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Cerebrospinal fluid influx drives acute ischemic tissue swelling

https://doi.org/10.1126/science.aax7171
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice
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Detection of necrotic neural response in super‐acute cerebral ischemia using activity‐induced manganese‐enhanced (AIM) MRI
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Pathophysiological Aspects of Brain Edema
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Relationship Between Cerebral Blood Flow and Blood-Brain Barrier Permeability of Sodium and Albumin in Cerebral Infarcts of Rats
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Pathophysiological aspects of brain edema
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Brain ion homeostasis in cerebral ischemia
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A quantitative study of three-dimensional Lagrangian particle tracking algorithms
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Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
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Glibenclamide in Cerebral Ischemia and Stroke
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Correcting for Brain Swelling’s Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats
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Multivariate Analysis of Structural and Diffusion Imaging in Traumatic Brain Injury
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The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema
inferredcites →https://doi.org/10.1016/j.jneumeth.2014.12.015openalex-snapshot
A novel method to study cerebrospinal fluid dynamics in rats
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Blood–brain barrier opening to large molecules does not imply blood–brain barrier opening to small ions
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Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia
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Waxholm Space: An image-based reference for coordinating mouse brain research
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A reproducible evaluation of ANTs similarity metric performance in brain image registration
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Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke
inferredcites →https://doi.org/10.1016/j.neuron.2015.04.004openalex-snapshot
The Stroke-Migraine Depolarization Continuum
inferredcites →https://doi.org/10.1016/j.neuropharm.2017.09.027openalex-snapshot
Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke
inferredcites →https://doi.org/10.1016/j.neuroscience.2012.08.049openalex-snapshot
Peri-infarct flow transients predict outcome in rat focal brain ischemia
inferredcites →https://doi.org/10.1016/j.neuroscience.2013.12.032openalex-snapshot
Ischemia-induced depolarizations and associated hemodynamic responses in incomplete global forebrain ischemia in rats
inferredcites →https://doi.org/10.1016/j.tins.2014.08.010openalex-snapshot
Drowning stars: reassessing the role of astrocytes in brain edema
inferredcites →https://doi.org/10.1016/s1474-4422(07)70055-8openalex-snapshot
Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
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Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [ 14 C]2-Deoxyglucose Phosphorylation
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Ischemic Brain Edema and the Osmotic Gradient between Blood and Brain
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Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury
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The Effect of Glutamate Receptor Blockade on Anoxic Depolarization and Cortical Spreading Depression
inferredcites →https://doi.org/10.1038/jcbfm.1992.54openalex-snapshot
The Effect of MK-801 on Cortical Spreading Depression in the Penumbral Zone following Focal Ischaemia in the Rat
inferredcites →https://doi.org/10.1038/jcbfm.1994.5openalex-snapshot
Blood—Brain Barrier Permeability and Brain Concentration of Sodium, Potassium, and Chloride during Focal Ischemia
inferredcites →https://doi.org/10.1038/jcbfm.2010.97openalex-snapshot
Temporary Focal Cerebral Ischemia Results in Swollen Astrocytic End-Feet That Compress Microvessels and Lead to Focal Cortical Infarction
inferredcites →https://doi.org/10.1038/jcbfm.2013.63openalex-snapshot
In Vivo NADH Fluorescence Imaging Indicates Effect of Aquaporin-4 Deletion on Oxygen Microdistribution in Cortical Spreading Depression
