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Transcriptional Programming in Arteriosclerotic Disease

https://doi.org/10.1161/atvbaha.120.313791

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1097-4652(200009)184:3<341::aid-jcp8>3.0.co;2-zopenalex-snapshot

Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene

inferredcites →https://doi.org/10.1002/jbmr.1548openalex-snapshot

c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104

inferredcites →https://doi.org/10.1002/jbmr.1607openalex-snapshot

Serum response factor regulates bone formation via IGF-1 and Runx2 signals

inferredcites →https://doi.org/10.1002/jbmr.174openalex-snapshot

SOX9 determines RUNX2 transactivity by directing intracellular degradation

inferredcites →https://doi.org/10.1002/jbmr.3076openalex-snapshot

An HDAC Inhibitor, Entinostat/MS-275, Partially Prevents Delayed Cranial Suture Closure in Heterozygous Runx2 Null Mice

inferredcites →https://doi.org/10.1002/jcp.20258openalex-snapshot

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription

inferredcites →https://doi.org/10.1002/jcp.24339openalex-snapshot

Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

inferredcites →https://doi.org/10.1006/geno.1994.1519openalex-snapshot

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

inferredcites →https://doi.org/10.1007/s003920070101openalex-snapshot

Expression of mineralisation-regulating proteins in association with human vascular calcification

inferredcites →https://doi.org/10.1007/s004280050289openalex-snapshot

Observations on bone formation and remodelling in advanced atherosclerotic lesions of human carotid arteries

inferredcites →https://doi.org/10.1007/s10529-011-0756-8openalex-snapshot

Analysis of HDAC1-mediated regulation of Runx2-induced osteopontin gene expression in C3h10t1/2 cells

inferredcites →https://doi.org/10.1007/s11154-006-9001-5openalex-snapshot

Networks and hubs for the transcriptional control of osteoblastogenesis

inferredcites →https://doi.org/10.1007/s11914-015-0270-3openalex-snapshot

Molecular Mechanisms of Vascular Calcification in Chronic Kidney Disease: The Link between Bone and the Vasculature

inferredcites →https://doi.org/10.1007/s12079-009-0068-0openalex-snapshot

The role of osteopontin in inflammatory processes

inferredcites →https://doi.org/10.1016/j.ajpath.2015.03.020openalex-snapshot

Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice

inferredcites →https://doi.org/10.1016/j.bbamcr.2016.01.010openalex-snapshot

Skp2 inhibits osteogenesis by promoting ubiquitin–proteasome degradation of Runx2

inferredcites →https://doi.org/10.1016/j.bbrc.2007.07.149openalex-snapshot

O-GlcNAc modification modulates the expression of osteocalcin via OSE2 and Runx2

inferredcites →https://doi.org/10.1016/j.cell.2005.01.035openalex-snapshot

Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation

inferredcites →https://doi.org/10.1016/j.gene.2017.02.025openalex-snapshot

Krüppel-like factor 4 (KLF4): What we currently know

inferredcites →https://doi.org/10.1016/j.jacc.2019.07.012openalex-snapshot

Large-Artery Stiffness in Health and Disease

inferredcites →https://doi.org/10.1016/j.mce.2013.01.024openalex-snapshot

Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform

inferredcites →https://doi.org/10.1016/j.redox.2016.08.015openalex-snapshot

Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells

inferredcites →https://doi.org/10.1016/j.redox.2018.02.009openalex-snapshot

AKT-independent activation of p38 MAP kinase promotes vascular calcification

inferredcites →https://doi.org/10.1016/j.yexcr.2015.08.009openalex-snapshot

Global increase in O-linked N-acetylglucosamine modification promotes osteoblast differentiation

inferredcites →https://doi.org/10.1016/s0008-6363(01)00375-3openalex-snapshot

Vascular calcification: expression patterns of the osteoblast-specific gene core binding factor α-1 and the protective factor matrix gla protein in human atherogenesis

inferredcites →https://doi.org/10.1016/s0092-8674(00)80257-3openalex-snapshot

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

inferredcites →https://doi.org/10.1016/s0092-8674(00)80258-5openalex-snapshot

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

inferredcites →https://doi.org/10.1016/s0092-8674(00)80259-7openalex-snapshot

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

inferredcites →https://doi.org/10.1016/s0092-8674(00)80260-3openalex-snapshot

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

inferredcites →https://doi.org/10.1016/s1097-2765(00)80139-2openalex-snapshot

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

inferredcites →https://doi.org/10.1016/s1534-5807(04)00058-9openalex-snapshot

A Twist Code Determines the Onset of Osteoblast Differentiation

inferredcites →https://doi.org/10.1038/29788openalex-snapshot

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

inferredcites →https://doi.org/10.1038/373081a0openalex-snapshot

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

inferredcites →https://doi.org/10.1038/nature05473openalex-snapshot

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2

inferredcites →https://doi.org/10.1038/ng0797-307openalex-snapshot

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

inferredcites →https://doi.org/10.1038/sj.ki.5001663openalex-snapshot

The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells

inferredcites →https://doi.org/10.1067/mnc.2003.0012openalex-snapshot

Vascular calcification and its relation to bone calcification: Possible underlying mechanisms

