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Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

https://doi.org/10.1126/science.abb8575
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneurol.2011.221openalex-snapshot
Autosomal Recessive Causes Likely in Early-Onset Alzheimer Disease
inferredcites →https://doi.org/10.1001/archpsyc.63.2.168openalex-snapshot
Role of Genes and Environments for Explaining Alzheimer Disease
inferredcites →https://doi.org/10.1002/alz.043897openalex-snapshot
Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms
inferredcites →https://doi.org/10.1002/ana.24999openalex-snapshot
Polygenic risk score analysis of pathologically confirmed Alzheimer disease
inferredcites →https://doi.org/10.1002/ana.25530openalex-snapshot
Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition
inferredcites →https://doi.org/10.1007/s00401-019-01991-4openalex-snapshot
SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data
inferredcites →https://doi.org/10.1007/s00401-019-01994-1openalex-snapshot
The role of ABCA7 in Alzheimer’s disease: evidence from genomics, transcriptomics and methylomics
inferredcites →https://doi.org/10.1007/s00401-019-02026-8openalex-snapshot
A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy-Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity
inferredcites →https://doi.org/10.1016/j.cell.2005.02.008openalex-snapshot
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
inferredcites →https://doi.org/10.1016/j.cell.2015.12.056openalex-snapshot
The Cellular Phase of Alzheimer’s Disease
inferredcites →https://doi.org/10.1016/j.cell.2017.07.004openalex-snapshot
Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions
inferredcites →https://doi.org/10.1016/j.cell.2019.04.014openalex-snapshot
Trans Effects on Gene Expression Can Drive Omnigenic Inheritance
inferredcites →https://doi.org/10.1016/j.cell.2019.09.001openalex-snapshot
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
inferredcites →https://doi.org/10.1016/j.cell.2020.06.038openalex-snapshot
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease
inferredcites →https://doi.org/10.1016/j.jalz.2018.02.018openalex-snapshot
NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2017.07.001openalex-snapshot
Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2020.04.024openalex-snapshot
Age-dependent effect of APOE and polygenic component on Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.neuron.2017.02.001openalex-snapshot
Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
inferredcites →https://doi.org/10.1016/j.neuron.2019.01.056openalex-snapshot
A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward
inferredcites →https://doi.org/10.1016/j.neuron.2019.05.002openalex-snapshot
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
inferredcites →https://doi.org/10.1016/j.neuron.2019.07.002openalex-snapshot
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo
inferredcites →https://doi.org/10.1016/j.semcdb.2020.05.012openalex-snapshot
Modelling neurodegenerative disease using brain organoids
inferredcites →https://doi.org/10.1016/j.trci.2016.09.002openalex-snapshot
Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development
inferredcites →https://doi.org/10.1016/s0140-6736(17)31363-6openalex-snapshot
Dementia prevention, intervention, and care
inferredcites →https://doi.org/10.1038/ejhg.2017.87openalex-snapshot
Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy
inferredcites →https://doi.org/10.1038/nature08185openalex-snapshot
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
inferredcites →https://doi.org/10.1038/nature14252openalex-snapshot
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
inferredcites →https://doi.org/10.1038/ng.3916openalex-snapshot
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
inferredcites →https://doi.org/10.1038/nn.4587openalex-snapshot
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
inferredcites →https://doi.org/10.1038/s41398-018-0150-6openalex-snapshot
GWAS on family history of Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41582-018-0072-1openalex-snapshot
TREM2 — a key player in microglial biology and Alzheimer disease
inferredcites →https://doi.org/10.1038/s41586-020-2247-3openalex-snapshot
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
inferredcites →https://doi.org/10.1038/s41588-018-0311-9openalex-snapshot
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
inferredcites →https://doi.org/10.1038/s41588-019-0358-2openalex-snapshot
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
inferredcites →https://doi.org/10.1038/s41591-019-0695-9openalex-snapshot
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41593-018-0175-4openalex-snapshot
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41593-018-0296-9openalex-snapshot
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
inferredcites →https://doi.org/10.1038/s41593-019-0525-xopenalex-snapshot
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
inferredcites →https://doi.org/10.1038/s41593-020-0599-5openalex-snapshot
The multiplex model of the genetics of Alzheimer’s disease
inferredcites →https://doi.org/10.1056/nejmoa1504327openalex-snapshot
Incidence of Dementia over Three Decades in the Framingham Heart Study
inferredcites →https://doi.org/10.1073/pnas.1908529116openalex-snapshot
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain
inferredcites →https://doi.org/10.1074/jbc.m114.599027openalex-snapshot
The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation
inferredcites →https://doi.org/10.1083/jcb.201709069openalex-snapshot
Microglia in Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/awv268openalex-snapshot
Common polygenic variation enhances risk prediction for Alzheimer’s disease
inferredcites →https://doi.org/10.1097/nen.0b013e31824b211bopenalex-snapshot
Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010
inferredcites →https://doi.org/10.1101/19012021openalex-snapshot
Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores
inferredcites →https://doi.org/10.1101/cshperspect.a024539openalex-snapshot
Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease
inferredcites →https://doi.org/10.1126/science.8346443openalex-snapshot
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
inferredcites →https://doi.org/10.1126/science.aal3222openalex-snapshot
An environment-dependent transcriptional network specifies human microglia identity
inferredcites →https://doi.org/10.1126/science.aay0793openalex-snapshot
Brain cell type–specific enhancer–promoter interactome maps and disease - risk association
inferredcites →https://doi.org/10.1186/s13195-019-0469-0openalex-snapshot
Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
inferredcites →https://doi.org/10.1371/journal.pgen.1008489openalex-snapshot
Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval
inferredcites →https://doi.org/10.1371/journal.pmed.1002258openalex-snapshot
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
inferredcites →https://doi.org/10.14283/jpad.2018.46openalex-snapshot
