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DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1521-4141(200002)30:2<697::aid-immu697>3.0.co;2-mopenalex-snapshot

Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells

inferredcites →https://doi.org/10.1002/cbf.1113openalex-snapshot

HCV infective virions can be carried by human platelets

inferredcites →https://doi.org/10.1002/path.1026openalex-snapshot

Placental expression of DC‐SIGN may mediate intrauterine vertical transmission of HIV

inferredcites →https://doi.org/10.1006/viro.1995.1016openalex-snapshot

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

inferredcites →https://doi.org/10.1006/viro.1996.0206openalex-snapshot

The Amount of Host HLA-DR Proteins Acquired by HIV-1 Is Virus Strain- and Cell Type-Specific

inferredcites →https://doi.org/10.1006/viro.2000.0193openalex-snapshot

Productive Infection of CD34+-Cell-Derived Megakaryocytes by X4 and R5 HIV-1 Isolates

inferredcites →https://doi.org/10.1006/viro.2002.1730openalex-snapshot

DC-SIGN and DC-SIGNR Bind Ebola Glycoproteins and Enhance Infection of Macrophages and Endothelial Cells

inferredcites →https://doi.org/10.1016/j.micinf.2004.02.004openalex-snapshot

Syndecans and HIV-1 pathogenesis

inferredcites →https://doi.org/10.1016/j.virol.2003.09.028openalex-snapshot

Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission

inferredcites →https://doi.org/10.1016/j.virol.2004.05.022openalex-snapshot

Quantification of infectious HIV-1 plasma viral load using a boosted in vitro infection protocol

inferredcites →https://doi.org/10.1016/s0092-8674(00)80693-5openalex-snapshot

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

inferredcites →https://doi.org/10.1016/s0092-8674(00)80694-7openalex-snapshot

DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

inferredcites →https://doi.org/10.1016/s0092-8674(01)00477-9openalex-snapshot

Complement-Independent, Peroxide-Induced Antibody Lysis of Platelets in HIV-1-Related Immune Thrombocytopenia

inferredcites →https://doi.org/10.1016/s0966-842x(99)01474-2openalex-snapshot

HIV-1 attachment: another look

inferredcites →https://doi.org/10.1016/s1074-7613(02)00259-5openalex-snapshot

DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell Infection

inferredcites →https://doi.org/10.1038/79815openalex-snapshot

DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking

inferredcites →https://doi.org/10.1038/82161openalex-snapshot

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

inferredcites →https://doi.org/10.1038/ni841openalex-snapshot

Diversity of receptors binding HIV on dendritic cell subsets

inferredcites →https://doi.org/10.1038/nm1246openalex-snapshot

TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells

inferredcites →https://doi.org/10.1038/nri1182openalex-snapshot

DC-SIGN: escape mechanism for pathogens

inferredcites →https://doi.org/10.1038/nsmb784openalex-snapshot

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR

inferredcites →https://doi.org/10.1046/j.1537-2995.1998.38698326338.xopenalex-snapshot

Distribution of HIV type 1 (HIV‐1) in blood components: detection and significance of high levels of HIV‐1 associated with platelets

inferredcites →https://doi.org/10.1054/blre.2001.0188openalex-snapshot

HIV-related thrombocytopenia

inferredcites →https://doi.org/10.1073/pnas.032654399openalex-snapshot

Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN

inferredcites →https://doi.org/10.1073/pnas.051631398openalex-snapshot

DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans

inferredcites →https://doi.org/10.1073/pnas.0831128100openalex-snapshot

L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus

inferredcites →https://doi.org/10.1073/pnas.89.5.1582openalex-snapshot

Primary cultures of endothelial cells from the human liver sinusoid are permissive for human immunodeficiency virus type 1.

inferredcites →https://doi.org/10.1074/jbc.m301284200openalex-snapshot

DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2

inferredcites →https://doi.org/10.1084/jem.20022212openalex-snapshot

Blockade of Attachment and Fusion Receptors Inhibits HIV-1 Infection of Human Cervical Tissue

inferredcites →https://doi.org/10.1084/jem.20030648openalex-snapshot

HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse

inferredcites →https://doi.org/10.1086/423209openalex-snapshot

Analysis of Genetic Polymorphisms in CCR5, CCR2, Stromal Cell–Derived Factor–1, RANTES, and Dendritic Cell–Specific Intercellular Adhesion Molecule–3–Grabbing Nonintegrin in Seronegative Individuals Repeatedly Exposed to HIV‐1

inferredcites →https://doi.org/10.1089/088922202753472838openalex-snapshot

Cellular Factors Influence the Binding of HIV Type 1 to Cells

inferredcites →https://doi.org/10.1099/vir.0.80852-0openalex-snapshot

Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration

inferredcites →https://doi.org/10.1111/j.1365-2249.1992.tb03066.xopenalex-snapshot

