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Genetic Control of Melatonin Synthesis in the Pineal Gland of the Mouse

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1126/science.3881822openalex-snapshot
Melatonin: A Coordinating Signal for Mammalian Reproduction?
inferredcites →https://doi.org/10.1152/physrev.1979.59.3.449openalex-snapshot
Neural regulation of circadian rhythms.
inferredcites →https://doi.org/10.1159/000123579openalex-snapshot
The Pineal Gland and Mammalian Photoperiodism
inferredcites →https://doi.org/10.1210/endo-98-2-482openalex-snapshot
Radioimmunoassay of Serum Concentrations of Melatonin in Sheep Exposed to Different Lighting Regimens

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Quantitative light microscopic study on the heterogeneity in the superficial pineal gland of the rat
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α-Synuclein reduces acetylserotonin O-methyltransferase mediated melatonin biosynthesis by microtubule-associated protein 1 light chain 3 beta-related degradation pathway
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inferred← citeshttps://doi.org/10.1007/s00441-002-0583-2openalex-snapshot
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Beneficial Effects of Exogenous Melatonin in Acute Staphylococcus aureus and Escherichia coli Infection-Induced Inflammation and Associated Behavioral Response in Mice After Exposure to Short Photoperiod
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Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia
inferred← citeshttps://doi.org/10.1007/s43390-024-00941-9openalex-snapshot
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Pineal indole metabolism in the mouse
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Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test
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Autoradiographic localization of 2-[125I]iodomelatonin binding sites in the brains of C3H/HeN and C57BL/6J strains of mice
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Examination of in vitro melatonin secretion from superfused trout (Salmo gairdneri) pineal organs maintained under diel illumination or continuous darkness
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The melatonin message: Duration versus coincidence hypotheses
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Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice
inferred← citeshttps://doi.org/10.1016/0165-1781(91)90048-topenalex-snapshot
Melatonin response to bright light in recovered, drug-free, bipolar patients
inferred← citeshttps://doi.org/10.1016/0165-1838(88)90089-6openalex-snapshot
Effect of superior cervical ganglionectomy on insulin release by murine pancreas slices
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The pineal neurohormone melatonin stimulates activated CD4+, Thy-1+ cells to release opioid agonist(s) with immunoenhancing and anti-stress properties
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The immuno-reconstituting effectof melatonin or pineal grafting and its relation to zinc pool in aging mice
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Melatonin receptors in the mammalian suprachiasmatic nucleus
inferred← citeshttps://doi.org/10.1016/0169-328x(94)90266-6openalex-snapshot
The locus controlling pineal serotonin N-acetyltransferase activity (Nat-2) is located on mouse chromosome 11
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Absence of a nocturnal rise in either norepinephrine, N-acetyltransferase, hydroxyindole-O-methyltransferase or melatonin in the pineal gland of the domestic pig kept under natural environment photoperiods
inferred← citeshttps://doi.org/10.1016/0304-3940(90)90652-popenalex-snapshot
The influence of different light intensities on pineal melatonin content in the retinal degenerate C3H mouse and the normal CBA mouse
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Influence of intensity of illumination during the light period on diurnal variations of pineal indoles in rats and mice
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Effect of bright light in the morning on diurnal variations of pineal indoles in NZBWF1 mice
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A proposed mechanism for the visions of dream sleep
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Simultaneous determination of serotonin, N-acetylserotonin and melatonin in the pineal gland of the juvenile golden hamster by high-performance liquid chromatography with electrochemical detection
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Lithium, Lymphocytes and Labyrinths: Insights into Biological Regulation and Diversity
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Electric Power and Risk of Hormone-Related Cancers
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An Objective Appraisal of the Free Radical Theory of Aging
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Health Consequences of Circadian Disruption in Humans and Animal Models
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Melatonin Regulation of Circadian Rhythmicity in Vertebrates☆
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Chrononutritional Modulation of Sleep and the Circadian Clock by Amino Acids
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The impact of melatonin on maternal and fetal health during pregnancy
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Melatonin Regulation of Circadian Rhythmicity in Vertebrates
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A role of the circadian system and circadian proteins in aging
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Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice
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The role of circadian clock gene Arntl in the winter depression-like behavior in melatonin-proficient female CBA/N mice
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Chronodisruption: An untimely cause of preterm birth?
