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Impaired sinoatrial node function and increased susceptibility to atrial fibrillation in mice lacking natriuretic peptide receptor C

https://doi.org/10.1113/jphysiol.2014.283135
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcp.20793openalex-snapshot
BNP‐induced activation of cGMP in human cardiac fibroblasts: Interactions with fibronectin and natriuretic peptide receptors
inferredcites →https://doi.org/10.1007/s00109-011-0801-zopenalex-snapshot
Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides
inferredcites →https://doi.org/10.1007/s00424-007-0375-3openalex-snapshot
Blebbistatin: use as inhibitor of muscle contraction
inferredcites →https://doi.org/10.1007/s10741-007-9016-3openalex-snapshot
Natriuretic peptides and therapeutic applications
inferredcites →https://doi.org/10.1007/s11010-013-1612-zopenalex-snapshot
Suppression of atrial natriuretic peptide/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts
inferredcites →https://doi.org/10.1016/0002-9149(91)90648-5openalex-snapshot
Quantitative analysis of signal-averaged P waves in idiopathic paroxysmal atrial fibrillation
inferredcites →https://doi.org/10.1016/0165-0270(91)90017-topenalex-snapshot
Low access resistance perforated patch recordings using amphotericin B
inferredcites →https://doi.org/10.1016/0735-1097(95)80028-fopenalex-snapshot
Effects of autonomic stimulation and blockade on signal-averaged P wave duration
inferredcites →https://doi.org/10.1016/j.cardiores.2004.08.020openalex-snapshot
Structural and functional characterisation of cardiac fibroblasts
inferredcites →https://doi.org/10.1016/j.cardiores.2006.11.016openalex-snapshot
Organisation of the mouse sinoatrial node: structure and expression of HCN channels
inferredcites →https://doi.org/10.1016/j.hrthm.2009.02.038openalex-snapshot
Myofibroblasts in diseased hearts: New players in cardiac arrhythmias?
inferredcites →https://doi.org/10.1016/j.jacc.2004.10.067openalex-snapshot
C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction
inferredcites →https://doi.org/10.1016/j.jacc.2007.09.064openalex-snapshot
Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation
inferredcites →https://doi.org/10.1016/j.peptides.2004.09.023openalex-snapshot
Natriuretic peptide receptor-C signaling and regulation
inferredcites →https://doi.org/10.1016/j.yjmcc.2012.01.018openalex-snapshot
The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors
inferredcites →https://doi.org/10.1016/j.yjmcc.2012.08.020openalex-snapshot
Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptors
inferredcites →https://doi.org/10.1016/s0008-6363(01)00364-9openalex-snapshot
Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution
inferredcites →https://doi.org/10.1016/s0008-6363(01)00370-4openalex-snapshot
Properties of the hyperpolarization-activated current (If) in isolated mouse sino-atrial cells
inferredcites →https://doi.org/10.1016/s0008-6363(02)00223-7openalex-snapshot
Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation
inferredcites →https://doi.org/10.1016/s0021-9258(19)37002-4openalex-snapshot
Ligand-independent oligomerization of natriuretic peptide receptors. Identification of heteromeric receptors and a dominant negative mutant.
inferredcites →https://doi.org/10.1016/s0031-6997(24)01457-1openalex-snapshot
Guanylyl Cyclases and Signaling by Cyclic GMP
inferredcites →https://doi.org/10.1016/s0031-6997(25)00429-6openalex-snapshot
Atrial natriuretic factor receptors and signal transduction mechanisms.
