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Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload‐induced increases in Ca2+ transient and Ca2+ sparks

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.ceca.2005.06.017openalex-snapshot
The control of sarcoplasmic reticulum Ca content in cardiac muscle
inferredcites →https://doi.org/10.1016/j.cell.2008.02.048openalex-snapshot
A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation
inferredcites →https://doi.org/10.1016/j.yjmcc.2006.12.007openalex-snapshot
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII
inferredcites →https://doi.org/10.1016/j.yjmcc.2009.12.017openalex-snapshot
Myofilament length dependent activation
inferredcites →https://doi.org/10.1016/j.yjmcc.2011.01.012openalex-snapshot
CaMKII in myocardial hypertrophy and heart failure
inferredcites →https://doi.org/10.1016/j.yjmcc.2016.06.007openalex-snapshot
CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift
inferredcites →https://doi.org/10.1016/j.yjmcc.2017.04.005openalex-snapshot
β-Adrenergic induced SR Ca 2+ leak is mediated by an Epac-NOS pathway
inferredcites →https://doi.org/10.1016/j.yjmcc.2019.01.001openalex-snapshot
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy
inferredcites →https://doi.org/10.1016/s0022-2828(85)80097-3openalex-snapshot
The cellular basis of the length-tension relation in cardiac muscle
inferredcites →https://doi.org/10.1038/415198aopenalex-snapshot
Cardiac excitation–contraction coupling
inferredcites →https://doi.org/10.1038/nature12537openalex-snapshot
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
inferredcites →https://doi.org/10.1038/ncb1001-867openalex-snapshot
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes
inferredcites →https://doi.org/10.1038/s41467-021-25601-8openalex-snapshot
The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
inferredcites →https://doi.org/10.1042/bj20020228openalex-snapshot
Structure–function of the multifunctional Ca2+/calmodulin-dependent protein kinase II
inferredcites →https://doi.org/10.1073/pnas.1516732113openalex-snapshot
Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins
inferredcites →https://doi.org/10.1073/pnas.2108484118openalex-snapshot
Mechanoelectric coupling and arrhythmogenesis in cardiomyocytes contracting under mechanical afterload in a 3D viscoelastic hydrogel
inferredcites →https://doi.org/10.1074/jbc.c000253200openalex-snapshot
Frequency-encoding Thr17 Phospholamban Phosphorylation Is Independent of Ser16 Phosphorylation in Cardiac Myocytes
inferredcites →https://doi.org/10.1074/jbc.m114.558254openalex-snapshot
Nitric Oxide Induces Ca2+-independent Activity of the Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)
inferredcites →https://doi.org/10.1074/jbc.m115.650234openalex-snapshot
S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ
inferredcites →https://doi.org/10.1074/jbc.m404175200openalex-snapshot
Redox Regulation of the Calcium/Calmodulin-dependent Protein Kinases
inferredcites →https://doi.org/10.1093/cvr/cvt201openalex-snapshot
NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle
inferredcites →https://doi.org/10.1111/apha.13250openalex-snapshot
The slow force response to stretch: Controversy and contradictions
inferredcites →https://doi.org/10.1113/jp276494openalex-snapshot
Mechano‐electric and mechano‐chemo‐transduction in cardiomyocytes
inferredcites →https://doi.org/10.1113/jp279607openalex-snapshot
CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect
inferredcites →https://doi.org/10.1113/jphysiol.1966.sp007909openalex-snapshot
The variation in isometric tension with sarcomere length in vertebrate muscle fibres
inferredcites →https://doi.org/10.1126/science.1202768openalex-snapshot
X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart
inferredcites →https://doi.org/10.1126/scisignal.2005046openalex-snapshot
Mechanochemotransduction During Cardiomyocyte Contraction Is Mediated by Localized Nitric Oxide Signaling
inferredcites →https://doi.org/10.1152/ajpcell.00586.2006openalex-snapshot
SparkMaster: automated calcium spark analysis with ImageJ
inferredcites →https://doi.org/10.1152/ajpcell.1995.268.1.c271openalex-snapshot
Kinetics of [Ca]i decline in cardiac myocytes depend on peak [Ca]i
inferredcites →https://doi.org/10.1152/ajpheart.00508.2012openalex-snapshot
The Anrep effect: 100 years later
inferredcites →https://doi.org/10.1161/01.res.0000125626.33738.e2openalex-snapshot
Ca 2+ /Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor
inferredcites →https://doi.org/10.1161/01.res.0000194329.41863.89openalex-snapshot
Ca 2+ /Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca 2+ Leak in Heart Failure
inferredcites →https://doi.org/10.1161/01.res.0000236756.06252.13openalex-snapshot
Ca 2+ /Calmodulin-Dependent Protein Kinase II Phosphorylation of Ryanodine Receptor Does Affect Calcium Sparks in Mouse Ventricular Myocytes
inferredcites →https://doi.org/10.1161/circheartfailure.108.785279openalex-snapshot
Elevated Afterload, Neuroendocrine Stimulation, and Human Heart Failure Increase BNP Levels and Inhibit Preload-Dependent SERCA Upregulation
inferredcites →https://doi.org/10.1161/circresaha.107.152140openalex-snapshot
Intra–Sarcoplasmic Reticulum Free [Ca 2+ ] and Buffering in Arrhythmogenic Failing Rabbit Heart
inferredcites →https://doi.org/10.1161/circresaha.111.247148openalex-snapshot
