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Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/bf00400417openalex-snapshot
Assessment of insulin sensitivity in glucokinase-deficient subjects
inferredcites →https://doi.org/10.1007/s001250051289openalex-snapshot
Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis
inferredcites →https://doi.org/10.1016/0020-711x(94)90021-3openalex-snapshot
Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems
inferredcites →https://doi.org/10.1016/s0021-9258(18)82456-5openalex-snapshot
Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants
inferredcites →https://doi.org/10.1038/356721a0openalex-snapshot
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1042/bj3090167openalex-snapshot
Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme
inferredcites →https://doi.org/10.1056/nejm199801223380404openalex-snapshot
Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation
inferredcites →https://doi.org/10.1073/pnas.90.5.1932openalex-snapshot
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
inferredcites →https://doi.org/10.1073/pnas.93.14.7225openalex-snapshot
Correction of diabetic alterations by glucokinase.
inferredcites →https://doi.org/10.1089/10430340260201653openalex-snapshot
Adenovirus-Mediated Expression of Glucokinase in the Liver as an Adjuvant Treatment for Type 1 Diabetes
inferredcites →https://doi.org/10.1172/jci118974openalex-snapshot
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
inferredcites →https://doi.org/10.2337/diab.37.6.667openalex-snapshot
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
inferredcites →https://doi.org/10.2337/diab.43.8.1066openalex-snapshot
Insulin Action, Diabetogenes, and the Cause of Type II Diabetes
inferredcites →https://doi.org/10.2337/diab.45.2.223openalex-snapshot
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
inferredcites →https://doi.org/10.2337/diabetes.48.8.1645openalex-snapshot
Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.
inferredcites →https://doi.org/10.2337/diabetes.50.10.2287openalex-snapshot
Phenotypic Correction of Diabetic Mice by Adenovirus-Mediated Glucokinase Expression
inferredcites →https://doi.org/10.2337/diabetes.50.3.622openalex-snapshot
Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diabetes.51.4.1240openalex-snapshot
The Second Activating Glucokinase Mutation (A456V)
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.3897/pharmacia.71.e131072zenodo-depositor-declared
Novel glucokinase activators: A structure-based pharmacophore modeling, QSAR analysis, and molecular dynamics approach
inferred← citeshttps://doi.org/10.1002/0470862092.d0303openalex-snapshot
Regulation of Glucose Metabolism in the Liver
inferred← citeshttps://doi.org/10.1002/0471266949.bmc165openalex-snapshot
Enzymatic Assays for High‐Throughput Screening
inferred← citeshttps://doi.org/10.1002/0471266949.bmc198openalex-snapshot
Diabetes Drugs: Present and Emerging
inferred← citeshttps://doi.org/10.1002/0471266949.bmc265openalex-snapshot
Fragment‐Based Lead Discovery
inferred← citeshttps://doi.org/10.1002/9780470910016.ch5openalex-snapshot
Hepatic Metabolic Dysfunctions in Type 2 Diabetes: Insulin Resistance and Impaired Glucose Production and Lipid Synthesis
inferred← citeshttps://doi.org/10.1002/9781118098141.ch4openalex-snapshot
Kinases as Antitargets in Genotoxicity
inferred← citeshttps://doi.org/10.1002/9781118924853.ch67openalex-snapshot
Future Drug Treatments for Type 2 Diabetes
inferred← citeshttps://doi.org/10.1002/9781119460053.ch10openalex-snapshot
Enzymes as Therapeutic Agents in Human Disease Management
inferred← citeshttps://doi.org/10.1002/9781444324808.ch60openalex-snapshot
Future Drug Treatments for Type 2 Diabetes
inferred← citeshttps://doi.org/10.1002/9781444391374.ch5openalex-snapshot
Normal Physiology of Insulin Secretion and Action
inferred← citeshttps://doi.org/10.1002/ange.202014632openalex-snapshot
Three‐Component Alkene Difunctionalization by Direct and Selective Activation of Aliphatic C−H Bonds
inferred← citeshttps://doi.org/10.1002/ange.202313717openalex-snapshot
Dual Nickel/Photoredox‐Catalyzed Asymmetric Carbamoylation of Benzylic C(sp3)−H Bonds
