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Inflamed brain: Targeting immune changes and inflammation for treatment of depression

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Outgoing claims: the papers this work cites, builds on, or argues with.

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A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression
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Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects
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Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes
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Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?
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Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States
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Association of Psychiatric Disorders With Mortality Among Patients With COVID-19
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Metabolic profiles revealed synergistically antidepressant effects of lilies and Rhizoma Anemarrhenae in a rat model of depression
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Altered serum levels of TNF-α, IL-6, and IL-18 in depressive disorder patients
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The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases
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Mental disorders in systemic lupus erythematosus: a cohort study
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PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation
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Oriental medicine as therapy for resistant depression: Use of some herbal drugs in the far east (Japan)
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Cytomegalovirus is associated with depression and anxiety in older adults
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Reducing post-traumatic anxiety by immunization
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Social defeat promotes specific cytokine variations within the prefrontal cortex upon subsequent aggressive or endotoxin challenges
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Higher CSF interleukin-6 and CSF interleukin-8 in current depression in older women. Results from a population-based sample
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Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
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The effects of interleukin-6 neutralizing antibodies on symptoms of depressed mood and anhedonia in patients with rheumatoid arthritis and multicentric Castleman’s disease
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Novel therapeutic targets in depression: Minocycline as a candidate treatment
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Small molecule glutaminase inhibitors block glutamate release from stimulated microglia
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The P2X7 receptor: A main player in inflammation
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Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
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A Meta-Analysis of Cytokines in Major Depression
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Coordinated Messenger RNA/MicroRNA Changes in Fibroblasts of Patients with Major Depression
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Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression
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Testing Psychosis Phenotypes From Bipolar–Schizophrenia Network for Intermediate Phenotypes for Clinical Application: Biotype Characteristics and Targets
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Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior
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Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression
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The gut microbiota in anxiety and depression – A systematic review
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Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice
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The effect of adalimumab on reducing depression symptoms in patients with moderate to severe psoriasis: A randomized clinical trial
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Antibiotic-Induced Microbiome Depletion Is Associated with Resilience in Mice after Chronic Social Defeat Stress
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Gut microbiota and major depressive disorder: A systematic review and meta-analysis
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Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice
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Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammation
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Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
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Interleukin-1β is associated with depressive episode in major depression but not in bipolar disorder
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Astrocytes-induced neuronal inhibition contributes to depressive-like behaviors during chronic stress
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Treatment resistant depression: A multi-scale, systems biology approach
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The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation
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Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study
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Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis
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Effects of adjunctive N-acetylcysteine on depressive symptoms: Modulation by baseline high-sensitivity C-reactive protein
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The promise of N-acetylcysteine in neuropsychiatry
inferredcites →https://doi.org/10.1016/j.yjmcc.2015.07.027openalex-snapshot
The mammalian target of rapamycin modulates the immunoproteasome system in the heart
inferredcites →https://doi.org/10.1016/j.yjmcc.2015.09.014openalex-snapshot
Links between mTOR and the immunoproteasome: Therapeutic targets for cardiac hypertrophy?
inferredcites →https://doi.org/10.1016/s0006-3223(99)00230-9openalex-snapshot
Antidepressant effects of ketamine in depressed patients
inferredcites →https://doi.org/10.1016/s0140-6736(05)67763-xopenalex-snapshot
Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial
inferredcites →https://doi.org/10.1016/s0140-6736(18)31948-2openalex-snapshot
Depression
inferredcites →https://doi.org/10.1016/s2215-0366(18)30255-4openalex-snapshot
Rheumatoid arthritis and depression: an inflammatory perspective
inferredcites →https://doi.org/10.1016/s2215-0366(20)30255-8openalex-snapshot
Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
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A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
inferredcites →https://doi.org/10.1038/mp.2014.21openalex-snapshot
Astrocytic abnormalities and global DNA methylation patterns in depression and suicide
inferredcites →https://doi.org/10.1038/mp.2017.205openalex-snapshot
Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1038/mp.2017.64openalex-snapshot
Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety
inferredcites →https://doi.org/10.1038/nature18626openalex-snapshot
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
inferredcites →https://doi.org/10.1038/nm.3162openalex-snapshot
Astrocyte-derived ATP modulates depressive-like behaviors
inferredcites →https://doi.org/10.1038/nm.4246openalex-snapshot
Resting-state connectivity biomarkers define neurophysiological subtypes of depression
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Imaging biomarkers and biotypes for depression
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Neuroimmune mechanisms of depression
inferredcites →https://doi.org/10.1038/npp.2011.151openalex-snapshot
Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology
inferredcites →https://doi.org/10.1038/npp.2016.90openalex-snapshot
Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience
inferredcites →https://doi.org/10.1038/nrd.2017.16openalex-snapshot
Targeting glutamate signalling in depression: progress and prospects
inferredcites →https://doi.org/10.1038/nrdp.2016.65openalex-snapshot
Major depressive disorder
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The role of inflammation in depression: from evolutionary imperative to modern treatment target
inferredcites →https://doi.org/10.1038/s41380-018-0096-3openalex-snapshot
What does plasma CRP tell us about peripheral and central inflammation in depression?
