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SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication

https://doi.org/10.1128/jvi.01756-16
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/rmv.1725openalex-snapshot
The ubiquitin‐proteasome system in positive‐strand RNA virus infection
inferredcites →https://doi.org/10.1006/excr.2002.5634openalex-snapshot
Ubc9 Is Essential for Viability of Higher Eukaryotic Cells
inferredcites →https://doi.org/10.1006/jmbi.1998.1839openalex-snapshot
Structure determination of the small ubiquitin-related modifier SUMO-1
inferredcites →https://doi.org/10.1006/prep.1999.1100openalex-snapshot
Production of “Authentic” Poliovirus RNA-Dependent RNA Polymerase (3Dpol) by Ubiquitin–Protease-Mediated Cleavage in Escherichia coli
inferredcites →https://doi.org/10.1007/978-1-4419-6676-6_16openalex-snapshot
Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation
inferredcites →https://doi.org/10.1007/s13238-010-0030-1openalex-snapshot
SUMOylation of RIG-I positively regulates the type I interferon signaling
inferredcites →https://doi.org/10.1007/s13238-010-0061-7openalex-snapshot
Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China
inferredcites →https://doi.org/10.1016/j.ab.2009.04.035openalex-snapshot
A quantitative stopped-flow fluorescence assay for measuring polymerase elongation rates
inferredcites →https://doi.org/10.1016/j.cell.2007.08.045openalex-snapshot
SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia
inferredcites →https://doi.org/10.1016/j.molcel.2005.03.012openalex-snapshot
SUMO
inferredcites →https://doi.org/10.1016/j.tcb.2007.08.002openalex-snapshot
SUMO-specific proteases: a twist in the tail
inferredcites →https://doi.org/10.1016/j.tibs.2011.09.002openalex-snapshot
SUMO playing tag with ubiquitin
inferredcites →https://doi.org/10.1016/j.virol.2009.10.005openalex-snapshot
Coxsackievirus B5 induced apoptosis of HeLa cells: Effects on p53 and SUMO
inferredcites →https://doi.org/10.1016/j.virusres.2011.02.017openalex-snapshot
Influenza A virus interacts extensively with the cellular SUMOylation system during infection
inferredcites →https://doi.org/10.1016/j.virusres.2014.10.012openalex-snapshot
Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin–proteasome system
inferredcites →https://doi.org/10.1016/s0076-6879(05)99017-4openalex-snapshot
Experimental Tests to Definitively Determine Ubiquitylation of a Substrate
inferredcites →https://doi.org/10.1016/s0092-8674(02)00630-xopenalex-snapshot
Structural Basis for E2-Mediated SUMO Conjugation Revealed by a Complex between Ubiquitin-Conjugating Enzyme Ubc9 and RanGAP1
inferredcites →https://doi.org/10.1016/s0168-1702(99)00019-2openalex-snapshot
Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia
inferredcites →https://doi.org/10.1016/s0168-6445(02)00070-0openalex-snapshot
An overview of the evolution of enterovirus 71 and its clinical and public health significance
inferredcites →https://doi.org/10.1016/s0264-410x(98)00043-7openalex-snapshot
Comparison of the ability of viral protein-expressing plasmid DNAs to protect against influenza
inferredcites →https://doi.org/10.1038/452709aopenalex-snapshot
SUMO
inferredcites →https://doi.org/10.1038/cr.2012.58openalex-snapshot
K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites
inferredcites →https://doi.org/10.1038/nrm3011openalex-snapshot
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
inferredcites →https://doi.org/10.1038/nrmicro3015openalex-snapshot
Interplay between viruses and host sumoylation pathways
inferredcites →https://doi.org/10.1042/bst0380034openalex-snapshot
SUMO and ubiquitin paths converge
inferredcites →https://doi.org/10.1073/pnas.0403498101openalex-snapshot
Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
inferredcites →https://doi.org/10.1073/pnas.1007626107openalex-snapshot
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
inferredcites →https://doi.org/10.1073/pnas.1300233110openalex-snapshot
Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions
inferredcites →https://doi.org/10.1073/pnas.1602591113openalex-snapshot
Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation
inferredcites →https://doi.org/10.1074/jbc.272.43.26799openalex-snapshot
Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p
inferredcites →https://doi.org/10.1074/jbc.273.6.3117openalex-snapshot
Covalent Modification of PML by the Sentrin Family of Ubiquitin-like Proteins
inferredcites →https://doi.org/10.1074/jbc.275.9.6252openalex-snapshot
Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3
inferredcites →https://doi.org/10.1074/jbc.m104214200openalex-snapshot
Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9
inferredcites →https://doi.org/10.1074/jbc.m110.149633openalex-snapshot
Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease
inferredcites →https://doi.org/10.1074/jbc.m110.189274openalex-snapshot
Impairment of Human Immunodeficiency Virus Type-1 Integrase SUMOylation Correlates with an Early Replication Defect
inferredcites →https://doi.org/10.1074/jbc.m111.254896openalex-snapshot
Sumoylation-promoted Enterovirus 71 3C Degradation Correlates with a Reduction in Viral Replication and Cell Apoptosis
inferredcites →https://doi.org/10.1074/jbc.m112.410985openalex-snapshot
Poly-Small Ubiquitin-like Modifier (PolySUMO)-binding Proteins Identified through a String Search
inferredcites →https://doi.org/10.1074/jbc.m308357200openalex-snapshot
The SUMO Isopeptidase Ulp2 Prevents Accumulation of SUMO Chains in Yeast
inferredcites →https://doi.org/10.1074/jbc.m403153200openalex-snapshot
Dual Role of Sumoylation in the Nuclear Localization and Transcriptional Activation of NFAT1
inferredcites →https://doi.org/10.1074/jbc.m507059200openalex-snapshot
Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif
inferredcites →https://doi.org/10.1074/jbc.m513703200openalex-snapshot
SUMO-1 Controls the Protein Stability and the Biological Function of Phosducin
inferredcites →https://doi.org/10.1074/mcp.m700173-mcp200openalex-snapshot
In Vivo Identification of Human Small Ubiquitin-like Modifier Polymerization Sites by High Accuracy Mass Spectrometry and an in Vitro to in Vivo Strategy
inferredcites →https://doi.org/10.1093/jmcb/mjr020openalex-snapshot
SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation
inferredcites →https://doi.org/10.1093/nar/24.11.2005openalex-snapshot
Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9
inferredcites →https://doi.org/10.1093/nar/gkg277openalex-snapshot
A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases
inferredcites →https://doi.org/10.1093/nar/gku383openalex-snapshot
GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs
inferredcites →https://doi.org/10.1099/0022-1317-77-11-2729openalex-snapshot
Characterization of RNA synthesis during a one-step growth curve and of the replication mechanism of bovine viral diarrhoea virus
inferredcites →https://doi.org/10.1099/vir.0.024984-0openalex-snapshot
Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2
inferredcites →https://doi.org/10.1099/vir.0.80784-0openalex-snapshot
Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys
inferredcites →https://doi.org/10.1128/jvi.00223-16openalex-snapshot
SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5 To Support Virus Replication
inferredcites →https://doi.org/10.1128/jvi.00459-10openalex-snapshot
Role of Noncovalent SUMO Binding by the Human Cytomegalovirus IE2 Transactivator in Lytic Growth
inferredcites →https://doi.org/10.1128/jvi.00509-14openalex-snapshot
Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Growth
inferredcites →https://doi.org/10.1128/jvi.00647-08openalex-snapshot
Crystal Structure of Coxsackievirus B3 3D pol Highlights the Functional Importance of Residue 5 in Picornavirus Polymerases
inferredcites →https://doi.org/10.1128/jvi.00877-10openalex-snapshot
Modification of Nonstructural Protein 1 of Influenza A Virus by SUMO1
inferredcites →https://doi.org/10.1128/jvi.01626-10openalex-snapshot
Antiviral Effects of a Transgenic RNA-Dependent RNA Polymerase
inferredcites →https://doi.org/10.1128/jvi.02085-14openalex-snapshot
Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation
inferredcites →https://doi.org/10.1128/jvi.02401-10openalex-snapshot
The SUMOylation of Matrix Protein M1 Modulates the Assembly and Morphogenesis of Influenza A Virus
inferredcites →https://doi.org/10.1128/jvi.02655-12openalex-snapshot
Human MicroRNA hsa-miR-296-5p Suppresses Enterovirus 71 Replication by Targeting the Viral Genome
inferredcites →https://doi.org/10.1128/jvi.02828-12openalex-snapshot
SCE1, the SUMO-Conjugating Enzyme in Plants That Interacts with NIb, the RNA-Dependent RNA Polymerase of Turnip Mosaic Virus, Is Required for Viral Infection
inferredcites →https://doi.org/10.1128/jvi.05628-11openalex-snapshot
Regulation of Vaccinia Virus E3 Protein by Small Ubiquitin-Like Modifier Proteins
inferredcites →https://doi.org/10.1128/jvi.06227-11openalex-snapshot
Human Pathogens and the Host Cell SUMOylation System
inferredcites →https://doi.org/10.1128/jvi.74.6.2510-2524.2000openalex-snapshot
Covalent Modification of the Transactivator Protein IE2-p86 of Human Cytomegalovirus by Conjugation to the Ubiquitin-Homologous Proteins SUMO-1 and hSMT3b
inferredcites →https://doi.org/10.1128/jvi.78.14.7803-7812.2004openalex-snapshot
SUMOylation of the Human Cytomegalovirus 72-Kilodalton IE1 Protein Facilitates Expression of the 86-Kilodalton IE2 Protein and Promotes Viral Replication
inferredcites →https://doi.org/10.1128/jvi.79.15.9912-9925.2005openalex-snapshot
Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Represses Gene Transcription via SUMO Modification
inferredcites →https://doi.org/10.1128/jvi.79.2.910-917.2005openalex-snapshot
Covalent Modification of Human Immunodeficiency Virus Type 1 p6 by SUMO-1
inferredcites →https://doi.org/10.1194/jlr.m035774openalex-snapshot
Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor
inferredcites →https://doi.org/10.1242/jcs.050542openalex-snapshot
SUMOylation and deSUMOylation at a glance
inferredcites →https://doi.org/10.1242/jcs.093567openalex-snapshot
Non-canonical ubiquitin-based signals for proteasomal degradation
inferredcites →https://doi.org/10.1261/rna.528007openalex-snapshot
Improved native affinity purification of RNA
inferredcites →https://doi.org/10.1371/journal.pone.0002585openalex-snapshot
Ubiquitination Is Required for Effective Replication of Coxsackievirus B3
inferredcites →https://doi.org/10.1371/journal.pone.0008794openalex-snapshot
A Role for Non-Covalent SUMO Interaction Motifs in Pc2/CBX4 E3 Activity
inferredcites →https://doi.org/10.1371/journal.pone.0049630openalex-snapshot
The Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Is Modified by SUMO in a DNA-Dependent Manner
inferredcites →https://doi.org/10.1371/journal.pone.0102157openalex-snapshot
Versatile Recombinant SUMOylation System for the Production of SUMO-Modified Protein
inferredcites →https://doi.org/10.1371/journal.ppat.1003506openalex-snapshot
Kaposi's Sarcoma-Associated Herpesvirus K-Rta Exhibits SUMO-Targeting Ubiquitin Ligase (STUbL) Like Activity and Is Essential for Viral Reactivation
inferredcites →https://doi.org/10.21769/bioprotoc.1374openalex-snapshot
Analysis of Protein Stability by the Cycloheximide Chase Assay
inferredcites →https://doi.org/10.4049/jimmunol.1100285openalex-snapshot
Enterovirus 71 2C Protein Inhibits TNF-α–Mediated Activation of NF-κB by Suppressing IκB Kinase β Phosphorylation
inferredcites →https://doi.org/10.4049/jimmunol.1202933openalex-snapshot
Human Bocavirus VP2 Upregulates IFN-β Pathway by Inhibiting Ring Finger Protein 125–Mediated Ubiquitination of Retinoic Acid–Inducible Gene-I
inferredcites →https://doi.org/10.4161/cc.24332openalex-snapshot
Expanding SUMO and ubiquitin-mediated signaling through hybrid SUMO-ubiquitin chains and their receptors
inferredcites →https://doi.org/10.5501/wjv.v2.i2.79openalex-snapshot
Viral manipulation of cellular protein conjugation pathways: The SUMO lesson

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.5127625openalex-extracted
Enhancement of Reactive Oxygen Species Metabolism by Antioxidant Enzyme Cu/Zn-Sod Can Block Betanodavirus-Induced Necroptosis and Suppress Viral Replication in Fish Cells
