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Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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US Health Care Spending by Payer and Health Condition, 1996-2016
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Proinflammatory macrophages promote degenerative phenotypes in rat nucleus pulpous cells partly through ERK and JNK signaling
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Cell‐Free Extracts from Human Fat Tissue with a Hyaluronan‐Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization
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Role of oxidative stress in depression
inferredcites →https://doi.org/10.1016/j.matbio.2009.06.004openalex-snapshot
The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology
inferredcites →https://doi.org/10.1016/j.molcel.2017.05.031openalex-snapshot
The UPR ER : Sensor and Coordinator of Organismal Homeostasis
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The Unfolded Protein Response and Cell Fate Control
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Exosome-Transported circRNA_0000253 Competitively Adsorbs MicroRNA-141-5p and Increases IDD
inferredcites →https://doi.org/10.1016/j.redox.2016.11.007openalex-snapshot
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission
inferredcites →https://doi.org/10.1016/j.redox.2019.101342openalex-snapshot
Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway
inferredcites →https://doi.org/10.1016/j.scitotenv.2019.135624openalex-snapshot
Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders
inferredcites →https://doi.org/10.1016/j.tifs.2017.02.002openalex-snapshot
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
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Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways
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Association Between Roussouly Classification and Characteristics of Lumbar Degeneration
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Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
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Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019
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Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways
inferredcites →https://doi.org/10.1038/s12276-018-0125-yopenalex-snapshot
CircularRNA_104670 plays a critical role in intervertebral disc degeneration by functioning as a ceRNA
inferredcites →https://doi.org/10.1038/s12276-022-00811-2openalex-snapshot
Exercise-induced FNDC5/irisin protects nucleus pulposus cells against senescence and apoptosis by activating autophagy
inferredcites →https://doi.org/10.1038/s41413-020-00125-xopenalex-snapshot
Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions
inferredcites →https://doi.org/10.1038/s42003-022-03189-zopenalex-snapshot
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice
inferredcites →https://doi.org/10.1073/pnas.1305687110openalex-snapshot
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
inferredcites →https://doi.org/10.1080/08941939.2021.1988771openalex-snapshot
Antioxidant Effects of Resveratrol in Intervertebral Disk
inferredcites →https://doi.org/10.1089/ars.2010.3221openalex-snapshot
Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
inferredcites →https://doi.org/10.1089/dna.2017.3736openalex-snapshot
Endoplasmic Reticulum Stress Is Involved in Nucleus Pulposus Degeneration and Attenuates Low pH-Induced Apoptosis of Rat Nucleus Pulposus Cells
inferredcites →https://doi.org/10.1097/brs.0000000000003548openalex-snapshot
Disc Degeneration of Young Low Back Pain Patients
inferredcites →https://doi.org/10.1111/jcmm.13316openalex-snapshot
Mesenchymal stem cells deliver exogenous miR‐21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration
inferredcites →https://doi.org/10.1124/jpet.116.237503openalex-snapshot
Oxidative Stress and the Central Nervous System
inferredcites →https://doi.org/10.1139/cjpp-2016-0447openalex-snapshot
Sulforaphane protects against sodium valproate–induced acute liver injury
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Biomechanical effects of interbody cage height on adjacent segments in patients with lumbar degeneration: a 3D finite element study
inferredcites →https://doi.org/10.2106/jbjs.e.01273openalex-snapshot
Lumbar Disc Disorders and Low-Back Pain: Socioeconomic Factors and Consequences
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inferredcites →https://doi.org/10.3389/fbioe.2020.610907openalex-snapshot
The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI
inferredcites →https://doi.org/10.3390/molecules190710074openalex-snapshot
Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway
inferredcites →https://doi.org/10.5435/00124635-201111000-00001openalex-snapshot