inferred← citeshttps://doi.org/10.1002/ange.202319158openalex-snapshot
Asymmetric, Remote C(sp3)−H Arylation via Sulfinyl‐Smiles Rearrangement
inferred← citeshttps://doi.org/10.1002/anie.202014632openalex-snapshot
Three‐Component Alkene Difunctionalization by Direct and Selective Activation of Aliphatic C−H Bonds
inferred← citeshttps://doi.org/10.1002/anie.202313717openalex-snapshot
Dual Nickel/Photoredox‐Catalyzed Asymmetric Carbamoylation of Benzylic C(sp3)−H Bonds
inferred← citeshttps://doi.org/10.1002/anie.202319158openalex-snapshot
Asymmetric, Remote C(sp 3 )−H Arylation via Sulfinyl‐Smiles Rearrangement
inferred← citeshttps://doi.org/10.1002/bab.2541openalex-snapshot
Tetrahydropalmatine from medicinal plants activates human glucokinase to regulate glucose homeostasis
inferred← citeshttps://doi.org/10.1002/cbic.201300315openalex-snapshot
Small‐Molecule Procaspase Activators Identified Using Fluorescence Polarization
inferred← citeshttps://doi.org/10.1002/chem.200600084openalex-snapshot
Absolute Configuration of New Cytotoxic and Other Bioactive Trichothecene Macrolides
inferred← citeshttps://doi.org/10.1002/cmdc.201400009openalex-snapshot
Design, Synthesis, and Activity Evaluation of GK/PPARγ Dual‐Target‐Directed Ligands as Hypoglycemic Agents
inferred← citeshttps://doi.org/10.1002/cmdc.202200020openalex-snapshot
Cyclobutanes in Small‐Molecule Drug Candidates
inferred← citeshttps://doi.org/10.1002/cpdd.289openalex-snapshot
Dose‐Dependent Effect of Piragliatin, a Glucokinase Activator, on the QT Interval Following Short‐Term Multiple Doses in Patients With Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1002/cpt.1419openalex-snapshot
Effect of Hepatic Organic Anion‐Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver‐Targeted Glucokinase Activator: A Model‐Based Evaluation
inferred← citeshttps://doi.org/10.1002/humu.21110openalex-snapshot
Update on mutations in glucokinase ( GCK ), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
inferred← citeshttps://doi.org/10.1002/iub.411openalex-snapshot
Liver glucokinase: An overview on the regulatorymechanisms of its activity
inferred← citeshttps://doi.org/10.1002/jcph.589openalex-snapshot
Effects of piragliatin, a glucokinase activator, on fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1002/jcph.617openalex-snapshot
Exploratory effects of a strong CYP3A inhibitor (ketoconazole), a strong CYP3A inducer (rifampicin), and concomitant ethanol on piragliatin pharmacokinetics and pharmacodynamics in type 2 diabetic patients
inferred← citeshttps://doi.org/10.1002/jcph.640openalex-snapshot
Lack of Potential Pharmacokinetic and Pharmacodynamic Interactions Between Piragliatin, a Glucokinase Activator, and Simvastatin in Patients With Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1002/med.20142openalex-snapshot
Recent and emerging anti‐diabetes targets
inferred← citeshttps://doi.org/10.1002/pro.2473openalex-snapshot
Role of connecting loop I in catalysis and allosteric regulation of human glucokinase
inferred← citeshttps://doi.org/10.1002/prot.20653openalex-snapshot
Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase
inferred← citeshttps://doi.org/10.1002/ptr.2351openalex-snapshot
Hypoglycemic effect of a novel dialysed fenugreek seeds extract is sustainable and is mediated, in part, by the activation of hepatic enzymes
inferred← citeshttps://doi.org/10.1007/978-0-387-72204-7_5openalex-snapshot
Hepatic Regulation of Fuel Metabolism
inferred← citeshttps://doi.org/10.1007/978-0-387-72891-9openalex-snapshot
Allosteric Regulatory Enzymes
inferred← citeshttps://doi.org/10.1007/978-1-4419-6956-9_13openalex-snapshot
Genetically Programmed Defects in β-Cell Function
inferred← citeshttps://doi.org/10.1007/978-1-4614-5441-0_24openalex-snapshot
Glucose-Induced Insulin Secretion
inferred← citeshttps://doi.org/10.1007/978-1-59745-439-1_20openalex-snapshot
Pharmacogenomic Applications in Children
inferred← citeshttps://doi.org/10.1007/978-1-61779-337-0_1openalex-snapshot
Targeting Cancer with Small-Molecular-Weight Kinase Inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-030-02961-6_3openalex-snapshot
Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism
