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HIV-1 Protease, Reverse Transcriptase, and Integrase Variation

https://doi.org/10.1128/jvi.00495-16
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: Performance evaluation of the new REGA version 3 and seven other tools
inferredcites →https://doi.org/10.1016/j.virusres.2004.11.011openalex-snapshot
Lethal mutagenesis of HIV
inferredcites →https://doi.org/10.1038/340397a0openalex-snapshot
Complete mutagenesis of the HIV-1 protease
inferredcites →https://doi.org/10.1038/nature01709openalex-snapshot
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
inferredcites →https://doi.org/10.1038/nrg1246openalex-snapshot
The causes and consequences of HIV evolution
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Primer ID Informs Next-Generation Sequencing Platforms and Reveals Preexisting Drug Resistance Mutations in the HIV-1 Reverse Transcriptase Coding Domain
inferredcites →https://doi.org/10.1093/jac/dkr389openalex-snapshot
The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02_AG HIV-1 subtype
inferredcites →https://doi.org/10.1093/jac/dkt200openalex-snapshot
Identification of a rare mutation at reverse transcriptase Lys65 (K65E) in HIV-1-infected patients failing on nucleos(t)ide reverse transcriptase inhibitors
inferredcites →https://doi.org/10.1093/jac/dkv333openalex-snapshot
Deep analysis of HIV-1 natural variability across HIV-1 variants at residues associated with integrase inhibitor (INI) resistance in INI-naive individuals
inferredcites →https://doi.org/10.1093/nar/13.9.3021openalex-snapshot
Nomenclature for incompletely specified bases in nucleic acid sequences: rcommendations 1984
inferredcites →https://doi.org/10.1093/nar/27.1.348openalex-snapshot
Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database
inferredcites →https://doi.org/10.1093/nar/gkg100openalex-snapshot
Human immunodeficiency virus reverse transcriptase and protease sequence database
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FastML: a web server for probabilistic reconstruction of ancestral sequences
inferredcites →https://doi.org/10.1097/00019048-200106000-00020openalex-snapshot
UPDATE ON DRUG RESISTANCE MUTATIONS IN HIV-1
inferredcites →https://doi.org/10.1097/qad.0b013e3282f5e07aopenalex-snapshot
Sequence editing by Apolipoprotein B RNA-editing catalytic component-B and epidemiological surveillance of transmitted HIV-1 drug resistance
inferredcites →https://doi.org/10.1097/qad.0b013e3283560703openalex-snapshot
E138K and M184I mutations in HIV-1 reverse transcriptase coemerge as a result of APOBEC3 editing in the absence of drug exposure
inferredcites →https://doi.org/10.1126/science.7824947openalex-snapshot
HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy
inferredcites →https://doi.org/10.1128/aac.00592-09openalex-snapshot
Nonpolymorphic Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Treatment-Selected Mutations
inferredcites →https://doi.org/10.1128/aac.00986-09openalex-snapshot
TMC278, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), Active against Wild-Type and NNRTI-Resistant HIV-1
inferredcites →https://doi.org/10.1128/aac.01835-13openalex-snapshot
Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase
inferredcites →https://doi.org/10.1128/jcm.06689-11openalex-snapshot
Automating HIV Drug Resistance Genotyping with RECall, a Freely Accessible Sequence Analysis Tool
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Evaluation of the Editing Process in Human Immunodeficiency Virus Type 1 Genotyping
inferredcites →https://doi.org/10.1128/jvi.00888-06openalex-snapshot
Population Level Analysis of Human Immunodeficiency Virus Type 1 Hypermutation and Its Relationship with APOBEC3G and vif Genetic Variation
inferredcites →https://doi.org/10.1128/jvi.00915-10openalex-snapshot
Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication
inferredcites →https://doi.org/10.1128/jvi.02451-14openalex-snapshot
Uneven Genetic Robustness of HIV-1 Integrase
inferredcites →https://doi.org/10.1128/jvi.06591-11openalex-snapshot
Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir
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Maintaining the integrity of human immunodeficiency virus sequence databases
inferredcites →https://doi.org/10.1128/jvi.71.3.2233-2240.1997openalex-snapshot
Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals
inferredcites →https://doi.org/10.1128/jvi.72.5.3520-3523.1998openalex-snapshot
Switch to Unusual Amino Acids at Codon 215 of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene in Seroconvertors Infected with Zidovudine-Resistant Variants
inferredcites →https://doi.org/10.1128/jvi.74.20.9339-9346.2000openalex-snapshot
Evidence of a Role for the Q151L Mutation and the Viral Background in Development of Multiple Dideoxynucleoside-Resistant Human Immunodeficiency Virus Type 1
inferredcites →https://doi.org/10.1128/jvi.79.3.1975-1980.2005openalex-snapshot
G→A Hypermutation in Protease and Reverse Transcriptase Regions of Human Immunodeficiency Virus Type 1 Residing in Resting CD4 + T Cells In Vivo
inferredcites →https://doi.org/10.1128/mmbr.00012-09openalex-snapshot
