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Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1521-4141(200209)32:9<2653::aid-immu2653>3.0.co;2-vopenalex-snapshot
Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice
inferredcites →https://doi.org/10.1002/eji.1830180115openalex-snapshot
Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
inferredcites →https://doi.org/10.1002/eji.200425932openalex-snapshot
KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions
inferredcites →https://doi.org/10.1002/eji.200535389openalex-snapshot
MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis
inferredcites →https://doi.org/10.1002/eji.200636788openalex-snapshot
Macrophage fusion induced by IL‐4 alternative activation is a multistage process involving multiple target molecules
inferredcites →https://doi.org/10.1002/jbm.820250205openalex-snapshot
Foreign‐body giant cells and polyurethane biostability: In vivo correlation of cell adhesion and surface cracking
inferredcites →https://doi.org/10.1002/jcp.1041170209openalex-snapshot
Optimal conditions for proliferation of bone marrow‐derived mouse macrophages in culture: The roles of CSF‐1, serum, Ca2+, and adherence
inferredcites →https://doi.org/10.1006/cimm.1998.1352openalex-snapshot
Multinucleated Giant Cell Formation Induced by IFN-γ/IL-3 Is Associated with Restriction of VirulentMycobacterium tuberculosisCell to Cell Invasion in Human Monocyte Monolayers
inferredcites →https://doi.org/10.1007/bf02006420openalex-snapshot
Ueber Riesenzellen mit wandständigen Kernen in Tuberkeln und die fibröse Form des Tuberkels
inferredcites →https://doi.org/10.1016/j.bbrc.2005.02.049openalex-snapshot
Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos: A possible mechanism for downregulation of osteoclastogenesis
inferredcites →https://doi.org/10.1016/j.febslet.2007.03.033openalex-snapshot
Cell–cell fusion
inferredcites →https://doi.org/10.1016/j.imbio.2007.09.012openalex-snapshot
The molecular basis of macrophage fusion
inferredcites →https://doi.org/10.1016/j.imlet.2007.11.021openalex-snapshot
The TREM-1/DAP12 pathway
inferredcites →https://doi.org/10.1016/j.micron.2005.12.011openalex-snapshot
Trophoblast fusion: Fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion
inferredcites →https://doi.org/10.1016/s0002-9440(10)62251-1openalex-snapshot
Brain and Bone Damage in KARAP/DAP12 Loss-of-Function Mice Correlate with Alterations in Microglia and Osteoclast Lineages
inferredcites →https://doi.org/10.1016/s0002-9440(10)63265-8openalex-snapshot
The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation
inferredcites →https://doi.org/10.1016/s0002-9440(10)64882-1openalex-snapshot
β1 and β2 Integrins Mediate Adhesion during Macrophage Fusion and Multinucleated Foreign Body Giant Cell Formation
inferredcites →https://doi.org/10.1016/s0021-9258(17)35860-xopenalex-snapshot
Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.
inferredcites →https://doi.org/10.1016/s0167-5699(00)01745-xopenalex-snapshot
The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
inferredcites →https://doi.org/10.1016/s0171-2985(82)80084-3openalex-snapshot
Inflammatory Giant Cells
inferredcites →https://doi.org/10.1016/s1074-7613(00)00034-0openalex-snapshot
DAP12-Deficient Mice Fail to Develop Autoimmunity Due to Impaired Antigen Priming
inferredcites →https://doi.org/10.1016/s1074-7613(00)00035-2openalex-snapshot
Combined Natural Killer Cell and Dendritic Cell Functional Deficiency in KARAP/DAP12 Loss-of-Function Mutant Mice
inferredcites →https://doi.org/10.1038/35642openalex-snapshot
Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
inferredcites →https://doi.org/10.1038/364343a0openalex-snapshot
Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor
inferredcites →https://doi.org/10.1038/378298a0openalex-snapshot
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
inferredcites →https://doi.org/10.1038/77153openalex-snapshot
Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
inferredcites →https://doi.org/10.1038/nature02444openalex-snapshot
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
inferredcites →https://doi.org/10.1038/ni1204openalex-snapshot
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
inferredcites →https://doi.org/10.1038/ni1407openalex-snapshot
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
inferredcites →https://doi.org/10.1038/nri2014openalex-snapshot
Activating and inhibitory functions of DAP12
inferredcites →https://doi.org/10.1067/mai.2000.107604openalex-snapshot
IL-4/IL-13 signaling beyond JAK/STAT
inferredcites →https://doi.org/10.1074/jbc.273.51.34115openalex-snapshot
Gene Structure, Expression Pattern, and Biological Activity of Mouse Killer Cell Activating Receptor-associated Protein (KARAP)/DAP-12
inferredcites →https://doi.org/10.1083/jcb.200611083openalex-snapshot
Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
inferredcites →https://doi.org/10.1084/jem.166.6.1685openalex-snapshot
Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo.