Polygenic Risk Score Analysis of Alzheimer's Disease in Cases without APOE4 or APOE2 Alleles
inferredcites →https://doi.org/10.15252/emmm.201910606openalex-snapshot
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
inferredcites →https://doi.org/10.15252/emmm.201911227openalex-snapshot
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
inferredcites →https://doi.org/10.2174/1389202918666170307161450openalex-snapshot
Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities
inferredcites →https://doi.org/10.7892/boris.125653openalex-snapshot
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H2O2-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans
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inferred← citeshttps://doi.org/10.1016/j.apsb.2022.01.008openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cmet.2021.07.006openalex-snapshot
Astrocyte-neuron metabolic cooperation shapes brain activity
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.118918openalex-snapshot
PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 mice
inferred← citeshttps://doi.org/10.1016/j.immuni.2025.04.018openalex-snapshot
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.isci.2023.105983openalex-snapshot
Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains
inferred← citeshttps://doi.org/10.1016/j.isci.2023.106829openalex-snapshot
microRNA-132 regulates gene expression programs involved in microglial homeostasis
inferred← citeshttps://doi.org/10.1016/j.jff.2021.104683openalex-snapshot
Mechanistic insights into procyanidins as therapies for Alzheimer's disease: A review
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Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice
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Neurodegeneration cell per cell
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Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease
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Human brain vascular multi-omics elucidates disease-risk associations
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Artificial intelligence for drug discovery and development in Alzheimer's disease
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Structural insights into human ABCA7-mediated lipid transport
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Alzheimer's disease
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Convergent mitochondrial impairment and apoptosis driven by simultaneous down-regulation of multiple genes at 11p11.2 in Alzheimer’s disease
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Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
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GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies
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Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
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Neuroinflammation in Alzheimer disease
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Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies
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Biomarkers for neurodegenerative diseases
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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
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Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer’s disease and/or major depressive disorder
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NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease
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Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
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Inhba, Homer1 and Bdnf are major targets of transcriptomic dysregulation by neurodegenerative disease-associated excitotoxic NMDA receptor signaling
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Deep neural networks with controlled variable selection for the identification of putative causal genetic variants
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Nanoparticle-based colorimetric sensors to detect neurodegenerative disease biomarkers
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MDGA1 negatively regulates amyloid precursor protein–mediated synapse inhibition in the hippocampus
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What is the gold standard model for Alzheimer’s disease drug discovery and development?
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Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks
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Machine learning for the life-time risk prediction of Alzheimer’s disease: a systematic review
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Summary statistics knockoff inference empowers identification of putative causal variants in genome-wide association studies
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Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer’s disease
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An Alzheimer’s disease pathway uncovered by functional omics: the risk gene CELF1 regulates KLC1 splice variant E expression, which drives Aβ pathology
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Genetic variation associated with human longevity and Alzheimer's disease risk act through microglia and oligodendrocyte cross-talk
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Neuronal overexpression of potassium channel subunit Kcnn1 prolongs survival of SOD1-linked ALS and A53T alpha-synuclein mouse models
inferred← citeshttps://doi.org/10.1101/2025.02.09.637107openalex-snapshot
Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model
inferred← citeshttps://doi.org/10.1101/2025.05.29.656728openalex-snapshot
Ubiquitin-Proteasome System Dysregulation in Alzheimer’s Disease Impacts Protein Abundance
inferred← citeshttps://doi.org/10.1111/ahg.12520openalex-snapshot
Pitfalls of predicting age‐related traits by polygenic risk scores
inferred← citeshttps://doi.org/10.1111/cns.14886openalex-snapshot
Effectiveness and mechanisms of combined use of antioxidant nutrients in protecting against oxidative stress‐induced neuronal loss and related neurological deficits
inferred← citeshttps://doi.org/10.1111/cns.70256openalex-snapshot
A Novel Missense Variant in SORBS2 Is Causative With Familial Alzheimer's Disease
inferred← citeshttps://doi.org/10.1111/febs.70126openalex-snapshot
Type I interferon signalling and interferon‐responsive microglia in health and disease
inferred← citeshttps://doi.org/10.1111/jfbc.14043openalex-snapshot
Etiology and management of Alzheimer’s disease: Potential role of gut microbiota modulation with probiotics supplementation
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Alzheimer disease and the periodontal patient: New insights, connections, and therapies
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Periodontal microorganisms and Alzheimer disease – A causative relationship?