inferredcites →https://doi.org/10.1038/415219aopenalex-snapshot
New ideas about atrial fibrillation 50 years on
inferredcites →https://doi.org/10.1056/nejm199807303390507openalex-snapshot
Natriuretic Peptides
inferredcites →https://doi.org/10.1056/nejmoa1100171openalex-snapshot
Effect of Nesiritide in Patients with Acute Decompensated Heart Failure
inferredcites →https://doi.org/10.1073/pnas.96.13.7403openalex-snapshot
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
inferredcites →https://doi.org/10.1073/pnas.96.18.10278openalex-snapshot
Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene ( Npr3 )
inferredcites →https://doi.org/10.1074/jbc.m101587200openalex-snapshot
Cytoplasmic Domain of Natriuretic Peptide Receptor C Constitutes Gi Activator Sequences That Inhibit Adenylyl Cyclase Activity
inferredcites →https://doi.org/10.1093/cvr/cvq329openalex-snapshot
Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation
inferredcites →https://doi.org/10.1111/j.1540-8167.1999.tb00192.xopenalex-snapshot
Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping
inferredcites →https://doi.org/10.1113/expphysiol.2011.057752openalex-snapshot
Ageing-dependent remodelling of ion channel and Ca2+clock genes underlying sino-atrial node pacemaking
inferredcites →https://doi.org/10.1113/jphysiol.2004.074047openalex-snapshot
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart
inferredcites →https://doi.org/10.1113/jphysiol.2006.120832openalex-snapshot
C‐type natriuretic peptide activates a non‐selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor‐mediated signalling
inferredcites →https://doi.org/10.1113/jphysiol.2007.144253openalex-snapshot
Natriuretic peptide C receptor signalling in the heart and vasculature
inferredcites →https://doi.org/10.1113/jphysiol.2013.265405openalex-snapshot
Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart
inferredcites →https://doi.org/10.1126/science.2823385openalex-snapshot
Physiological Role of Silent Receptors of Atrial Natriuretic Factor
inferredcites →https://doi.org/10.1152/ajpcell.00520.2002openalex-snapshot
Identification of the G protein-activating sequence of the single-transmembrane natriuretic peptide receptor C (NPR-C)
inferredcites →https://doi.org/10.1152/ajpheart.00022.2006openalex-snapshot
Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node
inferredcites →https://doi.org/10.1152/ajpheart.00380.2004openalex-snapshot
Heterogeneity of action potential durations in isolated mouse left and right atria recorded using voltage-sensitive dye mapping
inferredcites →https://doi.org/10.1152/ajpheart.00388.2003openalex-snapshot
Inhibition of L-type Ca2+current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect
inferredcites →https://doi.org/10.1152/ajpheart.00734.2012openalex-snapshot
Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis
inferredcites →https://doi.org/10.1152/ajpheart.00756.2009openalex-snapshot
Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice
inferredcites →https://doi.org/10.1152/ajpheart.00892.2011openalex-snapshot
Conduction barriers and pathways of the sinoatrial pacemaker complex: their role in normal rhythm and atrial arrhythmias
inferredcites →https://doi.org/10.1152/ajpheart.00893.2003openalex-snapshot
Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor
inferredcites →https://doi.org/10.1152/physrev.00018.2007openalex-snapshot
Genesis and Regulation of the Heart Automaticity
inferredcites →https://doi.org/10.1160/th04-08-0522openalex-snapshot
Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors
inferredcites →https://doi.org/10.1161/01.cir.0000147829.78357.c5openalex-snapshot
Overexpression of Brain Natriuretic Peptide Facilitates Neutrophil Infiltration and Cardiac Matrix Metalloproteinase-9 Expression After Acute Myocardial Infarction
inferredcites →https://doi.org/10.1161/01.cir.45.1.140openalex-snapshot
Significance of the Sinus-Node Recovery Time
inferredcites →https://doi.org/10.1161/01.cir.94.10.2641openalex-snapshot
In Vivo Cardiac Electrophysiology Studies in the Mouse
inferredcites →https://doi.org/10.1161/01.res.0000046234.73401.70openalex-snapshot
Brain Natriuretic Peptide Is Produced in Cardiac Fibroblasts and Induces Matrix Metalloproteinases
