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Natural compounds from freshwater mussels disrupt fungal virulence determinants and influence fluconazole susceptibility in the presence of macrophages in Cryptococcus neoformans
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cpmc.94openalex-snapshot
Quantitative Proteomic Profiling of Cryptococcus neoformans
inferredcites →https://doi.org/10.1002/wsbm.1610openalex-snapshot
A One Health approach to overcoming fungal disease and antifungal resistance
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Isolation of HIV-1 Protease-Inhibiting Peptides from Thermolysin Hydrolysate of Oyster Proteins
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Lactate Dehydrogenase Assay for Assessment of Polycation Cytotoxicity
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Antifungal and Antibiofilm In Vitro Activities of Ursolic Acid on Cryptococcus neoformans
inferredcites →https://doi.org/10.1007/s10528-013-9605-xopenalex-snapshot
Molecular Characterization of a Fungicidal Endoglucanase from the Cyanobacterium Calothrix elenkinii
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Investigation of Microplastics in Freshwater Mussels (Lasmigona costata) From the Grand River Watershed in Ontario, Canada
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
inferredcites →https://doi.org/10.1016/b978-032304048-8.50009-8openalex-snapshot
Host Defense Systems of the Lung
inferredcites →https://doi.org/10.1016/j.chom.2016.05.001openalex-snapshot
Intracellular Action of a Secreted Peptide Required for Fungal Virulence
inferredcites →https://doi.org/10.1016/j.dci.2008.06.005openalex-snapshot
Shrimp single WAP domain (SWD)-containing protein exhibits proteinase inhibitory and antimicrobial activities
inferredcites →https://doi.org/10.1016/j.dci.2014.01.002openalex-snapshot
Antibacterial activity of serine protease inhibitor 1 from kuruma shrimp Marsupenaeus japonicus
inferredcites →https://doi.org/10.1016/j.ibmb.2019.103258openalex-snapshot
Kunitz-type protease inhibitor BmSPI51 plays an antifungal role in the silkworm cocoon
inferredcites →https://doi.org/10.1016/j.imbio.2005.10.017openalex-snapshot
Host defence peptides from invertebrates – emerging antimicrobial strategies
inferredcites →https://doi.org/10.1016/j.jip.2019.107214openalex-snapshot
Pathogen proteases and host protease inhibitors in molluscan infectious diseases
inferredcites →https://doi.org/10.1016/j.tcsw.2018.05.002openalex-snapshot
Lack of chitin synthase genes impacts capsular architecture and cellular physiology in Cryptococcus neoformans
inferredcites →https://doi.org/10.1016/s0002-9440(10)63734-0openalex-snapshot
Urease Expression by Cryptococcus neoformans Promotes Microvascular Sequestration, Thereby Enhancing Central Nervous System Invasion
inferredcites →https://doi.org/10.1016/s0140-6736(05)74314-2openalex-snapshot
Access to fluconazole in less-developed countries
inferredcites →https://doi.org/10.1016/s0167-4838(00)00231-4openalex-snapshot
Bacterial 1,3-1,4-β-glucanases: structure, function and protein engineering
inferredcites →https://doi.org/10.1016/s0168-9525(01)02498-2openalex-snapshot
Fungi and humans: closer than you think
inferredcites →https://doi.org/10.1016/s1369-5274(02)00344-2openalex-snapshot
Resistance of human fungal pathogens to antifungal drugs
inferredcites →https://doi.org/10.1016/s1473-3099(22)00499-6openalex-snapshot
The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis
inferredcites →https://doi.org/10.1021/acs.jmedchem.0c02177openalex-snapshot
Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery
inferredcites →https://doi.org/10.1021/pr101065jopenalex-snapshot
Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment
inferredcites →https://doi.org/10.1021/pr401075fopenalex-snapshot
Proteomic Profile of Cryptococcus neoformans Biofilm Reveals Changes in Metabolic Processes
inferredcites →https://doi.org/10.1038/nbt.1511openalex-snapshot
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
inferredcites →https://doi.org/10.1038/nmeth.3901openalex-snapshot
