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Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin‐dependent kinase 5 activity in SH‐SY5Y neuroblastoma cells and primary neurons
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/dmrr.249openalex-snapshot
The mode of action of thiazolidinediones
inferredcites →https://doi.org/10.1006/abbi.1998.0813openalex-snapshot
Phosphorylation of Tau at Both Thr 231 and Ser 262 Is Required for Maximal Inhibition of Its Binding to Microtubules
inferredcites →https://doi.org/10.1007/s004010100423openalex-snapshot
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
inferredcites →https://doi.org/10.1007/s00702-004-0221-0openalex-snapshot
Post-translational modifications of tau protein in Alzheimer’s disease
inferredcites →https://doi.org/10.1007/s11064-006-9205-9openalex-snapshot
Regulation of Phosphorylation of tau by Protein Kinases in Rat Brain
inferredcites →https://doi.org/10.1007/s11481-011-9282-7openalex-snapshot
Rosiglitazone Improves Spatial Memory and Decreases Insoluble Aβ1–42 in APP/PS1 Mice
inferredcites →https://doi.org/10.1016/j.bbadis.2008.10.014openalex-snapshot
Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.bcp.2005.03.033openalex-snapshot
Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?
inferredcites →https://doi.org/10.1016/j.expneurol.2006.01.018openalex-snapshot
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
inferredcites →https://doi.org/10.1016/j.lfs.2010.06.004openalex-snapshot
The combination of sirolimus and rosiglitazone produces a renoprotective effect on diabetic kidney disease in rats
inferredcites →https://doi.org/10.1016/j.molmed.2009.01.003openalex-snapshot
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
inferredcites →https://doi.org/10.1016/j.nbd.2010.07.005openalex-snapshot
Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells
inferredcites →https://doi.org/10.1016/j.nurt.2008.05.003openalex-snapshot
PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease
inferredcites →https://doi.org/10.1016/j.tins.2009.07.002openalex-snapshot
Making a neuron: Cdk5 in embryonic and adult neurogenesis
inferredcites →https://doi.org/10.1016/j.yexmp.2006.09.002openalex-snapshot
Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5
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Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth
inferredcites →https://doi.org/10.1016/s0896-6273(03)00259-9openalex-snapshot
Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo
inferredcites →https://doi.org/10.1038/cddis.2011.2openalex-snapshot
Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
inferredcites →https://doi.org/10.1038/npp.2010.32openalex-snapshot
Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology
inferredcites →https://doi.org/10.1046/j.1471-4159.1998.71062465.xopenalex-snapshot
New Phosphorylation Sites Identified in Hyperphosphorylated Tau (Paired Helical Filament‐Tau) from Alzheimer's Disease Brain Using Nanoelectrospray Mass Spectrometry
inferredcites →https://doi.org/10.1056/nejm199803263381302openalex-snapshot
Effect of Troglitazone in Insulin-Treated Patients with Type II Diabetes Mellitus
inferredcites →https://doi.org/10.1073/pnas.0809158106openalex-snapshot
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
inferredcites →https://doi.org/10.1074/jbc.273.37.24057openalex-snapshot
p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway
inferredcites →https://doi.org/10.1074/jbc.m405131200openalex-snapshot
Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations
inferredcites →https://doi.org/10.1074/jbc.m413159200openalex-snapshot
Exceptional Disfavor for Proline at the P+1 Position among AGC and CAMK Kinases Establishes Reciprocal Specificity between Them and the Proline-directed Kinases
inferredcites →https://doi.org/10.1074/jbc.m802160200openalex-snapshot
A Novel Mechanism by Which Thiazolidinediones Facilitate the Proteasomal Degradation of Cyclin D1 in Cancer Cells
inferredcites →https://doi.org/10.1093/emboj/20.1.27openalex-snapshot
Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice
inferredcites →https://doi.org/10.1111/j.1471-4159.2006.03931.xopenalex-snapshot
Troglitazone, a peroxisome proliferator‐activated receptor‐γ agonist, decreases tau phosphorylation in CHOtau4R cells
inferredcites →https://doi.org/10.1111/j.1600-079x.2010.00820.xopenalex-snapshot
Melatonin synergistically increases resveratrol‐induced heme oxygenase‐1 expression through the inhibition of ubiquitin‐dependent proteasome pathway: a possible role in neuroprotection
inferredcites →https://doi.org/10.1146/annurev-cellbio-092910-154023openalex-snapshot
Cyclin-Dependent Kinases in Brain Development and Disease
inferredcites →https://doi.org/10.1146/annurev.neuro.24.1.1121openalex-snapshot
Neurodegenerative Tauopathies
inferredcites →https://doi.org/10.1152/ajpcell.00491.2005openalex-snapshot
Troglitazone acutely inhibits protein synthesis in endothelial cells via a novel mechanism involving protein phosphatase 2A-dependent p70 S6 kinase inhibition
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-0326openalex-snapshot
Peroxisome Proliferator-Activated Receptor γ Pathway Targeting in Carcinogenesis: Implications for Chemoprevention
inferredcites →https://doi.org/10.1161/hypertensionaha.109.140210openalex-snapshot
Cyclin-Dependent Kinase 5 Phosphorylates Endothelial Nitric Oxide Synthase at Serine 116
inferredcites →https://doi.org/10.1358/dnp.2006.19.8.1043961openalex-snapshot
The Role of CDK5/P25 Formation/Inhibition in Neurodegeneration
inferredcites →https://doi.org/10.1371/journal.pone.0016991openalex-snapshot
The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice
inferredcites →https://doi.org/10.1517/13543784.15.9.1039openalex-snapshot
The potential of antidiabetic thiazolidinediones for anticancer therapy
inferredcites →https://doi.org/10.2174/092986708785909111openalex-snapshot
Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease
inferredcites →https://doi.org/10.2174/138945010790711950openalex-snapshot
Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs
inferredcites →https://doi.org/10.2174/156720510793611592openalex-snapshot
Tau in Alzheimer Disease and Related Tauopathies
inferredcites →https://doi.org/10.2174/156720510793611600openalex-snapshot
TAU Aggregation is a Therapeutic Target for Alzheimers Disease
inferredcites →https://doi.org/10.2174/1874-470211205020272openalex-snapshot
Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Agonists on Glycemic Control, Lipid Profile and Cardiovascular Risk
inferredcites →https://doi.org/10.2174/1874609810801010056openalex-snapshot
Tau as a Molecular Marker of Development, Aging and Neurodegenerative Disorders
inferredcites →https://doi.org/10.2337/diabetes.53.2.474openalex-snapshot
Increased Risk of Type 2 Diabetes in Alzheimer Disease
inferredcites →https://doi.org/10.3233/jad-2003-5207openalex-snapshot
Cdk5: One of the links between senile plaques and neurofibrillary tangles?
inferredcites →https://doi.org/10.3233/jad-2005-8104openalex-snapshot
Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease
inferredcites →https://doi.org/10.3233/jad-2012-111661openalex-snapshot
Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease
inferredcites →https://doi.org/10.4161/cc.9.2.10466openalex-snapshot
Cdk5, the multifunctional surveyor
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Multi Organ Model Assessment of Neurotoxicity Following Exposure of Liver Spheroids to Drugs
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Emerging Diagnostic and Therapeutic Strategies for Tauopathies
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PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice
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Pioglitazone prevents tau oligomerization
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