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Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.21102openalex-snapshot

The non‐immunosuppressive cyclosporin DEBIO‐025 is a potent inhibitor of hepatitis C virus replication in vitro†

inferredcites →https://doi.org/10.1002/hep.21587openalex-snapshot

Evaluation of a cyclophilin inhibitor in hepatitis C virus–infected chimeric mice in vivo†

inferredcites →https://doi.org/10.1002/hep.21809openalex-snapshot

Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B

inferredcites →https://doi.org/10.1002/pro.5560061103openalex-snapshot

Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV‐1 capsid protein

inferredcites →https://doi.org/10.1007/3-540-26764-6_5openalex-snapshot

Viral RNA Replication in Association with Cellular Membranes

inferredcites →https://doi.org/10.1007/s00018-006-6215-3openalex-snapshot

Immunophilins: for the love of proteins

inferredcites →https://doi.org/10.1016/0014-5793(91)81258-aopenalex-snapshot

NMR studies of [U‐13C]cyclosporin A bound to human cyclophilin B

inferredcites →https://doi.org/10.1016/0014-5793(94)00794-2openalex-snapshot

GRP78 induction by cyclosporin A in human HeLa cells

inferredcites →https://doi.org/10.1016/0092-8674(86)90746-4openalex-snapshot

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

inferredcites →https://doi.org/10.1016/0092-8674(91)90124-hopenalex-snapshot

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

inferredcites →https://doi.org/10.1016/0092-8674(93)90637-6openalex-snapshot

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

inferredcites →https://doi.org/10.1016/j.bbrc.2003.11.080openalex-snapshot

Specific inhibition of hepatitis C virus replication by cyclosporin A

inferredcites →https://doi.org/10.1016/j.mib.2006.06.011openalex-snapshot

Cyclophilin, TRIM5, and innate immunity to HIV-1

inferredcites →https://doi.org/10.1016/j.molcel.2005.04.004openalex-snapshot

Identification of FBL2 As a Geranylgeranylated Cellular Protein Required for Hepatitis C Virus RNA Replication

inferredcites →https://doi.org/10.1016/j.molcel.2005.05.014openalex-snapshot

Cyclophilin B Is a Functional Regulator of Hepatitis C Virus RNA Polymerase

inferredcites →https://doi.org/10.1016/s0021-9258(18)54484-7openalex-snapshot

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

inferredcites →https://doi.org/10.1016/s0092-8674(00)81823-1openalex-snapshot

Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid

inferredcites →https://doi.org/10.1016/s0969-2126(97)00172-xopenalex-snapshot

Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity

inferredcites →https://doi.org/10.1038/332462a0openalex-snapshot

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

inferredcites →https://doi.org/10.1038/361091a0openalex-snapshot

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

inferredcites →https://doi.org/10.1038/nature02777openalex-snapshot

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

inferredcites →https://doi.org/10.1038/nature04077openalex-snapshot

Unravelling hepatitis C virus replication from genome to function

inferredcites →https://doi.org/10.1038/nm1268openalex-snapshot

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

inferredcites →https://doi.org/10.1038/sj.emboj.7601367openalex-snapshot

Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90

inferredcites →https://doi.org/10.1053/j.gastro.2005.06.031openalex-snapshot

Suppression of Hepatitis C Virus Replication by Cyclosporin A Is Mediated by Blockade of Cyclophilins

inferredcites →https://doi.org/10.1053/jhep.2003.50449openalex-snapshot

Cyclosporin A Suppresses Replication of Hepatitis C Virus Genome in Cultured Hepatocytes

inferredcites →https://doi.org/10.1073/pnas.0405152101openalex-snapshot

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

inferredcites →https://doi.org/10.1073/pnas.0503596102openalex-snapshot

Robust hepatitis C virus infection in vitro

inferredcites →https://doi.org/10.1073/pnas.0510727103openalex-snapshot

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells

inferredcites →https://doi.org/10.1073/pnas.90.24.11850openalex-snapshot

Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A.

inferredcites →https://doi.org/10.1073/pnas.91.11.5183openalex-snapshot

X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.

