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TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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DC-SIGN and DC-SIGNR Bind Ebola Glycoproteins and Enhance Infection of Macrophages and Endothelial Cells
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Technical innovations for the automated identification of gel-separated proteins by MALDI-TOF mass spectrometry
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TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds
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Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research
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Expression cloning of functional receptor used by SARS coronavirus
inferredcites →https://doi.org/10.1016/j.pharmthera.2010.06.003openalex-snapshot
Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters
inferredcites →https://doi.org/10.1016/j.tim.2004.08.008openalex-snapshot
Cellular entry of the SARS coronavirus
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SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells
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Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.
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A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells
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Angiotensin-Converting Enzyme 2 Ectodomain Shedding Cleavage-Site Identification: Determinants and Constraints
inferredcites →https://doi.org/10.1021/bi9602425openalex-snapshot
Proteolytic Release of Membrane-Bound Angiotensin-Converting Enzyme: Role of the Juxtamembrane Stalk Sequence
inferredcites →https://doi.org/10.1038/357417a0openalex-snapshot
Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV
inferredcites →https://doi.org/10.1038/nature02145openalex-snapshot
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
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Angiotensin-converting enzyme 2 protects from severe acute lung failure
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
inferredcites →https://doi.org/10.1038/nm1024openalex-snapshot
Identification of a new human coronavirus
inferredcites →https://doi.org/10.1038/nm1143openalex-snapshot
Severe acute respiratory syndrome
inferredcites →https://doi.org/10.1038/nm1267openalex-snapshot
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
inferredcites →https://doi.org/10.1038/nmeth.2089openalex-snapshot
NIH Image to ImageJ: 25 years of image analysis
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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
inferredcites →https://doi.org/10.1073/pnas.0409465102openalex-snapshot
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
inferredcites →https://doi.org/10.1073/pnas.0503203102openalex-snapshot
Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection
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Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
inferredcites →https://doi.org/10.1073/pnas.0506735102openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.0711241105openalex-snapshot
Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry
inferredcites →https://doi.org/10.1073/pnas.1432869100openalex-snapshot
Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
inferredcites →https://doi.org/10.1074/jbc.274.15.10511openalex-snapshot
Unaltered Cleavage and Secretion of Angiotensin-converting Enzyme in Tumor Necrosis Factor-α-converting Enzyme-deficient Mice
inferredcites →https://doi.org/10.1074/jbc.c300520200openalex-snapshot
A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2
inferredcites →https://doi.org/10.1074/jbc.m505111200openalex-snapshot
Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)
inferredcites →https://doi.org/10.1086/430301openalex-snapshot
Human Coronavirus NL63 Infection and Other Coronavirus Infections in Children Hospitalized with Acute Respiratory Disease in Hong Kong, China
inferredcites →https://doi.org/10.1086/597122openalex-snapshot
Human Coronavirus and Acute Respiratory Illness in Older Adults with Chronic Obstructive Pulmonary Disease
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Severity and Outcome Associated With Human Coronavirus OC43 Infections Among Children
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Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China
inferredcites →https://doi.org/10.1126/science.1118391openalex-snapshot
Bats Are Natural Reservoirs of SARS-Like Coronaviruses
inferredcites →https://doi.org/10.1128/jvi.00094-12openalex-snapshot
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inferredcites →https://doi.org/10.1128/jvi.00128-13openalex-snapshot
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inferredcites →https://doi.org/10.1128/jvi.00239-10openalex-snapshot
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inferredcites →https://doi.org/10.1128/jvi.00676-08openalex-snapshot
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inferredcites →https://doi.org/10.1128/jvi.01118-06openalex-snapshot
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inferredcites →https://doi.org/10.1128/jvi.01248-09openalex-snapshot
Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63
inferredcites →https://doi.org/10.1128/jvi.01542-10openalex-snapshot
Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2
inferredcites →https://doi.org/10.1128/jvi.02062-10openalex-snapshot
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
inferredcites →https://doi.org/10.1128/jvi.02205-08openalex-snapshot
Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin
inferredcites →https://doi.org/10.1128/jvi.02232-10openalex-snapshot
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
inferredcites →https://doi.org/10.1128/jvi.02744-05openalex-snapshot
Conformational States of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Ectodomain
inferredcites →https://doi.org/10.1128/jvi.03372-12openalex-snapshot
TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium
inferredcites →https://doi.org/10.1128/jvi.05300-11openalex-snapshot
Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease
inferredcites →https://doi.org/10.1128/jvi.78.12.6134-6142.2004openalex-snapshot
S Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Mediates Entry into Hepatoma Cell Lines and Is Targeted by Neutralizing Antibodies in Infected Patients
inferredcites →https://doi.org/10.1128/jvi.79.2.884-895.2005openalex-snapshot
Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia
inferredcites →https://doi.org/10.1136/bmj.3.5568.767openalex-snapshot
Effects of a "new" human respiratory virus in volunteers.