inferredcites →https://doi.org/10.1038/ncomms11100openalex-snapshot
Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain
inferredcites →https://doi.org/10.1038/nm.2333openalex-snapshot
The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease
inferredcites →https://doi.org/10.1038/nm.4361openalex-snapshot
Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus
inferredcites →https://doi.org/10.1038/nn.2953openalex-snapshot
Stroke research at a crossroad: asking the brain for directions
inferredcites →https://doi.org/10.1038/s41467-017-01068-4openalex-snapshot
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
inferredcites →https://doi.org/10.1038/s41467-018-07318-3openalex-snapshot
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
inferredcites →https://doi.org/10.1038/sj.jcbfm.9600252openalex-snapshot
Vasoconstrictive Neurovascular Coupling during Focal Ischemic Depolarizations
inferredcites →https://doi.org/10.1063/1.4979668openalex-snapshot
Front tracking for quantifying advection-reaction-diffusion
inferredcites →https://doi.org/10.1073/pnas.0509425103openalex-snapshot
In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space
inferredcites →https://doi.org/10.1073/pnas.1007239107openalex-snapshot
Topological basis for the robust distribution of blood to rodent neocortex
inferredcites →https://doi.org/10.1093/brain/awl392openalex-snapshot
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
inferredcites →https://doi.org/10.1093/brain/awp102openalex-snapshot
Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage
inferredcites →https://doi.org/10.1093/brain/awu241openalex-snapshot
Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma
inferredcites →https://doi.org/10.1093/brain/awx214openalex-snapshot
Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction
inferredcites →https://doi.org/10.1093/brain/awy102openalex-snapshot
The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex
inferredcites →https://doi.org/10.1093/brain/awy143openalex-snapshot
Active role of capillary pericytes during stimulation-induced activity and spreading depolarization
inferredcites →https://doi.org/10.1093/cercor/bhv054openalex-snapshot
Dynamics of Ionic Shifts in Cortical Spreading Depression
inferredcites →https://doi.org/10.1093/cercor/bhw359openalex-snapshot
Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice
inferredcites →https://doi.org/10.1097/00004647-199809000-00007openalex-snapshot
Nitric Oxide Scavenging by Hemoglobin or Nitric Oxide Synthase Inhibition by N -Nitro-L-Arginine Induces Cortical Spreading Ischemia When K + Is Increased in the Subarachnoid Space
inferredcites →https://doi.org/10.1097/00005072-196701000-00001openalex-snapshot
Presidential Address*
inferredcites →https://doi.org/10.1111/j.1469-7793.2001.0515i.xopenalex-snapshot
Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats
inferredcites →https://doi.org/10.1119/1.3536647openalex-snapshot
Using particle tracking to measure flow instabilities in an undergraduate laboratory experiment
inferredcites →https://doi.org/10.1126/science.1241224openalex-snapshot
Sleep Drives Metabolite Clearance from the Adult Brain
inferredcites →https://doi.org/10.1126/scitranslmed.3003748openalex-snapshot
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
inferredcites →https://doi.org/10.1152/ajplegacy.1956.187.1.180openalex-snapshot
Cerebral Impedance Changes After Circulatory Arrest
inferredcites →https://doi.org/10.1152/ajplegacy.1958.192.3.457openalex-snapshot
Changes in the Diameter of Apical Dendrites During Spreading Depression
inferredcites →https://doi.org/10.1152/ajplegacy.1971.221.1.214openalex-snapshot
Brain distribution spaces of mannitol-3H, inulin-14C, and dextran-14C in the rat
inferredcites →https://doi.org/10.1152/physrev.00027.2007openalex-snapshot
Diffusion in Brain Extracellular Space
inferredcites →https://doi.org/10.1159/000441085openalex-snapshot
Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study
inferredcites →https://doi.org/10.1161/01.str.16.1.101openalex-snapshot
Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin.
inferredcites →https://doi.org/10.1161/01.str.18.1.150openalex-snapshot
Transport of sodium from blood to brain in ischemic brain edema.
inferredcites →https://doi.org/10.1161/01.str.18.4.751openalex-snapshot
Regional brain sodium, potassium, and water changes in the rat middle cerebral artery occlusion model of ischemia.
inferredcites →https://doi.org/10.1161/01.str.21.4.582openalex-snapshot
Brain edema and cerebrovascular permeability during cerebral ischemia in rats.
