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Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.28021openalex-snapshot
Comprehensive analysis of PTEN status in breast carcinomas
inferredcites →https://doi.org/10.1002/jcb.26687openalex-snapshot
The prognostic value of PI3K mutational status in breast cancer: A meta‐analysis
inferredcites →https://doi.org/10.1002/tox.22238openalex-snapshot
Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase‐dependent pathways and associated with beclin‐1‐induced cell autophagy
inferredcites →https://doi.org/10.1007/s00432-017-2557-5openalex-snapshot
Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells
inferredcites →https://doi.org/10.1007/s11864-018-0539-8openalex-snapshot
Update on the Treatment of Early-Stage Triple-Negative Breast Cancer
inferredcites →https://doi.org/10.1016/j.biocel.2012.11.001openalex-snapshot
Statins, autophagy and cancer metastasis
inferredcites →https://doi.org/10.1016/j.ctrv.2014.03.004openalex-snapshot
Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer
inferredcites →https://doi.org/10.1016/j.pharmthera.2017.02.037openalex-snapshot
PI3K-AKT-mTOR inhibitors in breast cancers: From tumor cell signaling to clinical trials
inferredcites →https://doi.org/10.1016/j.prp.2018.03.020openalex-snapshot
Loss of PTEN in high grade advanced stage triple negative breast ductal cancers in African American women
inferredcites →https://doi.org/10.1016/j.semcancer.2017.04.015openalex-snapshot
PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux
inferredcites →https://doi.org/10.1038/nrc3860openalex-snapshot
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
inferredcites →https://doi.org/10.1093/abbs/gmv119openalex-snapshot
Autophagy regulation in the development and treatment of breast cancer
inferredcites →https://doi.org/10.1186/2045-3701-5-4openalex-snapshot
Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species
inferredcites →https://doi.org/10.1186/s12885-018-4231-yopenalex-snapshot
Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells
inferredcites →https://doi.org/10.18632/oncotarget.21058openalex-snapshot
SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling
inferredcites →https://doi.org/10.3389/fimmu.2018.00584openalex-snapshot
The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
inferredcites →https://doi.org/10.3389/fonc.2018.00031openalex-snapshot
Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis
inferredcites →https://doi.org/10.3389/fphar.2017.00266openalex-snapshot
Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway
inferredcites →https://doi.org/10.3389/fphar.2017.00351openalex-snapshot
Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms
inferredcites →https://doi.org/10.4014/jmb.1101.01020openalex-snapshot
Ferric Reductase Activity of the ArsH Protein from Acidithiobacillus ferrooxidans

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4633896openalex-extracted
Novel Sulfonyl-Substituted Tetrandrine Derivatives for Colon Cancer Treatment by Inducing Mitochondrial Apoptosis and Inhibiting PI3K/AKT/mTOR Pathway
inferred← citeshttps://doi.org/10.1002/biof.1799openalex-snapshot
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer
inferred← citeshttps://doi.org/10.1002/cam4.2894openalex-snapshot
Fangjihuangqi Decoction inhibits MDA‐MB‐231 cell invasion in vitro and decreases tumor growth and metastasis in triple‐negative breast cancer xenografts tumor zebrafish model
inferred← citeshttps://doi.org/10.1002/cam4.3356openalex-snapshot
Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway
inferred← citeshttps://doi.org/10.1002/cam4.4970openalex-snapshot
Inositol monophosphatase 1 ( IMPA1 ) promotes triple‐negative breast cancer progression through regulating mTOR pathway and EMT process
inferred← citeshttps://doi.org/10.1002/ccs3.70084openalex-snapshot
Imperatorin ameliorates myocardial ischemia‐reperfusion injury by inhibiting endoplasmic reticulum stress‐mediated apoptosis via the PI3K/AKT/Nrf2 pathway
inferred← citeshttps://doi.org/10.1002/ptr.8283openalex-snapshot
Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach
inferred← citeshttps://doi.org/10.1007/s00253-019-09921-wopenalex-snapshot
Insight into the roles of tyrosine on rCHO cell performance in fed-batch cultures
inferred← citeshttps://doi.org/10.1007/s11101-020-09673-wopenalex-snapshot
A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)
inferred← citeshttps://doi.org/10.1007/s11101-025-10095-9openalex-snapshot
Critical review and future perspectives on the anticancer effects of Stephania tetrandra S. Moore
inferred← citeshttps://doi.org/10.1007/s12032-023-02274-5openalex-snapshot
Nanoemulsion potentiates the anti-cancer activity of Myricetin by effective inhibition of PI3K/AKT/mTOR pathway in triple-negative breast cancer cells
inferred← citeshttps://doi.org/10.1007/s43032-020-00442-wopenalex-snapshot
The Effect and Mechanism of Asymmetric Dimethylarginine Regulating Trophoblastic Autophagy on Fetal Growth Restriction
inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.107069openalex-snapshot
Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K/AKT/mTOR pathway
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.112727openalex-snapshot
Autophagy and cancer: Can tetrandrine be a potent anticancer drug in the near future?
