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Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid‐induced constipation

https://doi.org/10.1111/nmo.12417
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00520-012-1494-8openalex-snapshot
Laxative prescriptions to cancer outpatients receiving opioids: a study from the Norwegian prescription database
inferredcites →https://doi.org/10.1007/s10620-010-1229-yopenalex-snapshot
Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation
inferredcites →https://doi.org/10.1007/s12013-012-9406-6openalex-snapshot
Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl− Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl− Currents
inferredcites →https://doi.org/10.1016/0016-5085(88)90673-7openalex-snapshot
Role of opiate receptors in the regulation of colonic transit
inferredcites →https://doi.org/10.1016/0016-5085(91)90717-yopenalex-snapshot
Epidemiology of colonic symptoms and the irritable bowel syndrome
inferredcites →https://doi.org/10.1016/j.amjmed.2012.04.032openalex-snapshot
Opioids for the Treatment of Chronic Noncancer Pain
inferredcites →https://doi.org/10.1016/j.brainresrev.2008.12.017openalex-snapshot
Peripheral mechanisms of pain and analgesia
inferredcites →https://doi.org/10.1016/j.cgh.2007.06.013openalex-snapshot
The Narcotic Bowel Syndrome: Clinical Features, Pathophysiology, and Management
inferredcites →https://doi.org/10.1016/j.jpain.2008.10.008openalex-snapshot
Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain
inferredcites →https://doi.org/10.1016/j.jpainsymman.2009.02.234openalex-snapshot
Methylnaltrexone Treatment of Opioid-Induced Constipation in Patients with Advanced Illness
inferredcites →https://doi.org/10.1016/j.jpainsymman.2010.02.019openalex-snapshot
The Direct and Indirect Costs of Opioid-Induced Constipation
inferredcites →https://doi.org/10.1016/j.jpainsymman.2012.03.016openalex-snapshot
Constipation in Palliative Care: What Do We Use as Definitions and Outcome Measures?
inferredcites →https://doi.org/10.1016/j.pain.2004.09.019openalex-snapshot
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
inferredcites →https://doi.org/10.1016/j.pain.2007.11.008openalex-snapshot
Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain
inferredcites →https://doi.org/10.1016/j.pain.2013.04.024openalex-snapshot
A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation
inferredcites →https://doi.org/10.1016/s0002-9610(01)00782-6openalex-snapshot
Incidence, Prevalence, and Management of Opioid Bowel Dysfunction
inferredcites →https://doi.org/10.1016/s0016-5085(12)60543-5openalex-snapshot
848a Lubiprostone Significantly Improves Treatment Response in Non-Methadone Opioid-Induced Bowel Dysfunction Patients with Chronic, Non-Cancer Pain: Results from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
inferredcites →https://doi.org/10.1016/s0025-6196(11)60749-0openalex-snapshot
A Comparison of Long- and Short-Acting Opioids for the Treatment of Chronic Noncancer Pain: Tailoring Therapy to Meet Patient Needs
inferredcites →https://doi.org/10.1016/s0885-3924(01)00369-4openalex-snapshot
Low-Dose Oral Naloxone Reverses Opioid-Induced Constipation and Analgesia
inferredcites →https://doi.org/10.1016/s1470-2045(12)70040-2openalex-snapshot
Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC
inferredcites →https://doi.org/10.1016/s1542-3565(05)00434-9openalex-snapshot
Effect of Alvimopan and Codeine on Gastrointestinal Transit: A Randomized Controlled Study
inferredcites →https://doi.org/10.1038/ajg.2010.431openalex-snapshot
Validation of a Bowel Function Diary for Assessing Opioid-Induced Constipation
inferredcites →https://doi.org/10.1038/ajg.2011.30openalex-snapshot
Opioid-Induced Constipation: Challenges and Therapeutic Opportunities
inferredcites →https://doi.org/10.1055/s-0032-1301753openalex-snapshot
Evaluation of Constipation
inferredcites →https://doi.org/10.1080/13854046.2012.715204openalex-snapshot
Risk Factor Assessment for Problematic Use of Opioids for Chronic Pain
inferredcites →https://doi.org/10.1089/jpm.2007.0200openalex-snapshot
Adverse Effects of Transdermal Opiates Treating Moderate-Severe Cancer Pain in Comparison to Long-Acting Morphine: A Meta-Analysis and Systematic Review of the Literature
inferredcites →https://doi.org/10.1089/jpm.2008.9839.suppopenalex-snapshot
Palliative Care and Pain: New Strategies for Managing Opioid Bowel Dysfunction
inferredcites →https://doi.org/10.1097/ajp.0b013e318237d626openalex-snapshot
A Multi-institutional Study Analyzing Effect of Prophylactic Medication for Prevention of Opioid-induced Gastrointestinal Dysfunction
inferredcites →https://doi.org/10.1097/bcr.0b013e31829b399dopenalex-snapshot
Use of Methylnaltrexone to Induce Laxation in Acutely Injured Patients With Burns and Necrotizing Soft-Tissue Infections
