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Antitumor Effects of Ononin by Modulation of Apoptosis in Non‐Small‐Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cncr.29045openalex-snapshot
Analysis of stage and clinical/prognostic factors for lung cancer from SEER registries: AJCC staging and collaborative stage data collection system
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Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K /Akt/ mTOR signaling pathway
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In vitro plant tissue culture: means for production of biological active compounds
inferredcites →https://doi.org/10.1007/s10495-016-1295-5openalex-snapshot
Mitochondrial dynamics during cell cycling
inferredcites →https://doi.org/10.1007/s12013-014-9972-xopenalex-snapshot
Simultaneous Determination of Calycosin-7-O-β-d-Glucoside, Ononin, Calycosin, Formononetin, Astragaloside IV, and Astragaloside II in Rat Plasma After Oral Administration of Radix Astragali Extraction for Their Pharmacokinetic Studies by Ultra-Pressure Liquid Chromatography with Tandem Mass…
inferredcites →https://doi.org/10.1016/j.ab.2017.07.009openalex-snapshot
Mitochondrial membrane potential
inferredcites →https://doi.org/10.1016/j.biocel.2012.01.015openalex-snapshot
Atorvastatin sensitizes human non-small cell lung carcinomas to carboplatin via suppression of AKT activation and upregulation of TIMP-1
inferredcites →https://doi.org/10.1016/j.jep.2015.03.033openalex-snapshot
Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract
inferredcites →https://doi.org/10.1016/j.jep.2017.01.044openalex-snapshot
Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review
inferredcites →https://doi.org/10.1016/j.jep.2020.112895openalex-snapshot
Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine
inferredcites →https://doi.org/10.1016/j.jphs.2022.07.001openalex-snapshot
PP2A regulates metastasis and vasculogenic mimicry formation via PI3K/AKT/ZEB1 axis in non-small cell lung cancers
inferredcites →https://doi.org/10.1016/j.phrs.2019.04.032openalex-snapshot
Ononin, sec-O-β-d-glucosylhamaudol and astragaloside I: antiviral lead compounds identified via high throughput screening and biological validation from traditional Chinese medicine Zhongjing formulary
inferredcites →https://doi.org/10.1016/j.semcdb.2017.05.023openalex-snapshot
ROS signalling in the biology of cancer
inferredcites →https://doi.org/10.1016/j.sjbs.2021.06.031openalex-snapshot
Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer’s disease in rats
inferredcites →https://doi.org/10.1016/j.taap.2020.115336openalex-snapshot
Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism
inferredcites →https://doi.org/10.1016/j.taap.2021.115576openalex-snapshot
Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer
inferredcites →https://doi.org/10.1016/j.taap.2022.116179openalex-snapshot
Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3
inferredcites →https://doi.org/10.1021/acs.jnatprod.1c00008openalex-snapshot
Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway
inferredcites →https://doi.org/10.1038/s41573-020-00114-zopenalex-snapshot
Natural products in drug discovery: advances and opportunities
inferredcites →https://doi.org/10.1039/c9fo02927copenalex-snapshot
Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via the PI3K/AKT pathway
inferredcites →https://doi.org/10.1039/c9ra04701hopenalex-snapshot
Astragali radix total flavonoid synergizes cisplatin to inhibit proliferation and enhances the chemosensitivity of laryngeal squamous cell carcinoma
inferredcites →https://doi.org/10.1055/s-0034-1383026openalex-snapshot
Naturally Occurring Homoisoflavonoids and Their Pharmacological Activities
inferredcites →https://doi.org/10.1111/1440-1681.13464openalex-snapshot
Salvianolic acid A blocks vasculogenic mimicry formation in human non‐small cell lung cancer via PI3K/Akt/mTOR signalling
inferredcites →https://doi.org/10.1111/nyas.13446openalex-snapshot
Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
inferredcites →https://doi.org/10.1155/2021/5187569openalex-snapshot
The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS‐Induced Noncanonical Inflammasome Pyroptotic Pathway
inferredcites →https://doi.org/10.1186/1743-7075-7-67openalex-snapshot
The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity
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Assessing the effectiveness and safety of liposomal paclitaxel in combination with cisplatin as first-line chemotherapy for patients with advanced NSCLC with regional lymph-node metastasis: study protocol for a randomized controlled trial (PLC-GC trial)
inferredcites →https://doi.org/10.1186/s11658-019-0164-yopenalex-snapshot
Progress in research on paclitaxel and tumor immunotherapy
inferredcites →https://doi.org/10.1186/s12935-016-0288-3openalex-snapshot
Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells
inferredcites →https://doi.org/10.1248/cpb.c18-00738openalex-snapshot
Semicarbazone Derivatives Bearing Phenyl Moiety: Synthesis, Anticancer Activity, Cell Cycle, Apoptosis-Inducing and Metabolic Stability Study
inferredcites →https://doi.org/10.1615/jenvironpatholtoxicoloncol.2018027418openalex-snapshot
Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells
inferredcites →https://doi.org/10.18388/abp.2020_5431openalex-snapshot
Development of paclitaxel loaded pegylated gelatin targeted nanoparticles for improved treatment efficacy in non-small cell lung cancer (NSCLC): an in vitro and in vivo evaluation study
inferredcites →https://doi.org/10.19540/j.cnki.cjcmm.20201207.402openalex-snapshot
[Study on intervention effect of Astragali Radix-Curcumae Rhizoma on growth and metastasis of colon cancer in orthotopic transplantation mice model of colon cancer].
inferredcites →https://doi.org/10.2147/cmar.s142650openalex-snapshot
Mechanical ventilation promotes lung metastasis in experimental 4T1 breast cancer lung-metastasized models
inferredcites →https://doi.org/10.2174/1874467213666200525010624openalex-snapshot
Recent Advances in Herbal Nanomedicines for Cancer Treatment
inferredcites →https://doi.org/10.3389/fonc.2022.939646openalex-snapshot
Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway
inferredcites →https://doi.org/10.3389/fphar.2020.00397openalex-snapshot
Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes
inferredcites →https://doi.org/10.3389/fphar.2020.580978openalex-snapshot
An Integrated Strategy for Effective-Component Discovery of Astragali Radix in the Treatment of Lung Cancer
inferredcites →https://doi.org/10.3390/biom9120789openalex-snapshot
Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer
inferredcites →https://doi.org/10.3390/ijms18112331openalex-snapshot
Polyphenol-Rich Dry Common Beans (Phaseolus vulgaris L.) and Their Health Benefits
inferredcites →https://doi.org/10.3390/ijms18112390openalex-snapshot
Polyphenol-Rich Lentils and Their Health Promoting Effects
inferredcites →https://doi.org/10.3390/ijms221910827openalex-snapshot
Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment
inferredcites →https://doi.org/10.3390/nu11102264openalex-snapshot
Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer
inferredcites →https://doi.org/10.3390/nu9050455openalex-snapshot
A Critical Review on Polyphenols and Health Benefits of Black Soybeans
inferredcites →https://doi.org/10.3892/etm.2021.10742openalex-snapshot
Ononin alleviates H2O2‑induced cardiomyocyte apoptosis and improves cardiac function by activating the AMPK/mTOR/autophagy pathway
inferredcites →https://doi.org/10.5306/wjco.v12.i4.217openalex-snapshot
Oncogenic driver mutations in non-small cell lung cancer: Past, present and future
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.3897/pharmacia.73.e159454zenodo-depositor-declared
Ononin synergistically enhances the cytotoxic effect of doxorubicin in MDA-MB-231 triple-negative breast cancer cell line
