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Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/emmm.201202273openalex-snapshot
Brain microvessel cross‐presentation is a hallmark of experimental cerebral malaria
inferredcites →https://doi.org/10.1007/s11481-012-9343-6openalex-snapshot
S-nitrosoglutathione Prevents Experimental Cerebral Malaria
inferredcites →https://doi.org/10.1007/s13365-013-0187-5openalex-snapshot
Theiler’s murine encephalomyelitis virus as an experimental model system to study the mechanism of blood–brain barrier disruption
inferredcites →https://doi.org/10.1016/0035-9203(82)90203-6openalex-snapshot
Cerebral malaria in inbred mice. I. A new model and its pathology
inferredcites →https://doi.org/10.1016/j.chom.2014.04.008openalex-snapshot
Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria
inferredcites →https://doi.org/10.1016/j.ijpara.2005.12.005openalex-snapshot
Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria
inferredcites →https://doi.org/10.1016/j.immuni.2014.11.012openalex-snapshot
Granzyme B Promotes Cytotoxic Lymphocyte Transmigration via Basement Membrane Remodeling
inferredcites →https://doi.org/10.1016/s0035-9203(00)90300-6openalex-snapshot
Severe falciparum malaria
inferredcites →https://doi.org/10.1016/s1474-4422(05)70247-7openalex-snapshot
Pathogenesis, clinical features, and neurological outcome of cerebral malaria
inferredcites →https://doi.org/10.1016/s1537-1891(02)00200-8openalex-snapshot
Tight junctions of the blood-brain barrier: development, composition and regulation.
inferredcites →https://doi.org/10.1017/s0031182000074072openalex-snapshot
Pathology of fatal and resolvingPlasmodium bergheicerebral malaria in mice
inferredcites →https://doi.org/10.1017/s0031182096008293openalex-snapshot
Depletion of CD4 + or CD8 + T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease
inferredcites →https://doi.org/10.1038/nrn1824openalex-snapshot
Astrocyte–endothelial interactions at the blood–brain barrier
inferredcites →https://doi.org/10.1038/nrneurol.2009.23openalex-snapshot
Diagnosis and management of the neurological complications of falciparum malaria
inferredcites →https://doi.org/10.1056/nejmoa1400116openalex-snapshot
Brain Swelling and Death in Children with Cerebral Malaria
inferredcites →https://doi.org/10.1073/pnas.0806727105openalex-snapshot
Blood-stage Plasmodium infection induces CD8 + T lymphocytes to parasite-expressed antigens, largely regulated by CD8α + dendritic cells
inferredcites →https://doi.org/10.1083/jcb.123.6.1777openalex-snapshot
Occludin: a novel integral membrane protein localizing at tight junctions.
inferredcites →https://doi.org/10.1084/jem.191.9.1459openalex-snapshot
Cd8+ T Cells Can Block Herpes Simplex Virus Type 1 (HSV-1) Reactivation from Latency in Sensory Neurons
inferredcites →https://doi.org/10.1093/infdis/jir058openalex-snapshot
Nitric Oxide Protection Against Murine Cerebral Malaria Is Associated With Improved Cerebral Microcirculatory Physiology
inferredcites →https://doi.org/10.1093/infdis/jir656openalex-snapshot
Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8+ T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery
inferredcites →https://doi.org/10.1093/intimm/11.9.1553openalex-snapshot
T cell response in malaria pathogenesis: selective increase in T cells carrying the TCR Vβ8 during experimental cerebral malaria
inferredcites →https://doi.org/10.1111/j.1365-3156.2006.01579.xopenalex-snapshot
The effect of Plasmodium falciparum on cognition: a systematic review
inferredcites →https://doi.org/10.1126/science.1164164openalex-snapshot
Noncytotoxic Lytic Granule–Mediated CD8 + T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency
inferredcites →https://doi.org/10.1128/.66.9.4093-4099.1998openalex-snapshot
Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria
inferredcites →https://doi.org/10.1128/cmr.14.4.810-820.2001openalex-snapshot
Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans
inferredcites →https://doi.org/10.1128/iai.02180-14openalex-snapshot
Damage to the Blood-Brain Barrier during Experimental Cerebral Malaria Results from Synergistic Effects of CD8+T Cells with Different Specificities
inferredcites →https://doi.org/10.1128/iai.68.9.5364-5376.2000openalex-snapshot
Immunopathology of Cerebral Malaria: Morphological Evidence of Parasite Sequestration in Murine Brain Microvasculature
inferredcites →https://doi.org/10.1152/physrev.1974.54.4.957openalex-snapshot
Cerebrocerebellar communication systems.