inferredcites →https://doi.org/10.1074/jbc.m305684200openalex-snapshot

Hepatitis C Virus Non-structural Proteins in the Probable Membranous Compartment Function in Viral Genome Replication

inferredcites →https://doi.org/10.1093/emboj/20.6.1300openalex-snapshot

Cyclophilin A regulates HIV‐1 infectivity, as demonstrated by gene targeting in human T cells

inferredcites →https://doi.org/10.1126/science.1114016openalex-snapshot

Complete Replication of Hepatitis C Virus in Cell Culture

inferredcites →https://doi.org/10.1126/science.6238408openalex-snapshot

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

inferredcites →https://doi.org/10.1128/aac.00310-06openalex-snapshot

NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

inferredcites →https://doi.org/10.1128/jvi.00032-07openalex-snapshot

Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras

inferredcites →https://doi.org/10.1128/jvi.01366-06openalex-snapshot

Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication Machinery

inferredcites →https://doi.org/10.1128/jvi.01519-06openalex-snapshot

Cyclophilin A, TRIM5, and Resistance to Human Immunodeficiency Virus Type 1 Infection

inferredcites →https://doi.org/10.1128/jvi.02524-06openalex-snapshot

Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro

inferredcites →https://doi.org/10.1128/jvi.71.3.2107-2113.1997openalex-snapshot

The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein

inferredcites →https://doi.org/10.1128/jvi.77.9.5487-5492.2003openalex-snapshot

Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

inferredcites →https://doi.org/10.1128/jvi.78.14.7400-7409.2004openalex-snapshot

Insertion of Green Fluorescent Protein into Nonstructural Protein 5A Allows Direct Visualization of Functional Hepatitis C Virus Replication Complexes

inferredcites →https://doi.org/10.1128/jvi.78.23.12829-12837.2004openalex-snapshot

Identification of Cellular Cofactors for Human Immunodeficiency Virus Replication via a Ribozyme-Based Genomics Approach

inferredcites →https://doi.org/10.1128/jvi.79.21.13473-13482.2005openalex-snapshot

Human VAP-B Is Involved in Hepatitis C Virus Replication through Interaction with NS5A and NS5B

inferredcites →https://doi.org/10.1128/jvi.79.21.13594-13605.2005openalex-snapshot

Quantitative Analysis of the Hepatitis C Virus Replication Complex

inferredcites →https://doi.org/10.1128/jvi.79.22.13963-13973.2005openalex-snapshot

Robust Production of Infectious Hepatitis C Virus (HCV) from Stably HCV cDNA-Transfected Human Hepatoma Cells

inferredcites →https://doi.org/10.1128/jvi.80.3.1181-1190.2006openalex-snapshot

Effect of Cell Growth on Hepatitis C Virus (HCV) Replication and a Mechanism of Cell Confluence-Based Inhibition of HCV RNA and Protein Expression

inferredcites →https://doi.org/10.1128/jvi.80.9.4510-4520.2006openalex-snapshot

Diverse Effects of Cyclosporine on Hepatitis C Virus Strain Replication

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Drug Repurposing Screens Reveal FDA Approved Drugs Active Against SARS-CoV-2

inferred← citeshttps://doi.org/10.1002/9780470929353.ch22openalex-snapshot

Discovery of Cyclophilin Inhibitor NIM811 as a Novel Therapeutic Agent for HCV

inferred← citeshttps://doi.org/10.1002/9783527635955.ch7openalex-snapshot

Cyclophilin Inhibitors

inferred← citeshttps://doi.org/10.1002/hep.22987openalex-snapshot

Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A #

inferred← citeshttps://doi.org/10.1002/hep.23026openalex-snapshot

Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase #

inferred← citeshttps://doi.org/10.1002/hep.23281openalex-snapshot

Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A #

inferred← citeshttps://doi.org/10.1002/hep.26982openalex-snapshot

Cyclosporin A and Its Analogs Inhibit Hepatitis B Virus Entry Into Cultured Hepatocytes Through Targeting a Membrane Transporter, Sodium Taurocholate Cotransporting Polypeptide (NTCP)

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Prevalence of hepatitis B and C and risk factors for nonvaccination in inflammatory bowel disease patients in Northeast France

