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Nascent DNA methylome mapping reveals inheritance of hemimethylation at CTCF/cohesin sites

https://doi.org/10.1126/science.aan5480
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpA sites
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Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
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Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
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Methylation-Dependent and -Independent Genomic Targeting Principles of the MBD Protein Family
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Programming and Inheritance of Parental DNA Methylomes in Mammals
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Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization
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Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom
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Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments
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ATRX Partners with Cohesin and MeCP2 and Contributes to Developmental Silencing of Imprinted Genes in the Brain
inferredcites →https://doi.org/10.1016/j.molcel.2017.07.022openalex-snapshot
Evolutionarily Conserved Principles Predict 3D Chromatin Organization
inferredcites →https://doi.org/10.1038/nature06397openalex-snapshot
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
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An integrated encyclopedia of DNA elements in the human genome
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Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells
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Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
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Intermediate DNA methylation is a conserved signature of genome regulation
inferredcites →https://doi.org/10.1038/ng.3258openalex-snapshot
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
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Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome
inferredcites →https://doi.org/10.1038/ng1570openalex-snapshot
Integrative analysis of the cancer transcriptome
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Fast gapped-read alignment with Bowtie 2
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Establishing, maintaining and modifying DNA methylation patterns in plants and animals
inferredcites →https://doi.org/10.1038/nrg3663openalex-snapshot
CTCF: an architectural protein bridging genome topology and function
inferredcites →https://doi.org/10.1073/pnas.2536758100openalex-snapshot
Hairpin-bisulfite PCR: Assessing epigenetic methylation patterns on complementary strands of individual DNA molecules
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Java Treeview—extensible visualization of microarray data
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The Sequence Alignment/Map format and SAMtools
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BEDTools: a flexible suite of utilities for comparing genomic features
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Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications
inferredcites →https://doi.org/10.1093/bioinformatics/btu170openalex-snapshot
Trimmomatic: a flexible trimmer for Illumina sequence data
inferredcites →https://doi.org/10.1093/nar/29.17.3506openalex-snapshot
Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases
inferredcites →https://doi.org/10.1093/nar/gku365openalex-snapshot
deepTools: a flexible platform for exploring deep-sequencing data
inferredcites →https://doi.org/10.1093/nar/gku564openalex-snapshot
Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping
inferredcites →https://doi.org/10.1101/gr.163147.113openalex-snapshot
The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation
inferredcites →https://doi.org/10.1111/j.1365-2443.2006.00984.xopenalex-snapshot
Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
inferredcites →https://doi.org/10.1126/science.1111098openalex-snapshot
How Are Alkynes Scrambled?
inferredcites →https://doi.org/10.1126/science.1147939openalex-snapshot
UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells
inferredcites →https://doi.org/10.1126/science.187.4173.226openalex-snapshot
DNA Modification Mechanisms and Gene Activity During Development
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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1
inferredcites →https://doi.org/10.1128/mcb.00484-09openalex-snapshot
Selective Anchoring of DNA Methyltransferases 3A and 3B to Nucleosomes Containing Methylated DNA
inferredcites →https://doi.org/10.1128/mcb.22.2.480-491.2002openalex-snapshot
Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements
inferredcites →https://doi.org/10.1128/mcb.23.16.5594-5605.2003openalex-snapshot
Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b
inferredcites →https://doi.org/10.1146/annurev-genom-090413-025437openalex-snapshot
Non-CG Methylation in the Human Genome
inferredcites →https://doi.org/10.1186/gb-2008-9-9-r137openalex-snapshot
Model-based Analysis of ChIP-Seq (MACS)
inferredcites →https://doi.org/10.1371/journal.pgen.1001286openalex-snapshot
Nucleosomes Containing Methylated DNA Stabilize DNA Methyltransferases 3A/3B and Ensure Faithful Epigenetic Inheritance
inferredcites →https://doi.org/10.1371/journal.pgen.1002750openalex-snapshot
In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Homeostasis of DNA Hemi‐Methylation in Arabidopsis through Methylation Maintenance, DNA Replication, and Nucleosome Positioning Mechanisms
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Epigenetic Tools in Chronic Pain Studies
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Assessment of the epigenetic nature of chromosomal proteins during DNA replication and mitosis
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The single-molecule accessibility landscape of newly replicated mammalian chromatin
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Replication-coupled inheritance of chromatin states
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Loss of Small-RNA-Directed DNA Methylation in the Plant Cell Cycle Promotes Germline Reprogramming and Somaclonal Variation
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DNA methylation maintenance at heterochromatin
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Considerations for the need of recommendations for the research and publication of DNA methylation results
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Regulation of 3D chromatin organization by CTCF
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DNA methylation heterogeneity in complex tumor microenvironment: Quantitative methods, influencing factors, and clinical implications
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RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B
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Epigenetic-mediated positive feedback loop facilitates the progression of lung adenocarcinoma
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Mitotic inheritance of DNA methylation: more than just copy and paste
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Epigenetic silencing of the DAPK1 gene in Egyptian patients with chronic myeloid Leukemia
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Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication
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Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA
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A tale of two strands: Decoding chromatin replication through strand-specific sequencing
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NuRD-enabled CTCF-TET crosstalk orchestrates epigenome reprogramming and genome architecture
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Chemical Biology Approaches to Identify and Profile Interactors of Chromatin Modifications
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Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration
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An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine
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Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
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Regulation of CTCF loop formation during pancreatic cell differentiation
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Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA
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Footprint-C reveals transcription factor modes in local clusters and long-range chromatin interactions
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High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics
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Chromatin replication and epigenetic cell memory
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Quantifying propagation of DNA methylation and hydroxymethylation with iDEMS
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Epigenomic heterogeneity as a source of tumour evolution
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DNA methylation in mammalian development and disease
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Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells
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Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance
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Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance
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Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity
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Resolution of the DNA methylation state of single CpG dyads using in silico strand annealing and WGBS data
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Simultaneously measuring the methylation of parent and daughter strands of replicated DNA at the single-molecule level by Hammer-seq
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Genome-wide and sister chromatid-resolved profiling of protein occupancy in replicated chromatin with ChOR-seq and SCAR-seq
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CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation
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DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift
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Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish
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Monitoring and quantifying replication fork dynamics with high-throughput methods
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Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing
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Transformer-based deep learning for accurate detection of multiple base modifications using single molecule real-time sequencing
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A continuum of zinc finger transcription factor retention on native chromatin underlies dynamic genome organization
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Mammalian DNA methyltransferases: new discoveries and open questions
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Sensitivity of transcription factors to DNA methylation
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DNA methylation shapes transcription factor binding beyond canonical CpG contexts
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Direct Detection of Hemi-methylated DNA by SRA-fused Luciferase Based on Bioluminescence Resonance Energy Transfer
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A mathematical model exhibiting the effect of DNA methylation on the stability boundary in cell-fate networks
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Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function
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An emerging paradigm in epigenetic marking: coordination of transcription and replication
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A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing
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Blood DNA Methylation and Aging: A Cross-Sectional Analysis and Longitudinal Validation in the InCHIANTI Study
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The TET-TDG axis in T cells and biological processes
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A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association
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Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
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DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding
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Structures of CTCF–DNA complexes including all 11 zinc fingers
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Uncovering the roles of DNA hemi-methylation in transcriptional regulation using MspJI-assisted hemi-methylation sequencing
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UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
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DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations
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Human DNA replication initiation sites are specified epigenetically by oxidation of 5-methyl-deoxycytidine
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Failures to maintain CpG-methylation of CoRSIVs in bovine sperm are associated with low sire conception
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Embryonic heat conditioning in chicks induces transgenerational heat/immunological resilience via methylation on regulatory elements
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Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns
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Locally correlated kinetics of post-replication DNA methylation reveals processivity and region specificity in DNA methylation maintenance
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ALU non-B-DNA conformations, flipons, binary codes and evolution
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Formation and recycling of an active epigenetic mark mediated by cell cycle-specific RNAs
inferred← citeshttps://doi.org/10.1101/2023.12.28.573516openalex-snapshot
Longitudinal conditional probability of symmetric DNA methylation in Arabidopsis plants
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Nanopore duplex sequencing reveals patterns of asymmetric states of 5hmC and 5mC in the medaka brain genome
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An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine
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DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries
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Epigenetic regulation of inflammation by CxxC domain‐containing proteins*
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The molecular basis of cell memory in mammals: The epigenetic cycle
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Architectural transcription factors collectively shape nuclear radial positioning of chromatin contacts
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Hemimethylation: DNA's lasting odd couple
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TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
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Hemimethylation Patterns in Breast Cancer Cell Lines
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Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies
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Statistical and bioinformatic analysis of hemimethylation patterns in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1186/s13059-021-02384-1openalex-snapshot
Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
inferred← citeshttps://doi.org/10.1186/s13072-019-0299-0openalex-snapshot
Detailed insight into the dynamics of the initial phases of de novo RNA-directed DNA methylation in plant cells
inferred← citeshttps://doi.org/10.1186/s40364-021-00331-7openalex-snapshot
Advances in the DNA methylation hydroxylase TET1
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Molecular mechanisms of maintenance DNA methylation
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Methylation dynamics during the maternal-to-zygotic genome transition in dioecious species
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Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays
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Analysis and synthesis of cellular decision making: modeling epigenetic regulation in cell fate networks and designing a distributed synthetic counter circuit
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Isolation of DNA by EdU-labelling for Mass Spectrometry (iDEMS)
inferred← citeshttps://doi.org/10.21203/rs.3.rs-464637/v1openalex-snapshot
Formation and recycling of an active epigenetic mark mediated by cell cycle-specific RNAs
inferred← citeshttps://doi.org/10.2217/epi-2022-0035openalex-snapshot
DNMT1: catalytic and non-catalytic roles in different biological processes
inferred← citeshttps://doi.org/10.3389/fimmu.2019.00210openalex-snapshot
TET Enzymes and 5hmC in Adaptive and Innate Immune Systems
inferred← citeshttps://doi.org/10.3389/fmicb.2020.00887openalex-snapshot
SMRT Sequencing of Paramecium Bursaria Chlorella Virus-1 Reveals Diverse Methylation Stability in Adenines Targeted by Restriction Modification Systems
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Large-Scale Chromatin Rearrangements in Cancer
inferred← citeshttps://doi.org/10.3390/genes13061002openalex-snapshot
Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
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Mechanisms of DNA Methyltransferase Recruitment in Mammals
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Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation
inferred← citeshttps://doi.org/10.3410/f.736464528.793566607openalex-snapshot
Faculty Opinions recommendation of Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells.
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Chromatin affinity purification coupled with mass spectrometry indetifies novel histone ubiquitylation interactors
inferred← citeshttps://doi.org/10.6084/m9.figshare.14211309openalex-snapshot
Additional file 1 of Statistical and bioinformatic analysis of hemimethylation patterns in non-small cell lung cancer
inferred← citeshttps://doi.org/10.6084/m9.figshare.14826131openalex-snapshot
Additional file 1 of Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.14826143openalex-snapshot
Additional file 5 of Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
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Targets and genomic constraints of ectopic Dnmt3b expression
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