inferredcites →https://doi.org/10.1161/01.res.0000255691.76142.4aopenalex-snapshot
Phenotypic Heterogeneity of the Endothelium
inferredcites →https://doi.org/10.1186/1475-2875-9-366openalex-snapshot
The 'hidden' burden of malaria: cognitive impairment following infection
inferredcites →https://doi.org/10.1186/1742-2094-9-60openalex-snapshot
A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption
inferredcites →https://doi.org/10.1371/journal.pone.0003037openalex-snapshot
Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells
inferredcites →https://doi.org/10.1371/journal.pone.0125565openalex-snapshot
Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses
inferredcites →https://doi.org/10.1371/journal.ppat.1002401openalex-snapshot
The Role of Animal Models for Research on Severe Malaria
inferredcites →https://doi.org/10.1371/journal.ppat.1002982openalex-snapshot
Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria
inferredcites →https://doi.org/10.1371/journal.ppat.1003444openalex-snapshot
Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria
inferredcites →https://doi.org/10.1371/journal.ppat.1004528openalex-snapshot
Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier
inferredcites →https://doi.org/10.1371/journal.ppat.1004963openalex-snapshot
Activated Brain Endothelial Cells Cross-Present Malaria Antigen
inferredcites →https://doi.org/10.1371/journal.ppat.1005210openalex-snapshot
Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria
inferredcites →https://doi.org/10.1371/journal.ppat.1005470openalex-snapshot
Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream
inferredcites →https://doi.org/10.1371/journal.ppat.1006022openalex-snapshot
CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature
inferredcites →https://doi.org/10.4049/jimmunol.1003955openalex-snapshot
Granzyme B Expression by CD8+ T Cells Is Required for the Development of Experimental Cerebral Malaria
inferredcites →https://doi.org/10.4049/jimmunol.1200658openalex-snapshot
CD8 T Cell-Initiated Blood–Brain Barrier Disruption Is Independent of Neutrophil Support
inferredcites →https://doi.org/10.4049/jimmunol.129.5.2213openalex-snapshot
Virulent P. berghei malaria: prolonged survival and decreased cerebral pathology in cell-dependent nude mice.
inferredcites →https://doi.org/10.4049/jimmunol.157.4.1620openalex-snapshot
Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria
inferredcites →https://doi.org/10.4049/jimmunol.170.4.2221openalex-snapshot
Perforin-Dependent Brain-Infiltrating Cytotoxic CD8+ T Lymphocytes Mediate Experimental Cerebral Malaria Pathogenesis
inferredcites →https://doi.org/10.4049/jimmunol.176.2.1180openalex-snapshot
TGF-β1 Released from Activated Platelets Can Induce TNF-Stimulated Human Brain Endothelium Apoptosis: A New Mechanism for Microvascular Lesion during Cerebral Malaria
inferredcites →https://doi.org/10.4049/jimmunol.181.2.1420openalex-snapshot
Malaria-Specific and Nonspecific Activation of CD8+ T Cells during Blood Stage of Plasmodium berghei Infection
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4115859openalex-extracted
Brain Resident Memory T Cells Rapidly Expand and Initiate Neuroinflammatory Responses Following CNS Injury and Viral Infection
inferred← citeshttps://doi.org/10.1002/1873-3468.13526openalex-snapshot
Erg mediates downregulation of claudin‐5 in the brain endothelium of a murine experimental model of cerebral malaria
inferred← citeshttps://doi.org/10.1002/eji.201646789openalex-snapshot
Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity
inferred← citeshttps://doi.org/10.1007/978-3-030-19515-1_7openalex-snapshot
Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases
inferred← citeshttps://doi.org/10.1007/978-3-031-60006-7_7openalex-snapshot
Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases
inferred← citeshttps://doi.org/10.1007/978-3-032-24254-9_5openalex-snapshot
Is the Association of Granzyme B and the Exported Parasite Hsp70 a Possible Trojan Horse of Severe Malaria?