inferredcites →https://doi.org/10.1097/meg.0b013e32834d1938openalex-snapshot
Clinical efficacy and safety of lactulose for minimal hepatic encephalopathy
inferredcites →https://doi.org/10.1111/j.1365-2036.2007.03540.xopenalex-snapshot
Cumulative incidence of chronic constipation: a population‐based study 1988–2003
inferredcites →https://doi.org/10.1111/j.1365-2036.2008.03689.xopenalex-snapshot
Gastrointestinal side effects in chronic opioid users: results from a population‐based survey
inferredcites →https://doi.org/10.1111/j.1365-2036.2009.04212.xopenalex-snapshot
Opiate‐induced oesophageal dysmotility
inferredcites →https://doi.org/10.1111/j.1365-2982.2009.01458.xopenalex-snapshot
Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain
inferredcites →https://doi.org/10.1111/j.1526-4637.2008.00495.xopenalex-snapshot
The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)
inferredcites →https://doi.org/10.1111/j.1526-4637.2009.00666.xopenalex-snapshot
Long-Acting Opioids and Short-Acting Opioids: Appropriate Use in Chronic Pain Management
inferredcites →https://doi.org/10.1111/j.1742-1241.2007.01415.xopenalex-snapshot
Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden
inferredcites →https://doi.org/10.1111/j.2042-7158.1992.tb05520.xopenalex-snapshot
Effects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum
inferredcites →https://doi.org/10.1124/jpet.108.143438openalex-snapshot
Morphine Tolerance in the Mouse Ileum and Colon
inferredcites →https://doi.org/10.1136/gut.33.6.818openalex-snapshot
Defecation frequency and timing, and stool form in the general population: a prospective study.
inferredcites →https://doi.org/10.1136/gut.9.2.139openalex-snapshot
Effect of irritant purgatives on the myenteric plexus in man and the mouse.
inferredcites →https://doi.org/10.1136/gutjnl-2011-301181openalex-snapshot
Regional colon transit in patients with dys-synergic defaecation or slow transit in patients with constipation
inferredcites →https://doi.org/10.1177/0269216308096908openalex-snapshot
The management of constipation in palliative care: clinical practice recommendations
inferredcites →https://doi.org/10.1177/026921639601000208openalex-snapshot
An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancer
inferredcites →https://doi.org/10.1191/026921698674125048openalex-snapshot
The relationship between opioid use and laxative use in terminally ill cancer patients
inferredcites →https://doi.org/10.1592/phco.30.pt2.4sopenalex-snapshot
Treatment Guidelines for Hepatic Encephalopathy
inferredcites →https://doi.org/10.2146/ajhp070430openalex-snapshot
Emerging pharmacologic options for treating postoperative ileus
inferredcites →https://doi.org/10.2165/10898630-000000000-00000openalex-snapshot
Pharmacotherapy for Hepatic Encephalopathy
inferredcites →https://doi.org/10.3111/13696990903430481openalex-snapshot
Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation
inferredcites →https://doi.org/10.36076/ppj.2008/11/s105openalex-snapshot
Opioid Complications and Side Effects
inferredcites →https://doi.org/10.5055/jom.2009.0015openalex-snapshot
Opioid-induced bowel dysfunction in cancer-related pain: Causes, consequences, and a novel approach for its management

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Antinociceptive Effects of Synthetics Peptides Derived from Phα1β in Mice Model of Cancer Pain
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Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care
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Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care
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Incidence of opioid‐induced constipation in Japanese patients with cancer pain: A prospective observational cohort study
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Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Studies on the Safety, Tolerability, and Pharmacokinetics of Naldemedine in Healthy Volunteers
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The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Naldemedine
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European Pain Federation position paper on appropriate opioid use in chronic pain management
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集中治療室患者におけるオピオイド誘発性便秘に対するナルデメジン早期投与の効果：単施設後ろ向きコホート研究(Effect of early naldemedine administration on opioid–induced constipation in ICU patients: A single–center retrospective cohort study)
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Incidence of opioid‐induced constipation in the pediatric intensive care unit: A descriptive cohort study
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Novel Oral Therapies for Opioid‐induced Bowel Dysfunction in Patients with Chronic Noncancer Pain
