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Bufalin Inhibits the Inflammatory Effects in Asthmatic Mice through the Suppression of Nuclear Factor-Kappa B Activity

https://doi.org/10.1159/000450754
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/embr.201337983openalex-snapshot
The IκB kinase complex in NF‐κB regulation and beyond
inferredcites →https://doi.org/10.1002/jcp.1041600114openalex-snapshot
Involvement of Na+, K+‐ATPase inhibition in K562 cell differentiation induced by bufalin
inferredcites →https://doi.org/10.1002/jps.2600561202openalex-snapshot
Pharmacology and toxicology of toad venom
inferredcites →https://doi.org/10.1002/pros.10172openalex-snapshot
Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells
inferredcites →https://doi.org/10.1007/bf03262206openalex-snapshot
Asthma Treatment Outcome in Children Is Associated with Vascular Endothelial Growth Factor A (VEGFA) Polymorphisms
inferredcites →https://doi.org/10.1007/s00011-008-7249-9openalex-snapshot
Digoxin and digoxin-like immunoreactive factors (DLIF) modulate the release of pro-inflammatory cytokines
inferredcites →https://doi.org/10.1007/s00011-011-0307-8openalex-snapshot
Anti-inflammatory effects of ivermectin in mouse model of allergic asthma
inferredcites →https://doi.org/10.1007/s10753-014-9828-yopenalex-snapshot
Bufalin, a Bioactive Component of the Chinese Medicine Chansu, Inhibits Inflammation and Invasion of Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes
inferredcites →https://doi.org/10.1016/j.biocel.2006.03.023openalex-snapshot
NFκB pathway: A good signaling paradigm and therapeutic target
inferredcites →https://doi.org/10.1016/j.cell.2015.12.057openalex-snapshot
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
inferredcites →https://doi.org/10.1016/j.ejphar.2007.10.034openalex-snapshot
Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma
inferredcites →https://doi.org/10.1016/j.intimp.2004.07.030openalex-snapshot
Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-κB inhibits established asthmatic reaction in mice
inferredcites →https://doi.org/10.1016/j.intimp.2009.01.005openalex-snapshot
Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma
inferredcites →https://doi.org/10.1016/j.pharmthera.2013.07.008openalex-snapshot
Bronchial epithelium as a target for innovative treatments in asthma
inferredcites →https://doi.org/10.1016/j.redox.2014.06.009openalex-snapshot
Zn/Ga−DFO iron–chelating complex attenuates the inflammatory process in a mouse model of asthma
inferredcites →https://doi.org/10.1016/s0002-9343(02)01105-1openalex-snapshot
A role for neutrophils in asthma?
inferredcites →https://doi.org/10.1016/s0031-9422(97)00426-3openalex-snapshot
Bufadienolides from animal and plant sources
inferredcites →https://doi.org/10.1017/s0007114511005265openalex-snapshot
Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma
inferredcites →https://doi.org/10.1038/83158openalex-snapshot
A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
inferredcites →https://doi.org/10.1038/sj.bjp.0707263openalex-snapshot
Chemokines and their receptors as potential targets for the treatment of asthma
inferredcites →https://doi.org/10.1038/sj.onc.1201592openalex-snapshot
Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells
inferredcites →https://doi.org/10.1046/j.1365-2222.2003.01615.xopenalex-snapshot
Anti‐inflammatory effects of high‐dose montelukast in an animal model of acute asthma
inferredcites →https://doi.org/10.1056/nejm199704103361506openalex-snapshot
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
inferredcites →https://doi.org/10.1097/cad.0b013e3283160fd6openalex-snapshot
PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells
inferredcites →https://doi.org/10.1097/maj.0b013e3182753175openalex-snapshot
Astragalus Extract Attenuates Allergic Airway Inflammation and Inhibits Nuclear Factor κB Expression in Asthmatic Mice
inferredcites →https://doi.org/10.1111/bph.13080openalex-snapshot
LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma
inferredcites →https://doi.org/10.1136/thx.2006.069229openalex-snapshot
Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma
inferredcites →https://doi.org/10.1155/2011/912925openalex-snapshot
Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice
inferredcites →https://doi.org/10.1155/2013/767689openalex-snapshot
Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF- κ B
inferredcites →https://doi.org/10.1155/2014/171839openalex-snapshot
Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents
inferredcites →https://doi.org/10.1164/rccm.200412-1647ocopenalex-snapshot
Iκ-B Kinase-2 Inhibitor Blocks Inflammation in Human Airway Smooth Muscle and a Rat Model of Asthma
inferredcites →https://doi.org/10.1248/bpb.34.967openalex-snapshot
Bufalin Inhibits Platelet-Derived Growth Factor-BB-Induced Mesangial Cell Proliferation through Mediating Cell Cycle Progression
inferredcites →https://doi.org/10.1371/journal.pone.0066130openalex-snapshot
Targeting Poly (ADP-Ribose) Polymerase Partially Contributes to Bufalin-Induced Cell Death in Multiple Myeloma Cells
inferredcites →https://doi.org/10.1513/pats.200806-054rmopenalex-snapshot
Nuclear Factor κB, Airway Epithelium, and Asthma: Avenues for Redox Control
inferredcites →https://doi.org/10.1677/joe.0.1780001openalex-snapshot
Mechanisms of steroid action and resistance in inflammation and disease
inferredcites →https://doi.org/10.3390/biom5031266openalex-snapshot
NF-kappaB Signaling in Chronic Inflammatory Airway Disease
inferredcites →https://doi.org/10.3390/ijms13022025openalex-snapshot
Bufalin Induces Lung Cancer Cell Apoptosis via the Inhibition of PI3K/Akt Pathway
inferredcites →https://doi.org/10.4049/jimmunol.1000630openalex-snapshot
Anti-Inflammatory Effects of the Neurotransmitter Agonist Honokiol in a Mouse Model of Allergic Asthma
inferredcites →https://doi.org/10.4049/jimmunol.1100573openalex-snapshot
SHP-1 As a Critical Regulator of Mycoplasma pneumoniae-Induced Inflammation in Human Asthmatic Airway Epithelial Cells
inferredcites →https://doi.org/10.4187/respcare.03200openalex-snapshot
Asthma and Adherence to Inhaled Corticosteroids: Current Status and Future Perspectives
inferredcites →https://doi.org/10.7150/ijbs.8056openalex-snapshot
Bufalin Induces the Interplay between Apoptosis and Autophagy in Glioma Cells through Endoplasmic Reticulum Stress
inferredcites →https://doi.org/10.7314/apjcp.2012.13.1.399openalex-snapshot
Bufalin, a Traditional Oriental Medicine, Induces Apoptosis in Human Cancer Cells
inferredcites →https://doi.org/10.7314/apjcp.2014.15.23.10495openalex-snapshot
Bufalin Induces Mitochondrial Pathway-Mediated Apoptosis in Lung Adenocarcinoma Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4667960openalex-extracted
Anti-inflammatory activity of the new cardiotonic steroid γ-Benzylidene Digoxin 8 (BD-8) on macrophages
inferred← citeshttps://doi.org/10.1002/adfm.202520727openalex-snapshot
Molecularly Engineered Controlled Release Systems for Local Anesthetics in Precise Pain Management
inferred← citeshttps://doi.org/10.1002/cmdc.202000996openalex-snapshot
The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products
inferred← citeshttps://doi.org/10.1007/s00210-017-1419-7openalex-snapshot
Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer
inferred← citeshttps://doi.org/10.1007/s10787-024-01517-9openalex-snapshot
Pharmacological insights and role of bufalin (bufadienolides) in inflammation modulation: a narrative review
inferred← citeshttps://doi.org/10.1016/b978-0-444-64183-0.00002-6openalex-snapshot
Bioactive Natural Products From the Genus Kalanchoe as Cancer Chemopreventive Agents: A Review
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109312openalex-snapshot
Resibufogenin, one of bufadienolides in toad venom, suppresses LPS-induced inflammation via inhibiting NF-κB and AP-1 pathways
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113113openalex-snapshot
Bufalin alleviates inflammatory response and oxidative stress in experimental severe acute pancreatitis through activating Keap1-Nrf2/HO-1 and inhibiting NF-κB pathways
inferred← citeshttps://doi.org/10.1016/j.jep.2019.112178openalex-snapshot