inferredcites →https://doi.org/10.1038/s41380-019-0363-yopenalex-snapshot
Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons
inferredcites →https://doi.org/10.1038/s41380-019-0377-5openalex-snapshot
Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons
inferredcites →https://doi.org/10.1038/s41380-019-0380-xopenalex-snapshot
The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats
inferredcites →https://doi.org/10.1038/s41386-018-0177-7openalex-snapshot
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress
inferredcites →https://doi.org/10.1038/s41386-020-0644-9openalex-snapshot
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
inferredcites →https://doi.org/10.1038/s41590-020-0776-4openalex-snapshot
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons
inferredcites →https://doi.org/10.1038/s41593-017-0010-3openalex-snapshot
Social stress induces neurovascular pathology promoting depression
inferredcites →https://doi.org/10.1038/sj.mp.4001805openalex-snapshot
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
inferredcites →https://doi.org/10.1038/tp.2015.14openalex-snapshot
Fibroblasts from patients with major depressive disorder show distinct transcriptional response to metabolic stressors
inferredcites →https://doi.org/10.1073/pnas.1415191111openalex-snapshot
Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
inferredcites →https://doi.org/10.1073/pnas.1720696115openalex-snapshot
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
inferredcites →https://doi.org/10.1080/10253890.2016.1191466openalex-snapshot
CD4+T cells confer anxiolytic and antidepressant-like effects, but enhance fear memory processes inRag2−/−mice
inferredcites →https://doi.org/10.1080/1028415x.2015.1103461openalex-snapshot
Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review
inferredcites →https://doi.org/10.1097/hjh.0000000000001086openalex-snapshot
Effects of pentoxifylline on inflammatory markers and blood pressure
inferredcites →https://doi.org/10.1111/acps.12211openalex-snapshot
Effectiveness and tolerance of anti‐inflammatory drugs' add‐on therapy in major mental disorders: a systematic qualitative review
inferredcites →https://doi.org/10.1111/acps.13016openalex-snapshot
Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials
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Ketamine and Peripheral Inflammation
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Effects of Adalimumab Maintenance Therapy on Health-Related Quality of Life of Patients With Crohn's Disease: Patient-Reported Outcomes of the CHARM Trial
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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
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Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
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Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
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Impact of Ixekizumab Treatment on Depressive Symptoms and Systemic Inflammation in Patients with Moderate-to-Severe Psoriasis: An Integrated Analysis of Three Phase 3 Clinical Studies
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DSM-5 Field Trials in the United States and Canada, Part II: Test-Retest Reliability of Selected Categorical Diagnoses
inferredcites →https://doi.org/10.1176/appi.ajp.2018.18070881openalex-snapshot
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples
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Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice
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Diagnostic and Statistical Manual of Mental Disorders
inferredcites →https://doi.org/10.1177/0269881117724352openalex-snapshot
Minocycline as an adjunct for treatment-resistant depressive symptoms: A pilot randomised placebo-controlled trial
inferredcites →https://doi.org/10.1177/1529100617727266openalex-snapshot
Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5 , and the National Institute of Mental Health’s Research Domain Criteria (RDoC)
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IL-6 Signaling in Monocytes: A Potential Therapeutic Avenue for Stress-Induced Mood Impairments
inferredcites →https://doi.org/10.1186/s12916-017-0916-3openalex-snapshot
The renin–angiotensin system: a possible new target for depression
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A systematic review of St. John’s wort for major depressive disorder