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Supportive and Palliative Care for Genitourinary Malignancies
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Topics, Opioid-Induced Constipation/Narcotic Bowel Syndrome
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The efficacy of laparoscopic transversus abdominis plane block on reducing postoperative narcotic usage in patients undergoing minimally invasive adrenalectomy
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Opioid-induced bowel dysfunction: suggestions from a multidisciplinary expert Board
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MASCC recommendations on the management of constipation in patients with advanced cancer
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Inadequate management of opioid-induced constipation in European cancer pain patients: results of a real-world, multicentre, observational study (“E-StOIC”)
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Dose-dependent association of naldemedine and magnesium oxide in the management of opioid-induced constipation
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Opioidinduzierte Obstipation
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Probleme effektiver Schmerztherapie
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Opioid-induced constipation in patients with cancer pain in Japan (OIC-J study): a post hoc subgroup analysis of patients with gastrointestinal cancer
inferred← citeshttps://doi.org/10.1007/s10620-017-4784-7openalex-snapshot
Prolonged-Release Oxycodone/Naloxone Improves Anal Sphincter Relaxation Compared to Oxycodone Plus Macrogol 3350
inferred← citeshttps://doi.org/10.1007/s11095-018-2501-7openalex-snapshot
Population Pharmacokinetics and Exposure-Response Relationships of Naldemedine
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Opioid-induced constipation in internal medicine: recognition and management pathways
inferred← citeshttps://doi.org/10.1007/s11864-019-0686-6openalex-snapshot
Opioid-Induced Constipation in Oncological Patients: New Strategies of Management
inferred← citeshttps://doi.org/10.1007/s11894-017-0560-2openalex-snapshot
Opioid-Related Constipation in Patients With Non-cancer Pain Syndromes: a Review of Evidence-Based Therapies and Justification for a Change in Nomenclature
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Gastrointestinal Motility Issues in Cancer Patients
inferred← citeshttps://doi.org/10.1007/s11912-015-0481-xopenalex-snapshot
New Options in Constipation Management
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Patient Preferences for Change in Symptoms Associated with Opioid-Induced Constipation
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When People with Opioid-Induced Constipation Speak: A Patient Survey
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Impact and Consequences of Opioid-Induced Constipation: A Survey of Patients
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Opioid-Induced Constipation in Real-World Practice: A Physician Survey, 1 Year Later
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A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer
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Oxycodone/Naloxone Prolonged Release: A Review in Severe Chronic Pain
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Clinical Drug-Drug Interaction Studies to Evaluate the Effects of a P-Glycoprotein Inhibitor, CYP3A Inhibitors, and a CYP3A Inducer on the Pharmacokinetics of Naldemedine in Healthy Subjects
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Naloxegol: A Review of Its Use in Patients with Opioid-Induced Constipation
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Naldemedine: First Global Approval
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Constipation in Elderly Patients with Noncancer Pain: Focus on Opioid-Induced Constipation
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Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patients ≥ 65 Years of Age
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Laxatives, targeted therapy and lubiprostone are options when individualizing treatment for opioid-induced constipation in the elderly
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Pharmacological Treatments for Constipation and Opioid-Induced Constipation
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Inpatient opioid use disorder treatment for the infectious disease physician
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Establishing Minimal Clinically Important Differences in Quality of Life Measures in Opioid-Induced Constipation
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Cumulative Laxation Response with Methylnaltrexone: Implications for Hospitalized Patients with Advanced Illness and Opioid-Induced Constipation