inferredcites →https://doi.org/10.1161/cir.0000000000000659openalex-snapshot
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
inferredcites →https://doi.org/10.1161/strokeaha.114.006617openalex-snapshot
Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI
inferredcites →https://doi.org/10.1161/strokeaha.114.006884openalex-snapshot
Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke
inferredcites →https://doi.org/10.1172/jci.insight.120922openalex-snapshot
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain
inferredcites →https://doi.org/10.1172/jci.insight.121537openalex-snapshot
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
inferredcites →https://doi.org/10.1172/jci67677openalex-snapshot
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
inferredcites →https://doi.org/10.1177/0271678x15617172openalex-snapshot
Molecular pathophysiology of cerebral edema
inferredcites →https://doi.org/10.1177/0271678x16654495openalex-snapshot
The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy
inferredcites →https://doi.org/10.1212/wnl.0b013e3182886932openalex-snapshot
Propagation of cortical spreading depolarization in the human cortex after malignant stroke
inferredcites →https://doi.org/10.1523/jneurosci.0721-07.2007openalex-snapshot
High-ResolutionIn VivoImaging of the Neurovascular Unit during Spreading Depression
inferredcites →https://doi.org/10.1523/jneurosci.3390-16.2017openalex-snapshot
Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache
inferredcites →https://doi.org/10.1523/jneurosci.3694-15.2016openalex-snapshot
Susceptibility of Primary Sensory Cortex to Spreading Depolarizations
inferredcites →https://doi.org/10.3171/foc.2007.22.5.3openalex-snapshot
Cytotoxic edema: mechanisms of pathological cell swelling
inferredcites →https://doi.org/10.3389/fphy.2017.00062openalex-snapshot
Transitions from Trees to Cycles in Adaptive Flow Networks
inferredcites →https://doi.org/10.3390/ijms19010046openalex-snapshot
Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways
inferredcites →https://doi.org/10.3791/57378openalex-snapshot
Cannula Implantation into the Cisterna Magna of Rodents
inferredcites →https://doi.org/10.7554/elife.40070openalex-snapshot
Aquaporin-4-dependent glymphatic solute transport in the rodent brain

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/glia.23924openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/glia.24515openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/glia.24639openalex-snapshot
Aquaporin‐4 activation facilitates glymphatic system function and hematoma clearance post‐intracerebral hemorrhage
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Predictive Utility of Cerebral Blood Flow Transients in Experimental Stroke
inferred← citeshttps://doi.org/10.1007/s12975-026-01442-9openalex-snapshot
Neuroinflammation in Ischemic Stroke: Mechanisms, Systemic Interactions, and Therapeutic Targets
inferred← citeshttps://doi.org/10.1007/s13139-022-00746-6openalex-snapshot
[64Cu]Cu-Albumin Clearance Imaging to Evaluate Lymphatic Efflux of Cerebrospinal Space Fluid in Mouse Model
inferred← citeshttps://doi.org/10.1007/s13311-020-00850-5openalex-snapshot
Spreading Depolarizations and Subarachnoid Hemorrhage
inferred← citeshttps://doi.org/10.1007/s13311-020-00925-3openalex-snapshot
Pituitary Adenylate Cyclase-Activating Polypeptide Attenuates Brain Edema by Protecting Blood–Brain Barrier and Glymphatic System After Subarachnoid Hemorrhage in Rats
inferred← citeshttps://doi.org/10.1007/s13577-022-00773-7openalex-snapshot
Long non-coding RNA RPL34-AS1 ameliorates oxygen–glucose deprivation-induced neuronal injury via modulating miR-223–3p/IGF1R axis
inferred← citeshttps://doi.org/10.1007/s44258-024-00021-7openalex-snapshot
Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases
inferred← citeshttps://doi.org/10.1016/b978-0-12-821565-4.00005-5openalex-snapshot
Principles of gliopathology
inferred← citeshttps://doi.org/10.1016/b978-0-12-822963-7.00236-xopenalex-snapshot
Sleep and the glymphatic system
inferred← citeshttps://doi.org/10.1016/b978-0-323-69424-7.00007-7openalex-snapshot
The Neurovascular Unit and Responses to Ischemia
inferred← citeshttps://doi.org/10.1016/b978-0-323-91688-2.00012-6openalex-snapshot
Physiological brain pulsations
inferred← citeshttps://doi.org/10.1016/b978-0-323-95702-1.00243-8openalex-snapshot
Lymphatic System of the Brain
inferred← citeshttps://doi.org/10.1016/b978-0-443-19104-6.00006-1openalex-snapshot
The glymphatic system
inferred← citeshttps://doi.org/10.1016/b978-0-443-32974-6.00001-xopenalex-snapshot
Imaging BBB dysfunction in brain disorders
inferred← citeshttps://doi.org/10.1016/j.accpm.2025.101669openalex-snapshot