During HIV-1 infection most blood dendritic cells are not productively infected and can induce allogeneic CD4+ T cells clonal expansion

inferredcites →https://doi.org/10.1111/j.1538-7836.2006.01749.xopenalex-snapshot

Lentivirus degradation and DC‐SIGN expression by human platelets and megakaryocytes

inferredcites →https://doi.org/10.1111/j.1600-0854.2004.00209.xopenalex-snapshot

Retroviral Spread by Induction of Virological Synapses

inferredcites →https://doi.org/10.1126/science.1084238openalex-snapshot

Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions

inferredcites →https://doi.org/10.1126/science.1352913openalex-snapshot

Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells

inferredcites →https://doi.org/10.1128/jvi.74.18.8550-8557.2000openalex-snapshot

CD4-Negative Cells Bind Human Immunodeficiency Virus Type 1 and Efficiently Transfer Virus to T Cells

inferredcites →https://doi.org/10.1128/jvi.74.21.10074-10080.2000openalex-snapshot

Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding

inferredcites →https://doi.org/10.1128/jvi.75.10.4664-4672.2001openalex-snapshot

DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus

inferredcites →https://doi.org/10.1128/jvi.75.21.10281-10289.2001openalex-snapshot

Functional and Antigenic Characterization of Human, Rhesus Macaque, Pigtailed Macaque, and Murine DC-SIGN

inferredcites →https://doi.org/10.1128/jvi.75.21.10523-10526.2001openalex-snapshot

DC-SIGN Interactions with Human Immunodeficiency Virus: Virus Binding and Transfer Are Dissociable Functions

inferredcites →https://doi.org/10.1128/jvi.76.12.5905-5914.2002openalex-snapshot

Functional Evaluation of DC-SIGN Monoclonal Antibodies Reveals DC-SIGN Interactions with ICAM-3 Do Not Promote Human Immunodeficiency Virus Type 1 Transmission

inferredcites →https://doi.org/10.1128/jvi.76.18.9135-9142.2002openalex-snapshot

Quantitative Expression and Virus Transmission Analysis of DC-SIGN on Monocyte-Derived Dendritic Cells

inferredcites →https://doi.org/10.1128/jvi.76.4.1866-1875.2002openalex-snapshot

Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques

inferredcites →https://doi.org/10.1128/jvi.77.2.989-998.2003openalex-snapshot

Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIV SF162P3 Maps to Envelope gp120

inferredcites →https://doi.org/10.1128/jvi.77.23.12865-12874.2003openalex-snapshot

Binding of Human Immunodeficiency Virus Type 1 to Immature Dendritic Cells Can Occur Independently of DC-SIGN and Mannose Binding C-Type Lectin Receptors via a Cholesterol-Dependent Pathway

inferredcites →https://doi.org/10.1128/jvi.77.7.4070-4080.2003openalex-snapshot

Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR

inferredcites →https://doi.org/10.1128/jvi.78.20.10848-10855.2004openalex-snapshot

Lentivirus-Mediated RNA Interference of DC-SIGN Expression Inhibits Human Immunodeficiency Virus Transmission from Dendritic Cells to T Cells

inferredcites →https://doi.org/10.1128/jvi.78.24.14053-14056.2004openalex-snapshot

Association of DC-SIGN Promoter Polymorphism with Increased Risk for Parenteral, but Not Mucosal, Acquisition of Human Immunodeficiency Virus Type 1 Infection

inferredcites →https://doi.org/10.1128/jvi.79.11.6577-6587.2005openalex-snapshot

Plunder and Stowaways: Incorporation of Cellular Proteins by Enveloped Viruses

inferredcites →https://doi.org/10.1128/jvi.79.9.5386-5399.2005openalex-snapshot

Covert Human Immunodeficiency Virus Replication in Dendritic Cells and in DC-SIGN-Expressing Cells Promotes Long-Term Transmission to Lymphocytes

inferredcites →https://doi.org/10.1139/y94-043openalex-snapshot

Role of platelets in thrombosis and hemostasis

inferredcites →https://doi.org/10.1182/blood-2001-12-0191openalex-snapshot

Host defense role of platelets: engulfment of HIV andStaphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation

inferredcites →https://doi.org/10.1182/blood-2003-09-3129openalex-snapshot

Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells

inferredcites →https://doi.org/10.1182/blood-2005-05-1994openalex-snapshot

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

inferredcites →https://doi.org/10.1182/blood.v75.10.1920.1920openalex-snapshot

Internalization of human immunodeficiency virus type I and other retroviruses by megakaryocytes and platelets

inferredcites →https://doi.org/10.1182/blood.v80.1.162.162openalex-snapshot

Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura

inferredcites →https://doi.org/10.1182/blood.v91.4.1225openalex-snapshot

Productive Human Immunodeficiency Virus-1 Infection of Purified Megakaryocytic Progenitors/Precursors and Maturing Megakaryocytes

inferredcites →https://doi.org/10.1189/jlb.71.3.445openalex-snapshot

Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro

inferredcites →https://doi.org/10.1517/14728222.6.4.423openalex-snapshot

The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?