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Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist
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Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice
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Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury
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Opioid-Related Constipation
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Symptom clustering in hospitalised older palliative cancer patients: A cross-sectional study
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First-Dose Efficacy of Methylnaltrexone in Patients with Severe Medical Illness and Opioid-Induced Constipation: A Pooled Analysis
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Qingtong treatment principle alleviates opioid-induced constipation by regulating bile acid homeostasis via an FXR-dependent manner
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Stercoral Perforation of the Colon: A Potentially Fatal Complication of Opioid-Induced Constipation
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Patients' Self-Assessment of the Symptoms and Impact of Opioid-Induced Constipation: Results From a Prospective Observational Cohort Study of Japanese Patients With Cancer
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Microvascular reconstruction in head and neck cancer - basis for the development of an enhanced recovery protocol
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Constipation induite par les opioïdes chez les patients suivis pour cancer du poumon
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Inhibitory modulation of gastrointestinal motility in mice by Tyr-c[D-Lys-Gly-p-F-Phe-Asp]-D-Pro-NH2, a novel cyclic hexapeptide with multifunctional opioid agonism
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Opioid-induced Constipation
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Experiences of patients with cancer and healthcare professionals with opioid-induced constipation: A qualitative study
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Guidelines add latest evidence for managing opioid-induced constipation
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Oral immediate and prolonged release oxycodone for safe and effective patient controlled analgesia after surgery Can opioid for acute postoperative pain be improved by adding a peripheral opioid antagonist?
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Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction–Recommendations of the Nordic Working Group
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Opioid-induced constipation, use of laxatives, and health-related quality of life
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Healthcare resource use and costs of opioid-induced constipation among non-cancer and cancer patients on opioid therapy: A nationwide register-based cohort study in Denmark
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Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials
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Pathophysiology, diagnosis, and management of opioid-induced constipation
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Enhanced Analgesic Efficacy and Reduced Side Effects of Morphine by Combination with PD-1 Agonist
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Diagnosis and management of chronic constipation in adults
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Opioid misuse in gastroenterology and non-opioid management of abdominal pain
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Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine
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Rome IV—Functional GI Disorders: Disorders of Gut-Brain Interaction
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American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation
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Nebenwirkungsmanagement der Opioid-Therapie
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Nebenwirkungsmanagement der Opioid-Therapie
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Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects
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High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments
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Emerging therapies for opioid-induced constipation: what can we expect?
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Safety concerns with long-term opioid use
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The effectiveness and safety of naldemedine in treating opioid-induced constipation among non-cancer adult patients: updated meta-analysis
