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Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

https://doi.org/10.1126/scisignal.aav2449

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What this work says

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Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

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Gαq allosterically activates and relieves autoinhibition of p63RhoGEF

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The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation

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Mutations in GNA11 in Uveal Melanoma

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An Alternative Transcript Derived from the Trio Locus Encodes a Guanosine Nucleotide Exchange Factor with Mouse Cell-transforming Potential

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Trio’s Rho-specific GEF domain is the missing Gαq effector in C. elegans

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G Protein–Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation

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inferredcites →https://doi.org/10.1126/science.279.5350.560openalex-snapshot

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

inferredcites →https://doi.org/10.1152/physrev.00003.2012openalex-snapshot

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Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)

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Function and regulation of the Rho guanine nucleotide exchange factor Trio

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease

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Trio and Kalirin as unique enactors of Rho/Rac spatiotemporal precision

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Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer

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Exploring the autoinhibition mechanism of the C-terminal guanine nucleotide exchange factor module of Trio through molecular dynamics simulations

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KALRN: A central regulator of synaptic function and synaptopathies

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Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity

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Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs

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Kalirin and Trio: RhoGEFs in Synaptic Transmission, Plasticity, and Complex Brain Disorders

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Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA

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Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

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Gαs directly drives PDZ-RhoGEF signaling to Cdc42

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The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

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Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4

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New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors

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Trio family proteins as regulators of cell migration and morphogenesis in development and disease – mechanisms and cellular contexts

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Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein

inferred← citeshttps://doi.org/10.3389/fcell.2020.00118openalex-snapshot

Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer

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A developmental delay linked missense mutation in Kalirin-7 disrupts protein function and neuronal morphology

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Integration of Chemoinformatics and Multi-Omics Analysis Defines ECT2 as a Potential Target for Cancer Drug Therapy

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The RhoGEF Trio: A Protein with a Wide Range of Functions in the Vascular Endothelium

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