inferredcites →https://doi.org/10.2174/156801605774322364openalex-snapshot

Thrombocytopenia in HIV Disease: Clinical Relevance, Physiopathology and Management

inferredcites →https://doi.org/10.4049/jimmunol.175.7.4265openalex-snapshot

Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin/CD209 Is Abundant on Macrophages in the Normal Human Lymph Node and Is Not Required for Dendritic Cell Stimulation of the Mixed Leukocyte Reaction

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/cphy.c140074openalex-snapshot

Platelets and Their Interactions with Other Immune Cells

inferred← citeshttps://doi.org/10.1002/eji.200737741openalex-snapshot

Syk kinase is required for collaborative cytokine production induced through Dectin‐1 and Toll‐like receptors

inferred← citeshttps://doi.org/10.1002/j.2040-4603.2015.tb00649.xopenalex-snapshot

Platelets and Their Interactions with Other Immune Cells

inferred← citeshttps://doi.org/10.1002/jev2.12513openalex-snapshot

Beyond basic characterization and omics: Immunomodulatory roles of platelet‐derived extracellular vesicles unveiled by functional testing

inferred← citeshttps://doi.org/10.1002/jlb.3mir0221-100ropenalex-snapshot

Platelet extracellular vesicles in COVID-19: Potential markers and makers

inferred← citeshttps://doi.org/10.1002/jlb.4mr0620-701ropenalex-snapshot

Innate immune receptors in platelets and platelet-leukocyte interactions

inferred← citeshttps://doi.org/10.1002/rmv.1753openalex-snapshot

Tissue dendritic cells as portals for HIV entry

inferred← citeshttps://doi.org/10.1002/rth2.12338openalex-snapshot

Platelet CLEC‐2 and lung development

inferred← citeshttps://doi.org/10.1002/rth2.12710openalex-snapshot

Clustering extent‐dependent differential signaling by CLEC‐2 receptors in platelets

inferred← citeshttps://doi.org/10.1007/978-1-4419-0461-4_570openalex-snapshot

CLEC-2

inferred← citeshttps://doi.org/10.1007/978-1-4614-6438-9_570-1openalex-snapshot

CLEC-2

inferred← citeshttps://doi.org/10.1007/978-1-4614-7651-1_7openalex-snapshot

Cellular Entry of Retroviruses

inferred← citeshttps://doi.org/10.1007/978-3-031-96340-7_14openalex-snapshot

Platelet CLEC-2

inferred← citeshttps://doi.org/10.1007/978-3-031-96352-0_17openalex-snapshot

Platelets in Viral Pathophysiology

inferred← citeshttps://doi.org/10.1007/978-3-319-47462-5_10openalex-snapshot

The Role of CLEC-2 in and Beyond the Vasculature

inferred← citeshttps://doi.org/10.1007/978-3-319-47462-5_34openalex-snapshot

Platelets and Immunity

inferred← citeshttps://doi.org/10.1007/978-3-319-47462-5_72openalex-snapshot

Virus–Platelet Associations

inferred← citeshttps://doi.org/10.1007/978-3-319-67199-4_570openalex-snapshot

CLEC-2

inferred← citeshttps://doi.org/10.1007/978-3-7091-1065-2_34openalex-snapshot

Dectin-1 Receptor Family

inferred← citeshttps://doi.org/10.1007/978-3-7091-1646-3_8openalex-snapshot

Platelets in Lymph Vessel Development and Integrity

inferred← citeshttps://doi.org/10.1007/978-3-7643-7783-0_3openalex-snapshot

Attachment of human immunodeficiency virus to cells and its inhibition

inferred← citeshttps://doi.org/10.1007/978-4-431-56015-9_6openalex-snapshot

C-Type Lectin-Like Receptor 2 (CLEC-2)

inferred← citeshttps://doi.org/10.1007/978-90-481-9295-3_34openalex-snapshot

The Biologic Activity of Aggretin/Rhodocytin, a Snake Venom C-Type Lectin Protein (Snaclec)

inferred← citeshttps://doi.org/10.1007/s00018-009-0209-xopenalex-snapshot

Platelets and viruses: an ambivalent relationship

inferred← citeshttps://doi.org/10.1007/s00281-011-0286-4openalex-snapshot

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

inferred← citeshttps://doi.org/10.1007/s10719-012-9413-2openalex-snapshot

The production of soluble C-type lectin-like receptor 2 is a regulated process

inferred← citeshttps://doi.org/10.1007/s10719-012-9419-9openalex-snapshot

The C-type lectin-like receptors of Dectin-1 cluster in natural killer gene complex

inferred← citeshttps://doi.org/10.1007/s11033-025-10222-xopenalex-snapshot

Dengue virus infection: how platelet-leukocyte crosstalk shapes thrombotic events and inflammation

inferred← citeshttps://doi.org/10.1007/s11684-015-0424-9openalex-snapshot

Emerging roles of podoplanin in vascular development and homeostasis

inferred← citeshttps://doi.org/10.1007/s12026-023-09357-5openalex-snapshot

COVID-19 vaccines adverse events: potential molecular mechanisms

inferred← citeshttps://doi.org/10.1007/s12185-019-02680-4openalex-snapshot

Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI

inferred← citeshttps://doi.org/10.1007/s15010-026-02838-3openalex-snapshot

Viral subversion of megakaryopoiesis: reshaping the landscapes of immune regulation

inferred← citeshttps://doi.org/10.1016/b978-0-12-374546-0.00028-6openalex-snapshot