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Rethinking Docusate’s Role in Opioid-Induced Constipation: A Critical Analysis of the Evidence
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A meta-analysis of naldemedine for the treatment of opioid-induced constipation
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Efficacy and Safety of Naldemedine for Opioid-Induced Constipation in Children
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Randomized phase III and extension studies: efficacy and impacts on quality of life of naldemedine in subjects with opioid-induced constipation and cancer
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Effect of add-on naldemedine treatment in patients with cancer and opioid-induced constipation insufficiently responding to magnesium oxide: a pooled, subgroup analysis of two randomized controlled trials
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Constipation
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Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis
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Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline
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A Phase 2b, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain
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Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial
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Naloxegol for managing opioid-induced constipation
inferred← citeshttps://doi.org/10.1097/aap.0000000000000341openalex-snapshot
Efficacy and Safety of Methylnaltrexone for Opioid-Induced Constipation in Patients With Chronic Noncancer Pain
inferred← citeshttps://doi.org/10.1097/aap.0000000000000671openalex-snapshot
The Efficacy of Peripheral Opioid Antagonists in Opioid-Induced Constipation and Postoperative Ileus
inferred← citeshttps://doi.org/10.1097/ajp.0000000000000852openalex-snapshot
Opioid-induced Constipation
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000001174openalex-snapshot
Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000001629openalex-snapshot
Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trials
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000001754openalex-snapshot
Efficacy and safety of linaclotide for opioid-induced constipation in patients with chronic noncancer pain syndromes from a phase 2 randomized study
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000002024openalex-snapshot
Opioid-induced constipation in patients with cancer: a “real-world,” multicentre, observational study of diagnostic criteria and clinical features
inferred← citeshttps://doi.org/10.1097/mcg.0000000000001801openalex-snapshot
Management of Opioid-induced Constipation in Older Adults
inferred← citeshttps://doi.org/10.1097/md.0000000000026547openalex-snapshot
Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy
inferred← citeshttps://doi.org/10.1097/med.0000000000000219openalex-snapshot
Expression and physiology of opioid receptors in the gastrointestinal tract
inferred← citeshttps://doi.org/10.1097/med.0000000000000220openalex-snapshot
Opioid-induced constipation in chronic noncancer pain
inferred← citeshttps://doi.org/10.1097/med.0000000000000222openalex-snapshot
Overview of gastrointestinal regulatory peptides
inferred← citeshttps://doi.org/10.1097/mpa.0000000000000864openalex-snapshot
Effect of Intravenous Fluids and Analgesia on Dysmotility in Patients With Acute Pancreatitis
inferred← citeshttps://doi.org/10.1097/sga.0000000000000807openalex-snapshot
Online Educational Module Improves Knowledge of Nurses on Bowel Preparation for Colonoscopy
inferred← citeshttps://doi.org/10.1101/cshperspect.a039263openalex-snapshot
Medications Development for Treatment of Opioid Use Disorder
inferred← citeshttps://doi.org/10.1111/apt.15791openalex-snapshot
Systematic review with meta‐analysis: efficacy and safety of treatments for opioid‐induced constipation
inferred← citeshttps://doi.org/10.1111/apt.16702openalex-snapshot
Incidence, pathophysiology, and implications of opioid‐induced constipation and suggestions for patient‐provider interactions
inferred← citeshttps://doi.org/10.1111/jcpt.12812openalex-snapshot
Treating opioid‐induced constipation in patients taking other medications: Avoiding CYP450 drug interactions
inferred← citeshttps://doi.org/10.1111/jgh.14586openalex-snapshot
Peripherally acting μ‐opioid antagonist for the treatment of opioid‐induced constipation: Systematic review and meta‐analysis
inferred← citeshttps://doi.org/10.1111/nmo.13000openalex-snapshot
Opioid analgesic use among patients presenting with acute abdominal pain and factors associated with surgical diagnoses
inferred← citeshttps://doi.org/10.1111/nmo.13367openalex-snapshot
Reduction in pain: Is it worth the gain? The effect of opioids on the GI tract