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Calcineurin inhibitor tacrolimus does not interfere with the suppression of hepatitis C virus infection by interferon-α

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Antiviral drug discovery: Ten more compounds, and ten more stories (part B)

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The race for interferon‐free HCV therapies: a snapshot by the spring of 2012

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The Hepatitis C Virus Replicon System and Its Role in Drug Development

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RNAi as Antiviral Therapy: The HIV-1 Case

inferred← citeshttps://doi.org/10.1007/978-1-4939-0667-3_3-1openalex-snapshot

Resistance to Cyclophilin Inhibitors

inferred← citeshttps://doi.org/10.1007/978-4-431-56098-2_8openalex-snapshot

The HCV Replicase Complex and Viral RNA Synthesis

inferred← citeshttps://doi.org/10.1007/978-4-431-56098-2_9openalex-snapshot

Hepatitis C Virus-Host Interactions

inferred← citeshttps://doi.org/10.1007/s00044-012-0148-1openalex-snapshot

Emerging hepatitis C virus inhibitors

inferred← citeshttps://doi.org/10.1007/s00430-018-0566-xopenalex-snapshot

Hepatitis C virus cell culture models: an encomium on basic research paving the road to therapy development

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HCV genotype 1b chimeric replicon with NS5B of JFH-1 exhibited resistance to cyclosporine A

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Targeting host cofactors to inhibit viral infection

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Cyclophilin Inhibitors

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Opportunities and Risks of Host-targeting Antiviral Strategies for Hepatitis C

inferred← citeshttps://doi.org/10.1007/s12026-011-8263-5openalex-snapshot

Cyclophilin inhibitors: a novel class of promising host-targeting anti-HCV agents

inferred← citeshttps://doi.org/10.1007/s12250-010-3140-2openalex-snapshot

Development of novel antiviral therapies for hepatitis C virus

inferred← citeshttps://doi.org/10.1016/b978-0-12-386009-5.00007-2openalex-snapshot

Peptidyl Prolyl Isomerase Inhibitors

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Hepatitis C

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Hepatitis C

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A cell-based reporter assay for inhibitor screening of hepatitis C virus RNA-dependent RNA polymerase

inferred← citeshttps://doi.org/10.1016/j.antiviral.2011.01.003openalex-snapshot

Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy

inferred← citeshttps://doi.org/10.1016/j.antiviral.2011.04.002openalex-snapshot

Molecular strategies to design an escape-proof antiviral therapy

inferred← citeshttps://doi.org/10.1016/j.antiviral.2013.03.020openalex-snapshot

Curing a viral infection by targeting the host: The example of cyclophilin inhibitors

inferred← citeshttps://doi.org/10.1016/j.bbagen.2012.08.017openalex-snapshot

Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro

inferred← citeshttps://doi.org/10.1016/j.bbagen.2014.11.011openalex-snapshot

The role of immunophilins in viral infection

inferred← citeshttps://doi.org/10.1016/j.bbrc.2014.04.053openalex-snapshot

Resistance to cyclosporin A derives from mutations in hepatitis C virus nonstructural proteins

inferred← citeshttps://doi.org/10.1016/j.bcp.2008.12.019openalex-snapshot

Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase

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SAR study of bisamides as cyclophilin a inhibitors for the development of host-targeting therapy for hepatitis C virus infection

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Synthesis and biological evaluation of [d-lysine]8cyclosporin A analogs as potential anti-HCV agents

inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.05.101openalex-snapshot

Cyclophilin inhibitors as antiviral agents

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Discovery of ASP5286: A novel non-immunosuppressive cyclophilin inhibitor for the treatment of HCV

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Bioengineering and Semisynthesis of an Optimized Cyclophilin Inhibitor for Treatment of Chronic Viral Infection

inferred← citeshttps://doi.org/10.1016/j.cld.2009.05.002openalex-snapshot

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Cyclophilin Inhibitors for Hepatitis C Therapy

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Hepatitis C NS5A protein: two drug targets within the same protein with different mechanisms of resistance

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Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

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A cyclophilin A (CypA) from Apostichopus japonicus modulates NF-κB translocation as a cofactor

