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Membrane-Mediated Activity of Local Anesthetics

https://doi.org/10.1124/molpharm.121.000252

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Functional evidence for presence of lipid rafts in erythrocyte membranes: Gsα in rafts is essential for signal transduction

inferredcites →https://doi.org/10.1002/ejlt.201100050openalex-snapshot

Lipids, curvature, and nano‐medicine

inferredcites →https://doi.org/10.1007/bf01485539openalex-snapshot

�ber den Wirkungsmechanismus der Lokalanaesthetica

inferredcites →https://doi.org/10.1007/s00101-003-0629-1openalex-snapshot

?Alternative? Effekte von Lokalan�sthetika

inferredcites →https://doi.org/10.1007/s00540-010-0943-0openalex-snapshot

Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes

inferredcites →https://doi.org/10.1007/s11064-017-2314-9openalex-snapshot

Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy

inferredcites →https://doi.org/10.1007/s12072-007-9014-5openalex-snapshot

Procaine inhibits the proliferation and DNA methylation in human hepatoma cells

inferredcites →https://doi.org/10.1016/0005-2736(86)90013-1openalex-snapshot

A 2H-NMR study on the interactions of the local anesthetic tetracaine with membranes containing phosphatidylserine

inferredcites →https://doi.org/10.1016/0005-2736(88)90070-3openalex-snapshot

Partitioning of local anesthetics into membranes: surface charge effects monitored by the phospholipid head-group

inferredcites →https://doi.org/10.1016/bs.ctm.2016.09.001openalex-snapshot

Origin of the Force

inferredcites →https://doi.org/10.1016/j.bbagen.2019.06.008openalex-snapshot

Mechanism of local anesthetic-induced disruption of raft-like ordered membrane domains

inferredcites →https://doi.org/10.1016/j.bbamem.2008.07.023openalex-snapshot

NMR investigations of interactions between anesthetics and lipid bilayers

inferredcites →https://doi.org/10.1016/j.bbamem.2012.07.014openalex-snapshot

Interaction of local anesthetics with lipid bilayers investigated by 1H MAS NMR spectroscopy

inferredcites →https://doi.org/10.1016/j.bbamem.2015.04.012openalex-snapshot

Lipid–protein interactions: Lessons learned from stress

inferredcites →https://doi.org/10.1016/j.bbamem.2016.07.011openalex-snapshot

Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABA A receptors

inferredcites →https://doi.org/10.1016/j.bpc.2016.06.005openalex-snapshot

Solitary electromechanical pulses in lobster neurons

inferredcites →https://doi.org/10.1016/j.bpj.2011.01.023openalex-snapshot

Bilayer-Mediated Clustering and Functional Interaction of MscL Channels

inferredcites →https://doi.org/10.1016/j.bpj.2011.02.027openalex-snapshot

Protein Shape Change Has a Major Effect on the Gating Energy of a Mechanosensitive Channel

inferredcites →https://doi.org/10.1016/j.cardiores.2005.11.013openalex-snapshot

Involvement of lipid rafts and caveolae in cardiac ion channel function

inferredcites →https://doi.org/10.1016/j.dza.2011.10.003openalex-snapshot

Handbuch Neuraltherapie, Diagnostik und Therapie mit Lokalanästhetika

inferredcites →https://doi.org/10.1016/j.ejps.2012.10.023openalex-snapshot

Anesthetics interacting with lipid rafts

inferredcites →https://doi.org/10.1016/j.exppara.2009.08.019openalex-snapshot

Disruption of lipid rafts by lidocaine inhibits erythrocyte invasion by Plasmodium falciparum

inferredcites →https://doi.org/10.1016/j.jmbbm.2017.12.026openalex-snapshot

“Force-from-lipids” gating of mechanosensitive channels modulated by PUFAs

inferredcites →https://doi.org/10.1016/j.neuron.2014.11.017openalex-snapshot

Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels

inferredcites →https://doi.org/10.1016/j.pbiomolbio.2009.01.012openalex-snapshot

Caveolae, ion channels and cardiac arrhythmias

inferredcites →https://doi.org/10.1016/j.rapm.2007.05.011openalex-snapshot

Stereospecific Interaction of Bupivacaine Enantiomers with Lipid Membranes

inferredcites →https://doi.org/10.1016/j.sbi.2016.11.022openalex-snapshot

Voltage-gated sodium channels viewed through a structural biology lens

inferredcites →https://doi.org/10.1016/j.str.2017.03.006openalex-snapshot

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

inferredcites →https://doi.org/10.1016/j.tcm.2003.10.002openalex-snapshot

Localization of Ion Channels to Lipid Raft Domains within the Cardiovascular System