inferred← citeshttps://doi.org/10.1111/nmo.13563openalex-snapshot
Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation
inferred← citeshttps://doi.org/10.1111/papr.12445openalex-snapshot
Opioid‐Induced Constipation Survey in Patients with Chronic Noncancer Pain
inferred← citeshttps://doi.org/10.1111/papr.12646openalex-snapshot
Oral Prolonged‐Release Oxycodone/Naloxone for Managing Pain and Opioid‐Induced Constipation: A Review of the Evidence
inferred← citeshttps://doi.org/10.1111/pme.12911openalex-snapshot
Opioid-Induced Constipation
inferred← citeshttps://doi.org/10.1111/pme.12937openalex-snapshot
Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation
inferred← citeshttps://doi.org/10.11114/ijsss.v5i5.2376openalex-snapshot
Compensatory Eating Behaviors, Alcohol Consumption and Opioid Use in a Clinical Sample
inferred← citeshttps://doi.org/10.1136/bmjspcare-2020-002754openalex-snapshot
Opioid-induced constipation: a stepwise treatment algorithm feasibility study
inferred← citeshttps://doi.org/10.1136/esmoopen-2019-000527openalex-snapshot
Safety and efficacy of naldemedine in cancer patients with opioid-induced constipation: a pooled, subgroup analysis of two randomised controlled studies
inferred← citeshttps://doi.org/10.1136/postgradmedj-2020-138960openalex-snapshot
Opioid analgesics, faecal stones and rectosigmoid perforation
inferred← citeshttps://doi.org/10.1152/ajpgi.00025.2018openalex-snapshot
Inflammation-associated changes in DOR expression and function in the mouse colon
inferred← citeshttps://doi.org/10.1152/ajpgi.00400.2020openalex-snapshot
An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction
inferred← citeshttps://doi.org/10.1152/ajpgi.00442.2015openalex-snapshot
Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications
inferred← citeshttps://doi.org/10.1159/000533548openalex-snapshot
Current Treatment Practices for Adult Patients with Constipation in Japan
inferred← citeshttps://doi.org/10.1177/0023677219832919openalex-snapshot
A comparative study about the immunomodulatory effects of tramadol and metamizole in a murine model of postoperative ileus
inferred← citeshttps://doi.org/10.1177/02692163251325711openalex-snapshot
‘Constipation’: One word, many meanings amongst persons with cancer: An observational study
inferred← citeshttps://doi.org/10.1177/0300060519874539openalex-snapshot
Transcutaneous electrical nerve stimulation of acupuncture points enhances therapeutic effects of oral lactulose solution on opioid-induced constipation
inferred← citeshttps://doi.org/10.1177/0897190017732263openalex-snapshot
Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications
inferred← citeshttps://doi.org/10.1177/0897190017745395openalex-snapshot
The Evolving Role of Long-Term Pharmacotherapy for Opioid-Induced Constipation in Patients Being Treated for Noncancer Pain
inferred← citeshttps://doi.org/10.1177/1060028014560191openalex-snapshot
Naloxegol
inferred← citeshttps://doi.org/10.1177/10600280221132851openalex-snapshot
Naloxone Versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients
inferred← citeshttps://doi.org/10.1177/1756283x15578608openalex-snapshot
Chronic opioid induced constipation in patients with nonmalignant pain: challenges and opportunities
inferred← citeshttps://doi.org/10.1177/1756283x15589526openalex-snapshot
Evolving paradigms in the treatment of opioid-induced bowel dysfunction
inferred← citeshttps://doi.org/10.1177/1756283x16648869openalex-snapshot
The role of naloxegol in the management of opioid-induced bowel dysfunction
inferred← citeshttps://doi.org/10.1177/17562848211032320openalex-snapshot
Naldemedine is effective in the treatment of opioid-induced constipation in patients with chronic non-cancer pain who had a poor response to laxatives
inferred← citeshttps://doi.org/10.1177/2040622315627801openalex-snapshot
Opioid-induced constipation: advances and clinical guidance
inferred← citeshttps://doi.org/10.1177/2050640615604543openalex-snapshot
Efficacy and safety of naloxegol in patients with opioid‐induced constipation and laxative‐inadequate response
inferred← citeshttps://doi.org/10.1177/2050640616659967openalex-snapshot
Prevalence and clinical features of opioid‐induced constipation in the general population: A French study of 15,000 individuals
inferred← citeshttps://doi.org/10.1177/2050640618796748openalex-snapshot
New developments in the treatment of opioid‐induced gastrointestinal symptoms
inferred← citeshttps://doi.org/10.1186/s12876-016-0466-8openalex-snapshot
An appraisal of clinical practice guidelines for constipation: a right attitude towards to guidelines
inferred← citeshttps://doi.org/10.1186/s12974-016-0625-4openalex-snapshot
Targeting inflammation as a treatment modality for neuropathic pain in spinal cord injury: a randomized clinical trial