Feasibility and safety of electrocorticography monitoring after acute brain injury to detect cortical spreading depolarisation, a prospective observational study in a neurological intensive care unit
inferred← citeshttps://doi.org/10.1016/j.addr.2024.115216openalex-snapshot
The interaction between particles and vascular endothelium in blood flow
inferred← citeshttps://doi.org/10.1016/j.arr.2023.101885openalex-snapshot
Glymphatic pathway in sporadic cerebral small vessel diseases: From bench to bedside
inferred← citeshttps://doi.org/10.1016/j.bas.2026.106252openalex-snapshot
Syndrome of the trephined: from pathophysiology to cranioplasty - an updated narrative review
inferred← citeshttps://doi.org/10.1016/j.bbr.2026.116138openalex-snapshot
Modulating glymphatic clearance in Alzheimer’s disease: Molecular mechanisms, imaging biomarkers, and emerging interventions
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.152588openalex-snapshot
SIRT2-mediated autophagy as a target of butylphthalide in the treatment of ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2026.124534openalex-snapshot
A unified magnetic nanoprobe enables multi-sequence MRI mapping of post-stroke cerebrovascular and glymphatic injuries
inferred← citeshttps://doi.org/10.1016/j.bj.2022.01.006openalex-snapshot
Altered diffusivity of the subarachnoid cisterns in the rat brain following neurological disorders
inferred← citeshttps://doi.org/10.1016/j.brainres.2020.147062openalex-snapshot
MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2021.05.015openalex-snapshot
Microphysiological models of the central nervous system with fluid flow
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2024.111045openalex-snapshot
Simvastatin alleviates glymphatic system damage via the VEGF-C/VEGFR3/PI3K-Akt pathway after experimental intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2026.111951openalex-snapshot
Longitudinal changes of BOLD-CSF coupling and its association with the clinical assessments in subcortical ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.brs.2025.05.003openalex-snapshot
Chemogenetic modulation in stroke recovery: A promising stroke therapy approach
inferred← citeshttps://doi.org/10.1016/j.cell.2023.11.001openalex-snapshot
Choroid plexus mast cells drive tumor-associated hydrocephalus
inferred← citeshttps://doi.org/10.1016/j.cell.2024.07.036openalex-snapshot
Multiphoton fluorescence microscopy for in vivo imaging
inferred← citeshttps://doi.org/10.1016/j.cell.2024.11.027openalex-snapshot
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114217openalex-snapshot
Lymphatic network drainage resolves cerebral edema and facilitates recovery from experimental cerebral malaria
inferred← citeshttps://doi.org/10.1016/j.clinph.2025.2110746openalex-snapshot
Reduction of sleep-like perilesional slow waves and clinical evolution after stroke: A TMS-EEG study
inferred← citeshttps://doi.org/10.1016/j.coi.2022.102182openalex-snapshot
The vicious cycle governing the brain–immune system relationship in neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175137openalex-snapshot
Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells
inferred← citeshttps://doi.org/10.1016/j.expneurol.2021.113685openalex-snapshot
The role of glymphatic system in the cerebral edema formation after ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.expneurol.2024.115036openalex-snapshot
Multifaceted role of thrombin in subarachnoid hemorrhage: Focusing on cerebrospinal fluid circulation disorder
inferred← citeshttps://doi.org/10.1016/j.expneurol.2026.115807openalex-snapshot
Aquaporin-4 depolarization in stroke: Mechanisms and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.expneurol.2026.115825openalex-snapshot
The Glymphatic system: A dynamic regulator of brain health and therapeutic target
inferred← citeshttps://doi.org/10.1016/j.hest.2022.06.001openalex-snapshot
Glymphatic system and post-hemorrhagic hydrocephalus
inferred← citeshttps://doi.org/10.1016/j.ibneur.2023.03.014openalex-snapshot
Beneficial effect of electroacupuncture on the distribution of foreign substances in the brain of rats developing depression-like behavior
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110800openalex-snapshot
Sepsis-associated encephalopathy: From pathophysiology to clinical management
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104258openalex-snapshot
A network model of glymphatic flow under different experimentally-motivated parametric scenarios
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104987openalex-snapshot
The glymphatic system: Current understanding and modeling
