatory response of airway epithelial cells in allergic asthma through MAPK1 and MAPK14
inferred← citeshttps://doi.org/10.1177/1753425920918911openalex-snapshot
IL-33/ST2 axis promotes the inflammatory response of nasal mucosal epithelial cells through inducing the ERK1/2 pathway
inferred← citeshttps://doi.org/10.1177/1945892419848188openalex-snapshot
Impacts of CD40- and CD86-Silenced Antigen-Specific B Cells on the Control of Allergies
inferred← citeshttps://doi.org/10.11817/j.issn.1672-7347.2021.190678openalex-snapshot
Dual role of interleukin-33 in tumors.
inferred← citeshttps://doi.org/10.1183/16000617.0110-2025openalex-snapshot
A translational view of airway epithelial dysfunction in COPD
inferred← citeshttps://doi.org/10.1183/16000617.0126-2023openalex-snapshot
Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease
inferred← citeshttps://doi.org/10.1183/23120541.00183-2025openalex-snapshot
FRONTIER-3: a randomised phase 2a study to investigate tozorakimab, an anti-interleukin-33 monoclonal antibody, in early-onset asthma
inferred← citeshttps://doi.org/10.1183/23120541.00249-2023openalex-snapshot
A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2
inferred← citeshttps://doi.org/10.1183/23120541.00747-2025openalex-snapshot
Beyond inflammation: alarmins as critical drivers of pulmonary fibrosis
inferred← citeshttps://doi.org/10.1186/s12865-022-00499-zopenalex-snapshot
Increased expression of IL1-RL1 is associated with type 2 and type 1 immune pathways in asthma
inferred← citeshttps://doi.org/10.1186/s12866-020-01974-6openalex-snapshot
Symbiotic microbiome Staphylococcus aureus from human nasal mucus modulates IL-33-mediated type 2 immune responses in allergic nasal mucosa
inferred← citeshttps://doi.org/10.1186/s12866-023-02898-7openalex-snapshot
Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis
inferred← citeshttps://doi.org/10.1186/s12950-025-00438-wopenalex-snapshot
Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease
inferred← citeshttps://doi.org/10.1186/s12967-020-02661-wopenalex-snapshot
Exogenous interleukin-33 promotes hepatocellular carcinoma growth by remodelling the tumour microenvironment
inferred← citeshttps://doi.org/10.1186/s12974-024-03264-8openalex-snapshot
IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
inferred← citeshttps://doi.org/10.1186/s13017-019-0256-zopenalex-snapshot
IL-33 and its increased serum levels as an alarmin for imminent pulmonary complications in polytraumatized patients
inferred← citeshttps://doi.org/10.1186/s40001-024-01932-2openalex-snapshot
Inflammation accelerating intestinal fibrosis: from mechanism to clinic
inferred← citeshttps://doi.org/10.1186/s40001-026-04170-wopenalex-snapshot
Targeting Type-2 inflammation in chronic rhinosinusitis with nasal polyps: mechanisms, eosinophilia, and emerging therapies
inferred← citeshttps://doi.org/10.1186/s40360-024-00751-9openalex-snapshot
Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
inferred← citeshttps://doi.org/10.12677/acm.2024.142639openalex-snapshot
Research Progress on the Role of aGVHD and Its Mesenchymal Stem Cells Intervention in IL-33/ST2 Signaling Pathway
inferred← citeshttps://doi.org/10.12688/f1000research.13170.1openalex-snapshot
Recent advances in biologic therapy of asthma and the role in therapy of chronic rhinosinusitis
inferred← citeshttps://doi.org/10.1371/journal.pone.0252199openalex-snapshot
Transient IL-33 upregulation in neonatal mouse lung promotes acute but not chronic type 2 immune responses induced by allergen later in life
inferred← citeshttps://doi.org/10.14670/hh-18-149openalex-snapshot
Dual immune functions of IL-33 in inflammatory bowel disease.