inferredcites →https://doi.org/10.1084/jem.20030027openalex-snapshot
DAP12/TREM2 Deficiency Results in Impaired Osteoclast Differentiation and Osteoporotic Features
inferredcites →https://doi.org/10.1084/jem.20050645openalex-snapshot
DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
inferredcites →https://doi.org/10.1084/jem.20051123openalex-snapshot
Macrophage fusion
inferredcites →https://doi.org/10.1086/342259openalex-snapshot
Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype
inferredcites →https://doi.org/10.1086/521030openalex-snapshot
Multinucleate Giant Cells Release Functionally Unopposed Matrix Metalloproteinase‐9 In Vitro and In Vivo
inferredcites →https://doi.org/10.1097/00062752-200001000-00008openalex-snapshot
Multinucleated giant cells
inferredcites →https://doi.org/10.1126/science.1103478openalex-snapshot
Natural Killer Cell Signaling Pathways
inferredcites →https://doi.org/10.1172/jci16923openalex-snapshot
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
inferredcites →https://doi.org/10.1189/jlb.0107058openalex-snapshot
IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin
inferredcites →https://doi.org/10.1359/jbmr.0301234openalex-snapshot
The Signaling Adapter Protein DAP12 Regulates Multinucleation During Osteoclast Development
inferredcites →https://doi.org/10.1359/jbmr.051016openalex-snapshot
TREM2, a DAP12-Associated Receptor, Regulates Osteoclast Differentiation and Function
inferredcites →https://doi.org/10.2353/ajpath.2007.061213openalex-snapshot
Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation
inferredcites →https://doi.org/10.4049/jimmunol.158.11.5083openalex-snapshot
Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells
inferredcites →https://doi.org/10.4049/jimmunol.165.7.3790openalex-snapshot
The Role of the DAP12 Signal in Mouse Myeloid Differentiation
inferredcites →https://doi.org/10.4049/jimmunol.171.2.594openalex-snapshot
Pattern Recognition by TREM-2: Binding of Anionic Ligands
inferredcites →https://doi.org/10.4049/jimmunol.172.10.5957openalex-snapshot
IL-4 Confers NK Stimulatory Capacity to Murine Dendritic Cells: A Signaling Pathway Involving KARAP/DAP12-Triggering Receptor Expressed on Myeloid Cell 2 Molecules
inferredcites →https://doi.org/10.4049/jimmunol.177.4.2051openalex-snapshot
Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/0471142735.im1428s96openalex-snapshot
Analysis of Gene Expression and Gene Silencing in Human Macrophages
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Excessive interleukin-15 transpresentation endows NKG2D+CD4+ T cells with innate-like capacity to lyse vascular endothelium in granulomatosis with polyangiitis (Wegener's)
inferred← citeshttps://doi.org/10.1002/biot.201800102openalex-snapshot
Tackling the Concept of Symbiotic Implantable Medical Devices with Nanobiotechnologies
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Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time
inferred← citeshttps://doi.org/10.1002/jbm.a.32971openalex-snapshot
Macrophage and dendritic cell phenotypic diversity in the context of biomaterials
inferred← citeshttps://doi.org/10.1002/jbmr.531openalex-snapshot
Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)
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Where Does Biomimetic Membrane Technology Fit into Biological Engineering?
