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Activation of the human chemokine receptor CX3CR1 regulated by cholesterol

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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UCSF Chimera—A visualization system for exploratory research and analysis
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Role of CX3CL1 in Diseases
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The Chemokine Superfamily Revisited
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Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV
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Gctf: Real-time CTF determination and correction
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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor
inferredcites →https://doi.org/10.1016/j.str.2020.11.007openalex-snapshot
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
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The Phenix software for automated determination of macromolecular structures
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Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion
inferredcites →https://doi.org/10.1016/s0165-6147(00)01810-1openalex-snapshot
Is Gα16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors?
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[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors
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Structural Analysis of Chemokine Receptor–Ligand Interactions
inferredcites →https://doi.org/10.1021/jm3012273openalex-snapshot
Substituted 7-Amino-5-thio-thiazolo[4,5- d ]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX 3 CR1)
inferredcites →https://doi.org/10.1038/aps.2013.92openalex-snapshot
Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway
inferredcites →https://doi.org/10.1038/aps.2016.69openalex-snapshot
The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer
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Structural basis of Smoothened regulation by its extracellular domains
inferredcites →https://doi.org/10.1038/nmeth.2727openalex-snapshot
Quantifying the local resolution of cryo-EM density maps
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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
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Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
inferredcites →https://doi.org/10.1038/s41467-021-24438-5openalex-snapshot
Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
inferredcites →https://doi.org/10.1038/s41586-018-0219-7openalex-snapshot
Structure of the µ-opioid receptor–Gi protein complex
inferredcites →https://doi.org/10.1038/s41586-018-0236-6openalex-snapshot
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
inferredcites →https://doi.org/10.1038/s41586-020-2492-5openalex-snapshot
Structural basis of CXC chemokine receptor 2 activation and signalling
inferredcites →https://doi.org/10.1038/s41586-021-03376-8openalex-snapshot
Structural insights into the lipid and ligand regulation of serotonin receptors
inferredcites →https://doi.org/10.1038/s41589-020-0535-8openalex-snapshot
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
inferredcites →https://doi.org/10.1042/bj20150520openalex-snapshot
AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor
inferredcites →https://doi.org/10.1074/jbc.m000776200openalex-snapshot
Identification of Residues of CXCR4 Critical for Human Immunodeficiency Virus Coreceptor and Chemokine Receptor Activities
inferredcites →https://doi.org/10.1080/19420862.2019.1709322openalex-snapshot
VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis
inferredcites →https://doi.org/10.1099/vir.0.047290-0openalex-snapshot
Human cytomegalovirus chemokine receptor US28 induces migration of cells on a CX3CL1-presenting surface
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1124/mol.105.015909openalex-snapshot
The Amino Terminus and the Third Extracellular Loop of CX3CR1 Contain Determinants Critical for Distinct Receptor Functions
inferredcites →https://doi.org/10.1124/mol.117.108381openalex-snapshot
E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis
inferredcites →https://doi.org/10.1126/sciadv.abl5442openalex-snapshot
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
inferredcites →https://doi.org/10.1126/science.1249489openalex-snapshot
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
inferredcites →https://doi.org/10.1126/science.1261064openalex-snapshot
Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine
inferredcites →https://doi.org/10.1126/science.aaa5026openalex-snapshot
Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor
inferredcites →https://doi.org/10.1155/2016/8090918openalex-snapshot
CX3CL1/CX3CR1 in Alzheimer’s Disease: A Target for Neuroprotection
inferredcites →https://doi.org/10.1158/1541-7786.mcr-16-0013openalex-snapshot
Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells
inferredcites →https://doi.org/10.1186/s41232-016-0017-2openalex-snapshot
Therapeutic intervention of inflammatory/immune diseases by inhibition of the fractalkine (CX3CL1)-CX3CR1 pathway
inferredcites →https://doi.org/10.1517/14728222.2012.682574openalex-snapshot
Therapeutic potential of the chemokine–receptor duo fractalkine/CX3CR1: an update
inferredcites →https://doi.org/10.2174/0929867321666140716093155openalex-snapshot
Interaction of Chemokines with their Receptors – From Initial Chemokine Binding to Receptor Activating Steps
inferredcites →https://doi.org/10.2174/138920111798357465openalex-snapshot
Fractalkine/CX3CR1 Signalling in Chronic Pain and Inflammation
inferredcites →https://doi.org/10.3389/fncel.2013.00026openalex-snapshot
Microglia, seen from the CX3CR1 angle
inferredcites →https://doi.org/10.3390/ijms18020342openalex-snapshot
Mechanisms of Regulation of the Chemokine-Receptor Network
inferredcites →https://doi.org/10.4110/in.2018.18.e5openalex-snapshot
Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease
inferredcites →https://doi.org/10.7554/elife.35850openalex-snapshot
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
inferredcites →https://doi.org/10.7554/elife.42166openalex-snapshot
New tools for automated high-resolution cryo-EM structure determination in RELION-3
inferredcites →https://doi.org/10.7554/elife.50279openalex-snapshot
Common activation mechanism of class A GPCRs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4 + T and NK Cells
inferred← citeshttps://doi.org/10.1002/cam4.70789openalex-snapshot
Chemokines: Orchestration of the Tumor Microenvironment and Control of Hepatocellular Carcinoma Progression
inferred← citeshttps://doi.org/10.1016/j.bbamem.2022.184100openalex-snapshot
Interactions of cholesterol molecules with GPCRs in different states: A comparative analysis of GPCRs' structures
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inferred← citeshttps://doi.org/10.1016/j.str.2023.05.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.str.2024.04.018openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.biochem.5c00145openalex-snapshot
Effects of Membrane Cholesterol on the Structure and Function of Selected Class A GPCRs─Challenges and Future Perspectives
inferred← citeshttps://doi.org/10.1021/acs.jcim.2c01546openalex-snapshot
Cholesterol Biases the Conformational Landscape of the Chemokine Receptor CCR3: A MAS SSNMR-Filtered Molecular Dynamics Study
inferred← citeshttps://doi.org/10.1021/acs.jcim.3c01835openalex-snapshot
Benchmarking AlphaFold-Generated Structures of Chemokine–Chemokine Receptor Complexes
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Fluorophore-Labeled Pyrrolones Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR1
inferred← citeshttps://doi.org/10.1021/jacsau.6c00851openalex-snapshot
Landscape of G Protein-Coupled Receptor Function from Structure Networks
inferred← citeshttps://doi.org/10.1038/s12276-025-01618-7openalex-snapshot
Microglial CX3CR1 deficiency regulates the selective vulnerability of cone photoreceptors via STAT3/CCL–ACKR1 signaling in the mouse retina
inferred← citeshttps://doi.org/10.1038/s41392-022-01197-3openalex-snapshot
Germline stem cells in human
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Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping
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Activation of cytomegalovirus-encoded G protein-coupled receptor UL33 by an innate N-terminal peptide
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