Fluorescence Resonance Energy Transfer–Based Sensor Camui Provides New Insight Into Mechanisms of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Intact Cardiomyocytes
inferredcites →https://doi.org/10.1161/circresaha.119.316288openalex-snapshot
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes
inferredcites →https://doi.org/10.1161/circresaha.120.318570openalex-snapshot
Mechanical Load Regulates Excitation-Ca 2+ Signaling-Contraction in Cardiomyocyte
inferredcites →https://doi.org/10.1161/circulationaha.109.863795openalex-snapshot
Mechanical Dyssynchrony After Myocardial Infarction in Patients With Left Ventricular Dysfunction, Heart Failure, or Both
inferredcites →https://doi.org/10.1161/circulationaha.110.943431openalex-snapshot
Differential Cardiac Remodeling in Preload Versus Afterload
inferredcites →https://doi.org/10.1161/circulationaha.110.982298openalex-snapshot
Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure
inferredcites →https://doi.org/10.1161/circulationaha.12.148619openalex-snapshot
Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca 2+ Leak and Arrhythmia
inferredcites →https://doi.org/10.1371/journal.pone.0087495openalex-snapshot
Nitric Oxide-Dependent Activation of CaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes in Response to Adrenergic Stimulation
inferredcites →https://doi.org/10.1523/jneurosci.0133-09.2009openalex-snapshot
NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4816680openalex-extracted
Modeling Autoregulation of Cardiac Excitation-Ca-Contraction in Response to Mechanical Load Changes and Arrhythmogenic Activities Under Overload
inferred← citeshttps://doi.org/10.1002/tcr.202500128openalex-snapshot
Crosstalk between Nitric Oxide and Bioinorganic Centers: Implications for Cellular Signaling
inferred← citeshttps://doi.org/10.1007/s13577-026-01425-wopenalex-snapshot
Exploring the role of CaMKII in exercise-induced cardioprotection
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102886openalex-snapshot
Ca2+/Calmodulin-dependent protein kinase II (CaMKII)-targeted drug discovery: Challenges and strategies
inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115571openalex-snapshot
Orally administered sodium nitrite prevents the increased α-1 adrenergic vasoconstriction induced by hypertension and promotes the S-nitrosylation of calcium/calmodulin-dependent protein kinase II
inferred← citeshttps://doi.org/10.1016/j.ceca.2023.102769openalex-snapshot
The ryanodine receptor microdomain in cardiomyocytes
inferred← citeshttps://doi.org/10.1016/j.isci.2025.111788openalex-snapshot
Modeling autoregulation of cardiac excitation-Ca-contraction and arrhythmogenic activities in response to mechanical load changes
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107790openalex-snapshot
Phytochemical regulation of CaMKII in Alzheimer’s disease: A review of molecular mechanisms and therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2026.02.007openalex-snapshot
Sex differences in mitochondrial Ca2+ during ischemia/reperfusion injury: A role for S-Nitrosylation
inferred← citeshttps://doi.org/10.1093/eurheartj/ehad100openalex-snapshot
Acyl ghrelin improves cardiac function in heart failure and increases fractional shortening in cardiomyocytes without calcium mobilization
inferred← citeshttps://doi.org/10.1101/2023.08.23.554546openalex-snapshot
Nitric Oxide modulates spontaneous Ca 2+ release and ventricular arrhythmias during β-adrenergic signalling through S -nitrosylation of Calcium/Calmodulin dependent kinase II
inferred← citeshttps://doi.org/10.1113/jp284739openalex-snapshot
Molecular and cellular neurocardiology in heart disease
inferred← citeshttps://doi.org/10.1113/jp286706openalex-snapshot
Cardiac mechano‐electric crosstalk: multi‐scale observations, computational integration, and clinical implications
inferred← citeshttps://doi.org/10.1113/jp287886openalex-snapshot
Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals
inferred← citeshttps://doi.org/10.1134/s1234567825600191openalex-snapshot
Protective Effect of Omega-3 Fatty Acid Supplementation against Immobilization Stress-Induced Cardiac Morphological and Functional Abnormalities in the Menopausal Rat Model
inferred← citeshttps://doi.org/10.1146/annurev-physiol-022724-104846openalex-snapshot
The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect
inferred← citeshttps://doi.org/10.1146/annurev-physiol-043024-114759openalex-snapshot
CaMKII in the Heart: From Homeostasis to Pathology
inferred← citeshttps://doi.org/10.1161/circresaha.123.323571openalex-snapshot
Nitric Oxide Modulates Ca 2+ Leak and Arrhythmias via S-Nitrosylation of CaMKII
inferred← citeshttps://doi.org/10.1177/17534259241249287openalex-snapshot
Mechanical gated ion channel Piezo1: Function, and role in macrophage inflammatory response
inferred← citeshttps://doi.org/10.14814/phy2.70709openalex-snapshot
Ca 2+ /calmodulin‐dependent protein kinase II and protein kinase G independently contribute to acutely enhance myocardial compliance with stretch
inferred← citeshttps://doi.org/10.3389/fphys.2025.1565917openalex-snapshot
S-nitrosylation of cardiac myocyte proteins may underlie sex differences in cardiac disease
inferred← citeshttps://doi.org/10.3390/ijms25179610openalex-snapshot
Left Ventricular Systolic Dysfunction in NBCe1-B/C-Knockout Mice
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