Metabolites from Bufo gargarizans (Cantor, 1842): A review of traditional uses, pharmacological activity, toxicity and quality control
inferred← citeshttps://doi.org/10.1016/j.phytol.2019.09.011openalex-snapshot
The newly discovered natural compounds against rheumatoid arthritis-an overview
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00840openalex-snapshot
Bufadienolides from the Eggs of the Toad Bufo bufo gargarizans and Their Antimelanoma Activities
inferred← citeshttps://doi.org/10.1038/s41598-025-89809-0openalex-snapshot
Epidemiological patterns and therapeutic approaches of toad toxin poisoning in a retrospective case study
inferred← citeshttps://doi.org/10.1111/fcp.12306openalex-snapshot
Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK 293 cells
inferred← citeshttps://doi.org/10.1155/2017/6710278openalex-snapshot
Advanced Role of Neutrophils in Common Respiratory Diseases
inferred← citeshttps://doi.org/10.1161/hypertensionaha.118.12605openalex-snapshot
Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells
inferred← citeshttps://doi.org/10.1161/jaha.119.013933openalex-snapshot
Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na + /K + ‐ATPase‐α‐1
inferred← citeshttps://doi.org/10.1186/s12935-019-0806-1openalex-snapshot
New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin
inferred← citeshttps://doi.org/10.20944/preprints202312.1057.v1openalex-snapshot
Mechanisms providing effects of cardiotonic steroids in mammalian cells with special attention to blood cells
inferred← citeshttps://doi.org/10.2147/ott.s185953openalex-snapshot
High-intensity focused ultrasound enhances the effect of bufalin by inducing apoptosis in pancreatic cancer cells
inferred← citeshttps://doi.org/10.22038/ijbms.2018.30598.7375openalex-snapshot
Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma.
inferred← citeshttps://doi.org/10.3389/fcimb.2023.1134321openalex-snapshot
The crosstalk between microbiota and metabolites in AP mice: an analysis based on metagenomics and untargeted metabolomics
inferred← citeshttps://doi.org/10.3389/fphar.2021.629968openalex-snapshot
Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen-Deficient Bone Loss in Mice by Suppressing RANKL-Induced NF-κB and ERK/MAPK Pathways
inferred← citeshttps://doi.org/10.3389/fphar.2022.824907openalex-snapshot
Neuroinflammation and Neutrophils: Modulation by Ouabain
inferred← citeshttps://doi.org/10.3389/fphar.2022.910885openalex-snapshot
Effect of Bufalin-PLGA Microspheres in the Alleviation of Neuropathic Pain via the CCI Model
inferred← citeshttps://doi.org/10.3389/fphar.2023.1274336openalex-snapshot
An overview of the past decade of bufalin in the treatment of refractory and drug-resistant cancers: current status, challenges, and future perspectives
inferred← citeshttps://doi.org/10.3389/fphar.2025.1520927openalex-snapshot
Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells
inferred← citeshttps://doi.org/10.3390/biom11050659openalex-snapshot
Cardiac Glycosides as Immune System Modulators
inferred← citeshttps://doi.org/10.3390/books978-3-03921-190-6openalex-snapshot
Venom and Toxin as Targeted Therapy
inferred← citeshttps://doi.org/10.3390/cells13181568openalex-snapshot
Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in Mice
inferred← citeshttps://doi.org/10.3390/ijms19092576openalex-snapshot
Cardiotonic Steroids and the Sodium Trade Balance: New Insights into Trade-Off Mechanisms Mediated by the Na+/K+-ATPase
inferred← citeshttps://doi.org/10.3390/ijms23074007openalex-snapshot
Synthesis and Biological Evaluation of Novel Bufalin Derivatives
inferred← citeshttps://doi.org/10.3390/molecules27010051openalex-snapshot
Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
inferred← citeshttps://doi.org/10.3390/molecules27196586openalex-snapshot
Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads
inferred← citeshttps://doi.org/10.3390/toxins10080336openalex-snapshot
The Development of Toad Toxins as Potential Therapeutic Agents
inferred← citeshttps://doi.org/10.7150/jca.38393openalex-snapshot
Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer
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