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Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation

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1 of the 68 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1038/onc.2008.319 (notice 2023-03-22).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcb.20613openalex-snapshot
Location, location, location: The role of cyclin D1 nuclear localization in cancer
inferredcites →https://doi.org/10.1002/jcb.20712openalex-snapshot
Beyond the cell cycle: A new role for Cdk6 in differentiation
inferredcites →https://doi.org/10.1007/s000180050290openalex-snapshot
The cdk-activating kinase (CAK): from yeast to mammals
inferredcites →https://doi.org/10.1007/springerreference_39918openalex-snapshot
Transforming growth factor beta
inferredcites →https://doi.org/10.1016/0092-8674(93)90136-eopenalex-snapshot
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
inferredcites →https://doi.org/10.1016/0092-8674(94)90257-7openalex-snapshot
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
inferredcites →https://doi.org/10.1016/0092-8674(94)90535-5openalex-snapshot
A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase
inferredcites →https://doi.org/10.1016/0092-8674(95)90385-2openalex-snapshot
The retinoblastoma protein and cell cycle control
inferredcites →https://doi.org/10.1016/j.cell.2004.07.025openalex-snapshot
Mouse Development and Cell Proliferation in the Absence of D-Cyclins
inferredcites →https://doi.org/10.1016/j.cell.2004.08.002openalex-snapshot
Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6
inferredcites →https://doi.org/10.1016/j.cell.2006.11.047openalex-snapshot
Cdk-Inhibitory Activity and Stability of p27 Are Directly Regulated by Oncogenic Tyrosine Kinases
inferredcites →https://doi.org/10.1016/j.devcel.2006.03.004openalex-snapshot
Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation
inferredcites →https://doi.org/10.1016/j.molcel.2007.02.003openalex-snapshot
Requirements for Cdk7 in the Assembly of Cdk1/Cyclin B and Activation of Cdk2 Revealed by Chemical Genetics in Human Cells
inferredcites →https://doi.org/10.1016/j.molcel.2008.10.022openalex-snapshot
Distinct Activation Pathways Confer Cyclin-Binding Specificity on Cdk1 and Cdk2 in Human Cells
inferredcites →https://doi.org/10.1016/s0002-9440(10)64196-xopenalex-snapshot
cdk4 Deficiency Inhibits Skin Tumor Development but Does Not Affect Normal Keratinocyte Proliferation
inferredcites →https://doi.org/10.1016/s0014-4827(03)00392-6openalex-snapshot
The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFβ, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis
inferredcites →https://doi.org/10.1016/s0304-419x(02)00037-9openalex-snapshot
Cyclin D-dependent kinases, INK4 inhibitors and cancer
inferredcites →https://doi.org/10.1016/s0955-0674(96)80081-0openalex-snapshot
The retinoblastoma protein pathway and the restriction point
inferredcites →https://doi.org/10.1016/s0968-0004(00)89005-2openalex-snapshot
D-type cyclins
inferredcites →https://doi.org/10.1016/s1535-6108(02)00102-2openalex-snapshot
The RB and p53 pathways in cancer
inferredcites →https://doi.org/10.1016/s1535-6108(03)00053-9openalex-snapshot
Proliferation of cancer cells despite CDK2 inhibition
inferredcites →https://doi.org/10.1038/nature02650openalex-snapshot
Cyclin-dependent kinases regulate the antiproliferative function of Smads
inferredcites →https://doi.org/10.1038/nsmb1028openalex-snapshot
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics
inferredcites →https://doi.org/10.1038/onc.2008.319openalex-snapshot
RETRACTED ARTICLE: Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly
inferredcites →https://doi.org/10.1038/sj.onc.1201570openalex-snapshot
Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
inferredcites →https://doi.org/10.1038/sj.onc.1202016openalex-snapshot
Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation
inferredcites →https://doi.org/10.1038/sj.onc.1203033openalex-snapshot
Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations
inferredcites →https://doi.org/10.1046/j.1432-1327.2000.01455.xopenalex-snapshot
Analysis of CAK activities from human cells
inferredcites →https://doi.org/10.1073/pnas.0809645106openalex-snapshot
Crystal structure of human CDK4 in complex with a D-type cyclin
inferredcites →https://doi.org/10.1073/pnas.0809674106openalex-snapshot
The structure of CDK4/cyclin D3 has implications for models of CDK activation
inferredcites →https://doi.org/10.1073/pnas.95.3.1091openalex-snapshot
Assembly of cyclin D-dependent kinase and titration of p27 Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
inferredcites →https://doi.org/10.1074/jbc.270.31.18195openalex-snapshot
Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase
inferredcites →https://doi.org/10.1074/jbc.272.41.25863openalex-snapshot
Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4
inferredcites →https://doi.org/10.1074/jbc.m200381200openalex-snapshot
Distinct Phosphorylation Events Regulate p130- and p107-mediated Repression of E2F-4
inferredcites →https://doi.org/10.1074/jbc.m202528200openalex-snapshot
The Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1to Facilitate the Activation of Cdk4/6 and Early G1Phase Progression
inferredcites →https://doi.org/10.1074/jbc.m205537200openalex-snapshot
Comparison of Cak1p-like Cyclin-dependent Kinase-activating Kinases
inferredcites →https://doi.org/10.1074/jbc.m212088200openalex-snapshot
The Cyclin D1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB·MCM7 Binding
inferredcites →https://doi.org/10.1074/jbc.m302492200openalex-snapshot
Cyclic AMP-dependent Phosphorylation of Cyclin D3-bound CDK4 Determines the Passage through the Cell Cycle Restriction Point in Thyroid Epithelial Cells
inferredcites →https://doi.org/10.1083/jcb.127.2.467openalex-snapshot
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).
inferredcites →https://doi.org/10.1083/jcb.140.6.1427openalex-snapshot
A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes
inferredcites →https://doi.org/10.1091/mbc.11.3.1061openalex-snapshot
Transforming Growth Factor β1Selectively Inhibits the Cyclic AMP-dependent Proliferation of Primary Thyroid Epithelial Cells by Preventing the Association of Cyclin D3–cdk4 with Nuclear p27kip1
inferredcites →https://doi.org/10.1091/mbc.12.12.3987openalex-snapshot
CAK-independent Activation of CDK6 by a Viral Cyclin
inferredcites →https://doi.org/10.1091/mbc.9.9.2545openalex-snapshot
Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities
inferredcites →https://doi.org/10.1091/mbc.e08-06-0617openalex-snapshot
Cyclic AMP Inhibits the Proliferation of Thyroid Carcinoma Cell Lines through Regulation of CDK4 Phosphorylation
inferredcites →https://doi.org/10.1093/emboj/20.23.6637openalex-snapshot
Wide spectrum of tumors in knock‐in mice carrying a Cdk4 protein insensitive to INK4 inhibitors
inferredcites →https://doi.org/10.1093/hmg/10.7.699openalex-snapshot
The Rb/E2F pathway and cancer
inferredcites →https://doi.org/10.1093/pcp/pci170openalex-snapshot
Control of Cell Division and Transcription by Cyclin-dependent Kinase-activating Kinases in Plants
inferredcites →https://doi.org/10.1101/gad.12.3.285openalex-snapshot
The role of Cdk7 in CAK function, a retro-retrospective
inferredcites →https://doi.org/10.1101/gad.13.12.1501openalex-snapshot
CDK inhibitors: positive and negative regulators of G1-phase progression
inferredcites →https://doi.org/10.1101/gad.7.3.331openalex-snapshot
