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Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Lymphopenia In Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1002/art.20745openalex-snapshot
Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus
inferredcites →https://doi.org/10.1002/art.23619openalex-snapshot
Age‐ and sex‐related patterns of serum interferon‐α activity in lupus families
inferredcites →https://doi.org/10.1002/art.40930openalex-snapshot
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1002/gepi.21765openalex-snapshot
Statistical Testing of Shared Genetic Control for Potentially Related Traits
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SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX
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GCTA: A Tool for Genome-wide Complex Trait Analysis
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Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies
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Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets
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Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits
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The role of B cells in lupus pathogenesis
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Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients
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Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data
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Plasmacytoid Dendritic Cells Activate Lymphoid-Specific Genetic Programs Irrespective of Their Cellular Origin
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Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases
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ORMDL3 and allergic asthma: From physiology to pathology
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Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations
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Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
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Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
inferredcites →https://doi.org/10.1038/nature04606openalex-snapshot
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
inferredcites →https://doi.org/10.1038/nature06014openalex-snapshot
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
inferredcites →https://doi.org/10.1038/nature10808openalex-snapshot
DNase I sensitivity QTLs are a major determinant of human expression variation
inferredcites →https://doi.org/10.1038/nature11582openalex-snapshot
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
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A global reference for human genetic variation
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Multiplexed droplet single-cell RNA-sequencing using natural genetic variation
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17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
inferredcites →https://doi.org/10.1038/ng.2213openalex-snapshot
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
inferredcites →https://doi.org/10.1038/ng.3434openalex-snapshot
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
inferredcites →https://doi.org/10.1038/ng.3656openalex-snapshot
Next-generation genotype imputation service and methods
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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
inferredcites →https://doi.org/10.1038/nrdp.2016.39openalex-snapshot
Systemic lupus erythematosus
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Epitope spreading in immune-mediated diseases: implications for immunotherapy
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The global burden of SLE: prevalence, health disparities and socioeconomic impact
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Causal associations between risk factors and common diseases inferred from GWAS summary data
inferredcites →https://doi.org/10.1038/s41467-022-33212-0openalex-snapshot
Multi-context genetic modeling of transcriptional regulation resolves novel disease loci
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RNA velocity of single cells
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The UK Biobank resource with deep phenotyping and genomic data
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Generalizing RNA velocity to transient cell states through dynamical modeling
inferredcites →https://doi.org/10.1038/s41588-018-0081-4openalex-snapshot
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
inferredcites →https://doi.org/10.1038/s41588-019-0505-9openalex-snapshot
Landscape of stimulation-responsive chromatin across diverse human immune cells
inferredcites →https://doi.org/10.1038/s41588-021-00850-xopenalex-snapshot
Author Correction: ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis
inferredcites →https://doi.org/10.1038/s41590-018-0051-0openalex-snapshot
Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
inferredcites →https://doi.org/10.1038/s41590-020-0743-0openalex-snapshot
Mapping systemic lupus erythematosus heterogeneity at the single-cell level
inferredcites →https://doi.org/10.1038/s41591-020-0769-8openalex-snapshot
Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus
inferredcites →https://doi.org/10.1038/s41592-019-0686-2openalex-snapshot
SciPy 1.0: fundamental algorithms for scientific computing in Python
inferredcites →https://doi.org/10.1038/s41598-019-41695-zopenalex-snapshot
From Louvain to Leiden: guaranteeing well-connected communities
inferredcites →https://doi.org/10.1056/nejmoa1912196openalex-snapshot
Trial of Anifrolumab in Active Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1073/pnas.1401343111openalex-snapshot
Interindividual variation in human T regulatory cells
inferredcites →https://doi.org/10.1073/pnas.2334336100openalex-snapshot
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold
inferredcites →https://doi.org/10.1084/jem.190.6.815openalex-snapshot
Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status
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PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
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edgeR : a Bioconductor package for differential expression analysis of digital gene expression data
inferredcites →https://doi.org/10.1093/bioinformatics/btq419openalex-snapshot
LocusZoom: regional visualization of genome-wide association scan results
inferredcites →https://doi.org/10.1093/bioinformatics/bts163openalex-snapshot
Matrix eQTL: ultra fast eQTL analysis via large matrix operations
inferredcites →https://doi.org/10.1093/bioinformatics/bty147openalex-snapshot
A Bayesian framework for multiple trait colocalization from summary association statistics
inferredcites →https://doi.org/10.1093/biostatistics/kxj037openalex-snapshot
Adjusting batch effects in microarray expression data using empirical Bayes methods
inferredcites →https://doi.org/10.1093/emboj/16.8.2004openalex-snapshot
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
inferredcites →https://doi.org/10.1093/nar/gkp427openalex-snapshot
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
inferredcites →https://doi.org/10.1101/2021.06.17.448889openalex-snapshot
FastGxC: Fast and Powerful Context-Specific eQTL Mapping in Bulk and Single-Cell Data
inferredcites →https://doi.org/10.1101/gr.240390.118openalex-snapshot
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
inferredcites →https://doi.org/10.1126/science.1246980openalex-snapshot
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
inferredcites →https://doi.org/10.1126/science.1249547openalex-snapshot
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
inferredcites →https://doi.org/10.1126/science.1254665openalex-snapshot
Intersection of population variation and autoimmunity genetics in human T cell activation
inferredcites →https://doi.org/10.1126/science.aah4573openalex-snapshot
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
inferredcites →https://doi.org/10.1164/rccm.201803-0438ocopenalex-snapshot
The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation
inferredcites →https://doi.org/10.1186/s13059-017-1382-0openalex-snapshot
SCANPY: large-scale single-cell gene expression data analysis
inferredcites →https://doi.org/10.1371/journal.pone.0199003openalex-snapshot
Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients
inferredcites →https://doi.org/10.1373/jalm.2018.026492openalex-snapshot
Comparing Ethnicity-Specific Reference Intervals for Clinical Laboratory Tests from EHR Data
inferredcites →https://doi.org/10.21105/joss.00861openalex-snapshot
UMAP: Uniform Manifold Approximation and Projection
inferredcites →https://doi.org/10.2147/cmar.s246948openalex-snapshot
Role of GSDMB in Pyroptosis and Cancer
inferredcites →https://doi.org/10.32388/n5g0vcopenalex-snapshot
Systemic Lupus Erythematosus Disease Activity Index
inferredcites →https://doi.org/10.4049/jimmunol.1501209openalex-snapshot
Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity
inferredcites →https://doi.org/10.4049/jimmunol.1602124openalex-snapshot
ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α–Endoplasmic Reticulum Stress–Beclin1 Autophagy Regulatory Pathway
inferredcites →https://doi.org/10.7326/0003-4819-142-12_part_1-200506210-00004openalex-snapshot
The Effect of Combined Estrogen and Progesterone Hormone Replacement Therapy on Disease Activity in Systemic Lupus Erythematosus: A Randomized Trial

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← backgroundhttps://doi.org/10.5281/zenodo.20406617zenodo-depositor-declared
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Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing
inferred← citeshttps://doi.org/10.1002/art.43227openalex-snapshot