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105250openalex-snapshot
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline
inferred← citeshttps://doi.org/10.1016/j.jare.2025.05.022openalex-snapshot
Aquaporin 4 and its isoforms regulation ameliorate AQP4 Mis-localization-induced glymphatic dysfunction in ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.jare.2026.02.032openalex-snapshot
Review of research advances in the cerebral lymphatic system and neurological disorders
inferred← citeshttps://doi.org/10.1016/j.jci.2026.100008openalex-snapshot
Beyond amyloid and tau: Emerging pathogenic mechanisms, biomarkers, and therapeutic prospects of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105541openalex-snapshot
The Cerebro-Renal System- Anatomical and Physiological Considerations
inferred← citeshttps://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106476openalex-snapshot
Spatiotemporal Patterns of Spreading Depolarization and its Correlation with Brain Injury During the Acute Stage of Subarachnoid Hemorrhage in Mice
inferred← citeshttps://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106570openalex-snapshot
Downregulation of NF-κB by Shp-1 Alleviates Cerebral Venous Sinus Thrombosis-Induced Brain Edema Via Suppression of AQP4
inferred← citeshttps://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107200openalex-snapshot
Correspondence between development of cytotoxic edema and cerebrospinal fluid volume and flow in the third ventricle after ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107557openalex-snapshot
The glymphatic system and cerebral small vessel disease
inferred← citeshttps://doi.org/10.1016/j.jtbi.2022.111103openalex-snapshot
Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.121814openalex-snapshot
Molecular mechanisms of ischemia and glutamate excitotoxicity
inferred← citeshttps://doi.org/10.1016/j.mehy.2021.110591openalex-snapshot
Origin of post-ictal and post-anesthesia adverse effects and possibly of SUDEP
inferred← citeshttps://doi.org/10.1016/j.mri.2024.110294openalex-snapshot
The fuzzy MAD stroke conjecture, using Fuzzy C Means to classify multimodal apparent diffusion for ischemic stroke lesion stratification
inferred← citeshttps://doi.org/10.1016/j.mvr.2023.104515openalex-snapshot
Perivascular Clearance of Blood Proteins after Blood-Brain Barrier Disruption in a Rat Model of Micro-Infarcts
inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105948openalex-snapshot
Brain edema formation and therapy after intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1016/j.nbd.2023.106029openalex-snapshot
Ischemic brain edema: Emerging cellular mechanisms and therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.nbd.2024.106586openalex-snapshot
Dystrophin 71 deficiency causes impaired aquaporin-4 polarization contributing to glymphatic dysfunction and brain edema in cerebral ischemia
inferred← citeshttps://doi.org/10.1016/j.nbd.2025.107214openalex-snapshot
Optic nerve glymphatic system: Physiological characterization, ischemia-induced changes, and neuroprotection in ischemic optic neuropathy
inferred← citeshttps://doi.org/10.1016/j.neuroimage.2022.119329openalex-snapshot
Imaging perivascular space structure and function using brain MRI
inferred← citeshttps://doi.org/10.1016/j.neuroimage.2022.119746openalex-snapshot
Older adults with perivascular spaces exhibit cerebrovascular reactivity deficits
inferred← citeshttps://doi.org/10.1016/j.neuroimage.2025.121143openalex-snapshot
Glymphatic dysfunction in moyamoya disease: The influence of arterial stenosis and ventricular enlargement
inferred← citeshttps://doi.org/10.1016/j.neuron.2021.01.024openalex-snapshot
Neuronal plumes initiate spreading depolarization, the electrophysiologic event driving migraine and stroke
inferred← citeshttps://doi.org/10.1016/j.neuron.2022.09.006openalex-snapshot
Multiscale imaging informs translational mouse modeling of neurological disease
inferred← citeshttps://doi.org/10.1016/j.neuron.2025.04.027openalex-snapshot
Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2026.110828openalex-snapshot
Peripheral alpha-2 antagonist vatinoxan improves dexmedetomidine-induced perivascular cerebrospinal fluid flow without affecting electroencephalogram activity in female rats
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2020.11.014openalex-snapshot
Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2023.04.017openalex-snapshot
Limb Remote Ischemic Postconditioning Improves Glymphatic Dysfunction After Cerebral Ischemia–Reperfusion Injury
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.05.035openalex-snapshot
Spreading Depolarization Induces a Transient Potentiation of Excitatory Synaptic Transmission