inferredcites →https://doi.org/10.1152/ajpcell.00036.2009openalex-snapshot
Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor α-converting enzyme
inferredcites →https://doi.org/10.1152/ajplung.00071.2009openalex-snapshot
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
inferredcites →https://doi.org/10.1165/ajrcmb.16.3.9070615openalex-snapshot
Purification, Characterization, and Localization of a Novel Trypsin-Like Protease Found in the Human Airway
inferredcites →https://doi.org/10.1186/1471-2334-12-365openalex-snapshot
Coronavirus infections in hospitalized pediatric patients with acute respiratory tract disease
inferredcites →https://doi.org/10.1242/jcs.069997openalex-snapshot
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site
inferredcites →https://doi.org/10.1371/journal.pone.0035876openalex-snapshot
Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts
inferredcites →https://doi.org/10.4103/1658-600x.120856openalex-snapshot
Status of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the Kingdom of Saudi Arabia

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/s13365-025-01267-6openalex-snapshot
Association between Guillain-Barré syndrome and SARS-CoV-2 virus infection, including the impact of COVID-19 vaccination in the context of the development and general clinical characteristics of the disease
inferred← citeshttps://doi.org/10.1007/s13365-025-01282-7openalex-snapshot
The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.1007/s40199-020-00359-4openalex-snapshot
Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection
inferred← citeshttps://doi.org/10.1007/s40618-023-02141-0openalex-snapshot
Combination of spironolactone and sitagliptin improves clinical outcomes of outpatients with COVID-19: a prospective cohort study
inferred← citeshttps://doi.org/10.1007/s40820-021-00771-8openalex-snapshot
From Bench to the Clinic: The Path to Translation of Nanotechnology-Enabled mRNA SARS-CoV-2 Vaccines
inferred← citeshttps://doi.org/10.1007/s42399-021-00985-2openalex-snapshot
“Post Coronavirus Disease (COVID-19) Reactivation of a Quiescent Unilateral Anterior Uveitis”
inferred← citeshttps://doi.org/10.1007/s42485-021-00074-xopenalex-snapshot
Therapeutically effective covalent spike protein inhibitors in treatment of SARS-CoV-2
inferred← citeshttps://doi.org/10.1007/s43032-020-00261-zopenalex-snapshot
SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology
inferred← citeshttps://doi.org/10.1007/s43032-025-01921-8openalex-snapshot
Placenta – A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier
inferred← citeshttps://doi.org/10.1016/b978-0-08-102723-3.00073-1openalex-snapshot
Serine Proteinases: Overview
inferred← citeshttps://doi.org/10.1016/b978-0-12-394447-4.10076-8openalex-snapshot
Extracellular: Plasma Membrane Proteases – Serine Proteases
inferred← citeshttps://doi.org/10.1016/b978-0-12-801364-9.00031-6openalex-snapshot
ACE2 and Glycemic Control
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00036-5openalex-snapshot
Extracellular: Plasma Membrane Proteases – Serine Proteases
inferred← citeshttps://doi.org/10.1016/b978-0-323-95374-0.00014-2openalex-snapshot
Understanding the molecular basis of pathogenesis of SARS-CoV-2
inferred← citeshttps://doi.org/10.1016/b978-0-323-99618-1.00021-0openalex-snapshot
ACE2 in pulmonary diseases
inferred← citeshttps://doi.org/10.1016/b978-0-323-99618-1.00023-4openalex-snapshot
Transgenic animal models for the functional analysis of ACE2
inferred← citeshttps://doi.org/10.1016/b978-0-323-99878-9.00012-1openalex-snapshot
COVID-19: Origin, epidemiology, virology, pathogenesis, and treatment
inferred← citeshttps://doi.org/10.1016/b978-0-443-18566-3.00041-4openalex-snapshot
Innate immune responses in COVID-19
inferred← citeshttps://doi.org/10.1016/b978-0-443-19170-1.00052-8openalex-snapshot
SARS-CoV-1, SARS-CoV-2, and MERS-CoV: Similarities and differences in origin and transmission
inferred← citeshttps://doi.org/10.1016/bs.aivir.2016.08.005openalex-snapshot
Supramolecular Architecture of the Coronavirus Particle
inferred← citeshttps://doi.org/10.1016/j.advms.2023.10.010openalex-snapshot
A comprehensive review of ACE2, ACE1, TMPRSS2 and IFITM3 gene polymorphisms and their effect on the severity of COVID-19
inferred← citeshttps://doi.org/10.1016/j.ajmo.2024.100068openalex-snapshot
Long COVID Definition, Symptoms, Risk Factors, Epidemiology and Autoimmunity: A Narrative Review
inferred← citeshttps://doi.org/10.1016/j.ajpath.2021.04.010openalex-snapshot
ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients
inferred← citeshttps://doi.org/10.1016/j.ajpath.2021.05.010openalex-snapshot
Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