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HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A–cyclophilin A interaction to cyclophilin inhibitors

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Simultaneous Reduction and Digestion of Proteins with Disulfide Bonds for Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry

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Isoform-Specific Inhibition of Cyclophilins

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Completion of the entire hepatitis C virus life cycle in genetically humanized mice

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Cyclophilin A stabilizes the capsid protein p72 to facilitate African swine fever virus replication

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Cyclophilin A protects mice against infection by influenza A virus

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Cellular and molecular biology of HCV infection and hepatitis

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Inhibition of HCV Replication by Cyclophilin Antagonists Is Linked to Replication Fitness and Occurs by Inhibition of Membranous Web Formation

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Cyclophilin Inhibitors Reduce Phosphorylation of RNA-Dependent Protein Kinase to Restore Expression of IFN-Stimulated Genes in HCV-Infected Cells

inferred← citeshttps://doi.org/10.1053/j.gastro.2017.10.041openalex-snapshot

Pan-Genotype Hepatitis E Virus Replication in Stem Cell–Derived Hepatocellular Systems

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A genome-wide genetic screen for host factors required for hepatitis C virus propagation

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A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle

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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

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Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome

inferred← citeshttps://doi.org/10.1074/jbc.m110.182436openalex-snapshot

Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

inferred← citeshttps://doi.org/10.1074/jbc.m112.392209openalex-snapshot

Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A

inferred← citeshttps://doi.org/10.1074/jbc.m808964200openalex-snapshot

Secreted Cyclophilin A, a Peptidylprolyl cis-trans Isomerase, Mediates Matrix Assembly of Hensin, a Protein Implicated in Epithelial Differentiation

inferred← citeshttps://doi.org/10.1074/jbc.m809244200openalex-snapshot

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B

inferred← citeshttps://doi.org/10.1074/jbc.ra119.009537openalex-snapshot

Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

inferred← citeshttps://doi.org/10.1074/mcp.m113.030155openalex-snapshot

Elucidating Novel Hepatitis C Virus–Host Interactions Using Combined Mass Spectrometry and Functional Genomics Approaches

inferred← citeshttps://doi.org/10.1093/jac/dkw338openalex-snapshot

A review of treatment modalities for Middle East Respiratory Syndrome

inferred← citeshttps://doi.org/10.1093/nar/gkp714openalex-snapshot

Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation

inferred← citeshttps://doi.org/10.1099/jgv.0.000663openalex-snapshot

Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B

inferred← citeshttps://doi.org/10.1099/vir.0.018531-0openalex-snapshot

Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes

inferred← citeshttps://doi.org/10.1099/vir.0.037309-0openalex-snapshot

Cyclophilin A is required for efficient human cytomegalovirus DNA replication and reactivation

inferred← citeshttps://doi.org/10.1101/2021.04.25.441316openalex-snapshot

Analysis of viral RNA-host protein interactomes enables rapid antiviral drug discovery

inferred← citeshttps://doi.org/10.1101/2023.11.22.568224openalex-snapshot

Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes

inferred← citeshttps://doi.org/10.1101/416560openalex-snapshot

Discovery of novel thrips vector proteins that bind to the viral attachment protein of the plant bunyavirus, tomato spotted wilt virus

inferred← citeshttps://doi.org/10.1101/cshperspect.a036970openalex-snapshot

Animal Models of Hepatitis C Virus Infection

inferred← citeshttps://doi.org/10.1111/j.1349-7006.2009.01263.xopenalex-snapshot

Identification of cellular and viral factors related to anti‐hepatitis C virus activity of cyclophilin inhibitor

inferred← citeshttps://doi.org/10.1111/j.1365-2036.2009.03927.xopenalex-snapshot

Review article: investigational agents for chronic hepatitis C

inferred← citeshttps://doi.org/10.1111/j.1365-2893.2008.01066.xopenalex-snapshot

Hepatitis C virus replicons: dinosaurs still in business?