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Tissue-Specific Posttranslational Modification Allows Functional Targeting of Thyrotropin
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Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1
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Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: Role of serotonin
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Heteromeric MT1/MT2 melatonin receptors modulate the scotopic electroretinogram via PKCζ in mice
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Advances in the study of the influence of photoreceptors on the development of myopia
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Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury
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Protein kinase Cδ mediates methamphetamine-induced dopaminergic neurotoxicity in mice via activation of microsomal epoxide hydrolase
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Hydroxyindole-O-methyltransferase (HIOMT) activity in the retina of melatonin-proficient mice
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Long days restore regular estrous cyclicity in mice lacking circadian rhythms
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A sensitive internal standard method for the determination of melatonin in mammals using precolumn oxidation reversed-phase high-performance liquid chromatography
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The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways
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Light and the laboratory mouse
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Gender- and Compartment-Specific Bone Loss in C57BL/6J Mice: Correlation to Season?
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Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice
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Mice, melatonin and the circadian system
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Circadian clocks and the measurement of daylength in seasonal reproduction
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Circadian aspects of mammalian parturition: A review
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Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis
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Tryptophan metabolism is a physiological integrator regulating circadian rhythms
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Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder
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Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood
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A local circadian clock for memory?
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Meta-analysis of light and circadian timekeeping in rodents
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Serotonin levels in the dorsal raphe nuclei of both chipmunks and mice are enhanced by long photoperiod, but brain dopamine level response to photoperiod is species-specific
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Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep
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Impact of the day/night cycle on functional connectome in ageing male and female mice
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Not Your Father's, or Mother's, Rodent: Moving Beyond B6
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Photoperiod-mediated impairment of long-term potention and learning and memory in male white-footed mice
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Rearing conditions and domestication background determine regulation of hippocampal cell proliferation and survival in adulthood – Laboratory CD1 and C57Bl/6 mice versus wild house mice
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Genetic deletion of MT1/MT2 melatonin receptors enhances murine cognitive and motor performance
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Early-life Photoperiod Influences Depression-like Behavior, Prepulse Inhibition of the Acoustic Startle Response, and Hippocampal Astrogenesis in Mice
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Circadian regulation of reproduction: From gamete to offspring
inferred← citeshttps://doi.org/10.1016/j.physbeh.2013.01.001openalex-snapshot
Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice
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Photoperiodic modulation of voluntary ethanol intake in C57BL/6 mice
inferred← citeshttps://doi.org/10.1016/j.placenta.2021.03.015openalex-snapshot
Hormonal fine-tuning of clock in decidual region of mouse placenta by dopamine, melatonin, insulin, leptin and ghrelin
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2022.101119openalex-snapshot
Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function
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Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice
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Melatonin insufficiency in the follicular fluid of aged mice; is it real?
inferred← citeshttps://doi.org/10.1016/j.smrv.2004.05.002openalex-snapshot
Melatonin as a chronobiotic
inferred← citeshttps://doi.org/10.1016/j.yfrne.2013.04.002openalex-snapshot
Thyroid hormone and seasonal regulation of reproduction
inferred← citeshttps://doi.org/10.1016/j.yfrne.2014.11.002openalex-snapshot
The suprachiasmatic nuclei as a seasonal clock
inferred← citeshttps://doi.org/10.1016/j.ygcen.2006.02.009openalex-snapshot
Mice convert melatonin to 6-sulphatoxymelatonin
inferred← citeshttps://doi.org/10.1016/j.ygcen.2010.11.006openalex-snapshot
The hypophysial pars tuberalis transduces photoperiodic signals via multiple pathways and messenger molecules
inferred← citeshttps://doi.org/10.1016/j.ygcen.2013.02.028openalex-snapshot
Melatonin-induced changes in the expression of thyroid hormone-converting enzymes in hypothalamus depend on the timing of melatonin injections and genetic background in mice
inferred← citeshttps://doi.org/10.1016/j.ygcen.2015.05.009openalex-snapshot
Comparative analysis reveals the underlying mechanism of vertebrate seasonal reproduction
inferred← citeshttps://doi.org/10.1016/j.ygcen.2017.05.013openalex-snapshot
Synchronizing effects of melatonin on diurnal and circadian rhythms
inferred← citeshttps://doi.org/10.1016/s0003-2697(03)00079-4openalex-snapshot
Determination of endogenous melatonin in the individual pineal glands of inbred mice using precolumn oxidation reversed-phase micro-high-performance liquid chromatography
inferred← citeshttps://doi.org/10.1016/s0006-8993(00)02409-4openalex-snapshot
Diurnal metabolism of dopamine in the mouse retina
inferred← citeshttps://doi.org/10.1016/s0006-8993(97)01446-7openalex-snapshot
The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration
inferred← citeshttps://doi.org/10.1016/s0021-9258(18)61591-1openalex-snapshot
Molecular cloning and nucleotide sequence of cDNA encoding hydroxyindole O-methyltransferase of bovine pineal glands.