The Remarkable Frequency of Human Immunodeficiency Virus Type 1 Genetic Recombination
inferredcites →https://doi.org/10.1177/135965350901400513openalex-snapshot
Dried Fluid Spots for HIV Type-1 Viral Load and Resistance Genotyping: A Systematic Review
inferredcites →https://doi.org/10.1186/1742-4690-10-18openalex-snapshot
Analysis of 454 sequencing error rate, error sources, and artifact recombination for detection of Low-frequency drug resistance mutations in HIV-1 DNA
inferredcites →https://doi.org/10.1186/s12977-015-0148-6openalex-snapshot
An integrated map of HIV genome-wide variation from a population perspective
inferredcites →https://doi.org/10.1371/journal.pone.0004724openalex-snapshot
Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update
inferredcites →https://doi.org/10.1371/journal.ppat.1000414openalex-snapshot
HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC
inferredcites →https://doi.org/10.2307/4615733openalex-snapshot
A Simple Sequentially Rejective Multiple Test Procedure
inferredcites →https://doi.org/10.3390/v2071476openalex-snapshot
The “Connection” Between HIV Drug Resistance and RNase H
inferredcites →https://doi.org/10.5167/uzh-122257openalex-snapshot
2015 update of the drug resistance mutations in HIV-1

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Mechanisms of Resistance to Antiviral Agents
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Mechanisms of Resistance to Antiviral Agents
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Viral evolution in the cell‐associated HIV‐1 DNA during early ART can lead to drug resistance and virological failure in children
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Antiviral activity of HIV‐1 integrase strand‐transfer inhibitors against mutants with integrase resistance‐associated mutations and their frequency in treatment‐naïve individuals
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Atom-based 3D-QSAR, molecular docking, DFT, and simulation studies of acylhydrazone, hydrazine, and diazene derivatives as IN-LEDGF/p75 inhibitors
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Investigation of potential inhibitor properties of violacein against HIV-1 RT and CoV-2 Spike RBD:ACE-2
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Ab-initio, Molecular Docking and MD Simulation of an Anti-HIV Drug (Lamivudine): An In-silico Approach
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The CARD8 inflammasome in HIV infection
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Performance evaluation of the Vela Dx Sentosa next-generation sequencing system for HIV-1 DNA genotypic resistance
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Prospective Evaluation of the Vela Diagnostics Next-Generation Sequencing Platform for HIV-1 Genotypic Resistance Testing
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Analysis of drug resistance mutations in whole blood DNA from HIV-1 infected patients by single genome and ultradeep sequencing analysis
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Performance of an in-house multiplex PCR assay for HIV-1 drug resistance testing – A cheaper alternative
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Clinical benefit of dolutegravir in HIV-1 management related to the high genetic barrier to drug resistance
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The need for a European hepatitis C programme monitoring resistance to direct-acting antiviral agents in real life to eliminate hepatitis C
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Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors
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Contingency and Entrenchment of Drug-Resistance Mutations in HIV Viral Proteins
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Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease
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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
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Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells
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Selection analyses of paired HIV-1 gag and gp41 sequences obtained before and after antiretroviral therapy
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Geographically-stratified HIV-1 group M pol subtype and circulating recombinant form sequences
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Amino Acid Prevalence of HIV-1 pol Mutations by Direct Polymerase Chain Reaction and Single Genome Sequencing
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Low Frequency of Protease Inhibitor Resistance Mutations and Insertions in HIV-1 Subtype C Protease Inhibitor-Naïve Sequences
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Trends in HIV-1 Drug Resistance Mutations from a U.S. Reference Laboratory from 2006 to 2017
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Integrase Strand Transfer Inhibitor Resistance in Integrase Strand Transfer Inhibitor-Naive Persons