inferredcites →https://doi.org/10.1016/j.tibs.2005.06.004openalex-snapshot

Detergent-resistant membranes should not be identified with membrane rafts

inferredcites →https://doi.org/10.1016/s0005-2736(02)00409-1openalex-snapshot

Amphiphilic effects of local anesthetics on rotational mobility in neuronal and model membranes

inferredcites →https://doi.org/10.1016/s0006-3495(00)76651-3openalex-snapshot

Direct Inhibition of Microtubule-Based Kinesin Motility by Local Anesthetics

inferredcites →https://doi.org/10.1016/s0006-3495(01)76200-5openalex-snapshot

Breaking the Meyer-Overton Rule: Predicted Effects of Varying Stiffness and Interfacial Activity on the Intrinsic Potency of Anesthetics

inferredcites →https://doi.org/10.1016/s0009-3084(99)00054-7openalex-snapshot

The influence of membrane lateral pressures on simple geometric models of protein conformational equilibria

inferredcites →https://doi.org/10.1016/s0014-2999(98)00769-9openalex-snapshot

Inhibition by local anesthetics of Ca2+ channels in rat anterior pituitary cells

inferredcites →https://doi.org/10.1016/s0026-895x(24)12653-3openalex-snapshot

Steric Hindrance Is Not Required for n-Alkanol Cutoff in Soluble Proteins

inferredcites →https://doi.org/10.1016/s0026-895x(24)12840-4openalex-snapshot

Local Anesthetic Inhibition of G Protein-Coupled Receptor Signaling by Interference with Gαq Protein Function

inferredcites →https://doi.org/10.1016/s0896-6273(03)00505-1openalex-snapshot

New TRP Channels in Hearing and Mechanosensation

inferredcites →https://doi.org/10.1016/s0960-9822(98)70984-4openalex-snapshot

Membrane biology: Do glycolipid microdomains really exist?

inferredcites →https://doi.org/10.1021/acs.jpcb.7b00990openalex-snapshot

Lateral Pressure Profile and Free Volume Properties in Phospholipid Membranes Containing Anesthetics

inferredcites →https://doi.org/10.1021/bi00527a013openalex-snapshot

Molecular details of anesthetic-lipid interaction as seen by deuterium and phosphorus-31 nuclear magnetic resonance

inferredcites →https://doi.org/10.1021/bi011995gopenalex-snapshot

Conformational Energetics of Rhodopsin Modulated by Nonlamellar-Forming Lipids

inferredcites →https://doi.org/10.1021/bi050822eopenalex-snapshot

Evidence for a Mechanism by Which ω-3 Polyunsaturated Lipids May Affect Membrane Protein Function

inferredcites →https://doi.org/10.1021/bi061941copenalex-snapshot

How Protein Transmembrane Segments Sense the Lipid Environment

inferredcites →https://doi.org/10.1021/bi9627323openalex-snapshot

The Lateral Pressure Profile in Membranes: A Physical Mechanism of General Anesthesia

inferredcites →https://doi.org/10.1021/cr60168a003openalex-snapshot

Some Physical Mechanisms in Narcosis.

inferredcites →https://doi.org/10.1021/ja910843dopenalex-snapshot

Membrane-Mediated Effect on Ion Channels Induced by the Anesthetic Drug Ketamine

inferredcites →https://doi.org/10.1021/jm049459kopenalex-snapshot

Anesthetic Potency of Two Novel Synthetic Polyhydric Alkanols Longer than the n-Alkanol Cutoff: Evidence for a Bilayer-Mediated Mechanism of Anesthesia?

inferredcites →https://doi.org/10.1038/277669a0openalex-snapshot

Effect of a local anaesthetic on hydrocarbon chain order in membranes

inferredcites →https://doi.org/10.1038/348261a0openalex-snapshot

Mechanosensitive ion channels of E. coli activated by amphipaths

inferredcites →https://doi.org/10.1038/35036052openalex-snapshot

Lipid rafts and signal transduction

inferredcites →https://doi.org/10.1038/368265a0openalex-snapshot

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

inferredcites →https://doi.org/10.1038/nature00992openalex-snapshot

Open channel structure of MscL and the gating mechanism of mechanosensitive channels

inferredcites →https://doi.org/10.1038/nature08147openalex-snapshot

Emerging roles for lipids in shaping membrane-protein function

inferredcites →https://doi.org/10.1038/nsb827openalex-snapshot

Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating

inferredcites →https://doi.org/10.1038/sj.bjp.0704040openalex-snapshot

Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics

inferredcites →https://doi.org/10.1039/c5md00108kopenalex-snapshot

Effect of dibucaine hydrochloride on raft-like lipid domains in model membrane systems

