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Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/dbio.1998.9164openalex-snapshot
Dynamic Expression oflunatic fringeSuggests a Link betweennotchSignaling and an Autonomous Cellular Oscillator Driving Somite Segmentation
inferredcites →https://doi.org/10.1006/dbio.2000.9884openalex-snapshot
Oscillating Expression of c-Hey2 in the Presomitic Mesoderm Suggests That the Segmentation Clock May Use Combinatorial Signaling through Multiple Interacting bHLH Factors
inferredcites →https://doi.org/10.1016/s0021-9258(17)37668-8openalex-snapshot
Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements.
inferredcites →https://doi.org/10.1016/s0092-8674(00)80451-1openalex-snapshot
Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis
inferredcites →https://doi.org/10.1016/s0092-8674(00)81199-xopenalex-snapshot
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
inferredcites →https://doi.org/10.1016/s0960-9822(07)00424-1openalex-snapshot
Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation
inferredcites →https://doi.org/10.1016/s0960-9822(98)70401-4openalex-snapshot
The lunatic Fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos
inferredcites →https://doi.org/10.1016/s1534-5807(01)00054-5openalex-snapshot
Molecular Targets of Vertebrate Segmentation
inferredcites →https://doi.org/10.1016/s1534-5807(02)00211-3openalex-snapshot
Periodic Lunatic fringe Expression Is Controlled during Segmentation by a Cyclic Transcriptional Enhancer Responsive to Notch Signaling
inferredcites →https://doi.org/10.1016/s1534-5807(02)00212-5openalex-snapshot
Clock Regulatory Elements Control Cyclic Expression of Lunatic fringe during Somitogenesis
inferredcites →https://doi.org/10.1038/35002125openalex-snapshot
A synthetic oscillatory network of transcriptional regulators
inferredcites →https://doi.org/10.1038/35044091openalex-snapshot
Notch signalling and the synchronization of the somite segmentation clock
inferredcites →https://doi.org/10.1038/35098552openalex-snapshot
The making of the somite: molecular events in vertebrate segmentation
inferredcites →https://doi.org/10.1038/377355a0openalex-snapshot
Signalling downstream of activated mammalian Notch
inferredcites →https://doi.org/10.1093/emboj/18.8.2196openalex-snapshot
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
inferredcites →https://doi.org/10.1101/gad.11.23.3168openalex-snapshot
Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix–loop–helix repressor of neuronal differentiation
inferredcites →https://doi.org/10.1101/gad.14.13.1678openalex-snapshot
Control of her1 expression during zebrafish somitogenesis by a Delta -dependent oscillator and an independent wave-front activity
inferredcites →https://doi.org/10.1101/gad.6.12b.2620openalex-snapshot
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.
inferredcites →https://doi.org/10.1101/gad.930601openalex-snapshot
Dynamic expression and essential functions of Hes7 in somite segmentation
inferredcites →https://doi.org/10.1146/annurev.biochem.67.1.425openalex-snapshot
THE UBIQUITIN SYSTEM
inferredcites →https://doi.org/10.1146/annurev.cellbio.17.1.311openalex-snapshot
Vertebrate Somitogenesis
inferredcites →https://doi.org/10.1146/annurev.ne.14.030191.002225openalex-snapshot
Stimulus-Transcription Coupling In The Nervous System: Involvement Of The Inducible Proto-oncogenes fos And jun
inferredcites →https://doi.org/10.1146/annurev.physiol.63.1.647openalex-snapshot
Molecular Analysis of Mammalian Circadian Rhythms
inferredcites →https://doi.org/10.1242/dev.127.7.1421openalex-snapshot
Notch signalling is required for cyclic expression of the hairy-like geneHES1in the presomitic mesoderm
inferredcites →https://doi.org/10.1242/dev.127.8.1691openalex-snapshot
Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites
inferredcites →https://doi.org/10.1242/dev.129.5.1175openalex-snapshot
her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/dvdy.22680openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/gene.20171openalex-snapshot
Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
inferred← citeshttps://doi.org/10.1002/glia.20553openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/glia.70234openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/jcb.22065openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/jcb.26306openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/mc.20865openalex-snapshot
Notch2‐induced COX‐2 expression enhancing gastric cancer progression
inferred← citeshttps://doi.org/10.1002/mma.8961openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/stem.1231openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/wdev.46openalex-snapshot
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Old Wares and New: Five Decades of Investigation of Somitogenesis in Xenopus laevis