inferred← citeshttps://doi.org/10.1016/s0031-9384(00)00251-1openalex-snapshot
Reentrainment of the spontaneous locomotor activity rhythm to a daylight reversal in C57BL/6 and C3H/He mice
inferred← citeshttps://doi.org/10.1016/s0031-9384(97)00491-5openalex-snapshot
Effects of a Daylight Cycle Reversal on Locomotor Activity in Several Inbred Strains of Mice
inferred← citeshttps://doi.org/10.1016/s0031-9384(99)00157-2openalex-snapshot
Maternal entrainment in the circadian activity rhythm of laboratory mouse (C57BL/6J)
inferred← citeshttps://doi.org/10.1016/s0091-3057(99)00023-4openalex-snapshot
Effects of Melatonin on Neophobic Responses in Different Strains of Mice
inferred← citeshttps://doi.org/10.1016/s0165-5728(01)00419-2openalex-snapshot
Assessment of melatonin's ability to regulate cytokine production by macrophage and microglia cell types
inferred← citeshttps://doi.org/10.1016/s0165-5728(97)00253-1openalex-snapshot
Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival
inferred← citeshttps://doi.org/10.1016/s0166-2236(97)01109-0openalex-snapshot
Rhythmic transcription: the molecular basis of circadian melatonin synthesis
inferred← citeshttps://doi.org/10.1016/s0166-4328(01)00471-5openalex-snapshot
Circadian modulation of learning and memory in fear-conditioned mice
inferred← citeshttps://doi.org/10.1016/s0169-328x(98)00273-3openalex-snapshot
Natural melatonin `knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase
inferred← citeshttps://doi.org/10.1016/s0192-0561(98)00067-8openalex-snapshot
Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2
inferred← citeshttps://doi.org/10.1016/s0248-4900(98)80004-xopenalex-snapshot
Rhythmic transcription: The molecular basis of circadian melatonin synthesis
inferred← citeshttps://doi.org/10.1016/s0304-3940(98)00462-5openalex-snapshot
Molecular cloning of serotonin N-acetyltransferase gene from the mouse and its daily expression in the retina
inferred← citeshttps://doi.org/10.1017/s0952523802195058openalex-snapshot
Circadian rhythms of dopamine in mouse retina: The role of melatonin
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Evidence for functional GABAA but not GABAC receptors in mouse cone photoreceptors
inferred← citeshttps://doi.org/10.1017/s1461145798001096openalex-snapshot
The effect of nifedipine, Ca2+ antagonist, on activity of MAO inhibitors, N-acetylserotonin and melatonin in the mouse tail suspension test
inferred← citeshttps://doi.org/10.1034/j.1600-0625.2003.00004.xopenalex-snapshot
Photoperiod modulates melanoma growth in C57BL/6 mice
inferred← citeshttps://doi.org/10.1034/j.1600-079x.2002.1823.xopenalex-snapshot
Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice
inferred← citeshttps://doi.org/10.1034/j.1600-079x.2002.1l990.xopenalex-snapshot
Melatonin has antioxidant effects in the brain
inferred← citeshttps://doi.org/10.1037/bne0000252openalex-snapshot
Effects of light at night on laboratory animals and research outcomes.