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Molecular Characterization of Macrophage-Biomaterial Interactions
inferred← citeshttps://doi.org/10.1007/978-90-481-9772-9_11openalex-snapshot
Molecules Regulating Macrophage Fusions
inferred← citeshttps://doi.org/10.1007/978-94-007-0763-4openalex-snapshot
Cell Fusion in Health and Disease
inferred← citeshttps://doi.org/10.1007/978-94-007-0763-4_4openalex-snapshot
Molecular and Cellular Mechanisms of Mammalian Cell Fusion
inferred← citeshttps://doi.org/10.1007/s00018-015-1910-6openalex-snapshot
Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system
inferred← citeshttps://doi.org/10.1007/s00018-021-03875-xopenalex-snapshot
Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tune
inferred← citeshttps://doi.org/10.1007/s00223-019-00575-4openalex-snapshot
Coordination of Fusion and Trafficking of Pre-osteoclasts at the Marrow–Bone Interface
inferred← citeshttps://doi.org/10.1016/b978-0-12-800196-7.00005-0openalex-snapshot
Molecular Events at Tissue–Biomaterial Interface
inferred← citeshttps://doi.org/10.1016/j.actbio.2024.08.034openalex-snapshot
Formation and biological activities of foreign body giant cells in response to biomaterials
inferred← citeshttps://doi.org/10.1016/j.actbio.2025.01.026openalex-snapshot
A call for standardization: Evaluating different methodologies to induce in vitro foreign body giant cell formation for biomaterials research and design
inferred← citeshttps://doi.org/10.1016/j.ajpath.2010.11.065openalex-snapshot
M2 Polarized Macrophages and Giant Cells Contribute to Myofibrosis in Neuromuscular Sarcoidosis
inferred← citeshttps://doi.org/10.1016/j.ajpath.2011.01.045openalex-snapshot
Lack of TNF-α–Induced MMP-9 Production and Abnormal E-Cadherin Redistribution Associated with Compromised Fusion in MCP-1–Null Macrophages
inferred← citeshttps://doi.org/10.1016/j.ajpath.2016.04.001openalex-snapshot
The Role of Integrins αMβ2 (Mac-1, CD11b/CD18) and αDβ2 (CD11d/CD18) in Macrophage Fusion
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2014.01.007openalex-snapshot
Integrin-directed modulation of macrophage responses to biomaterials
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2014.06.050openalex-snapshot
Inhibition of foreign body giant cell formation by 4- hexylresorcinol through suppression of diacylglycerol kinase delta gene expression
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2016.02.036openalex-snapshot
Nanoparticle delivery of miR-223 to attenuate macrophage fusion
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.07.032openalex-snapshot
Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112620openalex-snapshot
Multi-omics analysis reveals the chemoresistance mechanism of proliferating tissue-resident macrophages in PDAC via metabolic adaptation
inferred← citeshttps://doi.org/10.1016/j.clbc.2013.05.003openalex-snapshot
Breast Cancer Expression of DAP12 is Associated With Skeletal and Liver Metastases and Poor Survival
inferred← citeshttps://doi.org/10.1016/j.coi.2009.01.009openalex-snapshot
TREM and TREM-like receptors in inflammation and disease
inferred← citeshttps://doi.org/10.1016/j.gene.2020.145362openalex-snapshot
Serine/threonine phosphatases in osteoclastogenesis and bone resorption
inferred← citeshttps://doi.org/10.1016/j.humimm.2013.02.003openalex-snapshot
Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12
inferred← citeshttps://doi.org/10.1016/j.imbio.2019.08.002openalex-snapshot
Factors influencing multinucleated giant cell formation in vitro
inferred← citeshttps://doi.org/10.1016/j.imlet.2016.02.002openalex-snapshot
TREM-1, a negative regulator of human osteoclastogenesis
inferred← citeshttps://doi.org/10.1016/j.immuni.2010.05.007openalex-snapshot
Alternative Activation of Macrophages: Mechanism and Functions
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114247openalex-snapshot