inferred← citeshttps://doi.org/10.1002/jbt.70804openalex-snapshot
Ononin Inhibits the Growth and Metastasis of Hepatocellular Carcinoma by Suppressing MMP‐2 and MMP‐9 via PI3K/AKT/mTOR Signaling
inferred← citeshttps://doi.org/10.1002/jssc.70410openalex-snapshot
Prediction and Analysis of Quality Markers for Hedysari Radix Using Ultra‐High‐Performance Liquid Chromatography‐Tandem Mass Spectrometry, Network Pharmacology, Molecular Dynamics, and Chemometrics
inferred← citeshttps://doi.org/10.1007/s00210-026-05040-2openalex-snapshot
Network pharmacology and experimental validation to explore the effects and mechanisms of flavonoids luteolin and chrysoeriol against non‑small cell lung cancer
inferred← citeshttps://doi.org/10.1007/s00432-024-05862-8openalex-snapshot
UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1007/s10616-024-00692-5openalex-snapshot
miR-141-3p inhibited BPA-induced proliferation and migration of lung cancer cells through PTGER4
inferred← citeshttps://doi.org/10.1007/s11427-023-2499-2openalex-snapshot
Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.1007/s12013-024-01294-wopenalex-snapshot
Liquiritigenin Induces Cell Cycle Arrest and Apoptosis in Lung Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1007/s12032-026-03334-2openalex-snapshot
Effects of Astragalus membranaceus injection at Zusanli (ST36) acupoint on lung cancer with COPD
inferred← citeshttps://doi.org/10.1007/s12272-024-01489-yopenalex-snapshot
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
inferred← citeshttps://doi.org/10.1007/s43630-023-00453-xopenalex-snapshot
New developments in sunscreens
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Targeting ferroptosis with flavonoids for cancer therapy: Mechanisms and opportunities
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.112243openalex-snapshot
Immunomodulatory effects of ononin alleviates arthritis through modulation of macrophage polarization and JAK/STAT3 signaling
inferred← citeshttps://doi.org/10.1016/j.chphi.2024.100793openalex-snapshot
Targeting PI3K/AKT/mTOR signalling pathway in non-small-cell lung carcinoma: Exploring promising bioactive natural compounds as anti-cancer agents
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2026.109111openalex-snapshot
An integrative multi-modal computational framework identified hub prognostic targets and natural inhibitors for tobacco-specific nitrosamine-induced lung adenocarcinoma
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.178052openalex-snapshot
Potential of ononin as a safe and effective anti-melanogenic agent: In vitro and zebrafish embryo study
inferred← citeshttps://doi.org/10.1016/j.fbio.2023.103302openalex-snapshot
Therapeutic potentials of ononin with mechanistic insights: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.143344openalex-snapshot
Structural characterization and protective activity of α-glucans derived from Cynomorium songaricum Rupr. against homocysteine-induced oxidative stress in MC3T3-E1 cells
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.111959openalex-snapshot
Ononin triggers ferroptosis-mediated disruption in the triple negative breast cancer both in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2024.11.003openalex-snapshot
Efficient biosynthesis of three rare formononetin derivatives by newly discovered Bacillus velezensis LQ5
inferred← citeshttps://doi.org/10.1016/j.jddst.2024.105609openalex-snapshot
Isoliquiritigenin-infused electrospun nanofiber inhibits breast cancer proliferation and invasion through downregulation of PI3K/Akt/mTOR and MMP2/9 pathways
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117375openalex-snapshot
Ononin ameliorates depression-like behaviors by regulating BDNF-TrkB-CREB signaling in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.jep.2025.119724openalex-snapshot
Combining network pharmacology and transcriptomics to validate and explore the efficacy and mechanism of Huayu Wan in treating non-small cell lung cancer