inferred← citeshttps://doi.org/10.1016/j.nicl.2022.103229openalex-snapshot
Reduced coupling between the global blood-oxygen-level-dependent signal and cerebrospinal fluid inflow is associated with the severity of small vessel disease
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2026.109068openalex-snapshot
The neurovascular unit under siege: Molecular mechanisms and potential drug target for cerebral edema
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2020.101917openalex-snapshot
Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2023.102512openalex-snapshot
The state of brain activity modulates cerebrospinal fluid transport
inferred← citeshttps://doi.org/10.1016/j.scib.2026.09.067openalex-snapshot
Two-dimensional vermiculite neuroprotectants attenuate multifaceted complications in ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.sleep.2022.11.012openalex-snapshot
The impact of sleep components, quality and patterns on glymphatic system functioning in healthy adults: A systematic review
inferred← citeshttps://doi.org/10.1016/j.sleep.2023.02.019openalex-snapshot
Post-stroke sleep disturbance and recurrent cardiovascular and cerebrovascular events: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.sna.2022.113937openalex-snapshot
A data compensation method for reducing impact of scalp dehydration in electrical impedance tomography
inferred← citeshttps://doi.org/10.1016/j.tins.2020.04.003openalex-snapshot
The Brain’s Glymphatic System: Current Controversies
inferred← citeshttps://doi.org/10.1016/j.tips.2024.01.005openalex-snapshot
Glymphatic-stagnated edema induced by traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.wneu.2024.05.101openalex-snapshot
Enhanced Prediction of Malignant Cerebral Edema in Large Vessel Occlusion with Successful Recanalization Through Automated Weighted Net Water Uptake
inferred← citeshttps://doi.org/10.1016/j.wneu.2024.07.062openalex-snapshot
The Glymphatic System and Subarachnoid Lymphatic-Like Membrane: Recent Developments in Cerebrospinal Fluid Research
inferred← citeshttps://doi.org/10.1016/s1474-4422(25)00115-2openalex-snapshot
CSF transport at the brain–meningeal border: effects on neurological health and disease
inferred← citeshttps://doi.org/10.1017/jfm.2026.11573openalex-snapshot
Enhanced Taylor–Aris dispersion in slender pulsatile annular channels: implications for perivascular solute transport
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c05143openalex-snapshot
Alternating Current-Driven Silver Needle-Based Electrochemiluminescence Biosensor for Rapid and Low-Damage Diagnosis of Cerebral Hemorrhage with Edema
inferred← citeshttps://doi.org/10.1021/jacs.0c09011openalex-snapshot
Electrochemically Probing Dynamics of Ascorbate during Cytotoxic Edema in Living Rat Brain
inferred← citeshttps://doi.org/10.1038/s41377-022-00836-2openalex-snapshot
Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy
inferred← citeshttps://doi.org/10.1038/s41377-024-01450-0openalex-snapshot
Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy
inferred← citeshttps://doi.org/10.1038/s41380-020-0731-7openalex-snapshot
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework
inferred← citeshttps://doi.org/10.1038/s41380-025-03126-6openalex-snapshot
Perceiving traumatic brain injury from glymphatic system
inferred← citeshttps://doi.org/10.1038/s41380-026-03730-0openalex-snapshot
Cross-ancestry pleiotropic analysis of imaging-derived phenotypes enhances risk stratification of depression
inferred← citeshttps://doi.org/10.1038/s41380-026-03750-wopenalex-snapshot
The glymphatic system in sleep: a nexus of waste clearance, brain homeostasis, and disease intervention
inferred← citeshttps://doi.org/10.1038/s41401-020-00503-5openalex-snapshot
Drug development in targeting ion channels for brain edema
inferred← citeshttps://doi.org/10.1038/s41422-025-01106-7openalex-snapshot
The night shift: norepinephrine drives glymphatics
inferred← citeshttps://doi.org/10.1038/s41467-020-18115-2openalex-snapshot
Circadian control of brain glymphatic and lymphatic fluid flow
inferred← citeshttps://doi.org/10.1038/s41467-022-31257-9openalex-snapshot
Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease
inferred← citeshttps://doi.org/10.1038/s41467-023-36643-5openalex-snapshot
Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport
inferred← citeshttps://doi.org/10.1038/s41467-023-43509-3openalex-snapshot
Diversity of cortical activity changes beyond depression during Spreading Depolarizations
inferred← citeshttps://doi.org/10.1038/s41551-025-01433-5openalex-snapshot
Imaging the brain by traversing the skull with light and sound