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The inverse association between the apolipoprotein E ε4 allele and C‐reactive protein levels is stronger in persons with obesity and diabetes
inferred← citeshttps://doi.org/10.1126/science.abp9556openalex-snapshot
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
inferred← citeshttps://doi.org/10.1126/scitranslmed.ads6111openalex-snapshot
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders
inferred← citeshttps://doi.org/10.1177/13872877261450630openalex-snapshot
Potential biases associated with reported parental history of dementia in the Alzheimer's Disease Research Center cohorts: Implications for secondary data analyses
inferred← citeshttps://doi.org/10.1177/25424823241309268openalex-snapshot
Novel donepezil-tacrine hybrid (TAHB3) induces neurodifferentiation, neuroprotective effects, and activates the PI3K/AKT pathway on PC12 cells
inferred← citeshttps://doi.org/10.1177/25424823261468711openalex-snapshot
Brain transcriptome-wide association study reveals selective long-term potentiation enrichment and negative directional skew of senescence-regulation pathways in Alzheimer's disease
inferred← citeshttps://doi.org/10.1186/s13020-021-00482-7openalex-snapshot
Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.
inferred← citeshttps://doi.org/10.1186/s13024-021-00449-0openalex-snapshot
Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer’s disease risk
inferred← citeshttps://doi.org/10.1186/s13024-021-00496-7openalex-snapshot
The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
inferred← citeshttps://doi.org/10.1186/s13024-022-00524-0openalex-snapshot
Solving neurodegeneration: common mechanisms and strategies for new treatments
inferred← citeshttps://doi.org/10.1186/s13024-026-00935-3openalex-snapshot
PLCG2 signaling and genetic resilience in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1186/s13195-025-01759-xopenalex-snapshot
Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model
inferred← citeshttps://doi.org/10.1186/s40246-024-00704-7openalex-snapshot
Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens
inferred← citeshttps://doi.org/10.1212/nxg.0000000000200012openalex-snapshot
A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data
inferred← citeshttps://doi.org/10.1371/journal.pone.0296959openalex-snapshot
Sex- and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer’s disease mice
inferred← citeshttps://doi.org/10.17816/rcf334925openalex-snapshot
Circular RNAs — a modern perspective on the molecular mechanisms of neurologic diseases in humans and prospects for therapeutic agents
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2092941/v1openalex-snapshot
Endophenotype-based polygenic risk scores: Prediction of biomarker and clinical progression and dementia
inferred← citeshttps://doi.org/10.2174/0115672050299004240129051655openalex-snapshot
Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2174/0115672050410489250930175402openalex-snapshot
Recent Advances in the Application of Artificial Intelligence in Alzheimer's Disease
inferred← citeshttps://doi.org/10.2174/0118746098376646250715094707openalex-snapshot
Revolutionizing Therapeutic Approaches Against Pathophysiology of Alzheimer’s Disease: A Therapeutic Review
inferred← citeshttps://doi.org/10.2174/1568026623666221026091010openalex-snapshot
Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.26481/dis.20240523pkopenalex-snapshot
Hugging it out
inferred← citeshttps://doi.org/10.3233/adr-230130openalex-snapshot
Novel Development and Prospects in Pathogenesis, Diagnosis, and Therapy of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3233/jad-201556openalex-snapshot
Copper Imbalance in Alzheimer’s Disease and Its Link with the Amyloid Hypothesis: Towards a Combined Clinical, Chemical, and Genetic Etiology
inferred← citeshttps://doi.org/10.3233/jad-201606openalex-snapshot
The Proportion of APOE4 Carriers Among Non-Demented Individuals: A Pooled Analysis of 389,000 Community-Dwellers
inferred← citeshttps://doi.org/10.3233/jad-210171openalex-snapshot
Ventral Tegmental Area Disconnection Contributes Two Years Early to Correctly Classify Patients Converted to Alzheimer’s Disease: Implications for Treatment
inferred← citeshttps://doi.org/10.3233/jad-215194openalex-snapshot
lncRNA MIR600HG Knockdown Alleviates Cognitive Impairment in Alzheimer’s Disease Through NEDD4L Mediated PINK1 Degradation
inferred← citeshttps://doi.org/10.3233/jad-220680openalex-snapshot
Novel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3233/jad-231489openalex-snapshot
Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3389/fcell.2021.825729openalex-snapshot
Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer’s Disease: An Integrated Epigenomic-Transcriptomic Analysis
inferred← citeshttps://doi.org/10.3389/fgene.2023.1209416openalex-snapshot
Unraveling patient heterogeneity in complex diseases through individualized co-expression networks: a perspective
inferred← citeshttps://doi.org/10.3389/fgene.2024.1379865openalex-snapshot
The causal effect of Alzheimer’s disease and family history of Alzheimer’s disease on non-ischemic cardiomyopathy and left ventricular structure and function: a Mendelian randomization study
inferred← citeshttps://doi.org/10.3389/fnagi.2022.1073905openalex-snapshot
The role of structural variations in Alzheimer’s disease and other neurodegenerative diseases
inferred← citeshttps://doi.org/10.3389/fnagi.2022.821789openalex-snapshot
Identification of Genetic Networks Reveals Complex Associations and Risk Trajectory Linking Mild Cognitive Impairment to Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3389/fnagi.2023.1281748openalex-snapshot
An interpretable Alzheimer’s disease oligogenic risk score informed by neuroimaging biomarkers improves risk prediction and stratification
inferred← citeshttps://doi.org/10.3389/fnins.2021.742065openalex-snapshot
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
inferred← citeshttps://doi.org/10.3389/fnins.2023.1216686openalex-snapshot
Associations of air pollution with all-cause dementia, Alzheimer’s disease, and vascular dementia: a prospective cohort study based on 437,932 participants from the UK biobank
inferred← citeshttps://doi.org/10.3389/fphar.2021.766120openalex-snapshot
Rheum tanguticum Alleviates Cognitive Impairment in APP/PS1 Mice by Regulating Drug-Responsive Bacteria and Their Corresponding Microbial Metabolites
inferred← citeshttps://doi.org/10.3389/fphar.2024.1459655openalex-snapshot
Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?
inferred← citeshttps://doi.org/10.3389/fphar.2026.1933454openalex-snapshot
Multi-omics integration identifies a gut-microbiota-associated plasma metabolite signature for alzheimer disease diagnosis and metabolic pathway targeting
inferred← citeshttps://doi.org/10.3389/fpubh.2023.1178017openalex-snapshot
Education counteracts the genetic risk of Alzheimer’s disease without an interaction effect
inferred← citeshttps://doi.org/10.3389/fragi.2022.846977openalex-snapshot
Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and Extends Lifespan via the Heat Shock Response in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.3390/biology10080707openalex-snapshot
Mutual Interactions between Brain States and Alzheimer’s Disease Pathology: A Focus on Gamma and Slow Oscillations
inferred← citeshttps://doi.org/10.3390/biomedicines10081890openalex-snapshot
Direct Oral Anticoagulants (DOACs) for Therapeutic Targeting of Thrombin, a Key Mediator of Cerebrovascular and Neuronal Dysfunction in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/biomedicines12081737openalex-snapshot
Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection
inferred← citeshttps://doi.org/10.3390/cells10030546openalex-snapshot
An Analysis of the Neurological and Molecular Alterations Underlying the Pathogenesis of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/cimb47090724openalex-snapshot
Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential
inferred← citeshttps://doi.org/10.3390/ijms21239318openalex-snapshot
Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms22094805openalex-snapshot
Alzheimer’s Disease—Rationales for Potential Treatment with the Thrombin Inhibitor Dabigatran
inferred← citeshttps://doi.org/10.3390/ijms22189734openalex-snapshot
Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms24044085openalex-snapshot
TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/molecules27113516openalex-snapshot
A Prospective Viewpoint on Neurological Diseases and Their Biomarkers
inferred← citeshttps://doi.org/10.4018/979-8-3693-4070-7.ch007openalex-snapshot
Current Trends in Biomarkers and Diagnosis of Prevalent Neurological Infectious Diseases
inferred← citeshttps://doi.org/10.4103/1673-5374.303029openalex-snapshot
Direct oral anticoagulants: a new therapy against Alzheimer’s disease?
inferred← citeshttps://doi.org/10.4103/1673-5374.353484openalex-snapshot
Targeting neuroinflammation in Alzheimer’s disease: from mechanisms to clinical applications
inferred← citeshttps://doi.org/10.70675/35211b03z3b19z478czb3e2z8d35ab2170d6openalex-snapshot
An RNA interference strategy for the treatment of Alzheimer's disease
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