inferredcites →https://doi.org/10.1055/b-004-129967openalex-snapshot

Handbuch Neuraltherapie

inferredcites →https://doi.org/10.1073/pnas.0503823102openalex-snapshot

On soliton propagation in biomembranes and nerves

inferredcites →https://doi.org/10.1073/pnas.0609916104openalex-snapshot

Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1

inferredcites →https://doi.org/10.1073/pnas.1408710111openalex-snapshot

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

inferredcites →https://doi.org/10.1073/pnas.1611717114openalex-snapshot

Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties

inferredcites →https://doi.org/10.1073/pnas.1714131115openalex-snapshot

Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels

inferredcites →https://doi.org/10.1073/pnas.84.8.2297openalex-snapshot

Pressure-sensitive ion channel in Escherichia coli.

inferredcites →https://doi.org/10.1073/pnas.93.8.3542openalex-snapshot

Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins.

inferredcites →https://doi.org/10.1074/jbc.271.32.19037openalex-snapshot

Modulation of Human Muscle Sodium Channels by Intracellular Fatty Acids Is Dependent on the Channel Isoform

inferredcites →https://doi.org/10.1074/jbc.m113.478321openalex-snapshot

The Purified Mechanosensitive Channel TREK-1 Is Directly Sensitive to Membrane Tension

inferredcites →https://doi.org/10.1085/jgp.201811993openalex-snapshot

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites

inferredcites →https://doi.org/10.1093/bja/aei271openalex-snapshot

Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C

inferredcites →https://doi.org/10.1093/pm/pnz139openalex-snapshot

Mechanisms of Action by Which Local Anesthetics Reduce Cancer Recurrence: A Systematic Review

inferredcites →https://doi.org/10.1097/00000539-199708000-00017openalex-snapshot

Structure-Affinity Relationships and Stereospecificity of Several Homologous Series of Local Anesthetics for the beta2-Adrenergic Receptor

inferredcites →https://doi.org/10.1097/00000539-200111000-00040openalex-snapshot

Local Anesthetic Actions on Thromboxane-Induced Platelet Aggregation

inferredcites →https://doi.org/10.1097/00000542-199004000-00022openalex-snapshot

Molecular Mechanisms of Local Anesthesia

inferredcites →https://doi.org/10.1097/00000542-199307000-00014openalex-snapshot

Bupivacaine Inhibits Cyclic-3', 5'-Adenosine Monophosphate Production A Possible Contributing Factor to Cardiovascular Toxicity

inferredcites →https://doi.org/10.1097/00000542-200107000-00021openalex-snapshot

Local Anesthetic Effects on Priming and Activation of Human Neutrophils

inferredcites →https://doi.org/10.1097/00000542-200212000-00017openalex-snapshot

Inhibition of Mammalian Gq Protein Function by Local Anesthetics

inferredcites →https://doi.org/10.1097/00000542-200311000-00015openalex-snapshot

Lidocaine Enhances GαiProtein Function

inferredcites →https://doi.org/10.1097/00001503-200112000-00023openalex-snapshot

Novel local anaesthetics and novel indications for local anaesthetics

inferredcites →https://doi.org/10.1097/00115550-200807000-00004openalex-snapshot

Stereospecific Interaction of Bupivacaine Enantiomers with Lipid Membranes

inferredcites →https://doi.org/10.1097/eja.0000000000000137openalex-snapshot

Local anaesthetics

inferredcites →https://doi.org/10.1098/rsif.2014.0098openalex-snapshot

Evidence for two-dimensional solitary sound waves in a lipid controlled interface and its implications for biological signalling

inferredcites →https://doi.org/10.1103/physrevlett.102.078101openalex-snapshot

3D Pressure Field in Lipid Membranes and Membrane-Protein Complexes

inferredcites →https://doi.org/10.1111/j.1399-6576.2006.00936.xopenalex-snapshot

Anti‐inflammatory properties of local anesthetics and their present and potential clinical implications

inferredcites →https://doi.org/10.1111/j.1471-4159.2004.03009.xopenalex-snapshot

Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post‐synaptic densities following transient global ischemia in the rat brain

inferredcites →https://doi.org/10.1111/j.1471-4159.2007.04635.xopenalex-snapshot

Two pools of Triton X‐100‐insoluble GABAA receptors are present in the brain, one associated to lipid rafts and another one to the post‐synaptic GABAergic complex

inferredcites →https://doi.org/10.1111/j.1749-6632.1991.tb33841.xopenalex-snapshot