inferred← citeshttps://doi.org/10.1007/978-3-642-17214-4_15openalex-snapshot
Research and Development of Glucokinase Activators for Diabetes Therapy: Theoretical and Practical Aspects
inferred← citeshttps://doi.org/10.1007/978-4-431-75452-7_21openalex-snapshot
Glucokinase in Glucose Homeostasis, Diabetes Mellitus, Hypoglycemia, and as Drug Receptor
inferred← citeshttps://doi.org/10.1007/978-94-007-5971-8_3openalex-snapshot
Diabetes Mellitus: New Challenges and Innovative Therapies
inferred← citeshttps://doi.org/10.1007/978-981-97-7568-2_1openalex-snapshot
The History of the Development of SGLT2 Inhibitors for the Treatment of Diabetes: From Biology to Chemistry
inferred← citeshttps://doi.org/10.1007/s00018-008-8322-9openalex-snapshot
Molecular Physiology of Mammalian Glucokinase
inferred← citeshttps://doi.org/10.1007/s00125-007-0646-8openalex-snapshot
Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions
inferred← citeshttps://doi.org/10.1007/s00125-009-1446-0openalex-snapshot
Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells
inferred← citeshttps://doi.org/10.1007/s00125-011-2439-3openalex-snapshot
Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat
inferred← citeshttps://doi.org/10.1007/s00125-012-2521-5openalex-snapshot
Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions
inferred← citeshttps://doi.org/10.1007/s00125-021-05553-wopenalex-snapshot
The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes
inferred← citeshttps://doi.org/10.1007/s10441-014-9241-9openalex-snapshot
An Embedded Automaton to Monitor the Glycolysis Process in Pancreatic β-Cells
inferred← citeshttps://doi.org/10.1007/s10822-024-00583-zopenalex-snapshot
In silico design of dehydrophenylalanine containing peptide activators of glucokinase using pharmacophore modelling, molecular dynamics and machine learning: implications in type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s10895-017-2099-xopenalex-snapshot
Tryptophan Fluorescence Yields and Lifetimes as a Probe of Conformational Changes in Human Glucokinase
inferred← citeshttps://doi.org/10.1007/s10928-014-9351-7openalex-snapshot
Preclinical PK/PD modeling and human efficacious dose projection for a glucokinase activator in the treatment of diabetes
inferred← citeshttps://doi.org/10.1007/s11154-010-9147-zopenalex-snapshot
Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s11739-011-0677-5openalex-snapshot
New oral antidiabetic agents
inferred← citeshttps://doi.org/10.1007/s11892-005-0005-4openalex-snapshot
Glucokinase, glucose homeostasis, and diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s12010-019-02998-zopenalex-snapshot
Characterization of Glucokinase Catalysis from a Pseudo-Dimeric View
inferred← citeshttps://doi.org/10.1007/s12154-008-0012-4openalex-snapshot
Brought to life: targeted activation of enzyme function with small molecules
inferred← citeshttps://doi.org/10.1007/s12272-012-1201-9openalex-snapshot
Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s13167-010-0010-9openalex-snapshot
Diabetes mellitus: new challenges and innovative therapies
inferred← citeshttps://doi.org/10.1007/s40200-022-01019-xopenalex-snapshot
Targeting human Glucokinase for the treatment of type 2 diabetes: an overview of allosteric Glucokinase activators
inferred← citeshttps://doi.org/10.1007/s40203-021-00116-8openalex-snapshot
Investigation of phytoconstituents of Enicostemma littorale as potential glucokinase activators through molecular docking for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s40262-018-0631-zopenalex-snapshot
Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration–Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics
inferred← citeshttps://doi.org/10.1007/s40265-020-01278-zopenalex-snapshot
Glucokinase Activators for Type 2 Diabetes: Challenges and Future Developments
inferred← citeshttps://doi.org/10.1016/b0-12-443710-9/00308-2openalex-snapshot
Hexokinases/Glucokinases
inferred← citeshttps://doi.org/10.1016/b0-12-443710-9/00330-6openalex-snapshot
Insulin- and Glucagon-Secreting Cells of the Pancreas
inferred← citeshttps://doi.org/10.1016/b978-0-12-378630-2.00046-3openalex-snapshot
Insulin- and Glucagon-Secreting Cells of the Pancreas