inferred← citeshttps://doi.org/10.1007/978-0-387-09606-3_7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-0-387-09794-7_5openalex-snapshot
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her11 is involved in the somitogenesis clock in zebrafish
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SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells
inferred← citeshttps://doi.org/10.1007/s10867-015-9391-2openalex-snapshot
Neural fate decisions mediated by combinatorial regulation of Hes1 and miR-9
inferred← citeshttps://doi.org/10.1007/s11033-020-05884-8openalex-snapshot
Distinct roles for Notch1 and Notch3 in human adipose-derived stem/stromal cell adipogenesis
inferred← citeshttps://doi.org/10.1007/s11432-016-0526-8openalex-snapshot
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Mean square exponential and robust stability of stochastic discrete-time genetic regulatory networks with uncertainties
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Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting Hes1 rhythm and down-regulating its expression
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Neurogenesis in the Vertebrate Embryo
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Neurogenesis in the Vertebrate Embryo
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bHLH Factors in Neurogenesis and Neuronal Subtype Specification
inferred← citeshttps://doi.org/10.1016/b978-0-12-397265-1.00070-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-397265-1.00079-4openalex-snapshot
Neural Stem Cells Among Glia
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inferred← citeshttps://doi.org/10.1016/b978-0-12-800174-5.00015-6openalex-snapshot
The NOTCH Pathway in β-Cell Growth and Differentiation
inferred← citeshttps://doi.org/10.1016/b978-0-12-814405-3.00013-8openalex-snapshot
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bHLH factors in neurogenesis and neuronal subtype specification
inferred← citeshttps://doi.org/10.1016/b978-0-12-814405-3.00031-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-008045046-9.01028-7openalex-snapshot
Helix–Loop–Helix (bHLH) Proteins: Hes Family
inferred← citeshttps://doi.org/10.1016/b978-012436643-5/50027-4openalex-snapshot
Neurogenesis in the Vertebrate Embryo
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Neurogenesis in the Vertebrate Embryo
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Signaling oscillations in embryonic development
inferred← citeshttps://doi.org/10.1016/j.ajpath.2012.06.003openalex-snapshot
The Alarmin IL-33 Is a Notch Target in Quiescent Endothelial Cells
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Stability and Hopf bifurcation in a model of gene expression with distributed time delays
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Delta-Notch signalling in segmentation
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Complex dynamics of transcription regulation
inferred← citeshttps://doi.org/10.1016/j.bbapap.2010.08.010openalex-snapshot
Different degrees of structural order in distinct regions of the transcriptional repressor HES-1
inferred← citeshttps://doi.org/10.1016/j.bbrc.2005.04.089openalex-snapshot
The conserved WRPW motif of Hes6 mediates proteasomal degradation
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HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion
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The role of microRNA in the delayed negative feedback regulation of gene expression
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Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7
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Neuronal differentiation of human iPS cells induced by baicalin via regulation of bHLH gene expression
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Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors
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Serum concentration modifies amplitude and kinetics of voltage-gated Na+ current in the Mat-LyLu cell line of rat prostate cancer
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Degradation-driven protein level oscillation in the yeast Saccharomyces cerevisiae
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A Wnt Oscillator Model for Somitogenesis
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Mechanistically Consistent Reduced Models of Synthetic Gene Networks
inferred← citeshttps://doi.org/10.1016/j.bpj.2014.06.011openalex-snapshot
Collective Cell Movement Promotes Synchronization of Coupled Genetic Oscillators
inferred← citeshttps://doi.org/10.1016/j.bpj.2014.09.042openalex-snapshot
Stochastic Oscillations Induced by Intrinsic Fluctuations in a Self-Repressing Gene
inferred← citeshttps://doi.org/10.1016/j.brainresrev.2005.03.008openalex-snapshot
Thinking clockwise
inferred← citeshttps://doi.org/10.1016/j.cam.2006.02.063openalex-snapshot