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
inferredcites →https://doi.org/10.1126/science.274.5293.1672openalex-snapshot
Cancer Cell Cycles
inferredcites →https://doi.org/10.1128/mcb.00898-08openalex-snapshot
p27 Kip1 Inhibits Cyclin D-Cyclin-Dependent Kinase 4 by Two Independent Modes
inferredcites →https://doi.org/10.1128/mcb.02006-05openalex-snapshot
Regulated Activating Thr172 Phosphorylation of Cyclin-Dependent Kinase 4(CDK4): Its Relationship with Cyclins and CDK “Inhibitors”
inferredcites →https://doi.org/10.1128/mcb.02171-06openalex-snapshot
Differential Modification of p27 Kip1 Controls Its Cyclin D-cdk4 Inhibitory Activity
inferredcites →https://doi.org/10.1128/mcb.14.11.7265openalex-snapshot
Activation of Cyclin-Dependent Kinase 4 (cdk4) by Mouse MO15-Associated Kinase
inferredcites →https://doi.org/10.1128/mcb.14.4.2713openalex-snapshot
Regulation of Cyclin D-Dependent Kinase 4 (cdk4) by cdk4-activating kinase
inferredcites →https://doi.org/10.1128/mcb.17.12.7362openalex-snapshot
A Dominant-Negative Cyclin D1 Mutant Prevents Nuclear Import of Cyclin-Dependent Kinase 4 (CDK4) and Its Phosphorylation by CDK-Activating Kinase
inferredcites →https://doi.org/10.1128/mcb.21.1.88-99.2001openalex-snapshot
Reciprocal Activation by Cyclin-Dependent Kinases 2 and 7 Is Directed by Substrate Specificity Determinants outside the T Loop
inferredcites →https://doi.org/10.1128/mcb.22.7.2242-2254.2002openalex-snapshot
Reversal of Growth Suppression by p107 via Direct Phosphorylation by Cyclin D1/Cyclin-Dependent Kinase 4
inferredcites →https://doi.org/10.1128/mcb.23.20.7285-7290.2003openalex-snapshot
p27 Kip1 and p21 Cip1 Are Not Required for the Formation of Active D Cyclin-cdk4 Complexes
inferredcites →https://doi.org/10.1128/mcb.24.17.7538-7547.2004openalex-snapshot
Lack of Cyclin-Dependent Kinase 4 Inhibits c- myc Tumorigenic Activities in Epithelial Tissues
inferredcites →https://doi.org/10.1158/0008-5472.can-06-4218openalex-snapshot
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3260openalex-snapshot
Combined Inhibition of MEK and Mammalian Target of Rapamycin Abolishes Phosphorylation of Cyclin-Dependent Kinase 4 in Glioblastoma Cell Lines and Prevents Their Proliferation
inferredcites →https://doi.org/10.1186/1747-1028-1-25openalex-snapshot
Regulation of CDK4
inferredcites →https://doi.org/10.1210/me.2005-0515openalex-snapshot
Differential Utilization of Cyclin D1 and Cyclin D3 in the Distinct Mitogenic Stimulations by Growth Factors and TSH of Human Thyrocytes in Primary Culture
inferredcites →https://doi.org/10.1242/jcs.02718openalex-snapshot
Secrets of a double agent: CDK7 in cell-cycle control and transcription
inferredcites →https://doi.org/10.1242/jcs.109.7.1759openalex-snapshot
Paradoxical accumulation of the cyclin-dependent kinase inhibitor p27kip1 during the cAMP-dependent mitogenic stimulation of thyroid epithelial cells
inferredcites →https://doi.org/10.4161/cc.5.5.2541openalex-snapshot
The Cyclin-Dependent Kinase (CDK) Family Member PNQALRE/CCRK Supports Cell Proliferation but has no Intrinsic CDK-Activating Kinase (CAK) Activity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4765196openalex-extracted
Discovery and Preclinical Evaluations of Tqb3616, a Novel Cdk4-Biased Inhibitor
inferred← citeshttps://doi.org/10.1002/1878-0261.13351openalex-snapshot
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4 /6 inhibition
inferred← citeshttps://doi.org/10.1002/cmdc.202500279openalex-snapshot
Recent Advances of Quinoline‐Based Small Molecules as Kinase Inhibitors (2020–2024)
inferred← citeshttps://doi.org/10.1002/jcp.22426openalex-snapshot
Whether to target single or multiple CDKs for therapy? That is the question
inferred← citeshttps://doi.org/10.1002/stem.616openalex-snapshot