inferred← citeshttps://doi.org/10.1111/j.1399-3062.2010.00556.xopenalex-snapshot

Cyclosporin A inhibits hepatitis C virus replication and restores interferon‐alpha expression in hepatocytes

inferred← citeshttps://doi.org/10.1111/j.1462-5822.2009.01286.xopenalex-snapshot

Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication

inferred← citeshttps://doi.org/10.1111/j.1478-3231.2011.02701.xopenalex-snapshot

New targets for antiviral therapy of chronic hepatitis C

inferred← citeshttps://doi.org/10.1111/j.1600-6143.2012.04116.xopenalex-snapshot

Cyclophilin A and Nuclear Factor of Activated T Cells Are Essential in Cyclosporine-Mediated Suppression of Polyomavirus BK Replication

inferred← citeshttps://doi.org/10.1128/aac.00189-09openalex-snapshot

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein

inferred← citeshttps://doi.org/10.1128/aac.00660-09openalex-snapshot

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA ReplicationIn Vitro

inferred← citeshttps://doi.org/10.1128/aac.00693-12openalex-snapshot

The Cyclophilin Inhibitor SCY-635 Disrupts Hepatitis C Virus NS5A-Cyclophilin A Complexes

inferred← citeshttps://doi.org/10.1128/aac.00939-08openalex-snapshot

Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

inferred← citeshttps://doi.org/10.1128/aac.01627-10openalex-snapshot

Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

inferred← citeshttps://doi.org/10.1128/aac.04958-14openalex-snapshot

Cyclophilin and NS5A Inhibitors, but Not Other Anti-Hepatitis C Virus (HCV) Agents, Preclude HCV-Mediated Formation of Double-Membrane-Vesicle Viral Factories

inferred← citeshttps://doi.org/10.1128/jvi.00081-14openalex-snapshot

Cell Death-Inducing DFFA-Like Effector b Is Required for Hepatitis C Virus Entry into Hepatocytes

inferred← citeshttps://doi.org/10.1128/jvi.00532-20openalex-snapshot

ISGylation of Hepatitis C Virus NS5A Protein Promotes Viral RNA Replication via Recruitment of Cyclophilin A

inferred← citeshttps://doi.org/10.1128/jvi.00699-19openalex-snapshot

Discovery of Novel Thrips Vector Proteins That Bind to the Viral Attachment Protein of the Plant Bunyavirus Tomato Spotted Wilt Virus

inferred← citeshttps://doi.org/10.1128/jvi.00793-25openalex-snapshot

Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice

inferred← citeshttps://doi.org/10.1128/jvi.01351-12openalex-snapshot

Suppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles In Vitro by Cyclophilin Inhibitors

inferred← citeshttps://doi.org/10.1128/jvi.01714-15openalex-snapshot

HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3′ Untranslated Region and Enhances Hepatitis C Virus Replication

inferred← citeshttps://doi.org/10.1128/jvi.01921-23openalex-snapshot

Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes

inferred← citeshttps://doi.org/10.1128/jvi.01985-18openalex-snapshot

The Dengue Virus Nonstructural Protein 1 (NS1) Is Secreted from Mosquito Cells in Association with the Intracellular Cholesterol Transporter Chaperone Caveolin Complex

inferred← citeshttps://doi.org/10.1128/jvi.02406-08openalex-snapshot

A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

inferred← citeshttps://doi.org/10.1128/jvi.02533-10openalex-snapshot

Peptidyl-Prolyl Isomerase Pin1 Is a Cellular Factor Required for Hepatitis C Virus Propagation

inferred← citeshttps://doi.org/10.1128/jvi.02550-08openalex-snapshot

Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

inferred← citeshttps://doi.org/10.1128/jvi.03839-13openalex-snapshot

Novel Permissive Cell Lines for Complete Propagation of Hepatitis C Virus

inferred← citeshttps://doi.org/10.1128/jvi.06641-11openalex-snapshot

A Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility

inferred← citeshttps://doi.org/10.1128/spectrum.01284-23openalex-snapshot

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

inferred← citeshttps://doi.org/10.1136/gutjnl-2012-302048openalex-snapshot

New advances in the molecular biology of hepatitis C virus infection: towards the identification of new treatment targets

inferred← citeshttps://doi.org/10.1155/2014/941767openalex-snapshot

Prevalence of Past and Reactivated Viral Infections and Efficacy of Cyclosporine A as Monotherapy or in Combination in Patients with Psoriatic Arthritis—Synergy Study: A Longitudinal Observational Study