Lectin-like interactions in virus–cell recognition

inferred← citeshttps://doi.org/10.1016/b978-0-12-387837-3.00009-2openalex-snapshot

Platelet Receptors

inferred← citeshttps://doi.org/10.1016/b978-0-12-387837-3.00011-0openalex-snapshot

GPVI and CLEC-2

inferred← citeshttps://doi.org/10.1016/b978-0-12-387837-3.00036-5openalex-snapshot

Inflammation

inferred← citeshttps://doi.org/10.1016/b978-0-12-813456-6.00009-6openalex-snapshot

Platelet Receptors

inferred← citeshttps://doi.org/10.1016/bs.ai.2022.09.001openalex-snapshot

Self-referential immune recognition through C-type lectin receptors

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2023.12.010openalex-snapshot

Platelets and inter-cellular communication in immune responses: Dialogue with both professional and non-professional immune cells

inferred← citeshttps://doi.org/10.1016/bs.pmbts.2014.10.004openalex-snapshot

The Evolution of HIV-1 Interactions with Coreceptors and Mannose C-Type Lectin Receptors

inferred← citeshttps://doi.org/10.1016/j.ajpath.2020.05.009openalex-snapshot

Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice

inferred← citeshttps://doi.org/10.1016/j.bbrc.2008.03.070openalex-snapshot

Molecular characterization of two novel isoforms and a soluble form of mouse CLEC-2

inferred← citeshttps://doi.org/10.1016/j.bbrc.2009.09.087openalex-snapshot

RACK1 associates with CLEC-2 and promotes its ubiquitin–proteasome degradation

inferred← citeshttps://doi.org/10.1016/j.bcp.2015.02.004openalex-snapshot

Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: Haemostasis, platelet activation and antithrombotic therapy

inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118100openalex-snapshot

SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole

inferred← citeshttps://doi.org/10.1016/j.blre.2017.03.005openalex-snapshot

Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?

inferred← citeshttps://doi.org/10.1016/j.bonr.2019.100196openalex-snapshot

Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82

inferred← citeshttps://doi.org/10.1016/j.carres.2014.07.005openalex-snapshot

Elucidation of differences in N-glycosylation between different molecular weight forms of recombinant CLEC-2 by LC MALDI tandem MS

inferred← citeshttps://doi.org/10.1016/j.cca.2019.06.014openalex-snapshot

Higher plasma C-type lectin-like receptor 2 concentrations for prediction of higher risk of 30-day mortality in isolated severe blunt traumatic brain injury

inferred← citeshttps://doi.org/10.1016/j.cellsig.2016.07.007openalex-snapshot

E3 ubiquitin ligase CHIP interacts with C-type lectin-like receptor CLEC-2 and promotes its ubiquitin-proteasome degradation

inferred← citeshttps://doi.org/10.1016/j.coph.2008.11.001openalex-snapshot

Thrombomodulation via CLEC-2 targeting

inferred← citeshttps://doi.org/10.1016/j.ddmec.2011.10.001openalex-snapshot

HIV and SIV associated thrombocytopenia: an expanding role for platelets in the pathogenesis of HIV

inferred← citeshttps://doi.org/10.1016/j.ebiom.2018.11.049openalex-snapshot

Platelet Factor 4 Promotes Rapid Replication and Propagation of Dengue and Japanese Encephalitis Viruses

inferred← citeshttps://doi.org/10.1016/j.eurox.2019.100039openalex-snapshot

Morphometric image analysis of placental C-type lectin domain family 2, member D (CLEC2D) immuno-expression in HIV associated pre-eclampsia

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Regulation of platelet function by natural bioactive compounds

inferred← citeshttps://doi.org/10.1016/j.imbio.2010.06.002openalex-snapshot

High glucose disrupts oligosaccharide recognition function via competitive inhibition: A potential mechanism for immune dysregulation in diabetes mellitus

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Inhibitory C-type lectin receptors in myeloid cells

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Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

inferred← citeshttps://doi.org/10.1016/j.immuni.2024.03.005openalex-snapshot

Myeloid C-type lectin receptors in innate immune recognition

inferred← citeshttps://doi.org/10.1016/j.immuni.2024.04.008openalex-snapshot

Platelets: Orchestrators of immunity in host defense and beyond

inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113599openalex-snapshot

Platelet’s plea to Immunologists: Please do not forget me

inferred← citeshttps://doi.org/10.1016/j.jcvp.2021.100039openalex-snapshot

Differential platelet receptor expression for viral capture (DC-SIGN) and plasma leakage in patients with dengue infection

inferred← citeshttps://doi.org/10.1016/j.jtha.2023.11.015openalex-snapshot

Inhibition of cellular activation induced by platelet factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis and dengue viral infections