inferredcites →https://doi.org/10.1161/01.res.0000117070.86556.9fopenalex-snapshot
B-Type Natriuretic Peptide Exerts Broad Functional Opposition to Transforming Growth Factor-β in Primary Human Cardiac Fibroblasts
inferredcites →https://doi.org/10.1161/circep.110.960401openalex-snapshot
Iron Overload Decreases Ca V 1.3-Dependent L-Type Ca 2+ Currents Leading to Bradycardia, Altered Electrical Conduction, and Atrial Fibrillation
inferredcites →https://doi.org/10.1161/circep.111.000104openalex-snapshot
Role of Leptin Signaling in the Pathogenesis of Angiotensin II–Mediated Atrial Fibrosis and Fibrillation
inferredcites →https://doi.org/10.1161/circheartfailure.108.776294openalex-snapshot
The Tumultuous Journey of Nesiritide
inferredcites →https://doi.org/10.1161/circresaha.107.157677openalex-snapshot
Atrial Natriuretic Peptide Inhibits Transforming Growth Factor β–Induced Smad Signaling and Myofibroblast Transformation in Mouse Cardiac Fibroblasts
inferredcites →https://doi.org/10.1161/circresaha.107.158428openalex-snapshot
Altered Heart Rate and Sinoatrial Node Function in Mice Lacking the cAMP Regulator Phosphoinositide 3-Kinase-γ
inferredcites →https://doi.org/10.1161/circulationaha.106.616011openalex-snapshot
New Insights Into Pacemaker Activity
inferredcites →https://doi.org/10.1161/circulationaha.109.935288openalex-snapshot
Complex Interactions Between the Sinoatrial Node and Atrium During Reentrant Arrhythmias in the Canine Heart
inferredcites →https://doi.org/10.1210/en.2003-0128openalex-snapshot
Gene Expression, Secretion, and Autocrine Action of C-Type Natriuretic Peptide in Cultured Adult Rat Cardiac Fibroblasts
inferredcites →https://doi.org/10.1210/er.2005-0014openalex-snapshot
Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions
inferredcites →https://doi.org/10.1242/dev.100370openalex-snapshot
Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development
inferredcites →https://doi.org/10.1371/journal.pcbi.1002390openalex-snapshot
Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study
inferredcites →https://doi.org/10.1371/journal.pone.0022801openalex-snapshot
Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes
inferredcites →https://doi.org/10.1371/journal.pone.0047652openalex-snapshot
Distinct Patterns of Constitutive Phosphodiesterase Activity in Mouse Sinoatrial Node and Atrial Myocardium
inferredcites →https://doi.org/10.1529/biophysj.108.136473openalex-snapshot
Electrotonic Myofibroblast-to-Myocyte Coupling Increases Propensity to Reentrant Arrhythmias in Two-Dimensional Cardiac Monolayers
inferredcites →https://doi.org/10.2310/6650.2005.53711openalex-snapshot
Natriuretic Peptides: Novel Therapeutic Targets in Heart Failure
inferredcites →https://doi.org/10.2310/jim.0b013e3181946fb2openalex-snapshot
Designer Natriuretic Peptides

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4640265openalex-extracted
Wnt/β-Catenin Signaling Causes Sinoatrial Node Dysfunction by Inhibition of T-type Calcium Current
inferred← citeshttps://doi.org/10.1002/clc.22715openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/pul2.70341openalex-snapshot
HIV‐Associated Pulmonary Arterial Hypertension in Resource‐Limited Settings: A “Forgotten” Diagnosis, a Great Imitator, and a Multi‐Hit Pulmonary Vasculopathy
inferred← citeshttps://doi.org/10.1007/978-3-319-17437-2_19openalex-snapshot
Natriuretic Peptides: Critical Regulators of Cardiac Fibroblasts and the Extracellular Matrix in the Heart
inferred← citeshttps://doi.org/10.1007/s00395-016-0584-zopenalex-snapshot
Cross-talk between macrophages and atrial myocytes in atrial fibrillation
inferred← citeshttps://doi.org/10.1007/s11886-023-01885-8openalex-snapshot
Emerging Signaling Regulation of Sinoatrial Node Dysfunction
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.99759-9openalex-snapshot
OBSOLETE: Cellular Sinoatrial Node and Atrioventricular Node Activity in the Heart
inferred← citeshttps://doi.org/10.1016/b978-0-12-809657-4.99759-xopenalex-snapshot
Cellular Sinoatrial Node and Atrioventricular Node Activity in the Heart
inferred← citeshttps://doi.org/10.1016/b978-0-443-15734-9.00032-7openalex-snapshot
Cellular Sinoatrial Node and Atrioventricular Node Activity in the Heart
inferred← citeshttps://doi.org/10.1016/j.cjca.2024.03.003openalex-snapshot
