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A Fluorinated Phenylbenzothiazole Arrests the Trypanosoma cruzi Cell Cycle and Diminishes the Infection of Mammalian Host Cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jcb.21864openalex-snapshot
Natural programmed cell death in T. cruzi epimastigotes maintained in axenic cultures
inferredcites →https://doi.org/10.1006/excr.1998.4346openalex-snapshot
Cyclin E–Cdk2 Activation Is Associated with Cell Cycle Arrest and Inhibition of DNA Replication Induced by the Thymidylate Synthase Inhibitor Tomudex
inferredcites →https://doi.org/10.1006/expr.1999.4423openalex-snapshot
Trypanosoma cruzi: Characterization of an Intracellular Epimastigote-like Form
inferredcites →https://doi.org/10.1007/s00044-011-9768-0openalex-snapshot
Design, synthesis, and anticonvulsant evaluation of some novel 1, 3 benzothiazol-2-yl hydrazones/acetohydrazones
inferredcites →https://doi.org/10.1007/s00044-015-1475-9openalex-snapshot
Fluorine-containing benzothiazole as a novel trypanocidal agent: design, in silico study, synthesis and activity evaluation
inferredcites →https://doi.org/10.1007/s00262-006-0211-1openalex-snapshot
CIMT meets Strategies for Immune Therapy: Mainz, Germany, 04–05 May 2006
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
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Progress in medicinal chemistry 24
inferredcites →https://doi.org/10.1016/bs.pmch.2014.11.001openalex-snapshot
Fluorine in Medicinal Chemistry
inferredcites →https://doi.org/10.1016/j.bmc.2009.05.039openalex-snapshot
Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles
inferredcites →https://doi.org/10.1016/j.bmcl.2006.09.029openalex-snapshot
Toward a rational design of selective multi-trypanosomatid inhibitors: A computational docking study
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Synthesis, structure–activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers
inferredcites →https://doi.org/10.1016/j.bmcl.2011.02.064openalex-snapshot
Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells
inferredcites →https://doi.org/10.1016/j.ejmech.2004.04.006openalex-snapshot
Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives
inferredcites →https://doi.org/10.1016/j.ejmech.2012.05.020openalex-snapshot
Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin
inferredcites →https://doi.org/10.1016/j.molbiopara.2014.02.001openalex-snapshot
How Trypanosoma cruzi handles cell cycle arrest promoted by camptothecin, a topoisomerase I inhibitor
inferredcites →https://doi.org/10.1016/s0006-291x(02)00796-9openalex-snapshot
Highly specific inactivation of triosephosphate isomerase from Trypanosoma cruzi
inferredcites →https://doi.org/10.1016/s0022-1139(01)00375-xopenalex-snapshot
Fluorine substituent effects (on bioactivity)
inferredcites →https://doi.org/10.1016/s0169-409x(00)00129-0openalex-snapshot
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
inferredcites →https://doi.org/10.1016/s0304-3940(00)01536-6openalex-snapshot
Neuroprotective effect of low dose riluzole in gerbil model of transient global ischemia
inferredcites →https://doi.org/10.1017/s003118201300142xopenalex-snapshot
Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections
inferredcites →https://doi.org/10.1021/acs.jmedchem.6b01163openalex-snapshot
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis
inferredcites →https://doi.org/10.1021/bi0522293openalex-snapshot
Structural Differences in Triosephosphate Isomerase from Different Species and Discovery of a Multitrypanosomatid Inhibitor
inferredcites →https://doi.org/10.1021/jm000942eopenalex-snapshot
Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties
inferredcites →https://doi.org/10.1021/jm050942kopenalex-snapshot
Antitumor Benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory Activity against Lung, Colon, and Breast Cancer Cell Lines
inferredcites →https://doi.org/10.1038/srep07095openalex-snapshot
2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP
inferredcites →https://doi.org/10.1042/bj20081981openalex-snapshot
Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death inTrypanosoma cruzi
inferredcites →https://doi.org/10.1051/parasite/2014012openalex-snapshot
Chagas disease in the 21st Century: a public health success or an emerging threat?