inferred← citeshttps://doi.org/10.1016/j.bmc.2024.117877openalex-snapshot
Recent advancement in developing small molecular inhibitors targeting key kinase pathways against triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.cbi.2019.108726openalex-snapshot
Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells
inferred← citeshttps://doi.org/10.1016/j.ceca.2023.102760openalex-snapshot
Calcium signal modulation in breast cancer aggressiveness
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112812openalex-snapshot
Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.09.029openalex-snapshot
Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review
inferred← citeshttps://doi.org/10.1016/j.jpha.2024.101036openalex-snapshot
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118239openalex-snapshot
Tumor suppressive activity of miR-424-5p in breast cancer cells through targeting PD-L1 and modulating PTEN/PI3K/AKT/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1016/j.synres.2020.100063openalex-snapshot
Combination of tetrandrine and cisplatin synergises cytotoxicity and apoptosis in triple negative breast cancer
inferred← citeshttps://doi.org/10.1080/01635581.2020.1750661openalex-snapshot
Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion via Induction of Autophagy in ER-Positive Breast Cancer Cell Lines (MCF7 and T47D)
inferred← citeshttps://doi.org/10.1080/21655979.2022.2031396openalex-snapshot
Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy
inferred← citeshttps://doi.org/10.1101/2025.11.26.690890openalex-snapshot
Silylation of hydroxychloroquine enhances autophagy inhibition and antiproliferative activity in breast and pancreatic cancer cells
inferred← citeshttps://doi.org/10.1111/jphp.13339openalex-snapshot
Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems
inferred← citeshttps://doi.org/10.1139/bcb-2025-0085openalex-snapshot
TGFB1-mediated autophagy facilitates oxaliplatin resistance in stomach adenocarcinoma
inferred← citeshttps://doi.org/10.1152/ajpcell.00428.2024openalex-snapshot
Natural compounds and strategies for fighting against drug resistance in cancer: a special focus on phenolic compounds and microRNAs
inferred← citeshttps://doi.org/10.1155/2020/6823520openalex-snapshot
Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA‐MB‐231 In Vivo
inferred← citeshttps://doi.org/10.1186/s13578-019-0332-9openalex-snapshot
Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0314500openalex-snapshot
Nitroxyl protects H9C2 cells from H/R-induced damage and inhibits autophagy via PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.18311/jnr/2026/49938openalex-snapshot
Immunomodulatory Effects of Natural Products in Breast Cancer: From Molecular Mechanisms to Clinical Translation
inferred← citeshttps://doi.org/10.18632/aging.205750openalex-snapshot
Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1
inferred← citeshttps://doi.org/10.21203/rs.3.rs-339147/v1openalex-snapshot
MiR-424-5p and miR -142-3p Combination Synergistically Regulates the Biological Features of Breast Cancer Cells
inferred← citeshttps://doi.org/10.2147/ott.s235533openalex-snapshot
Tetrandrine Reverses Paclitaxel Resistance in Human Ovarian Cancer via Inducing Apoptosis, Cell Cycle Arrest Through β-Catenin Pathway
inferred← citeshttps://doi.org/10.2174/0115680266282360240222062032openalex-snapshot
Tetrandrine for Targeting Therapy Resistance in Cancer
inferred← citeshttps://doi.org/10.2174/0115734072331654241211032635openalex-snapshot
Therapeutic Potential of Alkaloids to Combat Breast Cancer: A Mechanistic Overview
inferred← citeshttps://doi.org/10.2174/1574892815666200910164641openalex-snapshot
Phytochemicals as PI3K/ Akt/ mTOR Inhibitors and Their Role in Breast Cancer Treatment
inferred← citeshttps://doi.org/10.2174/1871520619666190722101207openalex-snapshot
Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion of MDA-MB-231 Triple-Negative Breast Cancer Cell via Induction of Autophagy
inferred← citeshttps://doi.org/10.2174/1871520620666200619180716openalex-snapshot
New Insight into Triple-Negative Breast Cancer Therapy: The Potential Roles of Endoplasmic Reticulum Stress and Autophagy Mechanisms
inferred← citeshttps://doi.org/10.2174/9789815079784123010010openalex-snapshot
Unveiling the Potency of Phyto-Constituents to Target TNBC: Mechanism to Therapeutics
inferred← citeshttps://doi.org/10.22038/ijbms.2024.79405.17201openalex-snapshot
Targeting autophagy for breast cancer prevention and therapy: From classical methods to phytochemical agents.