inferredcites →https://doi.org/10.1192/bjpo.bp.115.000786openalex-snapshot
High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs
inferredcites →https://doi.org/10.1371/journal.pone.0042054openalex-snapshot
CD4+CD25+ Regulatory T Cell Depletion Modulates Anxiety and Depression-Like Behaviors in Mice
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Glutamate Released from Glial Cells Synchronizes Neuronal Activity in the Hippocampus
inferredcites →https://doi.org/10.1523/jneurosci.2278-14.2015openalex-snapshot
Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice
inferredcites →https://doi.org/10.1523/jneurosci.5966-09.2010openalex-snapshot
Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate
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Inflammation in Depression and the Potential for Anti-Inflammatory Treatment
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Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health’ s Research Domain Criteria (RDoC)
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Autonomic and Redox Imbalance Correlates With T-Lymphocyte Inflammation in a Model of Chronic Social Defeat Stress
inferredcites →https://doi.org/10.3389/fnmol.2020.00093openalex-snapshot
P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.3389/fnmol.2020.00094openalex-snapshot
The Role of P2X7 Receptor in Alzheimer’s Disease
inferredcites →https://doi.org/10.3390/molecules24244587openalex-snapshot
Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice
inferredcites →https://doi.org/10.3892/mmr.2020.11305openalex-snapshot
Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway
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Reduction in pain scores and improvement in depressive symptoms in patients with hidradenitis suppurativa treated with adalimumab in a phase 2, randomized, placebo-controlled trial

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Depressive Disorders
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Inflammation—Cause or consequence of late onset Alzheimer’s disease or both? A review of the evidence
inferred← citeshttps://doi.org/10.1186/s12888-025-07054-1openalex-snapshot
Differentially expressed microRNAs in human depression: a systematic review of case-control and longitudinal studies
inferred← citeshttps://doi.org/10.1186/s12915-025-02301-zopenalex-snapshot
Targeting the complement-mTOR-autophagy axis: the role of apolipoprotein E in depression
inferred← citeshttps://doi.org/10.1186/s12974-023-02768-zopenalex-snapshot
α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect
inferred← citeshttps://doi.org/10.1186/s43556-024-00205-yopenalex-snapshot
Treatment-resistant depression: molecular mechanisms and management
inferred← citeshttps://doi.org/10.1192/bjo.2024.787openalex-snapshot
Inflammatory biomarkers in depression: scoping review
inferred← citeshttps://doi.org/10.2174/0122103155288752240219095244openalex-snapshot
The Neuroprotective Properties of Thymol and Carvacrol: A Review Study
inferred← citeshttps://doi.org/10.22317/jcms.v8i3.1230openalex-snapshot
Curcumin attenuates development of depressive-like behavior in male rats after spinal cord injury: involvement of NLRP3 inflammasome
inferred← citeshttps://doi.org/10.3389/fpsyt.2022.932635openalex-snapshot
Case report: Depressive disorder with peripartum onset camouflages suspected intracranial tuberculoma
inferred← citeshttps://doi.org/10.3390/brainsci12101403openalex-snapshot
Current Perspectives on Pharmacological and Non-Pharmacological Interventions for the Inflammatory Mechanism of Unipolar Depression
inferred← citeshttps://doi.org/10.3390/brainsci13050719openalex-snapshot
Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression
inferred← citeshttps://doi.org/10.3390/cancers16091702openalex-snapshot
Review of Psilocybin Use for Depression among Cancer Patients after Approval in Oregon
inferred← citeshttps://doi.org/10.3390/cells13050423openalex-snapshot
Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets
inferred← citeshttps://doi.org/10.3390/ph19040629openalex-snapshot
Ferroptosis in Neuropsychiatric and Neurodegenerative Disorders: Shared Mechanisms and Disease-Specific Signatures
inferred← citeshttps://doi.org/10.56717/jpp.2023.v02i01.016openalex-snapshot
Neuroinflammation and depression: An update
inferred← citeshttps://doi.org/10.59237/conexsaudefib.v6i.544openalex-snapshot
Alterações inflamatórias envolvidas na Fisiopatologia da Depressão: revisão de literatura
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