inferred← citeshttps://doi.org/10.15212/amm-2025-0014openalex-snapshot
Advances in gasdermin activation, regulation, and targeted drug development
inferred← citeshttps://doi.org/10.1590/acb360501openalex-snapshot
Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-κB/p38 MAPK signaling pathway
inferred← citeshttps://doi.org/10.18632/oncotarget.24008openalex-snapshot
Gram-negative bacteria facilitate tumor progression through TLR4/IL-33 pathway in patients with non-small-cell lung cancer
inferred← citeshttps://doi.org/10.21037/atm.2019.09.34openalex-snapshot
Wenshen decoction suppresses inflammation in IL-33-induced asthma murine model via inhibiting ILC2 activation
inferred← citeshttps://doi.org/10.21037/tp-21-606openalex-snapshot
Expression and clinical significance of IL-33 and its receptor ST2 in children with obstructive sleep apnea syndrome
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2694520/v1openalex-snapshot
Surfactant deficiency increases SARS-CoV-2 canonical and non-canonical viral entry to lung epithelial cells and exacerbates intrapulmonary inflammatory responses
inferred← citeshttps://doi.org/10.21203/rs.3.rs-978714/v1openalex-snapshot
Expression and Clinical Significance of IL-33 and its Receptor ST2 in Children with Obstructive Sleep Apnea Syndrome
inferred← citeshttps://doi.org/10.2147/dmso.s251978openalex-snapshot
Correlation Profile of Suppression of Tumorigenicity 2 and/or Interleukin-33 with Biomarkers in the Adipose Tissue of Individuals with Different Metabolic States
inferred← citeshttps://doi.org/10.2147/ijn.s588680openalex-snapshot
Targeting the Epithelial Alarmin Axis with Biomedical Nanoparticles: A New Frontier in Allergic Asthma Therapy
inferred← citeshttps://doi.org/10.2147/jaa.s286695openalex-snapshot
In vitro Culture with Cytokines Provides a Tool to Assess the Effector Functions of ILC2s in Peripheral Blood in Asthma
inferred← citeshttps://doi.org/10.2147/jaa.s418596openalex-snapshot
Lipocalin 2 (LCN2) Knockdown Regulates Treg/Th17 Balance to Improve Asthma in Mice
inferred← citeshttps://doi.org/10.2174/0109298673423384251128081056openalex-snapshot
IL-33 Alleviates Sepsis-Induced Liver Injury by Regulating the NF-κB/BCL-2 Pathway
inferred← citeshttps://doi.org/10.2174/0118715206281991231222073858openalex-snapshot
Dexamethasone Suppresses IL-33-exacerbated Malignant Phenotype of U87MG Glioblastoma Cells via NF-κB and MAPK Signaling Pathways
inferred← citeshttps://doi.org/10.2174/2211536611666220428134324openalex-snapshot
The Interaction Network of MicroRNAs with Cytokines and Signaling Pathways in Allergic Asthma
inferred← citeshttps://doi.org/10.22246/jikm.2017.38.6.891openalex-snapshot
Anti-asthmatic Effect of Alismatis Rhizoma and Alisol Acetate B Combination Therapy in a Murine Asthma Model
inferred← citeshttps://doi.org/10.22363/2313-0245-2025-29-3-365-384openalex-snapshot
The role of type 2 inflammation in the pathogenesis of atopic dermatitis
inferred← citeshttps://doi.org/10.2478/sjecr-2023-0013openalex-snapshot
Associations Between Metabolic Syndrome, Ulcerative Colitis, and Fecal sST2 and CXCL8 Levels: Unveiling New Inflammatory Pathways
inferred← citeshttps://doi.org/10.33029/1816-2134-2024-45-2-245-255openalex-snapshot
The role of the triad of respiratory epithelial cell-derived cytokines in the pathogenesis of allergic rhinitis
inferred← citeshttps://doi.org/10.33393/jcb.2021.2327openalex-snapshot
Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?
inferred← citeshttps://doi.org/10.3389/falgy.2021.718267openalex-snapshot
Immunobiology of Steroid-Unresponsive Severe Asthma
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01595openalex-snapshot
Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02432openalex-snapshot
IL-33/ST2 Axis in Organ Fibrosis
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02601openalex-snapshot
The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01154openalex-snapshot
Cytokines in the Respiratory Airway as Biomarkers of Severity and Prognosis for Respiratory Syncytial Virus Infection: An Update
inferred← citeshttps://doi.org/10.3389/fimmu.2019.02212openalex-snapshot
Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00691openalex-snapshot
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure
inferred← citeshttps://doi.org/10.3389/fimmu.2020.01798openalex-snapshot
Contributions of IL-33 in Non-hematopoietic Lung Cells to Obstructive Lung Disease
inferred← citeshttps://doi.org/10.3389/fimmu.2020.571593openalex-snapshot
Anti-Tumorigenic Activities of IL-33: A Mechanistic Insight
inferred← citeshttps://doi.org/10.3389/fimmu.2021.631235openalex-snapshot
The Epithelial-Immune Crosstalk in Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.3389/fimmu.2021.631603openalex-snapshot
IL-33 Gene Polymorphisms as Potential Biomarkers of Disease Susceptibility and Response to TNF Inhibitors in Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Patients
inferred← citeshttps://doi.org/10.3389/fimmu.2022.897356openalex-snapshot
The Controversial Role of IL-33 in Lung Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2022.900826openalex-snapshot
Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1304758openalex-snapshot
Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1279976openalex-snapshot
Atopy in chronic urticaria: an important yet overlooked issue
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1436437openalex-snapshot
The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1481989openalex-snapshot
The role of DC subgroups in the pathogenesis of asthma
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