inferred← citeshttps://doi.org/10.2217/nnm-2022-0171openalex-snapshot
Hyperthermia and Doxorubicin Release by Fol-LSMO Nanoparticles Induce Apoptosis and Autophagy in Breast Cancer Cells
inferred← citeshttps://doi.org/10.22541/au.167939853.32039231/v1openalex-snapshot
Nanoemulsion Myricetin preparation increases the anticancer efficacy against Triple-negative Breast Cancer cells
inferred← citeshttps://doi.org/10.31832/smj.1683545openalex-snapshot
Migration Suppressive Effect of Rapamycin in MDA-MB-231 Cells
inferred← citeshttps://doi.org/10.32604/oncologie.2021.017267openalex-snapshot
Integrated Network Pharmacology and Molecular Docking to Reveal the Mechanism of Tetrandrine in Tumor Chemoresistance
inferred← citeshttps://doi.org/10.32604/or.2023.044491openalex-snapshot
miR-125b reverses cisplatin resistance by regulating autophagy via targeting RORA/BNIP3L axis in lung adenocarcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2022.1000925openalex-snapshot
A functional role for Serum Amyloid A in the molecular regulation of autophagy in breast cancer
inferred← citeshttps://doi.org/10.3389/fonc.2022.922196openalex-snapshot
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
inferred← citeshttps://doi.org/10.3389/fphar.2021.731741openalex-snapshot
Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.3389/fphar.2022.820593openalex-snapshot
Tetrandrine Citrate Suppresses Breast Cancer via Depletion of Glutathione Peroxidase 4 and Activation of Nuclear Receptor Coactivator 4-Mediated Ferritinophagy
inferred← citeshttps://doi.org/10.3389/fphar.2022.978600openalex-snapshot
Progress on structural modification of Tetrandrine with wide range of pharmacological activities
inferred← citeshttps://doi.org/10.3389/fphar.2024.1349242openalex-snapshot
The therapeutic potential of natural metabolites in targeting endocrine-independent HER-2-negative breast cancer
inferred← citeshttps://doi.org/10.3390/biology8040076openalex-snapshot
Cytotoxic Potential of the Coelomic Fluid Extracted from the Sea Cucumber Holothuria tubulosa against Triple-Negative MDA-MB231 Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/biom15111561openalex-snapshot
Molecular Basis of Simalikalactone D Sensitivity in Triple-Negative Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/ijms22189807openalex-snapshot
Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer
inferred← citeshttps://doi.org/10.3390/ijms23158148openalex-snapshot
Tetrandrine Inhibits Skeletal Muscle Differentiation by Blocking Autophagic Flux
inferred← citeshttps://doi.org/10.3390/ijms26157523openalex-snapshot
Breast Cancer Cell Line-Specific Responses to Insulin: Effects on Proliferation and Migration
inferred← citeshttps://doi.org/10.3390/jmse8040261openalex-snapshot
Cell-Free Coelomic Fluid Extracts of the Sea Urchin Arbacia lixula Impair Mitochondrial Potential and Cell Cycle Distribution and Stimulate Reactive Oxygen Species Production and Autophagic Activity in Triple-Negative MDA-MB231 Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/molecules26237105openalex-snapshot
Tetrandrine Suppresses Human Brain Glioblastoma GBM 8401/luc2 Cell-Xenografted Subcutaneous Tumors in Nude Mice In Vivo
inferred← citeshttps://doi.org/10.3390/molecules27113513openalex-snapshot
Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways
inferred← citeshttps://doi.org/10.3390/molecules27134040openalex-snapshot
Design, Synthesis, and Biological Evaluation of N14-Amino Acid-Substituted Tetrandrine Derivatives as Potential Antitumor Agents against Human Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/molecules28155804openalex-snapshot
Natural-Product-Derived Adjunctive Treatments to Conventional Therapy and Their Immunoregulatory Activities in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.3390/pr10112340openalex-snapshot
Network Pharmacology and Molecular Docking Integrated Strategy to the Screening of Active Components and Mechanisms of Stephaniae Tetrandrae Radix on Breast Cancer
inferred← citeshttps://doi.org/10.37349/etat.2022.00072openalex-snapshot
Targeting the two-pore channel 2 in cancer progression and metastasis
inferred← citeshttps://doi.org/10.3892/mmr.2020.11585openalex-snapshot
Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/β‑catenin signaling pathway
inferred← citeshttps://doi.org/10.3892/mmr.2022.12619openalex-snapshot
Dihydromyricetin ameliorates oxygen‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway
inferred← citeshttps://doi.org/10.3892/ol.2020.12331openalex-snapshot
Proliferation, migration and invasion of triple negative breast cancer cells are suppressed by berbamine via the PI3K/Akt/MDM2/p53 and PI3K/Akt/mTOR signaling pathways
inferred← citeshttps://doi.org/10.3892/or.2019.7095openalex-snapshot
TRPC5‑induced autophagy promotes the TMZ‑resistance of glioma cells via the CAMMKβ/AMPKα/mTOR pathway
inferred← citeshttps://doi.org/10.4018/978-1-6684-6299-7.ch017openalex-snapshot
Current Update on Natural Agents Against Triple Negative Breast Cancer
inferred← citeshttps://doi.org/10.4018/978-1-7998-2094-9.ch005openalex-snapshot
Current Update on Natural Agents Against Triple Negative Breast Cancer
inferred← citeshttps://doi.org/10.4018/979-8-3693-3836-0.ch012openalex-snapshot
Natural Products Modulating Mitophagy
inferred← citeshttps://doi.org/10.52547/ijrr.20.2.14openalex-snapshot
HS-173, a novel PI3K inhibitor enhances radiosensitivity of breast cancer cells
inferred← citeshttps://doi.org/10.62347/noic1325openalex-snapshot
SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer: Am J Cancer Res. 2020; 10(9): 2832-2850
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