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Translational immunology: Applying fundamental discoveries to human health and autoimmune diseases
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Nanoparticle‐Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy‐Mediated CD8+T Cell Exhaustion
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Regulation and Mechanism of Deleted in Breast Cancer‐1 on Dendritic Cell Function in Systemic Lupus Erythematosus
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Single‐Cell and Spatial Omics: Methods and Applications
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Score Matching for Differential Abundance Testing of Compositional High‐Throughput Sequencing Data
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Diversity and heterogeneity in human pancreaticobiliary maljunction revealed by single-cell RNA sequencing
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Macrophages Unmasked: Their Pivotal Role in Driving Atherosclerosis in Systemic Lupus Erythematosus
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T cells
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B cells in SLE
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A gene-expression module identifies circulating immune cells with enhanced recruitment to sites of inflammation
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Single-cell landscape of immune cells in multiple autoimmune diseases
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scMILD: Single-cell multiple instance learning for sample classification and associated subpopulation discovery
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GWAS and autoimmunity: What have we learned and what next
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A single-cell map of peripheral alterations after FMT treatment in patients with systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1016/j.jaut.2026.103575openalex-snapshot
Single-cell RNA-seq reveals a persistent interferon signature in immune cells from systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment
inferred← citeshttps://doi.org/10.1016/j.jgg.2024.08.009openalex-snapshot
Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics
inferred← citeshttps://doi.org/10.1016/j.jgg.2026.07.013openalex-snapshot
Identification and quantification of alternative polyadenylation sites in single cell RNA-seq data using scPAISO
inferred← citeshttps://doi.org/10.1016/j.jia.2025.05.016openalex-snapshot
Single-cell transcriptome profiling of peripheral blood mononuclear cells reveals immune cell heterogeneity in chickens
inferred← citeshttps://doi.org/10.1016/j.jid.2025.10.596openalex-snapshot
Artificial intelligence–enabled precision medicine for inflammatory skin diseases
inferred← citeshttps://doi.org/10.1016/j.molcel.2024.06.001openalex-snapshot
PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
inferred← citeshttps://doi.org/10.1016/j.molimm.2024.10.005openalex-snapshot
Deciphering cell-specific genetic insights: Unraveling the immunogenetic landscape of systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1016/j.molmed.2024.11.002openalex-snapshot
The molecular underpinnings of female predominance in lupus
inferred← citeshttps://doi.org/10.1016/j.molp.2023.08.017openalex-snapshot
Improving photosynthetic efficiency toward food security: Strategies, advances, and perspectives
inferred← citeshttps://doi.org/10.1016/j.patter.2024.101096openalex-snapshot
Privacy of single-cell gene expression data
inferred← citeshttps://doi.org/10.1016/j.plipres.2023.101225openalex-snapshot
The Niemann-Pick type diseases – A synopsis of inborn errors in sphingolipid and cholesterol metabolism
inferred← citeshttps://doi.org/10.1016/j.revmed.2024.10.346openalex-snapshot
Implication des cellules myéloïdes suppressives au cours du lupus érythémateux systémique : approche phénotypique, immuno-métabolique et fonctionnelle
inferred← citeshttps://doi.org/10.1016/j.tig.2022.08.005openalex-snapshot
Insights from multi-omics integration in complex disease primary tissues
inferred← citeshttps://doi.org/10.1016/j.tig.2023.02.014openalex-snapshot
Functional characterization of human genomic variation linked to polygenic diseases
inferred← citeshttps://doi.org/10.1016/j.tig.2024.04.008openalex-snapshot
From genetic associations to genes: methods, applications, and challenges
inferred← citeshttps://doi.org/10.1016/j.tig.2026.02.008openalex-snapshot
Toward global representation in single-cell genomics
inferred← citeshttps://doi.org/10.1016/j.virusres.2024.199341openalex-snapshot
Exploring COVID-19 causal genes through disease-specific Cis-eQTLs
inferred← citeshttps://doi.org/10.1016/j.xcrm.2023.101038openalex-snapshot
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101569openalex-snapshot
Uncoupling interferons and the interferon signature explains clinical and transcriptional subsets in SLE
inferred← citeshttps://doi.org/10.1016/j.xgen.2023.100460openalex-snapshot