inferred← citeshttps://doi.org/10.1002/jmv.27246openalex-snapshot
Regulatory effect of m6A modification on different viruses
inferred← citeshttps://doi.org/10.1002/wrna.1810openalex-snapshot
Ghost authors revealed: The structure and function of human N6 ‐methyladenosine RNA methyltransferases
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SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends
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An improved method for identifying SUMOylation sites of viral proteins
inferred← citeshttps://doi.org/10.1007/s12250-020-00314-2openalex-snapshot
Sumoylation of Human Parainfluenza Virus Type 3 Phosphoprotein Correlates with A Reduction in Viral Replication
inferred← citeshttps://doi.org/10.1007/s12250-021-00417-4openalex-snapshot
ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles
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Proteomic and phosphoproteomic analysis of responses to enterovirus A71 infection reveals novel targets for antiviral and viral replication
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Epitranscriptomic regulation of host–virus interactions
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Direct-acting antivirals and host-targeting strategies to combat enterovirus infections
inferred← citeshttps://doi.org/10.1016/j.fsi.2025.110344openalex-snapshot
Enhancement of reactive oxygen species metabolism by antioxidant enzyme Cu/Zn-SOD can block betanodavirus-induced necroptosis and suppress viral replication in fish cells
inferred← citeshttps://doi.org/10.1016/j.gendis.2022.08.018openalex-snapshot
Multilevel regulation of N6-methyladenosine RNA modifications: Implications in tumorigenesis and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.meegid.2026.105928openalex-snapshot
Molecular epidemiological and genetic characteristics of coxsackievirus A6 circulating in mainland China from 1992 to 2023
inferred← citeshttps://doi.org/10.1016/j.tim.2021.12.011openalex-snapshot
Mitochondria-mediated oxidative stress during viral infection
inferred← citeshttps://doi.org/10.1016/j.virol.2026.111059openalex-snapshot
SUMO1 modification stabilizes polymerase protein VP1 of Blotched Snakehead Virus
inferred← citeshttps://doi.org/10.1016/j.virs.2024.05.002openalex-snapshot
NSUN2 mediates distinct pathways to regulate enterovirus 71 replication
inferred← citeshttps://doi.org/10.1016/j.virs.2024.06.009openalex-snapshot
AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase
inferred← citeshttps://doi.org/10.1073/pnas.2423465122openalex-snapshot
Co-opted SUMO machinery promotes condensate formation associated with membranous replication organelles of a positive-strand RNA virus
inferred← citeshttps://doi.org/10.1073/pnas.2608455123openalex-snapshot
The EV-A71 RNA-binding protein Matrin 3 facilitates viral replication by stabilizing viral RNA via ZDHHC20-mediated palmitoylation
inferred← citeshttps://doi.org/10.1080/15476286.2019.1620060openalex-snapshot
N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction
inferred← citeshttps://doi.org/10.1080/21505594.2024.2333562openalex-snapshot
The multiple roles of viral 3D pol protein in picornavirus infections
inferred← citeshttps://doi.org/10.1093/nar/gkac675openalex-snapshot
N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71
inferred← citeshttps://doi.org/10.1093/nar/gkad823openalex-snapshot
ATM, KAP1 and the Epstein–Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication
inferred← citeshttps://doi.org/10.1093/nar/gky1007openalex-snapshot
N 6-methyladenosine modification and METTL3 modulate enterovirus 71 replication
inferred← citeshttps://doi.org/10.1093/nar/gkz1170openalex-snapshot
A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability
inferred← citeshttps://doi.org/10.1093/procel/pwag003openalex-snapshot
NSUN2‑mediated epitranscriptomic and ubiquitin modulation of Nipah virus matrix protein reveals a dual-targeting antiviral strategy
inferred← citeshttps://doi.org/10.1105/tpc.16.00774openalex-snapshot
