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Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation
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1 of the 68 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1038/onc.2008.319 (notice 2023-03-22).
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dataset doi:10.7910/DVN/WT8VOA (CC BY 4.0).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/s0014-4827(03)00392-6openalex-snapshotThe cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFβ, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis
inferredcites →https://doi.org/10.1038/nsmb1028openalex-snapshotDichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics
inferredcites →https://doi.org/10.1038/onc.2008.319openalex-snapshotRETRACTED ARTICLE: Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly
inferredcites →https://doi.org/10.1038/sj.onc.1202016openalex-snapshotCyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation
inferredcites →https://doi.org/10.1038/sj.onc.1203033openalex-snapshotDysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations
inferredcites →https://doi.org/10.1073/pnas.95.3.1091openalex-snapshotAssembly of cyclin D-dependent kinase and titration of p27 Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
inferredcites →https://doi.org/10.1074/jbc.270.31.18195openalex-snapshotBoth p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase
inferredcites →https://doi.org/10.1074/jbc.m202528200openalex-snapshotThe Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1to Facilitate the Activation of Cdk4/6 and Early G1Phase Progression
inferredcites →https://doi.org/10.1074/jbc.m302492200openalex-snapshotCyclic AMP-dependent Phosphorylation of Cyclin D3-bound CDK4 Determines the Passage through the Cell Cycle Restriction Point in Thyroid Epithelial Cells
inferredcites →https://doi.org/10.1083/jcb.127.2.467openalex-snapshotCell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).
inferredcites →https://doi.org/10.1083/jcb.140.6.1427openalex-snapshotA Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes
inferredcites →https://doi.org/10.1091/mbc.11.3.1061openalex-snapshotTransforming Growth Factor β1Selectively Inhibits the Cyclic AMP-dependent Proliferation of Primary Thyroid Epithelial Cells by Preventing the Association of Cyclin D3–cdk4 with Nuclear p27kip1
inferredcites →https://doi.org/10.1101/gad.7.3.331openalex-snapshotDirect binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
inferredcites →https://doi.org/10.1128/mcb.02006-05openalex-snapshotRegulated Activating Thr172 Phosphorylation of Cyclin-Dependent Kinase 4(CDK4): Its Relationship with Cyclins and CDK “Inhibitors”
inferredcites →https://doi.org/10.1128/mcb.17.12.7362openalex-snapshotA Dominant-Negative Cyclin D1 Mutant Prevents Nuclear Import of Cyclin-Dependent Kinase 4 (CDK4) and Its Phosphorylation by CDK-Activating Kinase
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3260openalex-snapshotCombined Inhibition of MEK and Mammalian Target of Rapamycin Abolishes Phosphorylation of Cyclin-Dependent Kinase 4 in Glioblastoma Cell Lines and Prevents Their Proliferation
inferredcites →https://doi.org/10.1210/me.2005-0515openalex-snapshotDifferential Utilization of Cyclin D1 and Cyclin D3 in the Distinct Mitogenic Stimulations by Growth Factors and TSH of Human Thyrocytes in Primary Culture
inferredcites →https://doi.org/10.1242/jcs.109.7.1759openalex-snapshotParadoxical accumulation of the cyclin-dependent kinase inhibitor p27kip1 during the cAMP-dependent mitogenic stimulation of thyroid epithelial cells
inferredcites →https://doi.org/10.4161/cc.5.5.2541openalex-snapshotThe Cyclin-Dependent Kinase (CDK) Family Member PNQALRE/CCRK Supports Cell Proliferation but has no Intrinsic CDK-Activating Kinase (CAK) Activity
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.bbagen.2017.11.001openalex-snapshotReduced state transition barrier of CDK6 from open to closed state induced by Thr177 phosphorylation and its implication in binding modes of inhibitors
inferred← citeshttps://doi.org/10.1038/s41388-026-03753-5openalex-snapshotPIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment
inferred← citeshttps://doi.org/10.1039/c7mb00355bopenalex-snapshotNetwork-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms
inferred← citeshttps://doi.org/10.1039/d4cp04579copenalex-snapshotInsights into phosphorylation-induced influences on conformations and inhibitor binding of CDK6 through GaMD trajectory-based deep learning
inferred← citeshttps://doi.org/10.1080/15384101.2021.1984663openalex-snapshotMonoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27
inferred← citeshttps://doi.org/10.1101/2025.11.10.25339594openalex-snapshotAbsence of phosphorylated CDK4, a biomarker of intrinsic resistance to CDK4/6 inhibitors in head and neck squamous cell carcinoma, can be predicted by their gene expression profile
inferred← citeshttps://doi.org/10.1111/cas.16317openalex-snapshotRafoxanide negatively modulates STAT3 and NF ‐ κB activity and inflammation‐associated colon tumorigenesis
inferred← citeshttps://doi.org/10.1111/tpj.12872openalex-snapshotCyclin‐dependent kinase‐activating kinases CDKD ;1 and CDKD ;3 are essential for preserving mitotic activity in Arabidopsis thaliana
inferred← citeshttps://doi.org/10.1210/me.2010-0087openalex-snapshotcAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4
inferred← citeshttps://doi.org/10.1371/journal.pgen.1003546openalex-snapshotCDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point
inferred← citeshttps://doi.org/10.21873/cgp.20273openalex-snapshotCisplatin Activates the Growth Inhibitory Signaling Pathways by Enhancing the Production of Reactive Oxygen Species in Non-small Cell Lung Cancer Carrying an EGFR Exon 19 Deletion
inferred← citeshttps://doi.org/10.3389/978-2-88963-988-5openalex-snapshotGeneration of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts
inferred← citeshttps://doi.org/10.3390/ijms241914427openalex-snapshotProgression after First-Line Cyclin-Dependent Kinase 4/6 Inhibitor Treatment: Analysis of Molecular Mechanisms and Clinical Data
inferred← citeshttps://doi.org/10.3892/ijo.2017.4134openalex-snapshotLiquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo
inferred← citeshttps://doi.org/10.5607/en21004openalex-snapshotTumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling
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