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Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis

https://doi.org/10.1128/spectrum.00338-21
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2020.2648openalex-snapshot
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inferredcites →https://doi.org/10.1001/jamainternmed.2020.8193openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.bbi.2009.11.004openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4011920openalex-extracted
inferred← citeshttps://doi.org/10.2139/ssrn.4502086openalex-extracted
inferred← citeshttps://doi.org/10.1002/cbf.3883openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-981-99-3505-5_13openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11306-021-01859-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11306-023-02048-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11306-025-02264-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11306-026-02454-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11306-026-02507-4openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s13668-021-00369-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s43440-023-00517-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-323-91794-0.00026-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114847openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113254openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.compbiomed.2021.104859openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.compbiomed.2023.107661openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104791openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.gastha.2023.06.006openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.gene.2022.147047openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.hbpd.2024.12.006openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e15010openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.isci.2024.111727openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.isci.2026.116326openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.legalmed.2024.102461openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.micpath.2022.105685openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.vetmic.2026.110967openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jproteome.1c00215openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jproteome.3c00654openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acsomega.4c02557openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acsomega.4c04047openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41392-023-01399-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41418-021-00892-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-023-39049-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-025-87288-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s42003-023-05478-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s42004-025-01791-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1042/bsr20230595openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/21505594.2025.2609397openalex-snapshot
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inferred← citeshttps://doi.org/10.1093/femsle/fnag017openalex-snapshot
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inferred← citeshttps://doi.org/10.1101/2022.02.01.22270268openalex-snapshot
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inferred← citeshttps://doi.org/10.1101/2022.03.11.483930openalex-snapshot
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inferred← citeshttps://doi.org/10.1101/2023.05.08.23289637openalex-snapshot
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inferred← citeshttps://doi.org/10.1101/2024.10.24.620087openalex-snapshot
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inferred← citeshttps://doi.org/10.1128/msystems.00726-23openalex-snapshot
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inferred← citeshttps://doi.org/10.1128/spectrum.02194-22openalex-snapshot
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inferred← citeshttps://doi.org/10.1183/13993003.02411-2021openalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s12879-022-07582-1openalex-snapshot
The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1011912openalex-snapshot
Common data models to streamline metabolomics processing and annotation, and implementation in a Python pipeline
inferred← citeshttps://doi.org/10.1371/journal.pone.0274910openalex-snapshot
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inferred← citeshttps://doi.org/10.1371/journal.pone.0305065openalex-snapshot
Starve a cold or feed a fever? Identifying cellular metabolic changes following infection and exposure to SARS-CoV-2
inferred← citeshttps://doi.org/10.1371/journal.pone.0327244openalex-snapshot
Time-series metabolomic profiling of SARS-CoV-2 infection: Possible prognostic biomarkers in patients in the ICU by ¹H-NMR analysis
inferred← citeshttps://doi.org/10.14309/ctg.0000000000000524openalex-snapshot
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inferred← citeshttps://doi.org/10.15252/embr.202255747openalex-snapshot
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inferred← citeshttps://doi.org/10.17179/excli2023-6767openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0115733998404775251202121401openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fimmu.2022.925558openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fimmu.2022.936106openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fimmu.2023.1144224openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fimmu.2024.1353903openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fmolb.2023.1295216openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/ftubr.2024.1432880openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/biomedicines10061332openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/biophysica4020009openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/cells11071241openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/covid3040041openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/diseases12030043openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms23052414openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms232214089openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms24087593openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms25010346openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms25031523openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms25158370openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/metabo12060486openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/metabo12111056openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/metabo14040195openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/metabo14110617openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/metabo15030192openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/molecules29102198openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pathogens11121526openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/vaccines10101762openalex-snapshot
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inferred← citeshttps://doi.org/10.36106/ijsr/3200814openalex-snapshot
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inferred← citeshttps://doi.org/10.3906/biy-2105-53openalex-snapshot
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inferred← citeshttps://doi.org/10.6084/m9.figshare.20329524openalex-snapshot
Additional file 1 of The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.6084/m9.figshare.20329527openalex-snapshot
Additional file 2 of The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis
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