inferred← citeshttps://doi.org/10.1016/j.antiviral.2021.105115openalex-snapshot
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo
inferred← citeshttps://doi.org/10.1016/j.apsb.2020.10.006openalex-snapshot
Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator
inferred← citeshttps://doi.org/10.1016/j.apsb.2025.03.011openalex-snapshot
Overview of host-directed antiviral targets for future research and drug development
inferred← citeshttps://doi.org/10.1016/j.arabjc.2021.103092openalex-snapshot
Structure- and Ligand-Based in silico Studies towards the Repurposing of Marine Bioactive Compounds to Target SARS-CoV-2
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2021.105201openalex-snapshot
Altered expression of SARS-CoV-2 entry and processing genes by Porphyromonas gingivalis-derived lipopolysaccharide, inflammatory cytokines and prostaglandin E2 in human gingival fibroblasts
inferred← citeshttps://doi.org/10.1016/j.avsg.2024.06.039openalex-snapshot
Increased Risk of Acute Aortic Events following COVID-19 and Influenza Respiratory Viral Infections
inferred← citeshttps://doi.org/10.1016/j.bbadis.2021.166248openalex-snapshot
COVID-19 in pregnancy: What we know from the first year of the pandemic
inferred← citeshttps://doi.org/10.1016/j.bbadva.2022.100044openalex-snapshot
The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.08.040openalex-snapshot
A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.09.015openalex-snapshot
Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.01.038openalex-snapshot
How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17
inferred← citeshttps://doi.org/10.1016/j.bcab.2021.102056openalex-snapshot
Evidence-based traditional Siddha formulations for prophylaxis and management of respiratory symptoms in COVID-19 pandemic-a review
inferred← citeshttps://doi.org/10.1016/j.beem.2022.101662openalex-snapshot
Morbidity and mortality in men: Role of androgens
inferred← citeshttps://doi.org/10.1016/j.biochi.2017.07.016openalex-snapshot
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
inferred← citeshttps://doi.org/10.1016/j.biochi.2020.05.012openalex-snapshot
SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
inferred← citeshttps://doi.org/10.1016/j.biochi.2020.11.010openalex-snapshot
The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response
inferred← citeshttps://doi.org/10.1016/j.biochi.2024.02.006openalex-snapshot
Cytoskeletal β-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y
inferred← citeshttps://doi.org/10.1016/j.biochi.2024.05.004openalex-snapshot
In silico evidence that substitution of glycine for valine (p.G8V) in a common variant of TMPRSS2 isoform 1 increases accessibility to an endocytic signal: Implication for SARS-cov-2 entry into host cells and susceptibility to COVID-19
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110678openalex-snapshot
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110891openalex-snapshot
Decoding the silent walk of COVID-19: Halting its spread using old bullets
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.111193openalex-snapshot
Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112420openalex-snapshot
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.112718openalex-snapshot
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)
inferred← citeshttps://doi.org/10.1016/j.bj.2021.04.006openalex-snapshot
Role of SARS-CoV-2 and ACE2 variations in COVID-19
inferred← citeshttps://doi.org/10.1016/j.bpj.2020.08.022openalex-snapshot
The inhibitory effect of a coronavirus spike protein fragment with ACE2
inferred← citeshttps://doi.org/10.1016/j.cardfail.2020.05.006openalex-snapshot
Unique Patterns of Cardiovascular Involvement in Coronavirus Disease-2019
inferred← citeshttps://doi.org/10.1016/j.carpath.2020.107278openalex-snapshot
Current state of vaccine development and targeted therapies for COVID-19: impact of basic science discoveries
inferred← citeshttps://doi.org/10.1016/j.cbi.2022.110161openalex-snapshot
Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approaches
inferred← citeshttps://doi.org/10.1016/j.cca.2021.04.022openalex-snapshot
Clinical laboratory evaluation of COVID-19
inferred← citeshttps://doi.org/10.1016/j.cell.2021.03.036openalex-snapshot
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
inferred← citeshttps://doi.org/10.1016/j.cell.2024.06.006openalex-snapshot
Human coronavirus HKU1 recognition of the TMPRSS2 host receptor
inferred← citeshttps://doi.org/10.1016/j.cellimm.2023.104705openalex-snapshot
Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells
inferred← citeshttps://doi.org/10.1016/j.chembiol.2021.06.008openalex-snapshot
SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET
inferred← citeshttps://doi.org/10.1016/j.chmed.2020.03.004openalex-snapshot
Pay attention to situation of SARS-CoV-2 and TCM advantages in treatment of novel coronavirus infection
inferred← citeshttps://doi.org/10.1016/j.cmi.2020.05.019openalex-snapshot
Review of trials currently testing treatment and prevention of COVID-19
inferred← citeshttps://doi.org/10.1016/j.csbj.2020.08.002openalex-snapshot
ACE2 enhance viral infection or viral infection aggravate the underlying diseases
inferred← citeshttps://doi.org/10.1016/j.csbj.2020.08.016openalex-snapshot
Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2
inferred← citeshttps://doi.org/10.1016/j.csbj.2021.03.023openalex-snapshot
SARS-CoV-2 infection and smoking: What is the association? A brief review
inferred← citeshttps://doi.org/10.1016/j.ctarc.2020.100285openalex-snapshot
Cancer patients and COVID-19: Mortality, serious complications, biomarkers, and ways forward
inferred← citeshttps://doi.org/10.1016/j.cyto.2020.155228openalex-snapshot
A combinational approach to restore cytokine balance and to inhibit virus growth may promote patient recovery in severe COVID-19 cases
inferred← citeshttps://doi.org/10.1016/j.diamond.2022.109149openalex-snapshot
Functionalized SPION immobilized on graphene-oxide: Anticancer and antiviral study
inferred← citeshttps://doi.org/10.1016/j.earlhumdev.2020.105074openalex-snapshot
Understanding COVID-19: Digit ratio (2D:4D) and sex differences in national case fatality rates
inferred← citeshttps://doi.org/10.1016/j.earlhumdev.2020.105272openalex-snapshot
No credible evidence for links between 2D:4D and COVID-19 outcomes: A probabilistic perspective on digit ratio, ACE variants, and national case fatalities
inferred← citeshttps://doi.org/10.1016/j.ebiom.2020.102907openalex-snapshot
SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy
inferred← citeshttps://doi.org/10.1016/j.ebiom.2020.103182openalex-snapshot
SARS-CoV-2 leads to a small vessel endotheliitis in the heart
inferred← citeshttps://doi.org/10.1016/j.ebiom.2024.105415openalex-snapshot
Cross-sectional and longitudinal genotype to phenotype surveillance of SARS-CoV-2 variants over the first four years of the COVID-19 pandemic
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117579openalex-snapshot
Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173545openalex-snapshot
Should ACE2 be given a chance in COVID-19 therapeutics: A semi-systematic review of strategies enhancing ACE2
inferred← citeshttps://doi.org/10.1016/j.ejps.2020.105495openalex-snapshot
Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages
inferred← citeshttps://doi.org/10.1016/j.etap.2020.103411openalex-snapshot
Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking
inferred← citeshttps://doi.org/10.1016/j.etap.2020.103436openalex-snapshot
Dual function of sialic acid in gastrointestinal SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2026.03.011openalex-snapshot
The role of metabolic stress, xanthine oxidase, NOX2, and redox-related signalling in regulating ACE2 protein expression in exercising human skeletal muscle
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.109217openalex-snapshot
Functional study of Cygb in the immune response to Vibrio harveyi disease in yellow drum (Nibea albiflora)
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e06133openalex-snapshot
ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e07665openalex-snapshot
The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in myalgic encephalomyelitis/chronic fatigue syndrome: A meta-analysis of public DNA methylation and gene expression data
inferred← citeshttps://doi.org/10.1016/j.hipert.2020.05.005openalex-snapshot
El SRAA y el SARS-CoV-2: el acertijo a resolver
inferred← citeshttps://doi.org/10.1016/j.hsr.2021.100011openalex-snapshot
Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2020.105950openalex-snapshot
Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2020.106208openalex-snapshot
Therapeutic modalities and novel approaches in regenerative medicine for COVID-19
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.02.203openalex-snapshot
The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.124352openalex-snapshot
Molecular insights into the inhibition mechanism of harringtonine against essential proteins associated with SARS-CoV-2 entry
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.131324openalex-snapshot
An unprecedented global challenge, emerging trends and innovations in the fight against COVID-19: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.imbio.2020.152008openalex-snapshot
Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies
inferred← citeshttps://doi.org/10.1016/j.imu.2021.100725openalex-snapshot
Identification of novel transmembrane Protease Serine Type 2 drug candidates for COVID-19 using computational studies
inferred← citeshttps://doi.org/10.1016/j.imu.2021.100758openalex-snapshot
Identification of novel TMPRSS2 inhibitors for COVID-19 using e-pharmacophore modelling, molecular docking, molecular dynamics and quantum mechanics studies
inferred← citeshttps://doi.org/10.1016/j.imu.2022.100870openalex-snapshot
Discovery of novel TMPRSS2 inhibitors for COVID-19 using in silico fragment-based drug design, molecular docking, molecular dynamics, and quantum mechanics studies
inferred← citeshttps://doi.org/10.1016/j.imu.2022.100902openalex-snapshot
Can polyoxometalates (POMs) prevent of coronavirus 2019-nCoV cell entry? Interaction of POMs with TMPRSS2 and spike receptor domain complexed with ACE2 (ACE2-RBD): Virtual screening approaches
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107406openalex-snapshot
Type 2 diabetes mellitus impaired nasal immunity and increased the risk of hyposmia in COVID-19 mild pneumonia patients
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107630openalex-snapshot
Immunopharmacological perspective on zinc in SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101585openalex-snapshot
SARS-CoV-2 Infection Boosts MX1 Antiviral Effector in COVID-19 Patients
inferred← citeshttps://doi.org/10.1016/j.isci.2020.102021openalex-snapshot
A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening
inferred← citeshttps://doi.org/10.1016/j.isci.2021.102254openalex-snapshot
Targeting Androgen Regulation of TMPRSS2 and ACE2 as a Therapeutic Strategy to Combat COVID-19
inferred← citeshttps://doi.org/10.1016/j.isci.2021.102420openalex-snapshot
Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2
inferred← citeshttps://doi.org/10.1016/j.isci.2021.102770openalex-snapshot
ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105316openalex-snapshot
Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105701openalex-snapshot
Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes
inferred← citeshttps://doi.org/10.1016/j.jaad.2020.04.032openalex-snapshot
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated
inferred← citeshttps://doi.org/10.1016/j.jaci.2020.05.033openalex-snapshot
Molecular mechanisms and epidemiology of COVID-19 from an allergist’s perspective
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104820openalex-snapshot
Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.105201openalex-snapshot
The endoplasmic reticulum–localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113440openalex-snapshot
Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human type II transmembrane serine proteases
inferred← citeshttps://doi.org/10.1016/j.jchromb.2025.124861openalex-snapshot
Identification of potential TMPRSS2 inhibitors via high-throughput screening based on oriented immobilized cell membrane chromatography technology
inferred← citeshttps://doi.org/10.1016/j.jff.2021.104503openalex-snapshot
Promising role of curcumin against viral diseases emphasizing COVID-19 management: A review on the mechanistic insights with reference to host-pathogen interaction and immunomodulation
inferred← citeshttps://doi.org/10.1016/j.jjcc.2020.07.013openalex-snapshot
COVID-19 and cardiovascular diseases
inferred← citeshttps://doi.org/10.1016/j.jmgm.2020.107697openalex-snapshot
Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment
inferred← citeshttps://doi.org/10.1016/j.job.2022.04.004openalex-snapshot
Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
inferred← citeshttps://doi.org/10.1016/j.jpha.2021.12.003openalex-snapshot
Angiotensin-converting enzyme 2 as a potential therapeutic target for COVID-19: A review
inferred← citeshttps://doi.org/10.1016/j.jvs.2021.01.051openalex-snapshot
Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118075openalex-snapshot
The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118219openalex-snapshot
Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2
inferred← citeshttps://doi.org/10.1016/j.lfs.2025.124168openalex-snapshot
The Novel Triad of Atherosclerosis, ACE2, and Dysbiosis: A literature Review
inferred← citeshttps://doi.org/10.1016/j.mayocp.2021.01.009openalex-snapshot
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms
inferred← citeshttps://doi.org/10.1016/j.mcpro.2021.100103openalex-snapshot
Proteomics-Based Insights Into the SARS-CoV-2–Mediated COVID-19 Pandemic: A Review of the First Year of Research
inferred← citeshttps://doi.org/10.1016/j.meegid.2020.104502openalex-snapshot
From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses
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