inferred← citeshttps://doi.org/10.1038/379295a0openalex-snapshot
Melatonin hype hard to swallow
inferred← citeshttps://doi.org/10.1038/nrn2881openalex-snapshot
Circadian rhythms and memory formation
inferred← citeshttps://doi.org/10.1038/oby.2011.276openalex-snapshot
Adipokines and Adipocyte Function in Clock Mutant Mice That Retain Melatonin Rhythmicity
inferred← citeshttps://doi.org/10.1038/s41467-025-57994-1openalex-snapshot
Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases
inferred← citeshttps://doi.org/10.1038/s41598-017-12566-2openalex-snapshot
Overexpression of ovine AANAT and HIOMT genes in switchgrass leads to improved growth performance and salt-tolerance
inferred← citeshttps://doi.org/10.1038/s41598-018-19365-3openalex-snapshot
Time management in a co-housed social rodent species (Arvicanthis niloticus)
inferred← citeshttps://doi.org/10.1038/s41598-019-42442-0openalex-snapshot
Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model
inferred← citeshttps://doi.org/10.1038/s41598-021-81540-wopenalex-snapshot
Photoperiodic regulation of dopamine signaling regulates seasonal changes in retinal photosensitivity in mice
inferred← citeshttps://doi.org/10.1038/s41598-021-84141-9openalex-snapshot
Major oscillations in spontaneous home-cage activity in C57BL/6 mice housed under constant conditions
inferred← citeshttps://doi.org/10.1038/s41598-022-14903-6openalex-snapshot
A novel approach GRNTSTE to reconstruct gene regulatory interactions applied to a case study for rat pineal rhythm gene
inferred← citeshttps://doi.org/10.1038/s42003-023-05520-8openalex-snapshot
ASMT determines gut microbiota and increases neurobehavioral adaptability to exercise in female mice
inferred← citeshttps://doi.org/10.1038/s44323-024-00013-1openalex-snapshot
Melatonin’s role in the timing of sleep onset is conserved in nocturnal mice
inferred← citeshttps://doi.org/10.1039/bk9781839167553-00222openalex-snapshot
Circadian Rhythms and the Gastrointestinal System
inferred← citeshttps://doi.org/10.1039/bk9781839167553-00246openalex-snapshot
Circadian Clock Signals in Endocrine Glands
inferred← citeshttps://doi.org/10.1046/j.1460-9568.2000.00990.xopenalex-snapshot
Transcription factor dynamics and neuroendocrine signalling in the mouse pineal gland: a comparative analysis of melatonin‐deficient C57BL mice and melatonin‐proficient C3H mice
inferred← citeshttps://doi.org/10.1046/j.1600-079x.2003.00115.xopenalex-snapshot
Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase‐3 and is suitable as an add‐on treatment to tissue‐plasminogen activator
inferred← citeshttps://doi.org/10.1051/rnd:19990310openalex-snapshot
Melatonin mediates seasonal adjustments in immune function
inferred← citeshttps://doi.org/10.1071/rd04023openalex-snapshot
Reproductive performance in female Clock?19 mutant mice
inferred← citeshttps://doi.org/10.1071/wr9930745openalex-snapshot
Reproductive biology of the feral house mouse (Mus musculus) on subantarctic Macquarie Island
inferred← citeshttps://doi.org/10.1073/pnas.0808952105openalex-snapshot
Involvement of thyrotropin in photoperiodic signal transduction in mice
inferred← citeshttps://doi.org/10.1073/pnas.0914399107openalex-snapshot
Genetic variation of melatonin productivity in laboratory mice under domestication
inferred← citeshttps://doi.org/10.1073/pnas.1004368107openalex-snapshot
Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway
inferred← citeshttps://doi.org/10.1073/pnas.1323350111openalex-snapshot
Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin
inferred← citeshttps://doi.org/10.1073/pnas.93.24.14140openalex-snapshot
Transcriptional control of circadian hormone synthesis via the CREM feedback loop
inferred← citeshttps://doi.org/10.1080/00071668.2022.2090230openalex-snapshot
Transcriptional regulation of the chicken ASMT gene – a preliminary analysis
inferred← citeshttps://doi.org/10.1080/02713683.2019.1625408openalex-snapshot
Transcriptional Profiling of Daily Patterns of mRNA Expression in the C57BL/6J Mouse Cornea
inferred← citeshttps://doi.org/10.1080/03007995.2021.2000714openalex-snapshot
What do we really know about the safety and efficacy of melatonin for sleep disorders?