inferred← citeshttps://doi.org/10.1016/b978-0-12-411492-0.00026-2openalex-snapshot
Hyperglycemic and Hypoglycemic Drugs
inferred← citeshttps://doi.org/10.1016/b978-0-12-800101-1.00006-5openalex-snapshot
Factors Affecting Insulin-Regulated Hepatic Gene Expression
inferred← citeshttps://doi.org/10.1016/b978-0-12-819460-7.00034-7openalex-snapshot
Energy Metabolism | Hexokinase/Glucokinase
inferred← citeshttps://doi.org/10.1016/b978-0-12-819460-7.00579-xopenalex-snapshot
Regulation | Insulin- and Glucagon-Secreting Cells of the Pancreas
inferred← citeshttps://doi.org/10.1016/b978-0-444-62652-3.00001-6openalex-snapshot
Property-Based Design in the Optimisation of Benzamide Glucokinase Activators
inferred← citeshttps://doi.org/10.1016/bs.mie.2023.03.009openalex-snapshot
Biochemical methods to map and quantify allosteric motions in human glucokinase
inferred← citeshttps://doi.org/10.1016/j.ab.2009.09.012openalex-snapshot
A nonradioactive plate-based assay for stimulators of nonspecific DNA nicking by HIV-1 integrase and other nucleases
inferred← citeshttps://doi.org/10.1016/j.ab.2015.02.006openalex-snapshot
19F nuclear magnetic resonance screening of glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.abb.2011.11.007openalex-snapshot
Homotropic allosteric regulation in monomeric mammalian glucokinase
inferred← citeshttps://doi.org/10.1016/j.abb.2019.01.011openalex-snapshot
Molecular and cellular regulation of human glucokinase
inferred← citeshttps://doi.org/10.1016/j.apsb.2011.07.002openalex-snapshot
Novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives as dual-action hypoglycemic agents that activate GK and PPARγ
inferred← citeshttps://doi.org/10.1016/j.apsb.2012.06.002openalex-snapshot
Glycolysis in the control of blood glucose homeostasis
inferred← citeshttps://doi.org/10.1016/j.apsb.2012.10.002openalex-snapshot
Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ
inferred← citeshttps://doi.org/10.1016/j.bbapap.2012.03.003openalex-snapshot
Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea
inferred← citeshttps://doi.org/10.1016/j.bbapap.2018.12.008openalex-snapshot
First evidence of changes in enzyme kinetics and stability of glucokinase affected by somatic cancer-associated variations
inferred← citeshttps://doi.org/10.1016/j.bbrc.2005.01.024openalex-snapshot
Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.07.088openalex-snapshot
Characterization of two MODY2 mutations with different susceptibility to activation
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.01.020openalex-snapshot
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.09.019openalex-snapshot
High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.06.024openalex-snapshot
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116499openalex-snapshot
Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants
inferred← citeshttps://doi.org/10.1016/j.beem.2007.09.001openalex-snapshot
New hepatic targets for glycaemic control in diabetes
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.02.038openalex-snapshot
Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.05.037openalex-snapshot
The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.04.038openalex-snapshot
Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.03.008openalex-snapshot
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.02.009openalex-snapshot
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.115232openalex-snapshot
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator
inferred← citeshttps://doi.org/10.1016/j.bmcl.2004.12.083openalex-snapshot
Glucokinase-activating ureas
inferred← citeshttps://doi.org/10.1016/j.bmcl.2005.01.087openalex-snapshot
Discovery, synthesis and biological evaluation of novel glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2006.02.022openalex-snapshot
Design of a potent, soluble glucokinase activator with excellent in vivo efficacy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.01.053openalex-snapshot
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.03.137openalex-snapshot
Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.04.107openalex-snapshot
Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.08.064openalex-snapshot