Pediatric Disk Herniation
inferredcites →https://doi.org/10.5455/medarh.2019.73.421-424openalex-snapshot
A Brief Review of the Degenerative Intervertebral Disc Disease
inferredcites →https://doi.org/10.7150/thno.30658openalex-snapshot
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane
inferredcites →https://doi.org/10.7150/thno.33638openalex-snapshot
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Iron and Ammonia: A Deadly Combination for Head-Kidney Macrophages of Yellow Catfish (Pelteobagrus Fulvidraco) - Uncovering the Intensified Ferroptosis, Oxidative Stress, and Inflammatory Reactions
inferred← citeshttps://doi.org/10.1007/s00011-023-01784-2openalex-snapshot
Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies
inferred← citeshttps://doi.org/10.1007/s11626-025-01021-6openalex-snapshot
5-Azacytidine inhibits endoplasmic reticulum stress and apoptosis of nucleus pulposus cells by preserving PPARγ via promoter demethylation
inferred← citeshttps://doi.org/10.1007/s11655-024-3657-0openalex-snapshot
Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury
inferred← citeshttps://doi.org/10.1016/j.cej.2025.162191openalex-snapshot
Exosome-loaded methacrylated silk fibroin hydrogel delays intervertebral disc degeneration by DKK2-mediated mitochondrial unfolded protein response
inferred← citeshttps://doi.org/10.1016/j.dci.2024.105184openalex-snapshot
The differential impact of iron on ferroptosis, oxidative stress, and inflammatory reaction in head-kidney macrophages of yellow catfish (Pelteobagrus fulvidraco) with and without ammonia stress
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.130173openalex-snapshot
Advances in the regulation of radiation-induced apoptosis by polysaccharides: A review
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114668openalex-snapshot
A novel mechanism of FBXW7 in combating intervertebral disc degeneration: Mitigating ferroptosis in nucleus pulposus cells through the regulation of mitophagy
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155316openalex-snapshot
Pterostilbene suppresses gastric cancer proliferation and metastasis by inhibiting oncogenic JAK2/STAT3 signaling: In vitro and in vivo therapeutic intervention
inferred← citeshttps://doi.org/10.1097/md.0000000000048213openalex-snapshot
Transcriptome data combined with two-sample Mendelian randomization reveal IRF1 and PRKD1 as UPR-related key regulators in intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1111/acel.14210openalex-snapshot
HIF ‐1α‐induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation
inferred← citeshttps://doi.org/10.1111/cns.14150openalex-snapshot
Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53‐ALOX15 signaling pathway
inferred← citeshttps://doi.org/10.1111/jfb.70362openalex-snapshot
Amelioration of ammonia‐induced oxidative stress, ferroptosis and intestinal damage in Pelteobagrus fulvidraco through dietary tea polyphenols
inferred← citeshttps://doi.org/10.1186/s12967-024-05943-9openalex-snapshot
Mitochondrial quality control: the real dawn of intervertebral disc degeneration?
inferred← citeshttps://doi.org/10.1186/s40824-023-00339-0openalex-snapshot
Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis
inferred← citeshttps://doi.org/10.3389/fbioe.2026.1854242openalex-snapshot
Antioxidant biomaterials in intervertebral disc regeneration: current status and future clinical translation
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1703972openalex-snapshot
Molecular crosstalk between MASLD and IVDD revealed through integrated biomarker discovery analysis
inferred← citeshttps://doi.org/10.3389/fphar.2023.1188215openalex-snapshot
Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling
inferred← citeshttps://doi.org/10.3389/fphar.2026.1842913openalex-snapshot
Nystose treats intervertebral disc degeneration via the Nrf2 axis: a focus on oxidative stress and ferroptosis
inferred← citeshttps://doi.org/10.3390/cells14221758openalex-snapshot
The Potential of Bioactive Plant Phytochemicals, Pro-Resolving Anti-Inflammatory Lipids, and Statins in the Inhibition of Intervertebral Disc Degeneration, Low Back Pain Resolution, Disc Functional Repair, and Promotion of Intervertebral Disc Regeneration
inferred← citeshttps://doi.org/10.3390/nutraceuticals5040038openalex-snapshot
The Role and Safety of Plant-Derived Nutraceuticals as Adjuvant Treatments for Pain Management: A Narrative Review
inferred← citeshttps://doi.org/10.3390/pharmaceutics16081068openalex-snapshot
The Antinociceptive Role of Nrf2 in Neuropathic Pain: From Mechanisms to Clinical Perspectives
inferred← citeshttps://doi.org/10.6084/m9.figshare.26561851openalex-snapshot
Additional file 1 of Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis
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