A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs
inferred← citeshttps://doi.org/10.1016/j.xgen.2023.100473openalex-snapshot
Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.xgen.2024.100625openalex-snapshot
Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues
inferred← citeshttps://doi.org/10.1016/j.xgen.2025.100812openalex-snapshot
Single-cell eQTL mapping reveals cell-type-specific genes associated with the risk of gastric cancer
inferred← citeshttps://doi.org/10.1016/j.xgen.2025.100820openalex-snapshot
An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment
inferred← citeshttps://doi.org/10.1016/j.xgen.2025.101060openalex-snapshot
Transcriptome-wide association studies at cell-state level using single-cell eQTL data
inferred← citeshttps://doi.org/10.1016/j.xgen.2026.101250openalex-snapshot
FastGxC: Fast and powerful context-specific eQTL mapping in bulk and single-cell data
inferred← citeshttps://doi.org/10.1016/j.xhgg.2026.100564openalex-snapshot
Evaluating genetic ancestry inference from single-cell transcriptomic datasets
inferred← citeshttps://doi.org/10.1016/j.ygeno.2023.110770openalex-snapshot
A comprehensive exploration of the heterogeneity of immune cells in Han and Zang systemic lupus erythematosus patients via single-cell RNA sequencing
inferred← citeshttps://doi.org/10.1016/j.ygeno.2025.110994openalex-snapshot
scRNA-seq reveals involvement of monocytes in immune response in SLE patients
inferred← citeshttps://doi.org/10.1017/pcm.2023.14openalex-snapshot
Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr1openalex-snapshot
Author comment: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R0/PR1
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr2openalex-snapshot
Review: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R0/PR2
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr3openalex-snapshot
Review: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R0/PR3
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr4openalex-snapshot
Recommendation: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R0/PR4
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr5openalex-snapshot
Decision: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R0/PR5
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr6openalex-snapshot
Author comment: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R1/PR6
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr7openalex-snapshot
Review: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R1/PR7
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr8openalex-snapshot
Recommendation: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R1/PR8
inferred← citeshttps://doi.org/10.1017/pcm.2023.14.pr9openalex-snapshot
Decision: Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders — R1/PR9
inferred← citeshttps://doi.org/10.1038/s12276-025-01504-2openalex-snapshot
Tracking clonal dynamics of CD8 T cells and immune dysregulation in progression of systemic lupus erythematosus with nephritis
inferred← citeshttps://doi.org/10.1038/s41392-025-02438-xopenalex-snapshot
Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma
inferred← citeshttps://doi.org/10.1038/s41392-025-02533-zopenalex-snapshot
Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets
inferred← citeshttps://doi.org/10.1038/s41392-026-02677-6openalex-snapshot
Single-cell identifies and validates human circulating Treg subtype/state Tregfci in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1038/s41392-026-02724-2openalex-snapshot
Multi-omics reveals microbiota, metabolite, and immunological heterogeneity of age-related endotypes in type 1 diabetes
inferred← citeshttps://doi.org/10.1038/s41422-022-00752-5openalex-snapshot
RBP–RNA interactions in the control of autoimmunity and autoinflammation
inferred← citeshttps://doi.org/10.1038/s41423-025-01363-xopenalex-snapshot
FOXO1-driven metabolic reprogramming of hematomal CD8+ T cells drives the expansion of perihematomal edema following intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1038/s41435-023-00216-9openalex-snapshot
Research progress on the application of single-cell sequencing in autoimmune diseases
inferred← citeshttps://doi.org/10.1038/s41467-022-30893-5openalex-snapshot
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
inferred← citeshttps://doi.org/10.1038/s41467-022-33212-0openalex-snapshot
Multi-context genetic modeling of transcriptional regulation resolves novel disease loci
inferred← citeshttps://doi.org/10.1038/s41467-023-36306-5openalex-snapshot
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1038/s41467-023-39538-7openalex-snapshot
An analytical framework for decoding cell type-specific genetic variation of gene regulation
inferred← citeshttps://doi.org/10.1038/s41467-023-41328-0openalex-snapshot
Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis
inferred← citeshttps://doi.org/10.1038/s41467-024-45170-wopenalex-snapshot