Sumoylation of Turnip mosaic virus RNA Polymerase Promotes Viral Infection by Counteracting the Host NPR1-Mediated Immune Response
inferred← citeshttps://doi.org/10.1111/nph.17370openalex-snapshot
Carrot mottle virus ORF4 movement protein targets plasmodesmata by interacting with the host cell SUMOylation system
inferred← citeshttps://doi.org/10.1128/jvi.00030-25openalex-snapshot
ZYG11B suppresses multiple enteroviruses by triggering viral VP1 degradation
inferred← citeshttps://doi.org/10.1128/jvi.00598-22openalex-snapshot
Neddylation of Enterovirus 71 VP2 Protein Reduces Its Stability and Restricts Viral Replication
inferred← citeshttps://doi.org/10.1128/jvi.00806-17openalex-snapshot
The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency
inferred← citeshttps://doi.org/10.1128/jvi.02227-18openalex-snapshot
SUMO1 Modification Facilitates Avibirnavirus Replication by Stabilizing Polymerase VP1
inferred← citeshttps://doi.org/10.1128/mbio.01067-21openalex-snapshot
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication
inferred← citeshttps://doi.org/10.1155/2021/5564099openalex-snapshot
Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China
inferred← citeshttps://doi.org/10.1186/s12974-018-1311-5openalex-snapshot
ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells
inferred← citeshttps://doi.org/10.1186/s13099-022-00481-5openalex-snapshot
Curcumin assists anti-EV71 activity of IFN-α by inhibiting IFNAR1 reduction in SH-SY5Y cells
inferred← citeshttps://doi.org/10.1371/journal.ppat.1008970openalex-snapshot
E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase
inferred← citeshttps://doi.org/10.1371/journal.ppat.1010446openalex-snapshot
PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence
inferred← citeshttps://doi.org/10.1371/journal.ppat.1012130openalex-snapshot
Classical swine fever virus non-structural protein 5B hijacks host METTL14-mediated m6A modification to counteract host antiviral immune response
inferred← citeshttps://doi.org/10.1371/journal.ppat.1012594openalex-snapshot
TRIM56 restricts Coxsackievirus B infection by mediating the ubiquitination of viral RNA-dependent RNA polymerase 3D
inferred← citeshttps://doi.org/10.3389/fimmu.2021.750969openalex-snapshot
SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1365521openalex-snapshot
Multiple functions of the nonstructural protein 3D in picornavirus infection
inferred← citeshttps://doi.org/10.3389/fmicb.2018.00286openalex-snapshot
Enterovirus A71 Proteins: Structure and Function
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00417openalex-snapshot
N6-Methyladenosine and Viral Infection
inferred← citeshttps://doi.org/10.3389/fmicb.2024.1341599openalex-snapshot
Role of protein Post-translational modifications in enterovirus infection
inferred← citeshttps://doi.org/10.3389/fmicb.2025.1621137openalex-snapshot
Host SUMOylation in bacterial infections and immune defense mechanisms
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1775950openalex-snapshot
CBX4 facilitates EV71 replication by SUMOylation and stabilizing 3D polymerase
inferred← citeshttps://doi.org/10.3390/ijms22010323openalex-snapshot
Role of Host-Mediated Post-Translational Modifications (PTMs) in RNA Virus Pathogenesis
inferred← citeshttps://doi.org/10.3390/ijms26167992openalex-snapshot
Hijacking the Host Cell for Replication: Pro-Viral Host Factors Involved in EVA71 Infection
inferred← citeshttps://doi.org/10.3390/v10120674openalex-snapshot
Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy
inferred← citeshttps://doi.org/10.3390/v11010013openalex-snapshot
Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein
inferred← citeshttps://doi.org/10.3390/v13071360openalex-snapshot
Coxsackievirus B3 Exploits the Ubiquitin-Proteasome System to Facilitate Viral Replication
inferred← citeshttps://doi.org/10.3390/v16091448openalex-snapshot
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication
inferred← citeshttps://doi.org/10.3390/v17020181openalex-snapshot
Insight into the Life Cycle of Enterovirus-A71
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