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Near Real-Time Identification of Recent Human Immunodeficiency Virus Transmissions, Transmitted Drug Resistance Mutations, and Transmission Networks by Multiplexed Primer ID–Next-Generation Sequencing in North Carolina
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HIV-1 APOBEC-context Mutations Detected by Next-Generation Sequencing in Plasma: Implications for Drug Resistance Interpretation
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Prevalence of Drug-Resistant Minority Variants in Untreated HIV-1–Infected Individuals With and Those Without Transmitted Drug Resistance Detected by Sanger Sequencing
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HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters
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Detection of pretreatment minority HIV-1 reverse transcriptase inhibitor-resistant variants by ultra-deep sequencing has a limited impact on virological outcomes
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High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO
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A systematic review of the genetic mechanisms of dolutegravir resistance
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Prevalence and Evolution of Transmitted Human Immunodeficiency Virus Drug Resistance in Belgium Between 2013 and 2019
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In-depth analysis of HIV-1 drug resistance mutations in HIV-infected individuals failing first-line regimens in West and Central Africa
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High-level dolutegravir resistance can emerge rapidly from few variants and spread by recombination: implications for INSTI salvage therapy
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Improved HIV-1 drug resistance mutation prediction using quasispecies reconstruction supported analysis
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CARD8 inflammasome sensitization through DPP9 inhibition enhances NNRTI-triggered killing of HIV-1-infected cells
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Detection of novel HIV-1 drug resistance mutations by support vector analysis of deep sequence data and experimental validation
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Trends in Transmitted Drug Resistance and Prevalence of Non-B Subtype in Newly Diagnosed Individuals with HIV-1 in the Tokai Area
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Prevalence of HIV-1 Integrase Polymorphisms and Drug Resistance Mutations in Newly Diagnosed Individuals with HIV-1 in the Tokai Area
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Novel Protease Inhibitors Containing C-5-Modifiedbis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance
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Comparison of an In Vitro Diagnostic Next-Generation Sequencing Assay with Sanger Sequencing for HIV-1 Genotypic Resistance Testing
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HIV-1 Drug Resistance Assay Using Ion Torrent Next Generation Sequencing and On-Instrument End-to-End Analysis Software
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Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
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HIV-1 Gag, Pol, and Env diversified with limited adaptation since the 1980s
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Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and in Silico Anti-HIV-1 Studies
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Extraction and Characterization of Tetralin‐Pentacyclic Triterpenoid Conjugates From Water Hyacinth ( Pontederia crassipes ) (Mart.) Solms: A Computational Approach to Evaluate Their Pharmacokinetics and Anti‐HIV Potential
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The Human Immunodeficiency Virus Type 1 Budding Machinery: Deconstructing the Endosomal Sorting Complexes Required for Transport-Mediated Scission Pathway
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Non-integrase mechanisms for dolutegravir resistance
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Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria
inferred← citeshttps://doi.org/10.1186/s12985-017-0887-1openalex-snapshot
Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors
inferred← citeshttps://doi.org/10.1186/s12985-022-01772-8openalex-snapshot
Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages
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Prevalence of resistance to integrase strand-transfer inhibitors (INSTIs) among untreated HIV-1 infected patients in Morocco
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Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome
inferred← citeshttps://doi.org/10.1371/journal.pone.0181357openalex-snapshot
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation
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Analysis of unusual and signature APOBEC-mutations in HIV-1 pol next-generation sequences
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A systematic review on effect of COVID-19 in pregnant women