TREM2 protects against LPS-induced murine acute lung injury through suppressing macrophage ferroptosis
inferred← citeshttps://doi.org/10.1016/j.it.2024.04.013openalex-snapshot
Sarcoidosis immunopathogenesis – a new concept of maladaptive trained immunity
inferred← citeshttps://doi.org/10.1016/j.molimm.2012.12.004openalex-snapshot
Interleukin-4-induced β-catenin regulates the conversion of macrophages to multinucleated giant cells
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2018.10.003openalex-snapshot
Immune regulation in the aging retina
inferred← citeshttps://doi.org/10.1016/j.tcb.2009.07.005openalex-snapshot
Molecular mediators of macrophage fusion
inferred← citeshttps://doi.org/10.1016/j.tig.2013.01.011openalex-snapshot
Genetic basis of cell–cell fusion mechanisms
inferred← citeshttps://doi.org/10.1016/s0580-9517(10)37010-3openalex-snapshot
Isolation and Measuring the Function of Professional Phagocytes
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.9b01180openalex-snapshot
Prostaglandin E2 and Its Receptor EP2 Modulate Macrophage Activation and Fusion in Vitro
inferred← citeshttps://doi.org/10.1021/cb5007773openalex-snapshot
Visualizing Cell Proximity with Genetically Encoded Bioluminescent Reporters
inferred← citeshttps://doi.org/10.1038/cdd.2010.145openalex-snapshot
Illicit survival of cancer cells during polyploidization and depolyploidization
inferred← citeshttps://doi.org/10.1038/ni.1706openalex-snapshot
Cross-regulation of signaling by ITAM-associated receptors
inferred← citeshttps://doi.org/10.1038/ni0709-681openalex-snapshot
CSF-1R, DAP12 and β-catenin: a ménage à trois
inferred← citeshttps://doi.org/10.1038/s41467-021-21884-zopenalex-snapshot
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
inferred← citeshttps://doi.org/10.1038/s41467-023-36810-8openalex-snapshot
Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis
inferred← citeshttps://doi.org/10.1038/srep12599openalex-snapshot
E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo
inferred← citeshttps://doi.org/10.1053/j.gastro.2012.10.040openalex-snapshot
Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response
inferred← citeshttps://doi.org/10.1073/pnas.1105152108openalex-snapshot
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response
inferred← citeshttps://doi.org/10.1074/jbc.m112.358226openalex-snapshot
An Essential Role for STAT6-STAT1 Protein Signaling in Promoting Macrophage Cell-Cell Fusion
inferred← citeshttps://doi.org/10.1074/jbc.ra120.014597openalex-snapshot
Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation
inferred← citeshttps://doi.org/10.1080/1744666x.2016.1196138openalex-snapshot
Triggering receptor expressed on myeloid cells and 5’adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target
inferred← citeshttps://doi.org/10.1089/neu.2015.4163openalex-snapshot
Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock
inferred← citeshttps://doi.org/10.1096/fj.10-169854openalex-snapshot
P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration
inferred← citeshttps://doi.org/10.1097/prs.0000000000001193openalex-snapshot
The Foreign Body Response
inferred← citeshttps://doi.org/10.1101/2022.04.29.489846openalex-snapshot
Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development
inferred← citeshttps://doi.org/10.1101/2025.11.03.686191openalex-snapshot
IRF4 is a master regulator of multinucleated giant cell formation
inferred← citeshttps://doi.org/10.1111/j.1365-3083.2012.02689.xopenalex-snapshot
Claudin‐1, Claudin‐2 and Claudin‐11 Genes Differentially Associate with Distinct Types of Anti‐inflammatory Macrophages In vitro and with Parasite‐ and Tumour‐elicited Macrophages In vivo
inferred← citeshttps://doi.org/10.1111/j.1600-065x.2009.00841.xopenalex-snapshot
The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells
inferred← citeshttps://doi.org/10.1111/jre.12417openalex-snapshot
Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva
inferred← citeshttps://doi.org/10.1111/nan.12231openalex-snapshot
T h2‐ M 2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis
inferred← citeshttps://doi.org/10.1111/nan.70040openalex-snapshot
Myopathology and Immune Profile of Granulomatous Myositis in Sarcoid Myopathy
inferred← citeshttps://doi.org/10.1111/resp.12028openalex-snapshot
Triggering receptor expressed on myeloid cells‐1 and 2 in bronchoalveolar lavage fluid in pulmonary sarcoidosis
inferred← citeshttps://doi.org/10.1126/sciadv.add0422openalex-snapshot
Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development
inferred← citeshttps://doi.org/10.1126/scisignal.abd4077openalex-snapshot
Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation
inferred← citeshttps://doi.org/10.1128/mcb.00197-13openalex-snapshot
Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12
inferred← citeshttps://doi.org/10.1128/spectrum.01790-25openalex-snapshot
Sex-specific transcriptional regulation in lung macrophages during sub-acute Mycobacterium tuberculosis infection
inferred← citeshttps://doi.org/10.1146/annurev-immunol-032712-100022openalex-snapshot
The Formation and Function of Granulomas
inferred← citeshttps://doi.org/10.1152/ajpcell.00595.2025openalex-snapshot
Molecular signaling in biomaterial-induced foreign body response: current perspectives
inferred← citeshttps://doi.org/10.1155/2015/181986openalex-snapshot
TREM‐2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis
inferred← citeshttps://doi.org/10.1155/2020/9501617openalex-snapshot
TREM-1 and TREM-2 Expression on CD14+ Cells in Bronchoalveolar Lavage Fluid in Pulmonary Sarcoidosis and Hypersensitivity Pneumonitis in the Context of T Cell Immune Response
inferred← citeshttps://doi.org/10.1164/rccm.201211-1967ocopenalex-snapshot
Triggering Receptor Expressed on Myeloid Cells-2 Protects against Polymicrobial Sepsis by Enhancing Bacterial Clearance
inferred← citeshttps://doi.org/10.1172/jci159400openalex-snapshot
TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the SHP1/BTK axis
inferred← citeshttps://doi.org/10.1172/jci45913openalex-snapshot
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice
inferred← citeshttps://doi.org/10.1182/blood-2009-05-221598openalex-snapshot
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes
inferred← citeshttps://doi.org/10.1182/blood-2011-10-384289openalex-snapshot
Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs
inferred← citeshttps://doi.org/10.1186/1471-2180-14-98openalex-snapshot
A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages
inferred← citeshttps://doi.org/10.1186/ar2915openalex-snapshot
CD16 (FcRγIII) as a potential marker of osteoclast precursors in psoriatic arthritis
inferred← citeshttps://doi.org/10.1186/s12915-021-01181-3openalex-snapshot
Adipoclast: a multinucleated fat-eating macrophage
inferred← citeshttps://doi.org/10.1186/s12964-018-0226-1openalex-snapshot
Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells
inferred← citeshttps://doi.org/10.1186/s41232-024-00360-3openalex-snapshot
Cell fusion dynamics: mechanisms of multinucleation in osteoclasts and macrophages
inferred← citeshttps://doi.org/10.1189/jlb.1008588openalex-snapshot
Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9
inferred← citeshttps://doi.org/10.1242/jcs.216267openalex-snapshot
Common signalling pathways in macrophage and osteoclast multinucleation
inferred← citeshttps://doi.org/10.1615/critrevoncog.v18.i1-2.30openalex-snapshot
Cell Fusion In Tumor Development: Accelerated Genetic Evolution
inferred← citeshttps://doi.org/10.18632/oncotarget.8813openalex-snapshot
TREM-2 serves as a negative immune regulator through Syk pathway in an IL-10 dependent manner in lung cancer
inferred← citeshttps://doi.org/10.23868/201808014openalex-snapshot