inferred← citeshttps://doi.org/10.1186/s13063-020-04385-0openalex-snapshot
Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: a proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study
inferred← citeshttps://doi.org/10.1188/20.onf.e211-e224openalex-snapshot
Management of Opioid-Induced and Non–Opioid-Related Constipation in Patients With Cancer: Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.1200/jco.2016.70.8453openalex-snapshot
Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients With Cancer
inferred← citeshttps://doi.org/10.1200/jco.2017.73.0853openalex-snapshot
Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-Induced Constipation and Cancer
inferred← citeshttps://doi.org/10.12968/bjon.2015.24.22.1129openalex-snapshot
Managing opioid-induced constipation
inferred← citeshttps://doi.org/10.12968/bjon.2016.25.10.s4openalex-snapshot
Management of opioid-induced constipation
inferred← citeshttps://doi.org/10.12968/ijpn.2015.21.6.272openalex-snapshot
Management of opioid-induced constipation for people in palliative care
inferred← citeshttps://doi.org/10.12968/npre.2016.14.11.560openalex-snapshot
Opioid-induced constipation: Pathophysiology, treatment and management
inferred← citeshttps://doi.org/10.1371/journal.pone.0295952openalex-snapshot
Naldemedine is associated with earlier defecation in critically ill patients with opioid-induced constipation: A retrospective, single-center cohort study
inferred← citeshttps://doi.org/10.14309/ajg.0000000000000496openalex-snapshot
How to Manage Opioid-Related Constipation in Individuals With Chronic Nonmalignant Pain Syndromes
inferred← citeshttps://doi.org/10.14309/ajg.0000000000001945openalex-snapshot
Recognizing and Defining Occasional Constipation: Expert Consensus Recommendations
inferred← citeshttps://doi.org/10.14814/phy2.70391openalex-snapshot
Autonomic effects of electroacupuncture in opioid‐induced constipation in male rats
inferred← citeshttps://doi.org/10.15403/jgld.2014.1121.281.anyopenalex-snapshot
Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation: A Meta-Analysis
inferred← citeshttps://doi.org/10.1586/17474124.2016.1129275openalex-snapshot
The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot study
inferred← citeshttps://doi.org/10.17352/ojpm.000015openalex-snapshot
Analysis of care for cancer patients with opioid-induced constipation in clinical practice: EIO-PRAXIS Project
inferred← citeshttps://doi.org/10.17352/ojpm.000016openalex-snapshot
Clinical practice evaluation of opioids induced constipation management in patients with cancer: The EIO-50 project
inferred← citeshttps://doi.org/10.17827/aktd.1305162openalex-snapshot
Bir Opioid Olan Tramadolün Farmakolojik Etkileri
inferred← citeshttps://doi.org/10.18553/jmcp.2016.22.3.236openalex-snapshot
The Burden of Opioid-Induced Constipation: Discordance Between Patient and Health Care Provider Reports
inferred← citeshttps://doi.org/10.2139/ssrn.5395821openalex-snapshot
Inhibitory Modulation of Gastrointestinal Motility in Mice by Tyr-c[D-Lys-Gly-p-F-Phe-Asp]-D-Pro-NH2, a Novel Cyclic Hexapeptide with Multifunctional Opioid Agonism
inferred← citeshttps://doi.org/10.2147/jpr.s141322openalex-snapshot
Spotlight on naldemedine in the treatment of opioid-induced constipation in adult patients with chronic noncancer pain: design, development, and place in therapy
inferred← citeshttps://doi.org/10.2147/jpr.s160625openalex-snapshot
Oral methylnaltrexone is efficacious and well tolerated for the treatment of opioid-induced constipation in patients with chronic noncancer pain receiving concomitant methadone
inferred← citeshttps://doi.org/10.2147/jpr.s170086openalex-snapshot
Safety of oral methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain
inferred← citeshttps://doi.org/10.2147/jpr.s175900openalex-snapshot
Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies
inferred← citeshttps://doi.org/10.2147/jpr.s220859openalex-snapshot
Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions
inferred← citeshttps://doi.org/10.2147/jpr.s237833openalex-snapshot
A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy
inferred← citeshttps://doi.org/10.2147/jpr.s405825openalex-snapshot
Methylnaltrexone Treatment for Opioid-Induced Constipation in Patients with and without Cancer: Effect of Initial Dose
inferred← citeshttps://doi.org/10.2147/jpr.s417045openalex-snapshot
Efficacy and Safety of Naloxegol in Patients with Chronic Non-Cancer Pain Who Experience Opioid-Induced Constipation: A Pooled Analysis of Two Global, Randomized Controlled Studies
inferred← citeshttps://doi.org/10.2147/ppa.s99412openalex-snapshot
Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem
inferred← citeshttps://doi.org/10.2217/pmt-2019-0045openalex-snapshot
Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Advanced-Illness Patients With or Without Active Cancer