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Viral coagulation: pushing the envelope

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Platelets to surrogate lung inflammation in COVID-19 patients

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Platelets immune response against Mycobacterium tuberculosis infection

inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.101719openalex-snapshot

In vitro and in vivo metabolic tagging and modulation of platelets

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Abnormalities in C-type lectin-like receptor 2 in a patient with Gorham-Stout disease: the first case report

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Beyond hemostasis, the immunomodulatory nature of platelets

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A Platform of C-type Lectin-like Receptor CLEC-2 for Binding O-Glycosylated Podoplanin and Nonglycosylated Rhodocytin

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Step up to the platelet: Role of platelets in inflammation and infection

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The Immune Nature of Platelets Revisited

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Immunologie plaquettaire et réponse immune

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Plaquettes sanguines, réponses aux signaux de danger infectieux et inflammation : vers un nouveau paradigme ?

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Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

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Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding

inferred← citeshttps://doi.org/10.1021/bi800528topenalex-snapshot

The Crystal Structure of the Platelet Activator Aggretin Reveals a Novel (αβ)2Dimeric Structure

inferred← citeshttps://doi.org/10.1038/mp.a004057.01openalex-snapshot

CLEC-2

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Signalling through C-type lectin receptors: shaping immune responses

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The non-haemostatic role of platelets in systemic lupus erythematosus

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Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade

inferred← citeshttps://doi.org/10.1038/s41467-019-10360-4openalex-snapshot

Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2

inferred← citeshttps://doi.org/10.1038/s41598-018-33403-0openalex-snapshot

Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals

inferred← citeshttps://doi.org/10.1038/s41598-021-94307-0openalex-snapshot

Characterization and visualization of murine coagulation factor VIII-producing cells in vivo

inferred← citeshttps://doi.org/10.1039/d2cs00954dopenalex-snapshot

Glycomimetics for the inhibition and modulation of lectins

inferred← citeshttps://doi.org/10.1042/bj20071216openalex-snapshot

Renal cells activate the platelet receptor CLEC-2 through podoplanin

inferred← citeshttps://doi.org/10.1042/cs20220039openalex-snapshot

Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection

inferred← citeshttps://doi.org/10.1051/medsci/2021006openalex-snapshot

Un passager clandestin

inferred← citeshttps://doi.org/10.1055/a-2523-1821openalex-snapshot

Recent Advances in Immunothrombosis and Thromboinflammation

inferred← citeshttps://doi.org/10.1055/a-2731-2399openalex-snapshot

Platelets in Neonatal Sepsis: Beyond Clotting, from Silent Players to Immune Orchestrators

inferred← citeshttps://doi.org/10.1055/s-0037-1604090openalex-snapshot

Platelet CLEC-2: Roles Beyond Hemostasis

inferred← citeshttps://doi.org/10.1055/s-0037-1619045openalex-snapshot

Arterial thrombus formation

inferred← citeshttps://doi.org/10.1055/s-0040-1708827openalex-snapshot

A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection

inferred← citeshttps://doi.org/10.1055/s-0041-1726033openalex-snapshot

Platelet Function in Viral Immunity and SARS-CoV-2 Infection

inferred← citeshttps://doi.org/10.1055/s-0044-1791512openalex-snapshot

Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L

inferred← citeshttps://doi.org/10.1073/pnas.1207314109openalex-snapshot

Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor

inferred← citeshttps://doi.org/10.1074/jbc.m111.329987openalex-snapshot

Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

inferred← citeshttps://doi.org/10.1074/jbc.m117.791012openalex-snapshot

Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets

inferred← citeshttps://doi.org/10.1074/jbc.m609558200openalex-snapshot

The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade

inferred← citeshttps://doi.org/10.1074/jbc.m610383200openalex-snapshot

The Crystal Structure and Mutational Binding Analysis of the Extracellular Domain of the Platelet-activating Receptor CLEC-2

inferred← citeshttps://doi.org/10.1080/08830185.2017.1309528openalex-snapshot

Multiple functions of the E3 ubiquitin ligase CHIP in immunity

inferred← citeshttps://doi.org/10.1080/09537104.2018.1478401openalex-snapshot

Roles of the CLEC-2–podoplanin interaction in tumor progression

inferred← citeshttps://doi.org/10.1080/09537104.2020.1718631openalex-snapshot

Platelets and extracellular traps in infections

inferred← citeshttps://doi.org/10.1080/09537104.2020.1849606openalex-snapshot

Hiding in plain sight – platelets, the silent carriers of HIV-1

inferred← citeshttps://doi.org/10.1080/09537104.2021.1887842openalex-snapshot

Platelets and viruses

inferred← citeshttps://doi.org/10.1080/09537104.2021.1945571openalex-snapshot

Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors

inferred← citeshttps://doi.org/10.1080/09537104.2021.1952179openalex-snapshot

Platelet–leukocyte interactions in the pathogenesis of viral infections

inferred← citeshttps://doi.org/10.1080/10408363.2016.1200008openalex-snapshot

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

inferred← citeshttps://doi.org/10.1086/520607openalex-snapshot

Analysis of the Interaction of Ebola Virus Glycoprotein with DC‐SIGN (Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin) and Its Homologue DC‐SIGNR