inferred← citeshttps://doi.org/10.1007/s12035-020-02045-7openalex-snapshot
Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival
inferred← citeshttps://doi.org/10.1007/s12035-025-05315-4openalex-snapshot
β-Dystroglycan Downregulation and Astrocytic Alterations: A Possible Role in Blood-Brain Barrier Disruption During Experimental Cerebral Malaria
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.03.002openalex-snapshot
CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier
inferred← citeshttps://doi.org/10.1016/j.cbi.2021.109560openalex-snapshot
Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis
inferred← citeshttps://doi.org/10.1016/j.hsr.2024.100175openalex-snapshot
Review on cerebral malaria—Pathogenesis and role of EphA2 receptor in maintaining blood brain barrier integrity
inferred← citeshttps://doi.org/10.1016/j.immuni.2017.06.012openalex-snapshot
Protective and Pathological Immunity during Central Nervous System Infections
inferred← citeshttps://doi.org/10.1016/j.immuni.2018.03.012openalex-snapshot
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2023.109492openalex-snapshot
DHA-rich fish oil plays a protective role against experimental cerebral malaria by controlling inflammatory and mechanical events from infection
inferred← citeshttps://doi.org/10.1016/j.resuscitation.2020.08.005openalex-snapshot
Macrophage-specific protein perforin-2 is associated with poor neurological recovery and reduced survival after sudden cardiac arrest
inferred← citeshttps://doi.org/10.1016/j.tins.2025.05.008openalex-snapshot
CD8 T cells as drivers of blood–brain barrier disruption
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01338openalex-snapshot
Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity
inferred← citeshttps://doi.org/10.1038/s41467-018-03037-xopenalex-snapshot
Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
inferred← citeshttps://doi.org/10.1038/s41467-024-46617-wopenalex-snapshot
Beyond the microcirculation: sequestration of infected red blood cells and reduced flow in large draining veins in experimental cerebral malaria
inferred← citeshttps://doi.org/10.1038/s41582-023-00881-4openalex-snapshot
Pathogenetic mechanisms and treatment targets in cerebral malaria
inferred← citeshttps://doi.org/10.1080/00207454.2020.1796662openalex-snapshot
Perforin affects regeneration in a mouse spinal cord injury model
inferred← citeshttps://doi.org/10.1080/08830185.2024.2336539openalex-snapshot
Cerebral malaria pathogenesis: Dissecting the role of CD4 + and CD8 + T-cells as major effectors in disease pathology
inferred← citeshttps://doi.org/10.1080/21688370.2025.2607157openalex-snapshot
Potential of exosomes for targeted therapy in neuroinfectious disease management: crossing the blood–brain barrier
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Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators
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Discrete class I molecules on brain endothelium differentially regulate neuropathology in experimental cerebral malaria
inferred← citeshttps://doi.org/10.1093/intimm/dxab060openalex-snapshot
Using a new three-dimensional CUBIC tissue-clearing method to examine the brain during experimental cerebral malaria
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Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators
inferred← citeshttps://doi.org/10.1101/2020.08.01.230623openalex-snapshot
An equivalence of prokaryotic pore forming proteins of Plasmodium triggers cellular dysfunction responsible for malaria pathogenesis
inferred← citeshttps://doi.org/10.1101/2022.10.30.514412openalex-snapshot
Antigen presentation by discrete class I molecules on brain endothelium dynamically regulates T-cell mediated neuropathology in experimental cerebral malaria
inferred← citeshttps://doi.org/10.1111/brv.12566openalex-snapshot
Microglia in neuropathology caused by protozoan parasites
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The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria
inferred← citeshttps://doi.org/10.1128/mbio.02346-23openalex-snapshot
Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria
inferred← citeshttps://doi.org/10.1177/0271678x231214838openalex-snapshot
CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke
inferred← citeshttps://doi.org/10.1186/s12936-020-03336-zopenalex-snapshot
Pathophysiology and neurologic sequelae of cerebral malaria
inferred← citeshttps://doi.org/10.1186/s12967-025-07288-3openalex-snapshot
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Single-cell sequencing reveals intracranial microvasculature-derived CXCL12 promotes CD8+ T-cell infiltration and blood–brain barrier dysfunction after subarachnoid hemorrhage in mice
inferred← citeshttps://doi.org/10.1186/s13578-022-00830-6openalex-snapshot
Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions
inferred← citeshttps://doi.org/10.1371/journal.pntd.0007960openalex-snapshot
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TMEM119+ microglia MHC class I restricted antigen presentation impacts CD8 T cell memory, effector status, and blood-brain barrier disruption during neurotropic virus infection
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Compréhension de la résistance humaine au paludisme : des études génétiques aux approches fonctionnelles
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