Cdk6-Dependent Regulation of G1 Length Controls Adult Neurogenesis
inferred← citeshttps://doi.org/10.1007/5584_2019_449openalex-snapshot
Targeting Cancer Metabolism and Cell Cycle by Plant-Derived Compounds
inferred← citeshttps://doi.org/10.1007/978-3-642-19065-0_16openalex-snapshot
Established and Novel Cdk/Cyclin Complexes Regulating the Cell Cycle and Development
inferred← citeshttps://doi.org/10.1007/s11010-010-0470-1openalex-snapshot
Differential gene expression of human keratinocyte HaCaT cells induced by fibroblast growth factor 10 treatment
inferred← citeshttps://doi.org/10.1007/s11684-023-1027-5openalex-snapshot
Discovery of small molecule degraders for modulating cell cycle
inferred← citeshttps://doi.org/10.1016/j.ajpath.2010.11.032openalex-snapshot
Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis
inferred← citeshttps://doi.org/10.1016/j.bbagen.2017.11.001openalex-snapshot
Reduced state transition barrier of CDK6 from open to closed state induced by Thr177 phosphorylation and its implication in binding modes of inhibitors
inferred← citeshttps://doi.org/10.1016/j.bbcan.2022.188716openalex-snapshot
Cyclin-dependent kinases in DNA damage response
inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.03.068openalex-snapshot
Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.152126openalex-snapshot
CDKL3, a versatile kinase with increasing recognition
inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118282openalex-snapshot
10PL8 and 2fPL8 inhibit gastric cancer cell proliferation by targeting degradation of CDK6 proteins to arrest the cell cycle
inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.129769openalex-snapshot
Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.11.006openalex-snapshot
Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.02.023openalex-snapshot
MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance
inferred← citeshttps://doi.org/10.1016/j.devcel.2021.04.030openalex-snapshot
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
inferred← citeshttps://doi.org/10.1016/j.foodchem.2010.10.037openalex-snapshot
A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.gene.2022.147106openalex-snapshot
Potential target identification for osteosarcoma treatment: Gene expression re-analysis and drug repurposing
inferred← citeshttps://doi.org/10.1016/j.ijfoodmicro.2013.03.027openalex-snapshot
Comparative genomic analysis of Aspergillus oryzae strains 3.042 and RIB40 for soy sauce fermentation
inferred← citeshttps://doi.org/10.1016/j.jmb.2025.169121openalex-snapshot
Distinct Allosteric Networks in CDK4 and CDK6 in the Cell Cycle and in Drug Resistance
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2010.03.002openalex-snapshot
Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178
inferred← citeshttps://doi.org/10.1016/j.molcel.2013.04.003openalex-snapshot
A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression
inferred← citeshttps://doi.org/10.1016/j.molcel.2013.12.002openalex-snapshot
Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression
inferred← citeshttps://doi.org/10.1016/j.nantod.2023.101890openalex-snapshot
CDK4/6 nano-PROTAC enhances mitochondria-dependent photodynamic therapy and anti-tumor immunity
inferred← citeshttps://doi.org/10.1016/j.str.2024.04.012openalex-snapshot
Slower CDK4 and faster CDK2 activation in the cell cycle
inferred← citeshttps://doi.org/10.1016/j.trac.2026.118678openalex-snapshot
PROTAC-powered synergistic tumor therapy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00871openalex-snapshot
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders
inferred← citeshttps://doi.org/10.1021/acs.jpcb.4c03243openalex-snapshot