inferred← citeshttps://doi.org/10.1016/j.jep.2025.120637openalex-snapshot
Exploring the mechanisms of Hu-gu-xiao-ji formula and its components for treatment on non-small cell lung cancer using UPLC-QTOF-MS/MS, network pharmacology, and experiments
inferred← citeshttps://doi.org/10.1016/j.jep.2025.120921openalex-snapshot
Microsorum membranaceum (D. Don) Ching protected dexamethasone-induced sarcopenia by targeting protein degradation and synthesis pathway in C2C12 cells and C57BL/6 mice
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.11.011openalex-snapshot
Regulation of nerve cells and therapeutic potential in central nervous system injury using microglia-derived exosomes
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155290openalex-snapshot
Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c00545openalex-snapshot
Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages
inferred← citeshttps://doi.org/10.1038/s41401-025-01560-4openalex-snapshot
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis
inferred← citeshttps://doi.org/10.1038/s41598-026-36762-1openalex-snapshot
Ononin suppresses tumor-induced platelet activation and invasion and enhances cell-cycle arrest and apoptosis in triple-negative breast cancer cells
inferred← citeshttps://doi.org/10.1055/a-2507-3598openalex-snapshot
Advancements in mTOR Inhibitors for Non-Small-Cell Lung Cancer: Mechanisms, Efficacy, and Future Perspectives
inferred← citeshttps://doi.org/10.1097/scs.0000000000012024openalex-snapshot
Piperlongumine Inhibits OSCC Epithelial-Mesenchymal Transition and Promotes Tumor Cell Apoptosis by Targeting TrxR1 to Activate ROS and Its Related Pathways
inferred← citeshttps://doi.org/10.1155/2023/6667315openalex-snapshot
Study on the Potential Mechanism of Traditional Marine Chinese Medicine Beishashen in Preventing Lung Injury Induced by Radiotherapy and Chemotherapy
inferred← citeshttps://doi.org/10.1177/09603271241229140openalex-snapshot
RETRACTED: Ginsenoside Rg5 induces NSCLC cell apoptosis and autophagy through PI3K/Akt/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1615/critreveukaryotgeneexpr.2023046722openalex-snapshot
Chloroquine Sensitizes Esophageal Carcinoma EC109 Cells to Paclitaxel by Inhibiting Autophagy
inferred← citeshttps://doi.org/10.2174/0109298673259973231023110945openalex-snapshot
Anti-migratory Properties of Cryoprotective Isoliquiritigenin-zein Phosphatidylcholine Nanoparticles Prevent Triple-negative Breast Cancer through PI3K-mTOR and MMP2/9 Pathways
inferred← citeshttps://doi.org/10.2174/0109298673331246241023095720openalex-snapshot
Ononin’s Antagonistic Activity towards TRPV1: Insights from Molecular Dynamics and Capsaicin-Evoked Calcium Response in DRG Neurons
inferred← citeshttps://doi.org/10.3390/cancers15030758openalex-snapshot
Anti-Invasive and Anti-Migratory Effects of Ononin on Human Osteosarcoma Cells by Limiting the MMP2/9 and EGFR-Erk1/2 Pathway
inferred← citeshttps://doi.org/10.3390/metabo13070796openalex-snapshot
Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells
inferred← citeshttps://doi.org/10.3390/ph19040607openalex-snapshot
Danggui Buxue Tang, a Traditional Chinese Herbal Formula, Potentiates Paclitaxel Efficacy in Non-Small-Cell Lung Cancer by Inducing Ferroptosis via the Nrf2/GPX4 Axis
inferred← citeshttps://doi.org/10.3390/plants12091840openalex-snapshot
An In Vitro and In Vivo Assessment of Antitumor Activity of Extracts Derived from Three Well-Known Plant Species
inferred← citeshttps://doi.org/10.34133/research.0553openalex-snapshot
Ononin Inhibits Tumor Bone Metastasis and Osteoclastogenesis By Targeting Mitogen-Activated Protein Kinase Pathway in Breast Cancer
inferred← citeshttps://doi.org/10.37349/eds.2024.00044openalex-snapshot
Subacute toxicity of isoliquiritigenin-zein phosphatidylcholine nanoparticles on biochemical, hematological, and histopathological parameters in Sprague-Dawley rats
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