Discovery and structure–activity relationships of a novel class of quinazoline glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.01.041openalex-snapshot
Metabolic activation of N-thiazol-2-yl benzamide as glucokinase activators: Impacts of glutathione trapping on covalent binding
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.08.029openalex-snapshot
2,3-Disubstituted acrylamides as potent glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.06.128openalex-snapshot
Discovery and hit-to-lead optimization of novel allosteric glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.09.082openalex-snapshot
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.11.018openalex-snapshot
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.01.093openalex-snapshot
Design, synthesis and SAR of novel glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.06.036openalex-snapshot
Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif
inferred← citeshttps://doi.org/10.1016/j.bmcl.2020.127249openalex-snapshot
Design, synthesis, and pharmacological evaluation of 2-(4-sulfonylphenyl)-2-[(E)-pyrrolidin-1-ylimino]-N-thiazoleacetamides as glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2025.130192openalex-snapshot
Discovery of liver-selective glucokinase activators comprising N-(4-alkylthiazol-2-yl)benzamides and N-(3-alkyl-1,2,4-thiadiazol-5-yl)benzamides for the treatment of metabolic disorders
inferred← citeshttps://doi.org/10.1016/j.cbpb.2011.07.006openalex-snapshot
Glucosensing and glucose homeostasis: From fish to mammals
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.12.056openalex-snapshot
Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes
inferred← citeshttps://doi.org/10.1016/j.chembiol.2004.08.006openalex-snapshot
Disruption of Protein-Membrane Binding and Identification of Small-Molecule Inhibitors of Coagulation Factor VIII
inferred← citeshttps://doi.org/10.1016/j.chembiol.2019.05.003openalex-snapshot
Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
inferred← citeshttps://doi.org/10.1016/j.cmet.2011.02.012openalex-snapshot
Control of Pancreatic β Cell Regeneration by Glucose Metabolism
inferred← citeshttps://doi.org/10.1016/j.cmet.2013.12.001openalex-snapshot
Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.10.007openalex-snapshot
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway
inferred← citeshttps://doi.org/10.1016/j.cmet.2023.11.011openalex-snapshot
Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2015.07.009openalex-snapshot
Theoretical investigations on the interactions of glucokinase regulatory protein with fructose phosphates
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2017.02.011openalex-snapshot
Structure based design, synthesis and biological evaluation of amino phosphonate derivatives as human glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.crmeth.2023.100602openalex-snapshot
Insulin C-peptide secretion on-a-chip to measure the dynamics of secretion and metabolism from individual islets
inferred← citeshttps://doi.org/10.1016/j.ddstr.2007.10.009openalex-snapshot
Glucokinase activation–a strategy for T2D therapy: recent developments
inferred← citeshttps://doi.org/10.1016/j.devcel.2012.05.014openalex-snapshot
Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT
inferred← citeshttps://doi.org/10.1016/j.devcel.2015.01.002openalex-snapshot
Weaning Triggers a Maturation Step of Pancreatic β Cells
inferred← citeshttps://doi.org/10.1016/j.diabres.2008.06.012openalex-snapshot
Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic β-cell function in type 2 diabetic mice
inferred← citeshttps://doi.org/10.1016/j.drudis.2009.05.013openalex-snapshot
Recent advances in glucokinase activators for the treatment of type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.06.020openalex-snapshot
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.02.024openalex-snapshot
Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPARγ
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.03.042openalex-snapshot
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.07.051openalex-snapshot
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.06.060openalex-snapshot
Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.ejphar.2010.04.054openalex-snapshot
A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat
inferred← citeshttps://doi.org/10.1016/j.ejphar.2011.05.009openalex-snapshot
Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice
inferred← citeshttps://doi.org/10.1016/j.ejphar.2013.06.014openalex-snapshot
Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960
inferred← citeshttps://doi.org/10.1016/j.ejphar.2018.02.036openalex-snapshot
The potential role of glucokinase activator SHP289-04 in anti-diabetes and hepatic protection
inferred← citeshttps://doi.org/10.1016/j.ejps.2013.09.005openalex-snapshot
Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells
inferred← citeshttps://doi.org/10.1016/j.febslet.2004.06.015openalex-snapshot
The presence of a high‐Km hexokinase activity in dog, but not in boar, sperm
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e15484openalex-snapshot
Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db/db mice via regulation of glycolysis/gluconeogenesis pathway and alteration of gut microbiota
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2012.03.018openalex-snapshot
Characterization and crystal structure of the thermophilic ROK hexokinase from Thermus thermophilus
inferred← citeshttps://doi.org/10.1016/j.jff.2016.08.010openalex-snapshot
A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet
inferred← citeshttps://doi.org/10.1016/j.jmb.2022.167626openalex-snapshot
Therapeutic Targeting the Allosteric Cysteinome of RAS and Kinase Families
inferred← citeshttps://doi.org/10.1016/j.jmgm.2012.12.011openalex-snapshot
Toward an understanding of the sequence and structural basis of allosteric proteins
inferred← citeshttps://doi.org/10.1016/j.jmgm.2014.12.003openalex-snapshot
Ligand-based modeling followed by in vitro bioassay yielded new potent glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2018.04.014openalex-snapshot
Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice
inferred← citeshttps://doi.org/10.1016/j.jtbi.2010.06.009openalex-snapshot
Molecular modeling of BAD complex resided in a mitochondrion integrating glycolysis and apoptosis
inferred← citeshttps://doi.org/10.1016/j.metabol.2010.07.029openalex-snapshot
Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion
inferred← citeshttps://doi.org/10.1016/j.metabol.2013.06.007openalex-snapshot
A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs
inferred← citeshttps://doi.org/10.1016/j.metabol.2015.06.014openalex-snapshot
Antidiabetic potential of a novel dual-target activator of glucokinase and peroxisome proliferator activated receptor-γ
inferred← citeshttps://doi.org/10.1016/j.metabol.2025.156150openalex-snapshot
Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinase
inferred← citeshttps://doi.org/10.1016/j.molmed.2003.08.003openalex-snapshot
In vivo gene therapy for diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.molmed.2015.08.004openalex-snapshot
Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101193openalex-snapshot
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2014.12.003openalex-snapshot
Synthesis and biological evaluation of [11C]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver
inferred← citeshttps://doi.org/10.1016/j.phymed.2014.06.011openalex-snapshot
In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β-d-xylopyranosyl isolated from Swertia corymbosa
inferred← citeshttps://doi.org/10.1016/j.pisc.2014.12.003openalex-snapshot
Understanding mechanisms of enzyme co-operativity: The importance of not being at equilibrium
inferred← citeshttps://doi.org/10.1016/j.sbi.2004.10.009openalex-snapshot
Searching for new allosteric sites in enzymes
inferred← citeshttps://doi.org/10.1016/j.slasd.2022.09.001openalex-snapshot
A perspective on the discovery of enzyme activators
inferred← citeshttps://doi.org/10.1016/j.str.2004.02.005openalex-snapshot
Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase
inferred← citeshttps://doi.org/10.1016/j.taap.2007.12.029openalex-snapshot
Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver
inferred← citeshttps://doi.org/10.1016/j.tem.2022.12.007openalex-snapshot
Glucokinase activity in diabetes: too much of a good thing?