The Perseus computational platform for comprehensive analysis of (prote)omics data
inferredcites →https://doi.org/10.1038/nprot.2007.261openalex-snapshot
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
inferredcites →https://doi.org/10.1038/nrd3801openalex-snapshot
The determination and interpretation of the therapeutic index in drug development
inferredcites →https://doi.org/10.1038/s41392-023-01452-1openalex-snapshot
Macrophages in immunoregulation and therapeutics
inferredcites →https://doi.org/10.1038/s41564-022-01091-2openalex-snapshot
Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment
inferredcites →https://doi.org/10.1038/s41598-017-02043-1openalex-snapshot
Structure and function of a broad-specificity chitin deacetylase from Aspergillus nidulans FGSC A4
inferredcites →https://doi.org/10.1038/s41598-023-32140-3openalex-snapshot
Differentiated extracts from freshwater and terrestrial mollusks inhibit virulence factor production in Cryptococcus neoformans
inferredcites →https://doi.org/10.1039/c2np20035jopenalex-snapshot
Plants as sources of new antimicrobials and resistance-modifying agents
inferredcites →https://doi.org/10.1074/jbc.ra119.012251openalex-snapshot
Exploring Cryptococcus neoformans capsule structure and assembly with a hydroxylamine-armed fluorescent probe
inferredcites →https://doi.org/10.1074/mcp.m113.031591openalex-snapshot
Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ
inferredcites →https://doi.org/10.1080/00021369.1978.10863014openalex-snapshot
Isolation and Characterization of E–64, a New Thiol Protease Inhibitor
inferredcites →https://doi.org/10.1080/21505594.2019.1614383openalex-snapshot
Basic principles of the virulence of Cryptococcus
inferredcites →https://doi.org/10.1093/emboj/20.5.1020openalex-snapshot
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans
inferredcites →https://doi.org/10.1093/infdis/172.6.1620openalex-snapshot
Synergy of Fluconazole with Human Monocytes or Monocyte-Derived Macrophages for Killing of Candida Species
inferredcites →https://doi.org/10.1093/labmed/lmac041openalex-snapshot
Metabolomics: A New Tool to Reveal the Nature of Diabetic Kidney Disease
inferredcites →https://doi.org/10.1093/nar/gkaa1100openalex-snapshot
UniProt: the universal protein knowledgebase in 2021
inferredcites →https://doi.org/10.1093/nar/gkab1112openalex-snapshot
Database resources of the national center for biotechnology information
inferredcites →https://doi.org/10.1093/nar/gkh073openalex-snapshot
Database resources of the National Center for Biotechnology Information: update
inferredcites →https://doi.org/10.1093/nar/gkx1134openalex-snapshot
The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database
inferredcites →https://doi.org/10.1111/j.1365-2958.2009.06895.xopenalex-snapshot
Cryptococcus neoformans Site‐2 protease is required for virulence and survival in the presence of azole drugs
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1111/mmi.14565openalex-snapshot
Combatting the evolution of antifungal resistance in Cryptococcus neoformans
inferredcites →https://doi.org/10.1111/myc.12650openalex-snapshot
An alternative method for the analysis of melanin production in Cryptococcus neoformans sensu lato and Cryptococcus gattii sensu lato
inferredcites →https://doi.org/10.1128/aac.45.1.96-104.2001openalex-snapshot
Effects of Cytokines and Fluconazole on the Activity of Human Monocytes against Candida albicans
inferredcites →https://doi.org/10.1128/aem.02506-06openalex-snapshot
Cryptococcus neoformans Biofilm Formation Depends on Surface Support and Carbon Source and Reduces Fungal Cell Susceptibility to Heat, Cold, and UV Light
inferredcites →https://doi.org/10.1128/ec.00103-15openalex-snapshot
Virulence-Associated Enzymes of Cryptococcus neoformans
inferredcites →https://doi.org/10.1128/ec.05011-11openalex-snapshot
Effects of Fluconazole on the Secretome, the Wall Proteome, and Wall Integrity of the Clinical Fungus Candida albicans
inferredcites →https://doi.org/10.1128/iai.67.2.885-890.1999openalex-snapshot