Binding Modalities and Phase-Specific Regulation of Cyclin/Cyclin-Dependent Kinase Complexes in the Cell Cycle
inferred← citeshttps://doi.org/10.1038/onc.2013.137openalex-snapshot
Signaling through cyclin D-dependent kinases
inferred← citeshttps://doi.org/10.1038/onc.2017.7openalex-snapshot
JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21
inferred← citeshttps://doi.org/10.1038/s41388-026-03753-5openalex-snapshot
PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment
inferred← citeshttps://doi.org/10.1038/s41698-025-00931-8openalex-snapshot
Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues
inferred← citeshttps://doi.org/10.1038/s43018-021-00174-zopenalex-snapshot
Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders
inferred← citeshttps://doi.org/10.1039/c7mb00355bopenalex-snapshot
Network-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms
inferred← citeshttps://doi.org/10.1039/d4cp04579copenalex-snapshot
Insights into phosphorylation-induced influences on conformations and inhibitor binding of CDK6 through GaMD trajectory-based deep learning
inferred← citeshttps://doi.org/10.1080/15384101.2021.1984663openalex-snapshot
Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27
inferred← citeshttps://doi.org/10.1089/dna.2017.3741openalex-snapshot
Resveratrol Improves Cell Cycle Arrest in Chronic Prostatitis Rats, by C-kit/SCF Suppression
inferred← citeshttps://doi.org/10.1091/mbc.e11-02-0136openalex-snapshot
Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation
inferred← citeshttps://doi.org/10.1096/fj.202201344ropenalex-snapshot
CDK6 activity in a recurring convergent kinase network motif
inferred← citeshttps://doi.org/10.1101/2023.08.16.553605openalex-snapshot
Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
inferred← citeshttps://doi.org/10.1101/2025.11.10.25339594openalex-snapshot
Absence of phosphorylated CDK4, a biomarker of intrinsic resistance to CDK4/6 inhibitors in head and neck squamous cell carcinoma, can be predicted by their gene expression profile
inferred← citeshttps://doi.org/10.1111/cas.16317openalex-snapshot
Rafoxanide negatively modulates STAT3 and NF ‐ κB activity and inflammation‐associated colon tumorigenesis
inferred← citeshttps://doi.org/10.1111/tpj.12872openalex-snapshot
Cyclin‐dependent kinase‐activating kinases CDKD ;1 and CDKD ;3 are essential for preserving mitotic activity in Arabidopsis thaliana
inferred← citeshttps://doi.org/10.1126/scitranslmed.adq5492openalex-snapshot
NF1-depleted ER + breast cancers are differentially sensitive to CDK4/6 inhibitors
inferred← citeshttps://doi.org/10.1134/s2079057011020147openalex-snapshot
The mechanism of phenoptosis: 2. The Hayflick limit is caused by programmed decrease of the bioenergetics level
inferred← citeshttps://doi.org/10.1159/000495392openalex-snapshot
CDK6 and miR-320c Co-Regulate Chondrocyte Catabolism Through NF-κB Signaling Pathways
inferred← citeshttps://doi.org/10.1172/jci178428openalex-snapshot
CDKL3 is a targetable regulator of cell cycle progression in cancers
inferred← citeshttps://doi.org/10.1177/1947601912473308openalex-snapshot
The CDK Network: Linking Cycles of Cell Division and Gene Expression
inferred← citeshttps://doi.org/10.1186/s13045-026-01794-7openalex-snapshot
Cell-cycle targeted cancer therapy: clinical advances, biological gaps, and the emergence of selective CDK4 inhibitors
inferred← citeshttps://doi.org/10.1210/me.2010-0087openalex-snapshot
cAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4
inferred← citeshttps://doi.org/10.1371/journal.pgen.1003546openalex-snapshot
CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point
inferred← citeshttps://doi.org/10.1371/journal.pone.0051847openalex-snapshot
Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression
inferred← citeshttps://doi.org/10.15252/emmm.201607084openalex-snapshot
CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib
inferred← citeshttps://doi.org/10.18632/oncotarget.23597openalex-snapshot
Clinical significance of detecting CSF-derived tumor cells in breast cancer patients with leptomeningeal metastasis
inferred← citeshttps://doi.org/10.2174/0115680096289260240311062343openalex-snapshot
Clinical Progress of Targeted Therapy for Breast Cancer: A Comprehensive Review
inferred← citeshttps://doi.org/10.2174/0115701808273043231130100833openalex-snapshot
Identification of Novel CDK 4/6 Inhibitors by High-throughput Virtual Screening
inferred← citeshttps://doi.org/10.21873/cgp.20273openalex-snapshot
Cisplatin Activates the Growth Inhibitory Signaling Pathways by Enhancing the Production of Reactive Oxygen Species in Non-small Cell Lung Cancer Carrying an EGFR Exon 19 Deletion
inferred← citeshttps://doi.org/10.2334/josnusd.15-0684openalex-snapshot
MyoD is regulated by the miR-29a-Tet1 pathway in C2C12 myoblast cells
inferred← citeshttps://doi.org/10.3180/r-hsa-69231.4openalex-snapshot
Cyclin D associated events in G1
inferred← citeshttps://doi.org/10.3389/978-2-88963-988-5openalex-snapshot
Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts
inferred← citeshttps://doi.org/10.3389/fcell.2019.00055openalex-snapshot
Divide or Commit – Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis
inferred← citeshttps://doi.org/10.3389/fendo.2023.1247542openalex-snapshot
CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas
inferred← citeshttps://doi.org/10.3390/cancers13195025openalex-snapshot
RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways
inferred← citeshttps://doi.org/10.3390/ijms21083018openalex-snapshot
CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets
inferred← citeshttps://doi.org/10.3390/ijms241914427openalex-snapshot
Progression after First-Line Cyclin-Dependent Kinase 4/6 Inhibitor Treatment: Analysis of Molecular Mechanisms and Clinical Data
inferred← citeshttps://doi.org/10.3390/ijms262110322openalex-snapshot
CDK4/6 Inhibitors in Breast Cancer—Who Should Receive Them?
inferred← citeshttps://doi.org/10.3390/molecules26154462openalex-snapshot
Cyclin-Dependent Kinase 4 and 6 Inhibitors in Cell Cycle Dysregulation for Breast Cancer Treatment
inferred← citeshttps://doi.org/10.3892/ijo.2017.4134openalex-snapshot
Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo
inferred← citeshttps://doi.org/10.3892/mmr.2014.3100openalex-snapshot
Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells
inferred← citeshttps://doi.org/10.3923/ijcr.2016.109.121openalex-snapshot
Withdrawn: Cyclic Dependent Kinases (CDKs) in Cancer Pathogenesis and Therapeutics
inferred← citeshttps://doi.org/10.4161/15384101.2014.946841openalex-snapshot
The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes
inferred← citeshttps://doi.org/10.4161/cc.19957openalex-snapshot
Regulation of p27 Kip1 by mitogen-induced tyrosine phosphorylation
inferred← citeshttps://doi.org/10.4161/cc.26355openalex-snapshot
The CDK-activating kinase Cdk7
inferred← citeshttps://doi.org/10.5607/en21004openalex-snapshot
Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling
inferred← citeshttps://doi.org/10.5772/31410openalex-snapshot
Bioenergetics Theory of Aging
inferred← citeshttps://doi.org/10.70675/2940ddd8z8031z4332z8a4az40015df9c667openalex-snapshot
Régulation et fonctions de l'E3 ubiquitine ligase TRIP12 au cours du cycle cellulaire
inferred← citeshttps://doi.org/10.70675/fba9fe32z5859z412fzb6cbz0feef249ea28openalex-snapshot
Le rôle et la régulation de la cycline D3 dans la prolifération des Cellules Epithéliales Intestinales et son blocage par le butyrate
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