inferred← citeshttps://doi.org/10.1016/j.tetlet.2006.02.110openalex-snapshot
Synthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.tetlet.2012.06.111openalex-snapshot
Investigation on the oxidation of aryl oxiranylmethanols and the synthesis of 2-aryl-N-thiazolyl-oxirane-2-carboxamides as glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.tibs.2024.12.007openalex-snapshot
Glucokinase: from allosteric glucose sensing to disease variants
inferred← citeshttps://doi.org/10.1016/j.tips.2012.11.007openalex-snapshot
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
inferred← citeshttps://doi.org/10.1016/j.ygcen.2010.09.002openalex-snapshot
Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2011.05.006openalex-snapshot
Cardiac myosin activation part 1: From concept to clinic
inferred← citeshttps://doi.org/10.1016/j.yrtph.2022.105119openalex-snapshot
Effects of glucokinase activator, DS-7309, on embryo-fetal developmental toxicity in rats and rabbits
inferred← citeshttps://doi.org/10.1016/s0003-4266(04)95630-2openalex-snapshot
Mouse models of insulin resistance and type 2 diabetes
inferred← citeshttps://doi.org/10.1016/s0065-7743(04)39004-4openalex-snapshot
Recent Advances in Therapeutic Approaches to Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/s0065-7743(05)40011-1openalex-snapshot
Recent Advances in Therapeutic Approaches toType 2 Diabetes
inferred← citeshttps://doi.org/10.1016/s0065-7743(06)41008-3openalex-snapshot
Glucokinase Activators for the Treatment of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/s0140-6736(11)60207-9openalex-snapshot
Management of type 2 diabetes: new and future developments in treatment
inferred← citeshttps://doi.org/10.1016/s0895-3988(09)60024-6openalex-snapshot
Establishment of Hypoglycemic Agent Screening Method Based on Human Glucokinase
inferred← citeshttps://doi.org/10.1016/s1262-3636(07)70133-7openalex-snapshot
Role of the liver in the control of carbohydrate and lipid homeostasis
inferred← citeshttps://doi.org/10.1016/s1262-3636(07)70226-4openalex-snapshot
Is non-insulin dependent glucose uptake a therapeutic alternative? Part 2: Do such mechanisms fulfil the required combination of power and tolerability?
inferred← citeshttps://doi.org/10.1016/s1499-2671(07)11013-3openalex-snapshot
Pancreatic Beta-cell Apoptosis in Maturity Onset Diabetes of the Young
inferred← citeshttps://doi.org/10.1017/s0954422414000018openalex-snapshot
Nutritional regulation of glucokinase: a cross-species story
inferred← citeshttps://doi.org/10.1021/ac0715219openalex-snapshot
Replication of DNA Microarrays Prepared by In Situ Oligonucleotide Polymerization and Mechanical Transfer
inferred← citeshttps://doi.org/10.1021/acs.biochem.6b00349openalex-snapshot
Kinetic Basis of Carbohydrate-Mediated Inhibition of Human Glucokinase by the Glucokinase Regulatory Protein
inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00377openalex-snapshot
Antidiabetic Disruptors of the Glucokinase−Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface
inferred← citeshttps://doi.org/10.1021/acs.chemrev.5b00541openalex-snapshot
Solution NMR Spectroscopy for the Study of Enzyme Allostery
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c04212openalex-snapshot
Naringenin Inhibits the Growth of Diaporthe citri by Targeting Fungal Glucokinase
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c02110openalex-snapshot
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132)
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01594openalex-snapshot
Structure–Activity Relationship of Azaindole-Based Glucokinase Activators
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6c00411openalex-snapshot
Prenylated Isoflavones Originating from East African Medicinal Plants Selectively Modulate the α-Glucosidase from Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b00272openalex-snapshot
Copper-Catalyzed Oxysulfenylation of Enolates with Sodium Sulfinates: A Strategy To Construct Sulfenylated Cyclic Ethers
inferred← citeshttps://doi.org/10.1021/acscatal.4c07743openalex-snapshot
Enantioselective Access to Chiral γ-Ketoamides via Photoredox Catalyzed Carbamoyl Radical Addition/Asymmetric Protonation
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6b00140openalex-snapshot
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6b00145openalex-snapshot
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties
inferred← citeshttps://doi.org/10.1021/bi400838topenalex-snapshot
Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein
inferred← citeshttps://doi.org/10.1021/bi702516yopenalex-snapshot
Glucose Modulation of Glucokinase Activation by Small Molecules
inferred← citeshttps://doi.org/10.1021/bi802142qopenalex-snapshot
Activating Mutations in the Human Glucokinase Gene Revealed by Genetic Selection
inferred← citeshttps://doi.org/10.1021/bi900020nopenalex-snapshot
Biochemical Characterization of MODY2 Glucokinase Variants V62M and G72R Reveals Reduced Enzymatic Activities Relative to Wild Type
inferred← citeshttps://doi.org/10.1021/bi900374copenalex-snapshot
Binding Kinetics of Glucose and Allosteric Activators to Human Glucokinase Reveal Multiple Conformational States
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