inferred← citeshttps://doi.org/10.1159/000360830openalex-snapshot

The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets

inferred← citeshttps://doi.org/10.1177/135965350901400104openalex-snapshot

Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment

inferred← citeshttps://doi.org/10.1177/2040206618811413openalex-snapshot

Cyclophilin A as a target in the treatment of cytomegalovirus infections

inferred← citeshttps://doi.org/10.1186/1743-422x-7-372openalex-snapshot

Chicken cyclophilin A is an inhibitory factor to influenza virus replication

inferred← citeshttps://doi.org/10.1186/1743-422x-8-329openalex-snapshot

Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion

inferred← citeshttps://doi.org/10.1371/annotation/29dffb2a-5d37-4196-b166-b0b15bc2f3fdopenalex-snapshot

Correction: Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

inferred← citeshttps://doi.org/10.1371/journal.pone.0009815openalex-snapshot

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A

inferred← citeshttps://doi.org/10.1371/journal.pone.0013687openalex-snapshot

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

inferred← citeshttps://doi.org/10.1371/journal.pone.0018285openalex-snapshot

Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B

inferred← citeshttps://doi.org/10.1371/journal.pone.0022625openalex-snapshot

Cyclophilin E Functions as a Negative Regulator to Influenza Virus Replication by Impairing the Formation of the Viral Ribonucleoprotein Complex

inferred← citeshttps://doi.org/10.1371/journal.pone.0031063openalex-snapshot

Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein

inferred← citeshttps://doi.org/10.1371/journal.pone.0134707openalex-snapshot

The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of Action

inferred← citeshttps://doi.org/10.1371/journal.pone.0152036openalex-snapshot

Characterization of the Anti-HCV Activities of the New Cyclophilin Inhibitor STG-175

inferred← citeshttps://doi.org/10.1371/journal.pone.0159511openalex-snapshot

Cyclophilin Inhibitors Remodel the Endoplasmic Reticulum of HCV-Infected Cells in a Unique Pattern Rendering Cells Impervious to a Reinfection

inferred← citeshttps://doi.org/10.1371/journal.ppat.1000546openalex-snapshot

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

inferred← citeshttps://doi.org/10.1371/journal.ppat.1001118openalex-snapshot

A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach

inferred← citeshttps://doi.org/10.1371/journal.ppat.1002617openalex-snapshot

Productive Hepatitis C Virus Infection of Stem Cell-Derived Hepatocytes Reveals a Critical Transition to Viral Permissiveness during Differentiation

inferred← citeshttps://doi.org/10.1371/journal.ppat.1003513openalex-snapshot

Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

inferred← citeshttps://doi.org/10.1371/journal.ppat.1004422openalex-snapshot

Cyclophilin A Associates with Enterovirus-71 Virus Capsid and Plays an Essential Role in Viral Infection as an Uncoating Regulator

inferred← citeshttps://doi.org/10.1371/journal.ppat.1004428openalex-snapshot

Inhibitors of Peptidyl Proline Isomerases As Antivirals in Hepatitis C and Other Viruses

inferred← citeshttps://doi.org/10.1515/hsz-2012-0151openalex-snapshot

Cyclophilin involvement in the replication of hepatitis C virus and other viruses

inferred← citeshttps://doi.org/10.1517/13543780802651583openalex-snapshot

An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C

inferred← citeshttps://doi.org/10.1517/13543784.2012.658641openalex-snapshot

Update on alisporivir in treatment of viral hepatitis C

inferred← citeshttps://doi.org/10.1517/14656560902731951openalex-snapshot

Treatment strategies for a patient with rheumatoid arthritis and hepatitis C

inferred← citeshttps://doi.org/10.1517/17460440902762802openalex-snapshot

Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase

inferred← citeshttps://doi.org/10.1586/egh.09.74openalex-snapshot

Know your enemy: translating insights about the molecular biology of hepatitis C virus into novel therapeutic approaches