Fusion-phenomenon in normal histogenesis and in pathology: part 1
inferred← citeshttps://doi.org/10.3389/fcell.2022.873226openalex-snapshot
Multinucleated Giant Cells: Current Insights in Phenotype, Biological Activities, and Mechanism of Formation
inferred← citeshttps://doi.org/10.3389/fcimb.2022.953785openalex-snapshot
Leishmania infection-induced multinucleated giant cell formation via upregulation of ATP6V0D2 expression
inferred← citeshttps://doi.org/10.3389/fimmu.2021.633639openalex-snapshot
The Activation and Regulation of β2 Integrins in Phagocytes and Phagocytosis
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1355012openalex-snapshot
Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1683872openalex-snapshot
Macrophages and osteoclasts: similarity and divergence between bone phagocytes
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1694985openalex-snapshot
Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR
inferred← citeshttps://doi.org/10.3389/fonc.2024.1375729openalex-snapshot
Mechanisms of TREM2 mediated immunosuppression and regulation of cancer progression
inferred← citeshttps://doi.org/10.3390/cancers17111804openalex-snapshot
Bone Marrow Myeloid–Lymphatic Progenitors Expand Tumor Lymphatic Vasculature Through Cell Fusion
inferred← citeshttps://doi.org/10.3390/ijms19010318openalex-snapshot
Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes
inferred← citeshttps://doi.org/10.3390/ijms21165685openalex-snapshot
Osteoclast Multinucleation: Review of Current Literature
inferred← citeshttps://doi.org/10.3390/ijms21176001openalex-snapshot
Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.3390/polym15051313openalex-snapshot
Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials
inferred← citeshttps://doi.org/10.36141/svdld.v35i3.5726openalex-snapshot
High mobility group box 1 protein in bronchoalveolar lavage fluid and correlation with other inflammatory markers in pulmonary diseases.
inferred← citeshttps://doi.org/10.3892/ijo.2016.3740openalex-snapshot
Depletion of the triggering receptor expressed on myeloid cells 2 inhibits progression of renal cell carcinoma via regulating related protein expression and PTEN-PI3K/Akt pathway
inferred← citeshttps://doi.org/10.3892/mmr.2017.7212openalex-snapshot
TREM-2 negatively regulates LPS-mediated inflammatory response in rat bone marrow-derived MSCs
inferred← citeshttps://doi.org/10.3892/ol.2020.12127openalex-snapshot
miR‑138‑5p suppresses glioblastoma cell viability and leads to cell cycle arrest by targeting cyclin D3
inferred← citeshttps://doi.org/10.4049/jimmunol.0903345openalex-snapshot
HIV-1 Nef Triggers Macrophage Fusion in a p61Hck- and Protease-Dependent Manner
inferred← citeshttps://doi.org/10.4049/jimmunol.1300988openalex-snapshot
Placental Macrophages Are Impaired in Chorioamnionitis, an Infectious Pathology of the Placenta
inferred← citeshttps://doi.org/10.4149/10.4149/bll_2021_065openalex-snapshot
Triggering receptor expressed on myeloid cells 1 and 2 in patients with chronic maxillary sinusitis
inferred← citeshttps://doi.org/10.4149/bll_2015_139openalex-snapshot
Diagnostic value of TREM-1 and TREM-2 expression in bronchoalveolar lavage fluid in sarcoidosis and other lung diseases
inferred← citeshttps://doi.org/10.4161/jkst.24777openalex-snapshot
STATs and macrophage fusion
inferred← citeshttps://doi.org/10.5312/wjo.v3.i12.212openalex-snapshot
Osteoclast fusion and regulation by RANKL-dependent and independent factors
inferred← citeshttps://doi.org/10.70675/2e3aacaazcd4fz49a5zb350zcd4933447d78openalex-snapshot
Etude de la transmission intercellulaire du VIH-1 vers les macrophages par fusion cellule-cellule
inferred← citeshttps://doi.org/10.70675/f354e58az6207z4e12zbeaezef5a12db862fopenalex-snapshot
Cellules dendritiques : infection et immunité tissulaire
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