The genetic basis of autoimmunity seen through the lens of T cell functional traits
inferred← citeshttps://doi.org/10.1038/s41467-024-48143-1openalex-snapshot
Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes
inferred← citeshttps://doi.org/10.1038/s41467-024-49242-9openalex-snapshot
A robust model for cell type-specific interindividual variation in single-cell RNA sequencing data
inferred← citeshttps://doi.org/10.1038/s41467-024-50710-5openalex-snapshot
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1038/s41467-024-52470-8openalex-snapshot
Sequence variants influencing the regulation of serum IgG subclass levels
inferred← citeshttps://doi.org/10.1038/s41467-025-64227-yopenalex-snapshot
scTFBridge: a disentangled deep generative model informed by TF-motif binding for gene regulation inference in single-cell multi-omics
inferred← citeshttps://doi.org/10.1038/s41467-025-68234-xopenalex-snapshot
Genetic and non-genetic factors distinctly shape the variation of the immune response in cattle
inferred← citeshttps://doi.org/10.1038/s41467-026-69102-yopenalex-snapshot
scLong: a billion-parameter foundation model for capturing long-range gene context in single-cell transcriptomics
inferred← citeshttps://doi.org/10.1038/s41467-026-69923-xopenalex-snapshot
Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes
inferred← citeshttps://doi.org/10.1038/s41467-026-70374-7openalex-snapshot
scTWAS: a powerful statistical framework for single-cell transcriptome-wide association studies
inferred← citeshttps://doi.org/10.1038/s41467-026-72248-4openalex-snapshot
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging
inferred← citeshttps://doi.org/10.1038/s41540-024-00447-0openalex-snapshot
Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients’ blood
inferred← citeshttps://doi.org/10.1038/s41540-026-00832-xopenalex-snapshot
Protein expression derived from scRNA-seq reveals lupus-induced acceleration of immune aging
inferred← citeshttps://doi.org/10.1038/s41576-023-00598-6openalex-snapshot
Interpreting non-coding disease-associated human variants using single-cell epigenomics
inferred← citeshttps://doi.org/10.1038/s41576-023-00599-5openalex-snapshot
Single-cell genomics meets human genetics
inferred← citeshttps://doi.org/10.1038/s41576-025-00821-6openalex-snapshot
Adapting systems biology to address the complexity of human disease in the single-cell era
inferred← citeshttps://doi.org/10.1038/s41577-024-01043-3openalex-snapshot
Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice
inferred← citeshttps://doi.org/10.1038/s41577-026-01344-9openalex-snapshot
Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease
inferred← citeshttps://doi.org/10.1038/s41581-023-00732-xopenalex-snapshot
Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants
inferred← citeshttps://doi.org/10.1038/s41581-023-00797-8openalex-snapshot
Vascular damage in systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1038/s41584-022-00802-7openalex-snapshot
Single-cell RNA sequencing sheds light on cell-type specific gene expression in immune cells
inferred← citeshttps://doi.org/10.1038/s41584-023-00948-yopenalex-snapshot
Precision medicine in systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1038/s41584-024-01109-5openalex-snapshot
Granzyme serine proteases in inflammation and rheumatic diseases
inferred← citeshttps://doi.org/10.1038/s41584-025-01218-9openalex-snapshot
Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies
inferred← citeshttps://doi.org/10.1038/s41584-025-01253-6openalex-snapshot
Understanding rheumatic disease through continuous cell state analysis
inferred← citeshttps://doi.org/10.1038/s41584-025-01291-0openalex-snapshot
Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases
inferred← citeshttps://doi.org/10.1038/s41584-025-01321-xopenalex-snapshot
Insights into the pathogenesis of childhood-onset SLE in the past decade
inferred← citeshttps://doi.org/10.1038/s41586-023-06422-9openalex-snapshot
Dissecting human population variation in single-cell responses to SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41586-024-07510-0openalex-snapshot
Deciphering the impact of genomic variation on function
inferred← citeshttps://doi.org/10.1038/s41586-024-08338-4openalex-snapshot
The Human Cell Atlas from a cell census to a unified foundation model
inferred← citeshttps://doi.org/10.1038/s41587-023-01873-xopenalex-snapshot
Single-nucleotide variant calling in single-cell sequencing data with Monopogen
inferred← citeshttps://doi.org/10.1038/s41587-024-02411-zopenalex-snapshot
Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition
inferred← citeshttps://doi.org/10.1038/s41588-022-01093-0openalex-snapshot
One step closer to linking GWAS SNPs with the right genes
inferred← citeshttps://doi.org/10.1038/s41588-023-01421-yopenalex-snapshot
Mapping interindividual dynamics of innate immune response at single-cell resolution
inferred← citeshttps://doi.org/10.1038/s41588-023-01474-zopenalex-snapshot