Preclinical Studies on the Effects of Frailty in the Aging Heart
inferred← citeshttps://doi.org/10.1016/j.ejmg.2020.104029openalex-snapshot
ISL1 loss-of-function variation causes familial atrial fibrillation
inferred← citeshttps://doi.org/10.1016/j.ijcard.2018.06.001openalex-snapshot
Evolving use of natriuretic peptide receptor type-C as part of strategies for the treatment of pulmonary hypertension due to left ventricle heart failure
inferred← citeshttps://doi.org/10.1016/j.jacbts.2018.08.004openalex-snapshot
Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2015.12.001openalex-snapshot
Electrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypes
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2017.07.012openalex-snapshot
Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemaking
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108708openalex-snapshot
C-type natriuretic peptide (CNP): The cardiovascular system and beyond
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107447openalex-snapshot
Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107870openalex-snapshot
Endothelium-derived C-type natriuretic peptide offsets the pathogenesis of pulmonary hypertension
inferred← citeshttps://doi.org/10.1016/j.yexcr.2023.113738openalex-snapshot
C-atrial natriuretic peptide (ANP)4-23 attenuates renal fibrosis in deoxycorticosterone-acetate-salt hypertensive mice
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2015.02.024openalex-snapshot
Altered parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2018.09.011openalex-snapshot
Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2023.04.004openalex-snapshot
The role of P21-activated kinase (Pak1) in sinus node function
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01974openalex-snapshot
A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C
inferred← citeshttps://doi.org/10.1038/s41598-017-17690-7openalex-snapshot
Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C)
inferred← citeshttps://doi.org/10.1038/s41598-021-91937-2openalex-snapshot
Impaired regulation of heart rate and sinoatrial node function by the parasympathetic nervous system in type 2 diabetic mice
inferred← citeshttps://doi.org/10.1038/s42003-024-06861-8openalex-snapshot
Dim light at night unmasks sex-specific differences in circadian and autonomic regulation of cardiovascular physiology
inferred← citeshttps://doi.org/10.1038/srep44336openalex-snapshot
Atrial structure, function and arrhythmogenesis in aged and frail mice
inferred← citeshttps://doi.org/10.1042/cs20231025openalex-snapshot
Aging and sinus node dysfunction: mechanisms and future directions
inferred← citeshttps://doi.org/10.1073/pnas.1914853117openalex-snapshot
Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes
inferred← citeshttps://doi.org/10.1080/14728222.2024.2351501openalex-snapshot
Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments
inferred← citeshttps://doi.org/10.1093/cvr/cvab080openalex-snapshot
New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation
inferred← citeshttps://doi.org/10.1093/cvr/cvab245openalex-snapshot
Natriuretic peptide receptor B maintains heart rate and sinoatrial node function via cyclic GMP-mediated signalling
inferred← citeshttps://doi.org/10.1093/cvr/cvy224openalex-snapshot
Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation
inferred← citeshttps://doi.org/10.1093/cvr/cvy287openalex-snapshot
Natriuretic peptide receptors and atrial-selective fibrosis: potential role in atrial fibrillation
inferred← citeshttps://doi.org/10.1093/eurheartj/ehz093openalex-snapshot
C-type natriuretic peptide co-ordinates cardiac structure and function
inferred← citeshttps://doi.org/10.1093/gerona/glab357openalex-snapshot
Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice
inferred← citeshttps://doi.org/10.1111/jch.14120openalex-snapshot
Angiotensin receptor neprilysin inhibitor as a novel antihypertensive drug: Evidence from Asia and around the globe
inferred← citeshttps://doi.org/10.1113/jp272979openalex-snapshot
The impacts of age and frailty on heart rate and sinoatrial node function
inferred← citeshttps://doi.org/10.1126/sciadv.add4222openalex-snapshot
NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways
inferred← citeshttps://doi.org/10.1152/ajpheart.00434.2021openalex-snapshot
Optimizing transesophageal atrial pacing in mice to detect atrial fibrillation
inferred← citeshttps://doi.org/10.1152/ajpheart.00439.2022openalex-snapshot
Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
inferred← citeshttps://doi.org/10.1152/ajpregu.00025.2024openalex-snapshot
Feeding behavior modifies the circadian variation in RR and QT intervals by distinct mechanisms in mice
inferred← citeshttps://doi.org/10.1152/physrev.00022.2019openalex-snapshot
Phylogenic Determinants of Cardiovascular Frailty, Focus on Hemodynamics and Arterial Smooth Muscle Cells
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Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View
inferred← citeshttps://doi.org/10.1161/circep.115.002896openalex-snapshot
Effects of Wild-Type and Mutant Forms of Atrial Natriuretic Peptide on Atrial Electrophysiology and Arrhythmogenesis
inferred← citeshttps://doi.org/10.1161/circep.118.006863openalex-snapshot
NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II–Mediated Atrial Fibrillation and Atrial Remodeling in Mice
inferred← citeshttps://doi.org/10.1161/circep.121.010077openalex-snapshot
Atrial Fibrillation in Aging and Frail Mice
inferred← citeshttps://doi.org/10.1161/circep.123.012199openalex-snapshot
Natriuretic Peptide Receptor B Protects Against Atrial Fibrillation by Controlling Atrial cAMP Via Phosphodiesterase 2
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Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling
inferred← citeshttps://doi.org/10.1161/jaha.121.022369openalex-snapshot
Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis
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Attenuating persistent sodium current–induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress
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Authors’ reply: role of natriuretic peptide receptor C signalling in obesity‐induced heart failure with preserved ejection fraction with pulmonary hypertension
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Research progress in natriuretic peptide receptor C and cardiovascular disease
inferred← citeshttps://doi.org/10.15406/jccr.2015.03.00121openalex-snapshot
Age-Related Electrophysiological Changes of the Atrial Myocardium in Patients with Paroxysmal Atrial Fibrillation
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inferred← citeshttps://doi.org/10.3389/fphys.2021.674254openalex-snapshot
Natriuretic Peptide Clearance Receptor (NPR-C) Pathway as a Novel Therapeutic Target in Obesity-Related Heart Failure With Preserved Ejection Fraction (HFpEF)
inferred← citeshttps://doi.org/10.3389/fphys.2022.1021807openalex-snapshot
Regional and temporal progression of atrial remodeling in angiotensin II mediated atrial fibrillation
inferred← citeshttps://doi.org/10.3389/fphys.2023.1149023openalex-snapshot
Overview of programmed electrical stimulation to assess atrial fibrillation susceptibility in mice
inferred← citeshttps://doi.org/10.3390/cells13110931openalex-snapshot
The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and Disease
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C-Type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature
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Pulmonary Arterial Hypertension Due to NPR-C Mutation: A Novel Paradigm for Normal and Pathologic Remodeling?
inferred← citeshttps://doi.org/10.3390/ijms232214415openalex-snapshot
Role of Cardiac Natriuretic Peptides in Heart Structure and Function.
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High-resolution Optical Mapping of the Mouse Sino-atrial Node
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High-resolution Optical Mapping of the Mouse Sino-atrial Node
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Isolation of Atrial Myocytes from Adult Mice
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Isolation of Atrial Myocytes from Adult Mice
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Endothelial dysfunction as a new concept of early prevention of diseases of the cardiorespiratory system in workers of dust occupations
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