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Genetic diversity of human immunodeficiency viruses and antiretroviral therapy
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Tackling the problem of HIV drug resistance
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Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages
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Deep Sequencing of the HIV-1 Polymerase Gene for Characterisation of Cytotoxic T-Lymphocyte Epitopes During Early and Chronic Disease Stages
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Deep Sequencing of The HIV-1 Polymerase Gene For Characterisation of Cytotoxic T-Lymphocyte Epitopes During Early And Chronic Disease Stages
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Molecular Evolution Methods to Study HIV-1 Epidemics
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Antiretroviral drug resistance in HIV-1 patients on first-line therapy or untreated across five treatment centers in Yaounde's Centre Region, Cameroon
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Computational Remodeling Mechanism Analysis of Three HIV Enzyme Partners (Protease (PR), Reverse Transcriptase (RT) and Integrase (IN)) on Behalf of Structural and Functional Analysis
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Resistance To Antiretroviral Therapy In People With HIV
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Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence
inferred← citeshttps://doi.org/10.3389/fmicb.2022.866705openalex-snapshot
Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins
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UL36 Encoded by Marek’s Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity
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The Origins and Genetic Diversity of HIV-1: Evolutionary Insights and Global Health Perspectives
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Molecular Docking Studies of HIV-1 Resistance to Reverse Transcriptase Inhibitors: Mini-Review
inferred← citeshttps://doi.org/10.3390/pathogens11050546openalex-snapshot
Spectrum of Atazanavir-Selected Protease Inhibitor-Resistance Mutations
inferred← citeshttps://doi.org/10.3390/pathogens11111321openalex-snapshot
Drug Resistance to Integrase Strand-Transfer Inhibitors among HIV-1-Infected Adults in Guangdong, China
inferred← citeshttps://doi.org/10.3390/v10010010openalex-snapshot
Genotypic and Phylogenetic Insights on Prevention of the Spread of HIV-1 and Drug Resistance in “Real-World” Settings
inferred← citeshttps://doi.org/10.3390/v13050879openalex-snapshot
Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance
inferred← citeshttps://doi.org/10.3390/v15020546openalex-snapshot
Prevalence of HIV-1 Natural Polymorphisms and Integrase-Resistance-Associated Mutations in African Children
inferred← citeshttps://doi.org/10.3390/v15040992openalex-snapshot
HIV-1 Group M Capsid Amino Acid Variability: Implications for Sequence Quality Control of Genotypic Resistance Testing
inferred← citeshttps://doi.org/10.3390/v16111715openalex-snapshot
Spectrum of Non-Nucleoside Reverse Transcriptase Inhibitor-Associated Drug Resistance Mutations in Persons Living with HIV-1 Receiving Rilpivirine
inferred← citeshttps://doi.org/10.35627/2219-5238/2019-317-8-50-55openalex-snapshot
SPREAD OF MUTATIONS OF RESISTANCE AND HIV-1 SUBTYPES AS AN INDICATOR OF DYNAMICS OF HIV INFECTION EPIDEMIC IN THE VOLGA FEDERAL DISTRICT IN 2016–2018
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Decoding HIV Resistance: From Genotype to Therapy
inferred← citeshttps://doi.org/10.56499/jppres21.1009_9.4.435openalex-snapshot
Tea catechin as antiviral agent via apoptosis agonist and triple inhibitor mechanism against HIV-1 infection: A bioinformatics approach
inferred← citeshttps://doi.org/10.6084/m9.figshare.19445444openalex-snapshot
Additional file 1 of Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages
inferred← citeshttps://doi.org/10.6084/m9.figshare.19445450openalex-snapshot
Additional file 2 of Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages
inferred← citeshttps://doi.org/10.6084/m9.figshare.19445453openalex-snapshot
Additional file 3 of Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages
inferred← citeshttps://doi.org/10.6084/m9.figshare.19445456openalex-snapshot
Additional file 4 of Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages
inferred← citeshttps://doi.org/10.70675/2f861d9fz0cc1z4031z905ez94f9066db0feopenalex-snapshot
Détection et quantification des ADN non intégrés linéaires responsables de la latence pré-intégrative du VIH-1
inferred← citeshttps://doi.org/10.70675/c548c34cz3362z42dazb03cza37907b802c7openalex-snapshot
Activités multiples des inhibiteurs allostériques de l’interaction entre l’Intégrase du VIH-1 et son cofacteur LEDGF/p75
inferred← citeshttps://doi.org/10.7448/ias.20.1.21846openalex-snapshot
Comparison between next‐generation and Sanger‐based sequencing for the detection of transmitted drug‐resistance mutations among recently infected HIV‐1 patients in Israel, 2000–2014
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