Stochastic delay differential equations for genetic regulatory networks
inferred← citeshttps://doi.org/10.1016/j.cbpb.2016.03.004openalex-snapshot
Effect of anthocyanidins on myogenic differentiation in induced and non-induced primary myoblasts from rainbow trout ( Oncorhynchus mykiss )
inferred← citeshttps://doi.org/10.1016/j.cdev.2021.203737openalex-snapshot
Positional information encoded in the dynamic differences between neighboring oscillators during vertebrate segmentation
inferred← citeshttps://doi.org/10.1016/j.ceb.2008.09.002openalex-snapshot
Oscillating signaling pathways during embryonic development
inferred← citeshttps://doi.org/10.1016/j.ceb.2009.08.009openalex-snapshot
Dynamic regulation of Notch signaling in neural progenitor cells
inferred← citeshttps://doi.org/10.1016/j.ceb.2022.102130openalex-snapshot
Signaling oscillations: Molecular mechanisms and functional roles
inferred← citeshttps://doi.org/10.1016/j.cell.2011.06.030openalex-snapshot
Development and Evolution of the Human Neocortex
inferred← citeshttps://doi.org/10.1016/j.cell.2012.02.018openalex-snapshot
Coding Region Polyadenylation Generates a Truncated tRNA Synthetase that Counters Translation Repression
inferred← citeshttps://doi.org/10.1016/j.cell.2016.01.028openalex-snapshot
Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns
inferred← citeshttps://doi.org/10.1016/j.cell.2017.08.043openalex-snapshot
Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock
inferred← citeshttps://doi.org/10.1016/j.cell.2018.01.002openalex-snapshot
Dynamic Ligand Discrimination in the Notch Signaling Pathway
inferred← citeshttps://doi.org/10.1016/j.cell.2018.05.035openalex-snapshot
Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH
inferred← citeshttps://doi.org/10.1016/j.cell.2024.04.050openalex-snapshot
Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development
inferred← citeshttps://doi.org/10.1016/j.cellsig.2012.09.014openalex-snapshot
Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer
inferred← citeshttps://doi.org/10.1016/j.celrep.2012.05.017openalex-snapshot
MicroRNA-9 Modulates Hes1 Ultradian Oscillations by Forming a Double-Negative Feedback Loop
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.115077openalex-snapshot
Activation-derepression synergy enables a bHLH network to coordinate a signal-specific fate response
inferred← citeshttps://doi.org/10.1016/j.cels.2019.10.010openalex-snapshot
Inferring Leading Interactions in the p53/Mdm2/Mdmx Circuit through Live-Cell Imaging and Modeling
inferred← citeshttps://doi.org/10.1016/j.cels.2024.10.002openalex-snapshot
Plausible, robust biological oscillations through allelic buffering
inferred← citeshttps://doi.org/10.1016/j.chaos.2008.03.010openalex-snapshot
A simple model of genetic oscillations through regulated degradation
inferred← citeshttps://doi.org/10.1016/j.chaos.2012.03.006openalex-snapshot
Robust filtering of uncertain stochastic genetic regulatory networks with time-varying delays
inferred← citeshttps://doi.org/10.1016/j.chaos.2012.11.011openalex-snapshot
Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems
inferred← citeshttps://doi.org/10.1016/j.chaos.2021.111659openalex-snapshot
Dynamics of fuzzy genetic regulatory networks with leakage and mixed delays in doubly-measure pseudo-almost periodic environment
inferred← citeshttps://doi.org/10.1016/j.chaos.2024.114479openalex-snapshot
Complex role of time delay in dynamical coordination of neural progenitor fate decisions mediated by Notch pathway
inferred← citeshttps://doi.org/10.1016/j.cnsns.2011.12.024openalex-snapshot
Delay-dependent stability criteria for genetic regulatory networks with time-varying delays and nonlinear disturbance
inferred← citeshttps://doi.org/10.1016/j.cnsns.2020.105166openalex-snapshot
Justification of quasi-stationary approximation in models of gene expression of a self-regulating protein
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2011.07.009openalex-snapshot
Measurement of phase synchrony of coupled segmentation clocks
inferred← citeshttps://doi.org/10.1016/j.cub.2008.03.013openalex-snapshot
FGF induces oscillations of Hes1 expression and Ras/ERK activation
inferred← citeshttps://doi.org/10.1016/j.cub.2008.06.044openalex-snapshot
Biological rhythms: Clocks for all times
inferred← citeshttps://doi.org/10.1016/j.devcel.2005.02.019openalex-snapshot
Analysis of Notch Function in Presomitic Mesoderm Suggests a γ-Secretase-Independent Role for Presenilins in Somite Differentiation
inferred← citeshttps://doi.org/10.1016/j.devcel.2007.05.014openalex-snapshot
Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1
inferred← citeshttps://doi.org/10.1016/j.devcel.2008.01.017openalex-snapshot
Multiple Roles of Notch Signaling in the Regulation of Epidermal Development
inferred← citeshttps://doi.org/10.1016/j.devcel.2010.11.018openalex-snapshot