Modeling tissue co-regulation estimates tissue-specific contributions to disease
inferred← citeshttps://doi.org/10.1038/s41588-023-01523-7openalex-snapshot
Precise identification of cell states altered in disease using healthy single-cell references
inferred← citeshttps://doi.org/10.1038/s41588-023-01525-5openalex-snapshot
The power paradox of detecting disease-associated and gene-expression-associated variants
inferred← citeshttps://doi.org/10.1038/s41588-024-01743-5openalex-snapshot
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells
inferred← citeshttps://doi.org/10.1038/s41588-024-01909-1openalex-snapshot
Identifying genetic variants that influence the abundance of cell states in single-cell data
inferred← citeshttps://doi.org/10.1038/s41588-024-01994-2openalex-snapshot
Fine-mapping causal tissues and genes at disease-associated loci
inferred← citeshttps://doi.org/10.1038/s41588-024-02019-8openalex-snapshot
Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases
inferred← citeshttps://doi.org/10.1038/s41588-025-02266-3openalex-snapshot
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution
inferred← citeshttps://doi.org/10.1038/s41590-024-01898-7openalex-snapshot
The immunology of systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1038/s41591-022-01880-6openalex-snapshot
The promise of precision medicine in rheumatology
inferred← citeshttps://doi.org/10.1038/s41591-022-02104-7openalex-snapshot
Impact of the Human Cell Atlas on medicine
inferred← citeshttps://doi.org/10.1038/s41591-024-02953-4openalex-snapshot
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes
inferred← citeshttps://doi.org/10.1038/s41591-025-04126-3openalex-snapshot
Interpretable inflammation landscape of circulating immune cells
inferred← citeshttps://doi.org/10.1038/s41592-023-02035-2openalex-snapshot
Population-level integration of single-cell datasets enables multi-scale analysis across samples
inferred← citeshttps://doi.org/10.1038/s41592-024-02555-5openalex-snapshot
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution
inferred← citeshttps://doi.org/10.1038/s41592-025-02808-xopenalex-snapshot
Deep generative modeling of sample-level heterogeneity in single-cell genomics
inferred← citeshttps://doi.org/10.1038/s41597-026-07489-5openalex-snapshot
Single cell transcriptome profiling of peripheral blood mononuclear cells in Guillain–Barré syndrome patients
inferred← citeshttps://doi.org/10.1038/s41598-024-74761-2openalex-snapshot
Characterization of AI-enhanced magnetophoretic transistors operating in a tri-axial magnetic field for on-chip bioparticle sorting
inferred← citeshttps://doi.org/10.1038/s41598-025-08808-3openalex-snapshot
Optimized summary-statistic-based single-cell eQTL meta-analysis
inferred← citeshttps://doi.org/10.1038/s41598-025-34726-5openalex-snapshot
sc-eQTL unveil immunogenetic architecture of polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1038/s42003-022-03831-wopenalex-snapshot
Shared regulation and functional relevance of local gene co-expression revealed by single cell analysis
inferred← citeshttps://doi.org/10.1038/s42003-023-04954-4openalex-snapshot
Multimodal single cell analysis infers widespread enhancer co-activity in a lymphoblastoid cell line
inferred← citeshttps://doi.org/10.1038/s42003-024-07238-7openalex-snapshot
Uncovering disease-related multicellular pathway modules on large-scale single-cell transcriptomes with scPAFA
inferred← citeshttps://doi.org/10.1038/s42003-025-09431-8openalex-snapshot
Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients
inferred← citeshttps://doi.org/10.1038/s43586-022-00188-6openalex-snapshot
Molecular quantitative trait loci
inferred← citeshttps://doi.org/10.1038/s43588-023-00487-2openalex-snapshot
Mixed model-based deconvolution of cell-state abundances (MeDuSA) along a one-dimensional trajectory
inferred← citeshttps://doi.org/10.1038/s44320-023-00003-8openalex-snapshot
Detection of PatIent-Level distances from single cell genomics and pathomics data with Optimal Transport (PILOT)
inferred← citeshttps://doi.org/10.1038/s44320-025-00088-3openalex-snapshot
Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data
inferred← citeshttps://doi.org/10.1038/s44320-026-00209-6openalex-snapshot
ParTIpy: a scalable framework for archetypal analysis and Pareto task inference
inferred← citeshttps://doi.org/10.1039/d2lc00841fopenalex-snapshot
High precision, high throughput generation of droplets containing single cells
inferred← citeshttps://doi.org/10.1073/pnas.2528513123openalex-snapshot
Phosphoproteomic dysregulation promotes tumor proliferation in Cushing’s disease
inferred← citeshttps://doi.org/10.1080/01621459.2025.2468014openalex-snapshot
Causal Inference for Genomic Data with Multiple Heterogeneous Outcomes
inferred← citeshttps://doi.org/10.1080/01621459.2025.2485379openalex-snapshot
Simultaneous Inference for Generalized Linear Models with Unmeasured Confounders
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