inferred← citeshttps://doi.org/10.1086/588710openalex-snapshot

Protective Role of DC‐SIGN(CD209)Neck‐Region Alleles with <5 Repeat Units in HIV‐1 Transmission

inferred← citeshttps://doi.org/10.1089/aid.2006.0311openalex-snapshot

Platelet Count Is Associated with Plasma HIV Type 1 RNA and Disease Progression

inferred← citeshttps://doi.org/10.1089/vim.2021.0135openalex-snapshot

Dengue Virus and Platelets: From the Biology to the Clinic

inferred← citeshttps://doi.org/10.1093/glycob/cwz097openalex-snapshot

Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2

inferred← citeshttps://doi.org/10.1093/jb/mvr079openalex-snapshot

Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation

inferred← citeshttps://doi.org/10.1093/jimmun/vkag197openalex-snapshot

Platelets are essential for survival of respiratory-restricted viral infection

inferred← citeshttps://doi.org/10.1093/jleuko/qiae048openalex-snapshot

Increased platelet–CD8+ T-cell aggregates displaying high activation, exhaustion, and tendency to death correlate with disease progression in people with HIV-1

inferred← citeshttps://doi.org/10.1097/coh.0b013e328356e9f3openalex-snapshot

Use of (alternative) coreceptors for HIV entry

inferred← citeshttps://doi.org/10.1097/moh.0b013e3283497dfbopenalex-snapshot

Recently recognized platelet agonists

inferred← citeshttps://doi.org/10.1097/qad.0b013e328336098copenalex-snapshot

Platelet function and HIV: a case–control study

inferred← citeshttps://doi.org/10.1099/acmi.0.000481.v3openalex-snapshot

Binding of respiratory syncytial virus particles to platelets does not result in their degranulation in vitro

inferred← citeshttps://doi.org/10.1100/2012/931386openalex-snapshot

Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex

inferred← citeshttps://doi.org/10.1111/1348-0421.13211openalex-snapshot

Classification of C‐Type Lectins and Recognition of Pathogens

inferred← citeshttps://doi.org/10.1111/1574-6976.12052openalex-snapshot

Bitter-sweet symphony: glycan–lectin interactions in virus biology

inferred← citeshttps://doi.org/10.1111/acel.13749openalex-snapshot

Platelet response to influenza vaccination reflects effects of aging

inferred← citeshttps://doi.org/10.1111/ejh.13705openalex-snapshot

T cell–mediated autoimmunity in immune thrombocytopenia

inferred← citeshttps://doi.org/10.1111/ijlh.12307openalex-snapshot

The evaluation of platelet indices and markers of inflammation, coagulation and disease progression in treatment‐naïve, asymptomatic HIV ‐infected individuals

inferred← citeshttps://doi.org/10.1111/j.0105-2896.2009.00882.xopenalex-snapshot

Syk‐coupled C‐type lectin receptors that mediate cellular activation via single tyrosine based activation motifs

inferred← citeshttps://doi.org/10.1111/j.1538-7836.2009.03372.xopenalex-snapshot

Novel interactions in platelet biology: CLEC-2/podoplanin and laminin/GPVI

inferred← citeshttps://doi.org/10.1111/j.1538-7836.2010.03875.xopenalex-snapshot

GPVI and CLEC‐2 in hemostasis and vascular integrity

inferred← citeshttps://doi.org/10.1111/j.1538-7836.2011.04335.xopenalex-snapshot

Novel platelet activation receptor CLEC‐2: from discovery to prospects

inferred← citeshttps://doi.org/10.1111/j.1538-7836.2011.04356.xopenalex-snapshot

Historical perspective and future directions in platelet research

inferred← citeshttps://doi.org/10.1111/j.1574-6968.2008.01418.xopenalex-snapshot

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

inferred← citeshttps://doi.org/10.1111/jth.12235openalex-snapshot

Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb‐IX‐V, and CLEC‐2

inferred← citeshttps://doi.org/10.1111/jth.13590openalex-snapshot

Physiologic and pathophysiologic roles of interaction between C‐type lectin‐like receptor 2 and podoplanin: partners from in utero to adulthood

inferred← citeshttps://doi.org/10.1111/jth.13669openalex-snapshot

Targeting of C‐type lectin‐like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides

inferred← citeshttps://doi.org/10.1111/mmi.14837openalex-snapshot

Fc‐conjugated C‐type lectin receptors: Tools for understanding host–pathogen interactions

inferred← citeshttps://doi.org/10.1126/scitranslmed.aat6263openalex-snapshot

Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 + T cell recovery can harbor replication-competent HIV despite viral suppression

inferred← citeshttps://doi.org/10.1128/jvi.00554-10openalex-snapshot

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

inferred← citeshttps://doi.org/10.11406/rinketsu.50.389openalex-snapshot

新規血小板活性化受容体CLEC-2とその生体内リガンド, ポドプラニン

inferred← citeshttps://doi.org/10.1152/ajprenal.00629.2009openalex-snapshot

DC-specific ICAM-3-grabbing nonintegrin mediates internalization of HIV-1 into human podocytes

inferred← citeshttps://doi.org/10.1155/2013/869718openalex-snapshot

Targeting Antigens to Dendritic Cell Receptors for Vaccine Development

inferred← citeshttps://doi.org/10.1160/th13-04-0341openalex-snapshot

Platelet chemokines in health and disease

inferred← citeshttps://doi.org/10.1160/ths10-11-0720openalex-snapshot

Platelets, inflammation and tissue regeneration

inferred← citeshttps://doi.org/10.1161/01.res.0000252802.25497.b7openalex-snapshot

Platelets as Immune Cells

inferred← citeshttps://doi.org/10.1161/atvbaha.120.314180openalex-snapshot

Platelets Endocytose Viral Particles and Are Activated via TLR (Toll-Like Receptor) Signaling

inferred← citeshttps://doi.org/10.1161/atvbaha.120.314645openalex-snapshot

Role of Platelets in Detection and Regulation of Infection

inferred← citeshttps://doi.org/10.1161/circresaha.121.319821openalex-snapshot

Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity

inferred← citeshttps://doi.org/10.1161/circresaha.122.321930openalex-snapshot

Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond

inferred← citeshttps://doi.org/10.1172/jci122955openalex-snapshot

Functional significance of the platelet immune receptors GPVI and CLEC-2

inferred← citeshttps://doi.org/10.1177/08892229251365583openalex-snapshot

Analysis of Factors Influencing Immunological Failure in Elderly People Living with HIV Undergoing Antiretroviral Therapy: A LASSO-Logistic Regression Approach

inferred← citeshttps://doi.org/10.1182/asheducation-2016.1.256openalex-snapshot

Platelets in infectious disease

inferred← citeshttps://doi.org/10.1182/blood-2009-05-222273openalex-snapshot

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

inferred← citeshttps://doi.org/10.1182/blood-2012-09-456004openalex-snapshot

A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation

inferred← citeshttps://doi.org/10.1182/blood-2014-05-572818openalex-snapshot

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

inferred← citeshttps://doi.org/10.1182/blood.2019003977openalex-snapshot

Aspirin and antiplatelet treatments in cancer

inferred← citeshttps://doi.org/10.1182/bloodadvances.2018016261openalex-snapshot

Cobalt hematoporphyrin inhibits CLEC-2–podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice

inferred← citeshttps://doi.org/10.1182/bloodadvances.2020001698openalex-snapshot

Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ

inferred← citeshttps://doi.org/10.1182/bloodadvances.2020002420openalex-snapshot

Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation

inferred← citeshttps://doi.org/10.1182/bloodadvances.2022007444openalex-snapshot

Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells

inferred← citeshttps://doi.org/10.1183/16000617.0062-2021openalex-snapshot

Platelets: a potential role in chronic respiratory diseases?

inferred← citeshttps://doi.org/10.1186/1742-4690-10-48openalex-snapshot

Platelet activation suppresses HIV-1 infection of T cells

inferred← citeshttps://doi.org/10.1186/1742-4690-7-47openalex-snapshot

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

inferred← citeshttps://doi.org/10.1186/s12865-015-0092-1openalex-snapshot

Human platelets and their capacity of binding viruses: meaning and challenges?

inferred← citeshttps://doi.org/10.1186/s12929-021-00741-7openalex-snapshot

C-type lectins and extracellular vesicles in virus-induced NETosis

inferred← citeshttps://doi.org/10.1186/s12959-018-0170-8openalex-snapshot

Human blood platelets and viruses: defense mechanism and role in the removal of viral pathogens

inferred← citeshttps://doi.org/10.1186/s12959-021-00311-9openalex-snapshot

Thrombosis in COVID-19 infection: Role of platelet activation-mediated immunity

inferred← citeshttps://doi.org/10.1186/s12967-025-06591-3openalex-snapshot

Over-activation and dysfunction of platelet-NK cell aggregates in HIV-infected individuals