MicroRNA-9 Reveals Regional Diversity of Neural Progenitors along the Anterior-Posterior Axis
inferred← citeshttps://doi.org/10.1016/j.devcel.2012.09.009openalex-snapshot
Single-Cell-Resolution Imaging of the Impact of Notch Signaling and Mitosis on Segmentation Clock Dynamics
inferred← citeshttps://doi.org/10.1016/j.devcel.2024.04.019openalex-snapshot
The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells
inferred← citeshttps://doi.org/10.1016/j.devcel.2026.01.006openalex-snapshot
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
inferred← citeshttps://doi.org/10.1016/j.dtrs.2026.100025openalex-snapshot
Notch signalling in alveolar bone development and regeneration: A critical regulator for osteoblasts to osteocytes transitioning
inferred← citeshttps://doi.org/10.1016/j.febslet.2012.07.041openalex-snapshot
Systems biology of cellular rhythms
inferred← citeshttps://doi.org/10.1016/j.gde.2004.06.001openalex-snapshot
Noise, delays, robustness, canalization and all that
inferred← citeshttps://doi.org/10.1016/j.gde.2004.06.014openalex-snapshot
The vertebrate segmentation clock
inferred← citeshttps://doi.org/10.1016/j.gde.2010.08.004openalex-snapshot
Oscillatory control of signalling molecules
inferred← citeshttps://doi.org/10.1016/j.gde.2013.02.011openalex-snapshot
A large-scale view of the evolution of amniote development: insights from somitogenesis in reptiles
inferred← citeshttps://doi.org/10.1016/j.gde.2020.04.008openalex-snapshot
Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks
inferred← citeshttps://doi.org/10.1016/j.gde.2026.102470openalex-snapshot
Oscillatory gene expression in cell differentiation and tissue patterning
inferred← citeshttps://doi.org/10.1016/j.gene.2012.08.022openalex-snapshot
Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES1
inferred← citeshttps://doi.org/10.1016/j.gene.2014.12.054openalex-snapshot
Control of hair cell development by molecular pathways involving Atoh1, Hes1 and Hes5
inferred← citeshttps://doi.org/10.1016/j.gep.2011.06.004openalex-snapshot
A BAC transgenic Hes1-EGFP reporter reveals novel expression domains in mouse embryos
inferred← citeshttps://doi.org/10.1016/j.gep.2019.119094openalex-snapshot
Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation
inferred← citeshttps://doi.org/10.1016/j.gep.2021.119170openalex-snapshot
Hes1 oscillation frequency correlates with activation of neural stem cells
inferred← citeshttps://doi.org/10.1016/j.gep.2021.119198openalex-snapshot
Oscillatory expression of Ascl1 in oligodendrogenesis
inferred← citeshttps://doi.org/10.1016/j.ifacol.2017.08.2248openalex-snapshot
Modeling & Analysis of Gene Expression as a Nonlinear Feedback Problem With State-Dependent Delay
inferred← citeshttps://doi.org/10.1016/j.immuni.2008.08.016openalex-snapshot
Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways
inferred← citeshttps://doi.org/10.1016/j.ins.2010.05.032openalex-snapshot
Robust stability for uncertain genetic regulatory networks with interval time-varying delays
inferred← citeshttps://doi.org/10.1016/j.ins.2010.10.007openalex-snapshot
Mean square exponential stability of stochastic genetic regulatory networks with time-varying delays
inferred← citeshttps://doi.org/10.1016/j.jbi.2011.11.016openalex-snapshot
Oscillabolastic model, a new model for oscillatory dynamics, applied to the analysis of Hes1 gene expression and Ehrlich ascites tumor growth
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2016.03.053openalex-snapshot
Transcriptional kinetics of the cross-talk between the ortho -cleavage and TOL pathways of toluene biodegradation in Pseudomonas putida mt-2
inferred← citeshttps://doi.org/10.1016/j.jfranklin.2013.05.016openalex-snapshot
Finite-time H control for discrete-time genetic regulatory networks with random delays and partly unknown transition probabilities
inferred← citeshttps://doi.org/10.1016/j.jmaa.2012.05.032openalex-snapshot
The stability and Hopf bifurcation analysis of a gene expression model
inferred← citeshttps://doi.org/10.1016/j.jmb.2007.01.089openalex-snapshot
A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth
inferred← citeshttps://doi.org/10.1016/j.jmb.2015.03.007openalex-snapshot
Metabolic Regulation of the Ultradian Oscillator Hes1 by Reactive Oxygen Species
inferred← citeshttps://doi.org/10.1016/j.jot.2021.09.007openalex-snapshot
Transient activation of notch signaling enhances endogenous stromal cell expansion and subsequent bone defect repair
inferred← citeshttps://doi.org/10.1016/j.jtbi.2006.11.012openalex-snapshot
Superstability of the yeast cell-cycle dynamics: Ensuring causality in the presence of biochemical stochasticity
inferred← citeshttps://doi.org/10.1016/j.jtbi.2007.05.014openalex-snapshot
Cell-based simulation of dynamic expression patterns in the presomitic mesoderm
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