inferred← citeshttps://doi.org/10.22246/jikm.2022.43.2.229openalex-snapshot
A Case Report on Opioid-Induced Constipation in a Patient with Cancer Treated by Jowiseunggi-tang
inferred← citeshttps://doi.org/10.23736/s0375-9393.23.17303-2openalex-snapshot
Pupillary monitoring decreases remifentanil consumption during laparoscopic uterine surgery and improves postoperative recovery
inferred← citeshttps://doi.org/10.25248/reas.e14905.2024openalex-snapshot
Controle dos sintomas com idosos hospitalizados em cuidados paliativos: estratégia centrada na pessoa idosa
inferred← citeshttps://doi.org/10.3322/caac.21453openalex-snapshot
Optimal pain management for patients with cancer in the modern era
inferred← citeshttps://doi.org/10.3389/fmed.2026.1869529openalex-snapshot
Acupuncture-related therapies for opioid-induced constipation in patients with cancer: a systematic review and network meta-analysis
inferred← citeshttps://doi.org/10.3389/fnins.2023.1146883openalex-snapshot
Regulation of enteric nervous system via sacral nerve stimulation in opioid-induced constipated rats
inferred← citeshttps://doi.org/10.3389/fnins.2023.1204233openalex-snapshot
New insight on the enteric cholinergic innervation of the pig colon by central and peripheral nervous systems: reduction by repeated loperamide administration
inferred← citeshttps://doi.org/10.3389/fphar.2025.1716974openalex-snapshot
Traditional herbal medicine for opioid-induced constipation in patients with cancer: a systematic review and meta-analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.3390/cancers14051128openalex-snapshot
A Prospective, Real-World, Multinational Study of Naloxegol for Patients with Cancer Pain Diagnosed with Opioid-Induced Constipation—The NACASY Study
inferred← citeshttps://doi.org/10.3390/cancers14092112openalex-snapshot
Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial
inferred← citeshttps://doi.org/10.3390/jcm10215203openalex-snapshot
Diet and Chronic Non-Cancer Pain: The State of the Art and Future Directions
inferred← citeshttps://doi.org/10.3390/jcm12196148openalex-snapshot
Management of Constipation in Hospitalized Patients
inferred← citeshttps://doi.org/10.3390/jcm13226689openalex-snapshot
Improving Diagnosis and Management of Opioid-Induced Constipation (OIC) in Clinical Practice: An Italian Expert Opinion
inferred← citeshttps://doi.org/10.37464/2020.392.410openalex-snapshot
Effectiveness of early mobilisation versus laxative use in reducing constipation in post-operative orthopaedic patients: an integrative review
inferred← citeshttps://doi.org/10.3748/wjg.v23.i36.6593openalex-snapshot
New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond
inferred← citeshttps://doi.org/10.3892/etm.2022.11766openalex-snapshot
P2Y1 receptor in the colonic submucosa of rats and its association with opioid‑induced constipation
inferred← citeshttps://doi.org/10.4103/ijpc.ijpc_187_20openalex-snapshot
Validity and reliability of the hindi version of the patient assessment of constipation quality of life questionnaire in cancer patients on opioids for pain management at tertiary care center, India
inferred← citeshttps://doi.org/10.4274/tjps.galenos.2024.80550openalex-snapshot
LACTULOSE VERSUS NALOXONE FOR OPIOID-INDUCED CONSTIPATION IN THE POISONING INTENSIVE CARE UNIT
inferred← citeshttps://doi.org/10.5056/jnm17058openalex-snapshot
Colorectal Transit and Volume During Treatment With Prolonged-release Oxycodone/Naloxone Versus Oxycodone Plus Macrogol 3350
inferred← citeshttps://doi.org/10.5056/jnm23144openalex-snapshot
Opioid-induced Constipation: Old and New Concepts in Diagnosis and Treatment
inferred← citeshttps://doi.org/10.5278/vbn.phd.med.00040openalex-snapshot
A Novel Approach to Assess Opioid-Induced Bowel Dysfunction
inferred← citeshttps://doi.org/10.5414/cp202276openalex-snapshot
Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects
inferred← citeshttps://doi.org/10.54337/aau306526107openalex-snapshot
Detailed motility and function of the opioid-affected colon: A study based on MRI and the electromagnetic capsule system
inferred← citeshttps://doi.org/10.5603/pmpi.a2023.0025openalex-snapshot
Pathophysiology and management of opioid-induced constipation: a narrative review
inferred← citeshttps://doi.org/10.6004/jadpro.2017.8.2.3openalex-snapshot
Managing Constipation in Adults With Cancer
inferred← citeshttps://doi.org/10.64719/pb.4616openalex-snapshot
Naldemedine for the Use of Management of Opioid Induced Constipation.
inferred← citeshttps://doi.org/10.7573/dic.2021-7-2openalex-snapshot
Impact of opioid-induced constipation on opioid substitution therapy management: the patient perspective
inferred← citeshttps://doi.org/10.7759/cureus.14386openalex-snapshot
Opioid-Induced Constipation in Advanced Cancer Patients
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