inferred← citeshttps://doi.org/10.1038/s41573-022-00500-9openalex-snapshot
The glymphatic system: implications for drugs for central nervous system diseases
inferred← citeshttps://doi.org/10.1038/s41574-022-00663-wopenalex-snapshot
Functional diversity of corticotropin-releasing hormone
inferred← citeshttps://doi.org/10.1038/s41582-020-0328-4openalex-snapshot
Flood of cerebrospinal fluid causes oedema after stroke
inferred← citeshttps://doi.org/10.1038/s41582-026-01194-yopenalex-snapshot
Glymphatic dysfunction: a unifying hypothesis for delirium
inferred← citeshttps://doi.org/10.1038/s41583-021-00514-zopenalex-snapshot
Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis
inferred← citeshttps://doi.org/10.1038/s41583-023-00690-0openalex-snapshot
Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair
inferred← citeshttps://doi.org/10.1038/s41586-022-05397-3openalex-snapshot
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
inferred← citeshttps://doi.org/10.1038/s41586-023-06737-7openalex-snapshot
Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema
inferred← citeshttps://doi.org/10.1038/s41591-023-02268-wopenalex-snapshot
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
inferred← citeshttps://doi.org/10.1038/s41593-020-00773-6openalex-snapshot
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury
inferred← citeshttps://doi.org/10.1038/s41593-021-00904-7openalex-snapshot
Revisiting the neurovascular unit
inferred← citeshttps://doi.org/10.1038/s41593-023-01327-2openalex-snapshot
Glymphatic influx and clearance are accelerated by neurovascular coupling
inferred← citeshttps://doi.org/10.1038/s41593-023-01515-0openalex-snapshot
Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling
inferred← citeshttps://doi.org/10.1038/s41593-025-02073-3openalex-snapshot
Region-specific drivers of CSF mobility measured with MRI in humans
inferred← citeshttps://doi.org/10.1038/s41598-021-83951-1openalex-snapshot
Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
inferred← citeshttps://doi.org/10.1038/s41598-021-87609-wopenalex-snapshot
Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization
inferred← citeshttps://doi.org/10.1038/s41598-022-15034-8openalex-snapshot
Immediate impact of yogic breathing on pulsatile cerebrospinal fluid dynamics
inferred← citeshttps://doi.org/10.1038/s41598-023-38938-5openalex-snapshot
Quantifying the relationship between spreading depolarization and perivascular cerebrospinal fluid flow
inferred← citeshttps://doi.org/10.1038/s41598-023-43920-2openalex-snapshot
Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents
inferred← citeshttps://doi.org/10.1038/s41598-025-04054-9openalex-snapshot
Glymphatic dysfunction as a biomarker for post-stroke cognitive impairment
inferred← citeshttps://doi.org/10.1038/s41598-025-14840-0openalex-snapshot
Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin
inferred← citeshttps://doi.org/10.1038/s41598-025-91751-0openalex-snapshot
MUSE and PROPELLER DWI for ADC in parasagittal dura: insights from high-resolution and reduced-distortion DWI
inferred← citeshttps://doi.org/10.1038/s42003-024-05911-5openalex-snapshot
Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system
inferred← citeshttps://doi.org/10.1038/s42256-023-00648-yopenalex-snapshot
Recurrent graph optimal transport for learning 3D flow motion in particle tracking
inferred← citeshttps://doi.org/10.1039/d1sc03069hopenalex-snapshot
A ratiometric photoelectrochemical microsensor based on a small-molecule organic semiconductor for reliable in vivo analysis
inferred← citeshttps://doi.org/10.1039/d5lc00015gopenalex-snapshot
Elevated interstitial flow in the cerebrospinal fluid microenvironment accelerates glioblastoma cell migration on a microfluidic chip
inferred← citeshttps://doi.org/10.1063/5.0133190openalex-snapshot
Complex dynamics in adaptive phase oscillator networks
inferred← citeshttps://doi.org/10.1063/5.0160170openalex-snapshot
Bifurcations in adaptive vascular networks: Toward model calibration
inferred← citeshttps://doi.org/10.1063/5.0226338openalex-snapshot
Co-evolutionary dynamics for two adaptively coupled Theta neurons
inferred← citeshttps://doi.org/10.1063/5.0226759openalex-snapshot
Continuum limit of the adaptive Kuramoto model
inferred← citeshttps://doi.org/10.1063/5.0289706openalex-snapshot
Multiple timescale dynamics of network adaptation with constraints
inferred← citeshttps://doi.org/10.1073/pnas.2217744120openalex-snapshot
Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows
inferred← citeshttps://doi.org/10.1073/pnas.2400024121openalex-snapshot
The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs
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