inferredcites →https://doi.org/10.1080/15216540701200084openalex-snapshot
Trypanosoma cruzi: Adhesion to the Host Cell and Intracellular Survival
inferredcites →https://doi.org/10.1111/j.1582-4934.2010.01007.xopenalex-snapshot
Chagas’ disease: an update on immune mechanisms and therapeutic strategies
inferredcites →https://doi.org/10.1128/aac.01595-15openalex-snapshot
An Aromatic Diamidine That Targets Kinetoplast DNA, Impairs the Cell Cycle in Trypanosoma cruzi, and Diminishes Trypomastigote Release from Infected Mammalian Host Cells
inferredcites →https://doi.org/10.1128/ec.00198-09openalex-snapshot
Overexpression of MitochondrialLeishmania majorAscorbate Peroxidase Enhances Tolerance to Oxidative Stress-Induced Programmed Cell Death and Protein Damage
inferredcites →https://doi.org/10.1128/mspheredirect.00338-18openalex-snapshot
Uptake of l -Alanine and Its Distinct Roles in the Bioenergetics of Trypanosoma cruzi
inferredcites →https://doi.org/10.1146/annurev-micro-092611-150057openalex-snapshot
Network News: The Replication of Kinetoplast DNA
inferredcites →https://doi.org/10.1146/annurev.mi.27.100173.002023openalex-snapshot
Biology of Trypanosoma Cruzi
inferredcites →https://doi.org/10.1186/1756-3305-3-107openalex-snapshot
Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death
inferredcites →https://doi.org/10.1186/s40249-015-0092-7openalex-snapshot
Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries
inferredcites →https://doi.org/10.1371/journal.pone.0004534openalex-snapshot
Actions of a Proline Analogue, L-Thiazolidine-4-Carboxylic Acid (T4C), on Trypanosoma cruzi
inferredcites →https://doi.org/10.1371/journal.pone.0063900openalex-snapshot
A Novel Benzothiazole Derivative YLT322 Induces Apoptosis via the Mitochondrial Apoptosis Pathway In Vitro with Anti-Tumor Activity in Solid Malignancies
inferredcites →https://doi.org/10.18632/oncotarget.2813openalex-snapshot
DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1
inferredcites →https://doi.org/10.1891/9780826179340.0062openalex-snapshot
Chagas Disease (American Trypanosomiasis)
inferredcites →https://doi.org/10.2174/1574891x11666161024165304openalex-snapshot
Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period
inferredcites →https://doi.org/10.2307/3275869openalex-snapshot
Aspects of Early Growth of Different Trypanosoma cruzi Strains in Culture Medium
inferredcites →https://doi.org/10.3390/cryst7060171openalex-snapshot
Helical Arrangement of 2-(4-hydroxy-3-methoxyphenyl)-Benzothiazole in Crystal Formation and Biological Evaluation on HeLa Cells
inferredcites →https://doi.org/10.4161/viru.2.3.16278openalex-snapshot
Trypanosomatid apoptosis: 'Apoptosis' without the canonical regulators
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4127024openalex-extracted
Anonaine from Annona Crassiflora Inhibits Glutathione S-Transferase and Improves Cypermethrin Activity on Rhipicephalus Microplus
inferred← citeshttps://doi.org/10.1007/s00436-021-07137-4openalex-snapshot
Phenylbenzothiazole derivatives: effects against a Trypanosoma cruzi infection and toxicological profiles
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117854openalex-snapshot
Syntheses of benzothiazole amidoximes and arylimidamides and evaluation of their ADME and DNA binding properties and activity against Trypanosoma brucei
inferred← citeshttps://doi.org/10.1016/j.exppara.2022.108398openalex-snapshot
Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887)
inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e09182openalex-snapshot
A terpenoid-rich extract from Clethra fimbriata exhibits anti-Trypanosoma cruzi activity and induces T cell cytokine production
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e38434openalex-snapshot
In vitro antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01051openalex-snapshot
Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose
inferred← citeshttps://doi.org/10.1021/acsinfecdis.5c00691openalex-snapshot
Extending Thioflavin T Fluorescence Probe to 2-Ethenyl-benzothiazole Derivatives: Drug-like Quadruplex Ligands with Potent Antitrypanosomatid Activity
inferred← citeshttps://doi.org/10.1039/d5ra03993bopenalex-snapshot
Synthetic strategies towards benzothiazole-based compounds of therapeutic potency: experimental, investigational and approved drugs
inferred← citeshttps://doi.org/10.1080/14756366.2021.1959572openalex-snapshot
Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles
inferred← citeshttps://doi.org/10.1111/cbdd.14294openalex-snapshot
Structure‐based design, optimization of lead, synthesis, and biological evaluation of compounds active against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1111/cbdd.14525openalex-snapshot
Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
inferred← citeshttps://doi.org/10.1371/journal.pntd.0009994openalex-snapshot
An aromatic imidazoline derived from chloroquinoline triggers cell cycle arrest and inhibits with high selectivity the Trypanosoma cruzi mammalian host-cells infection
inferred← citeshttps://doi.org/10.2139/ssrn.4861766openalex-snapshot
In Vitro Antiplasmodium and Antitrypanosomal Activities, Β-Haematin Formation Inhibition, Molecular Docking and DFT Computational Studies of Quinoline-Urea-Benzothiazole Hybrids
inferred← citeshttps://doi.org/10.2139/ssrn.5225160openalex-snapshot
Synthesis and Evaluation of the Antitrypanosomal Activity, Adme and DNA Binding Properties of Benzothiazoleamidoximes and Arylimidamides
inferred← citeshttps://doi.org/10.2174/1381612827666210216152654openalex-snapshot
Chagas Disease Chemotherapy: What Do We Know So Far?
inferred← citeshttps://doi.org/10.3390/molecules30081788openalex-snapshot
Recent Progress in Thiazole, Thiosemicarbazone, and Semicarbazone Derivatives as Antiparasitic Agents Against Trypanosomatids and Plasmodium spp.
inferred← citeshttps://doi.org/10.3390/ph16060896openalex-snapshot
Riluzole, a Derivative of Benzothiazole as a Potential Anti-Amoebic Agent against Entamoeba histolytica
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