Cryptococcus neoformansResides in an Acidic Phagolysosome of Human Macrophages
inferredcites →https://doi.org/10.1128/jb.52.4.461-466.1946openalex-snapshot
Urea Decomposition as a Means of Differentiating Proteus and Paracolon Cultures from Each Other and from Salmonella and Shigella Types
inferredcites →https://doi.org/10.1128/mbio.01020-20openalex-snapshot
Fun(gi)omics: Advanced and Diverse Technologies to Explore Emerging Fungal Pathogens and Define Mechanisms of Antifungal Resistance
inferredcites →https://doi.org/10.1128/mbio.01101-14openalex-snapshot
Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease
inferredcites →https://doi.org/10.1128/mbio.01249-20openalex-snapshot
An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease
inferredcites →https://doi.org/10.1128/mbio.01537-17openalex-snapshot
Disarming Fungal Pathogens: Bacillus safensis Inhibits Virulence Factor Production and Biofilm Formation by Cryptococcus neoformans and Candida albicans
inferredcites →https://doi.org/10.1128/mbio.01862-15openalex-snapshot
Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation
inferredcites →https://doi.org/10.1128/mbio.02183-16openalex-snapshot
Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen
inferredcites →https://doi.org/10.1128/msphere.00134-22openalex-snapshot
Membrane Integrity Contributes to Resistance of Cryptococcus neoformans to the Cell Wall Inhibitor Caspofungin
inferredcites →https://doi.org/10.1128/spectrum.02866-22openalex-snapshot
Unraveling Capsule Biosynthesis and Signaling Networks in Cryptococcus neoformans
inferredcites →https://doi.org/10.1139/facets-2021-0157openalex-snapshot
Peptidases: promising antifungal targets of the human fungal pathogen, Cryptococcus neoformans
inferredcites →https://doi.org/10.1247/csf.30.25openalex-snapshot
Defining the Roles of .BETA.-catenin and Plakoglobin in Cell-cell Adhesion: Isolation of .BETA.-catenin/plakoglobin-deficient F9 Cells
inferredcites →https://doi.org/10.1289/ehp7484openalex-snapshot
Trends in Agricultural Triazole Fungicide Use in the United States, 1992–2016 and Possible Implications for Antifungal-Resistant Fungi in Human Disease
inferredcites →https://doi.org/10.1371/journal.pgen.1005159openalex-snapshot
The Cryptococcus neoformans Alkaline Response Pathway: Identification of a Novel Rim Pathway Activator
inferredcites →https://doi.org/10.1371/journal.pone.0025092openalex-snapshot
Protection of Melanized Cryptococcus neoformans from Lethal Dose Gamma Irradiation Involves Changes in Melanin's Chemical Structure and Paramagnetism
inferredcites →https://doi.org/10.1371/journal.ppat.0020063openalex-snapshot
Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
inferredcites →https://doi.org/10.1371/journal.ppat.1006051openalex-snapshot
Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence
inferredcites →https://doi.org/10.1371/journal.ppat.1010073openalex-snapshot
Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond
inferredcites →https://doi.org/10.1371/journal.ppat.1011141openalex-snapshot
The Cryptococcus wall: A different wall for a unique lifestyle
inferredcites →https://doi.org/10.1385/0-89603-268-x:5openalex-snapshot
The Bicinchoninic Acid (BCA) Assay for Protein Quantitation
inferredcites →https://doi.org/10.1385/089603268xopenalex-snapshot
Basic Protein and Peptide Protocols
inferredcites →https://doi.org/10.1534/genetics.116.190595openalex-snapshot
Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans
inferredcites →https://doi.org/10.2174/138955713804484802openalex-snapshot
Aspartic Protease Inhibitors: Effective Drugs against the Human Fungal Pathogen Candida albicans
inferredcites →https://doi.org/10.2174/1389557511307010155openalex-snapshot
Aspartic Protease Inhibitors: Effective Drugs against the Human Fungal Pathogen Candida albicans
inferredcites →https://doi.org/10.29252/cmm.3.2.20openalex-snapshot
Isolation and molecular characterization of Cryptococcus species isolated from pigeon nests and Eucalyptus trees
inferredcites →https://doi.org/10.3201/eid1001.020779openalex-snapshot
Antifungal Susceptibilities ofCryptococcus neoformans