inferred← citeshttps://doi.org/10.1590/s0365-05962011000700050openalex-snapshot

Uso da ciclosporina em paciente portador de hepatite C e psoríase pustulosa

inferred← citeshttps://doi.org/10.20517/2394-5079.2018.25openalex-snapshot

Molecular targeting of antiviral drugs used against hepatitis C virus infection

inferred← citeshttps://doi.org/10.21248/gups.61849openalex-snapshot

Charakterisierung des Lipidbindungsverhaltens und der Proteinfaltung von HCV NS5A unter Einfluss des NS5A-Inhibitors Daclatasvir

inferred← citeshttps://doi.org/10.2174/138161212799436421openalex-snapshot

Identification of HIV Inhibitors Guided by Free Energy Perturbation Calculations

inferred← citeshttps://doi.org/10.2174/1874467208666150519115443openalex-snapshot

Cyclophilin function in Cancer; lessons from virus replication

inferred← citeshttps://doi.org/10.2217/fvl.11.137openalex-snapshot

Alisporivir for the Treatment of Chronic HCV

inferred← citeshttps://doi.org/10.3350/cmh.2013.19.1.17openalex-snapshot

Hepatitis C virus: virology and life cycle

inferred← citeshttps://doi.org/10.3389/fcimb.2024.1340017openalex-snapshot

Marmosets as models of infectious diseases

inferred← citeshttps://doi.org/10.3389/fmicb.2012.00054openalex-snapshot

Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection

inferred← citeshttps://doi.org/10.3389/fmicb.2022.849084openalex-snapshot

MxB Disrupts Hepatitis C Virus NS5A–CypA Complex: Insights From a Combined Theoretical and Experimental Approach

inferred← citeshttps://doi.org/10.3389/fphar.2024.1417945openalex-snapshot

Cyclophilin inhibition as a strategy for the treatment of human disease

inferred← citeshttps://doi.org/10.3390/ijms21113869openalex-snapshot

Animal Models Used in Hepatitis C Virus Research

inferred← citeshttps://doi.org/10.3390/molecules200610342openalex-snapshot

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization

inferred← citeshttps://doi.org/10.3390/pathogens10070902openalex-snapshot

Cyclophilins and Their Roles in Hepatitis C Virus and Flavivirus Infections: Perspectives for Novel Antiviral Approaches

inferred← citeshttps://doi.org/10.3390/v12010036openalex-snapshot

Gene Expression Profiling of Different Huh7 Variants Reveals Novel Hepatitis C Virus Host Factors

inferred← citeshttps://doi.org/10.3390/v12091044openalex-snapshot

Generation of Combinatorial Lentiviral Vectors Expressing Multiple Anti-Hepatitis C Virus shRNAs and Their Validation on a Novel HCV Replicon Double Reporter Cell Line

inferred← citeshttps://doi.org/10.3390/v15040981openalex-snapshot

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

inferred← citeshttps://doi.org/10.3390/v17010011openalex-snapshot

Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections

inferred← citeshttps://doi.org/10.3390/v2040826openalex-snapshot

Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care

inferred← citeshttps://doi.org/10.3390/v2051195openalex-snapshot

Lipid Metabolism and HCV Infection

inferred← citeshttps://doi.org/10.3390/v2081621openalex-snapshot

Cyclophilin Inhibitors as a Novel HCV Therapy

inferred← citeshttps://doi.org/10.3390/v4112558openalex-snapshot

Cyclophilin Inhibitors: An Emerging Class of Therapeutics for the Treatment of Chronic Hepatitis C Infection

inferred← citeshttps://doi.org/10.3390/v4123303openalex-snapshot

Subtype Specific Differences in NS5A Domain II Reveals Involvement of Proline at Position 310 in Cyclosporine Susceptibility of Hepatitis C Virus

inferred← citeshttps://doi.org/10.3390/v5010182openalex-snapshot

Insights into the Roles of Cyclophilin A During Influenza Virus Infection

inferred← citeshttps://doi.org/10.3390/v5020423openalex-snapshot

Is there a Role for Cyclophilin Inhibitors in the Management of Primary Biliary Cirrhosis?

inferred← citeshttps://doi.org/10.3390/v5030981openalex-snapshot

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms

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