inferred← citeshttps://doi.org/10.1186/s13045-020-00954-7openalex-snapshot

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

inferred← citeshttps://doi.org/10.1189/jlb.1206753openalex-snapshot

The role of the β-glucan receptor Dectin-1 in control of fungal infection

inferred← citeshttps://doi.org/10.1371/journal.pntd.0002858openalex-snapshot

The Role of Platelets in the Pathogenesis of Viral Hemorrhagic Fevers

inferred← citeshttps://doi.org/10.1371/journal.pntd.0011488openalex-snapshot

Dabie bandavirus infection induces macrophagic pyroptosis and this process is attenuated by platelets

inferred← citeshttps://doi.org/10.1371/journal.pone.0013139openalex-snapshot

Inference of Surface Membrane Factors of HIV-1 Infection through Functional Interaction Networks

inferred← citeshttps://doi.org/10.1371/journal.pone.0071051openalex-snapshot

Transcriptome Analysis of Duck Liver and Identification of Differentially Expressed Transcripts in Response to Duck Hepatitis A Virus Genotype C Infection

inferred← citeshttps://doi.org/10.1371/journal.pone.0081002openalex-snapshot

Platelets and Erythrocyte-Bound Platelets Bind Infectious HIV-1 in Plasma of Chronically Infected Patients

inferred← citeshttps://doi.org/10.1371/journal.pone.0130061openalex-snapshot

Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse

inferred← citeshttps://doi.org/10.1371/journal.pone.0194185openalex-snapshot

HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation

inferred← citeshttps://doi.org/10.1371/journal.pone.0206346openalex-snapshot

Dynamic modulation of DC-SIGN and FcΥR2A receptors expression on platelets in dengue

inferred← citeshttps://doi.org/10.1371/journal.ppat.1012190openalex-snapshot

Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity

inferred← citeshttps://doi.org/10.1371/journal.ppat.1013985openalex-snapshot

Platelet-like particles released from Ebola virus-infected megakaryocytic cells behave like virus-like particles

inferred← citeshttps://doi.org/10.15252/emmm.202216351openalex-snapshot

Inhibition of SARS‐CoV‐2‐mediated thromboinflammation by CLEC2.Fc

inferred← citeshttps://doi.org/10.1529/biophysj.107.106708openalex-snapshot

Stochastic Entry of Enveloped Viruses: Fusion versus Endocytosis

inferred← citeshttps://doi.org/10.1590/0037-8682-0105-2016openalex-snapshot

Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro

inferred← citeshttps://doi.org/10.17305/bb.2023.10135openalex-snapshot

The role of platelets in sepsis: A review

inferred← citeshttps://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.305openalex-snapshot

The role of platelets in antiviral immunity

inferred← citeshttps://doi.org/10.2147/jbm.s365218openalex-snapshot

Haematological Traits in Symptomatic and Asymptomatic COVID-19 Positive Patients for Predicting Severity and Hospitalization

inferred← citeshttps://doi.org/10.2174/187152810793937991openalex-snapshot

Platelet Toll-Like Receptor Expression: The Link Between “Danger” Ligands and Inflammation

inferred← citeshttps://doi.org/10.2174/187152908784533739openalex-snapshot

Beyond Hemostasis: The Role of Platelets in Inflammation, Malignancy and Infection

inferred← citeshttps://doi.org/10.21873/invivo.13766openalex-snapshot

Hyperexpression ofPTAFRandPF4as Possible Platelet Risk Biomarkers in Patients With COVID-19

inferred← citeshttps://doi.org/10.2217/fmb.13.104openalex-snapshot

Platelets as Immune Cells in Infectious Diseases

inferred← citeshttps://doi.org/10.24287/1726-1708-2021-20-1-184-191openalex-snapshot

Platelets in COVID-19: “innocent by-standers” or active participants?

inferred← citeshttps://doi.org/10.2491/jjsth.20.401openalex-snapshot

An overview of the novel platelet activation receptor CLEC-2

inferred← citeshttps://doi.org/10.2491/jjsth.22.348openalex-snapshot

Novel platelet activation receptor CLEC-2

inferred← citeshttps://doi.org/10.2491/jjsth.23.259openalex-snapshot

A role of platelets in infection and inflammation

inferred← citeshttps://doi.org/10.2491/jjsth.26.29openalex-snapshot

C-type lectin receptors

inferred← citeshttps://doi.org/10.2491/jjsth.28.518openalex-snapshot

Identification of the platelet activation receptor CLEC-2, its endogenous ligand podoplanin, and pathophysiological roles of their interaction

inferred← citeshttps://doi.org/10.2491/jjsth.34.414openalex-snapshot

The platelet activation receptor CLEC-2: from basic research to prospect of clinical application

inferred← citeshttps://doi.org/10.25439/rmt.27589824openalex-snapshot

Investigating novel platelet immunoreceptor ‘CEACAM2’ in contact-dependent events that modulate platelet thrombus formation

inferred← citeshttps://doi.org/10.30607/kvj.1524672openalex-snapshot

Determination of Hematological Indices in Dogs with Acute CDV Infection

inferred← citeshttps://doi.org/10.3109/09537104.2011.556274openalex-snapshot

The novel platelet activation receptor CLEC-2

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