inferredcites →https://doi.org/10.3389/fcimb.2019.00212openalex-snapshot
The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans
inferredcites →https://doi.org/10.3389/fmicb.2020.01027openalex-snapshot
Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms
inferredcites →https://doi.org/10.3390/antibiotics9110812openalex-snapshot
Antifungal Drug Repurposing
inferredcites →https://doi.org/10.3390/jof3010010openalex-snapshot
The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System
inferredcites →https://doi.org/10.3390/jof3030046openalex-snapshot
Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds
inferredcites →https://doi.org/10.3390/jof5020052openalex-snapshot
Mass Spectrometry-Based Proteomics of Fungal Pathogenesis, Host–Fungal Interactions, and Antifungal Development
inferredcites →https://doi.org/10.3390/jof7121016openalex-snapshot
From Naturally-Sourced Protease Inhibitors to New Treatments for Fungal Infections
inferredcites →https://doi.org/10.3390/jof9040487openalex-snapshot
Cyclosporine Affects the Main Virulence Factors of Cryptococcus neoformans In Vitro
inferredcites →https://doi.org/10.3791/64540openalex-snapshot
Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
inferredcites →https://doi.org/10.4155/fmc.15.6openalex-snapshot
Biofilm Formation Mechanisms and Targets for Developing Antibiofilm Agents
inferredcites →https://doi.org/10.5483/bmbrep.2005.38.2.128openalex-snapshot
Recent Advances in the Innate Immunity of Invertebrate Animals
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.3897/imafungus.17.171995zenodo-depositor-declared
Interconnected worlds: a comprehensive review of fungal defenses, antimicrobial resistance, and their evolutionary dynamics
inferred← citeshttps://doi.org/10.1002/cpz1.70133openalex-snapshot
Cryptococcus neoformans Biofilm Formation and Quantification
inferred← citeshttps://doi.org/10.1016/j.mcpro.2025.101083openalex-snapshot
Whole Blood Proteome Dynamics Defines Predictive Diagnostic and Prognostic Signatures of Cryptococcal Infection
inferred← citeshttps://doi.org/10.1016/j.nmni.2026.101735openalex-snapshot
A review of the current anti-Cryptococcus antifungals and emerging treatment strategies
inferred← citeshttps://doi.org/10.1016/j.tplants.2025.03.003openalex-snapshot
The plant proteome delivers from discovery to innovation
inferred← citeshttps://doi.org/10.1021/acsomega.6c04207openalex-snapshot
Repurposing the Insecticide Flufenerim, the Only Anti- Cryptococcus Compound Identified in the MMV Global Health Priority Box, as a Candidate for the Environmental Control of the Cryptococcosis Agents
inferred← citeshttps://doi.org/10.1038/s41467-025-61412-xopenalex-snapshot
Disruption of the ATP-dependent unfoldase ClpX reverses antifungal resistance in Cryptococcus neoformans
inferred← citeshttps://doi.org/10.1101/2025.05.30.657021openalex-snapshot
Spatiotemporal Dynamics of Cryptococcal Infection Reveal Novel Immune Modulatory Mechanisms and Antifungal Targets
inferred← citeshttps://doi.org/10.1128/mra.01138-24openalex-snapshot
Proteome remodeling upon disruption of virulence-associated CipC from Cryptococcus neoformans
inferred← citeshttps://doi.org/10.3390/jof11030236openalex-snapshot
The Hidden Fortress: A Comprehensive Review of Fungal Biofilms with Emphasis on Cryptococcus neoformans
inferred← citeshttps://doi.org/10.3390/jof11070529openalex-snapshot
Insights from Mass Spectrometry-Based Proteomics on Cryptococcus neoformans
inferred← citeshttps://doi.org/10.3390/molecules29215197openalex-snapshot
Combining Fluconazole with Benzo[a]phenoxazine Derivatives as a Promising Strategy Against Fluconazole-Resistant Candida Species
inferred← citeshttps://doi.org/10.64898/2026.04.10.717560openalex-snapshot
A structure-guided pipeline yields peptide inhibitors that disarm fungal peptidase-driven virulence and resistance
inferred← citeshttps://doi.org/10.70389/pjs.100276openalex-snapshot
A Comprehensive Review on Fluconazole: Clinical Efficacy, Pharmacokinetics, and Newly Emerging Challenges of Resistance
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