inferred← citeshttps://doi.org/10.1080/07420528.2016.1207661openalex-snapshot
The impact of prenatal circadian rhythm disruption on pregnancy outcomes and long-term metabolic health of mice progeny
inferred← citeshttps://doi.org/10.1080/07420528.2019.1624373openalex-snapshot
Melatonin research in mice: a review
inferred← citeshttps://doi.org/10.1080/07435809209035401openalex-snapshot
A Brief Survey of Pineal Gland-Immune System Interrelationships
inferred← citeshttps://doi.org/10.1080/15548627.2026.2689419openalex-snapshot
Melatonin alleviates rheumatoid arthritis via elimination of damaged mitochondria
inferred← citeshttps://doi.org/10.1081/cbi-100101067openalex-snapshot
MELATONIN CIRCADIAN RHYTHM IN THE RETINA OF MAMMALS
inferred← citeshttps://doi.org/10.1081/cbi-120022415openalex-snapshot
The Circadian System and Melatonin: Lessons from Rats and Mice
inferred← citeshttps://doi.org/10.1086/302219openalex-snapshot
When Less Is More: Gene Loss as an Engine of Evolutionary Change
inferred← citeshttps://doi.org/10.1086/393989openalex-snapshot
Photoperiodic Polyphenisms in Rodents: Neuroendocrine Mechanisms, Costs, and Functions
inferred← citeshttps://doi.org/10.1086/419555openalex-snapshot
Seasonal Changes in Immune Function
inferred← citeshttps://doi.org/10.1089/thy.2017.0186openalex-snapshot
Seasonal Rhythms: The Role of Thyrotropin and Thyroid Hormones
inferred← citeshttps://doi.org/10.1093/gerona/gly059openalex-snapshot
The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes
inferred← citeshttps://doi.org/10.1093/humupd/dmh054openalex-snapshot
The role of circadian rhythmicity in reproduction
inferred← citeshttps://doi.org/10.1093/icb/icp011openalex-snapshot
Comparative analysis of the molecular basis of photoperiodic signal transduction in vertebrates
inferred← citeshttps://doi.org/10.1093/ilar.47.2.94openalex-snapshot
Mouse Phenome Research: Implications of Genetic Background
inferred← citeshttps://doi.org/10.1093/ilar/ilaa010openalex-snapshot
Relevance of Electrical Light on Circadian, Neuroendocrine, and Neurobehavioral Regulation in Laboratory Animal Facilities
inferred← citeshttps://doi.org/10.1093/pnasnexus/pgaf159openalex-snapshot
Targeted disruption of the aralkylamine N-acetyltransferase gene in a seasonal mammal, Mesocricetus auratus
inferred← citeshttps://doi.org/10.1093/sleep/26.3.267openalex-snapshot
Sleep in Female Mice: A Strain Comparison Across the Estrous Cycle
inferred← citeshttps://doi.org/10.1093/toxsci/50.2.271openalex-snapshot
Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats
inferred← citeshttps://doi.org/10.1095/biolreprod37.1.14openalex-snapshot
Pinealectomy or Superior Cervical Ganglionectomy do not Alter Reproduction in the Wolf (Canis Lupus)
inferred← citeshttps://doi.org/10.1097/01.brs.0000134567.52303.1aopenalex-snapshot
Melatonin Signaling Dysfunction in Adolescent Idiopathic Scoliosis
inferred← citeshttps://doi.org/10.1097/ccm.0000000000003190openalex-snapshot
Blue Light Enhances Bacterial Clearance and Reduces Organ Injury During Sepsis*
inferred← citeshttps://doi.org/10.1098/rspb.2013.1354openalex-snapshot
Animal clocks: when science meets nature
inferred← citeshttps://doi.org/10.1098/rstb.2016.0249openalex-snapshot
Timing as a sexually selected trait: the right mate at the right moment
inferred← citeshttps://doi.org/10.1101/2025.03.12.642893openalex-snapshot
Circadian Control of Sleep by Melatonin via MT 1 -Dependent Activation of BK Channels in the Suprachiasmatic Nucleus
inferred← citeshttps://doi.org/10.1104/pp.19.00328openalex-snapshot
CRISPR-Based Assessment of Gene Specialization in the Gibberellin Metabolic Pathway in Rice
inferred← citeshttps://doi.org/10.1111/bph.70658openalex-snapshot
Melatonin exerts dual, concentration‐dependent effects on intestinal pacemaker networks via MT2 receptor activation and redox pathways
inferred← citeshttps://doi.org/10.1111/gbb.12369openalex-snapshot
Role of the MT1 and MT2 melatonin receptors in mediating depressive‐ and anxiety‐like behaviors in C3H / HeN mice
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