Comparative Inhibition of Voltage‐Gated Cation Channels by Local Anestheticsa

inferredcites →https://doi.org/10.1113/jphysiol.2010.191585openalex-snapshot

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

inferredcites →https://doi.org/10.1124/mol.59.2.294openalex-snapshot

Local Anesthetic Inhibition of G Protein-Coupled Receptor Signaling by Interference with Gα q Protein Function

inferredcites →https://doi.org/10.1140/epje/i2011-11057-0openalex-snapshot

The stability of solitons in biomembranes and nerves

inferredcites →https://doi.org/10.1146/annurev-biophys-083012-130326openalex-snapshot

Influences of Membrane Mimetic Environments on Membrane Protein Structures

inferredcites →https://doi.org/10.1152/ajpcell.1997.272.2.c592openalex-snapshot

Mechanism of modulation of the voltage-gated skeletal and cardiac muscle sodium channels by fatty acids

inferredcites →https://doi.org/10.1152/jn.00012.2013openalex-snapshot

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314

inferredcites →https://doi.org/10.1155/2013/297141openalex-snapshot

Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol: Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects

inferredcites →https://doi.org/10.1158/0008-5472.can-05-2821openalex-snapshot

Functional Diversity of DNA Methyltransferase Inhibitors in Human Cancer Cell Lines

inferredcites →https://doi.org/10.1172/jci32751openalex-snapshot

The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons

inferredcites →https://doi.org/10.1213/01.ane.0000261509.72234.a6openalex-snapshot

The Effects of the Local Anesthetics Lidocaine and Procaine on Glycine and γ-Aminobutyric Acid Receptors Expressed in Xenopus Oocytes

inferredcites →https://doi.org/10.1371/journal.pcbi.1003688openalex-snapshot

Locating the Route of Entry and Binding Sites of Benzocaine and Phenytoin in a Bacterial Voltage Gated Sodium Channel

inferredcites →https://doi.org/10.1371/journal.pone.0040079openalex-snapshot

Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability

inferredcites →https://doi.org/10.1515/revneuro-2012-0045openalex-snapshot

Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system

inferredcites →https://doi.org/10.1523/jneurosci.3578-14.2015openalex-snapshot

Actions of Bupivacaine, a Widely Used Local Anesthetic, on NMDA Receptor Responses

inferredcites →https://doi.org/10.15252/embj.201797349openalex-snapshot

Membrane cholesterol depletion as a trigger of Nav1.9 channel‐mediated inflammatory pain

inferredcites →https://doi.org/10.1529/biophysj.103.034322openalex-snapshot

Lipid Bilayer Pressure Profiles and Mechanosensitive Channel Gating

inferredcites →https://doi.org/10.1529/biophysj.107.107938openalex-snapshot

Lateral Pressure Profile, Spontaneous Curvature Frustration, and the Incorporation and Conformation of Proteins in Membranes

inferredcites →https://doi.org/10.1529/biophysj.107.109850openalex-snapshot

Gating of the Mechanosensitive Channel Protein MscL: The Interplay of Membrane and Protein

inferredcites →https://doi.org/10.3389/fphar.2011.00068openalex-snapshot

The Sodium Channel as a Target for Local Anesthetic Drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Antioxidative Mechanism of Radical Scavenger and Local Anesthetics

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Revisiting Local Anaesthesia Use in Regional Anaesthesia

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Therapie mit Lokalanästhetika in Endokrinologie und Gynäkologie

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Local Anesthetic Resistance: Pathophysiology, Clinical Recognition, and Management Strategies

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Commentary on Analgesia up to the Twentieth Century by Peter Holzer and Fred Lembeck

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Artificial nano-red blood cells nanoplatform with lysosomal escape capability for ultrasound imaging-guided on-demand pain management

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Establishment of the Meyer-Overton correlation in an artificial membrane without protein

inferred← citeshttps://doi.org/10.1016/j.bbamem.2026.184504openalex-snapshot

Role of the lipid matrix in the action of local anesthetics

inferred← citeshttps://doi.org/10.1016/j.bpj.2025.07.041openalex-snapshot

The lateral stress profile of fluid lipid membranes as revealed by the diffuse interface approach

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The role of solute polarizability and microenvironment in the spectroscopic behaviour of the local anesthetic drug - bupivacaine

inferred← citeshttps://doi.org/10.1021/acs.jcim.5c01784openalex-snapshot

Unraveling the Disruptive Mechanism of Local Anesthetics on Raft-Like Ordered Membranes: Simulation Studies

inferred← citeshttps://doi.org/10.1021/acs.langmuir.2c00876openalex-snapshot

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Anesthetic Mechanisms: Synergistic Interactions With Lipid Rafts and Voltage-Gated Sodium Channels

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