inferredcites →https://doi.org/10.1073/pnas.0605170103openalex-snapshot

Dominance of SOX9 function over RUNX2 during skeletogenesis

inferredcites →https://doi.org/10.1073/pnas.0611419104openalex-snapshot

Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2

inferredcites →https://doi.org/10.1073/pnas.151236498openalex-snapshot

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

inferredcites →https://doi.org/10.1073/pnas.180309597openalex-snapshot

A RUNX2/PEBP2 αA/ CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

inferredcites →https://doi.org/10.1073/pnas.90.14.6859openalex-snapshot

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

inferredcites →https://doi.org/10.1074/jbc.273.13.7547openalex-snapshot

cAMP Stimulates Osteoblast-like Differentiation of Calcifying Vascular Cells

inferredcites →https://doi.org/10.1074/jbc.274.11.6972openalex-snapshot

Cbfa1 Isoforms Exert Functional Differences in Osteoblast Differentiation

inferredcites →https://doi.org/10.1074/jbc.274.41.28875openalex-snapshot

Inhibition of Osteoblast-specific Transcription Factor Cbfa1 by the cAMP Pathway in Osteoblastic Cells

inferredcites →https://doi.org/10.1074/jbc.275.6.4453openalex-snapshot

MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1

inferredcites →https://doi.org/10.1074/jbc.m109.040980openalex-snapshot

Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

inferredcites →https://doi.org/10.1074/jbc.m109.055053openalex-snapshot

FGF2-activated ERK Mitogen-activated Protein Kinase Enhances Runx2 Acetylation and Stabilization

inferredcites →https://doi.org/10.1074/jbc.m110.142307openalex-snapshot

BMP2-activated Erk/MAP Kinase Stabilizes Runx2 by Increasing p300 Levels and Histone Acetyltransferase Activity

inferredcites →https://doi.org/10.1074/jbc.m111.241505openalex-snapshot

Runx2 Protein Expression Utilizes the Runx2 P1 Promoter to Establish Osteoprogenitor Cell Number for Normal Bone Formation

inferredcites →https://doi.org/10.1074/jbc.m112.354241openalex-snapshot

The Increase in O-Linked N-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Both in Vitro and in Vivo

inferredcites →https://doi.org/10.1074/jbc.m112.361360openalex-snapshot

Krüppel-like Factor 4 Contributes to High Phosphate-induced Phenotypic Switching of Vascular Smooth Muscle Cells into Osteogenic Cells

inferredcites →https://doi.org/10.1074/jbc.m116.772277openalex-snapshot

The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation

inferredcites →https://doi.org/10.1074/jbc.m203750200openalex-snapshot

The Protein Kinase C Pathway Plays a Central Role in the Fibroblast Growth Factor-stimulated Expression and Transactivation Activity of Runx2

inferredcites →https://doi.org/10.1074/jbc.m204271200openalex-snapshot

Characterization of an Osteoblast-specific Enhancer Element in the CBFA1 Gene

inferredcites →https://doi.org/10.1074/jbc.m313294200openalex-snapshot

Smurf1 Inhibits Osteoblast Differentiation and Bone Formation in Vitro and in Vivo

inferredcites →https://doi.org/10.1074/jbc.m403702200openalex-snapshot

Histone Deacetylase 3 Interacts with Runx2 to Repress the Osteocalcin Promoter and Regulate Osteoblast Differentiation

inferredcites →https://doi.org/10.1074/jbc.m502267200openalex-snapshot

Dlx5 Specifically Regulates Runx2 Type II Expression by Binding to Homeodomain-response Elements in the Runx2 Distal Promoter

inferredcites →https://doi.org/10.1074/jbc.m512494200openalex-snapshot

Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation

inferredcites →https://doi.org/10.1074/jbc.m603439200openalex-snapshot

Cyclin D1-Cdk4 Induce Runx2 Ubiquitination and Degradation

inferredcites →https://doi.org/10.1074/jbc.m701847200openalex-snapshot

Krüppel-like Factor 4 Is Acetylated by p300 and Regulates Gene Transcription via Modulation of Histone Acetylation

inferredcites →https://doi.org/10.1074/jbc.m800021200openalex-snapshot

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

inferredcites →https://doi.org/10.1074/jbc.ra119.009758openalex-snapshot

Hyperhomocysteinemia induces vascular calcification by activating the transcription factor RUNX2 via Krüppel-like factor 4 up-regulation in mice

inferredcites →https://doi.org/10.1074/mcp.m114.040691openalex-snapshot

O-GlcNAc Modification of the runt-Related Transcription Factor 2 (Runx2) Links Osteogenesis and Nutrient Metabolism in Bone Marrow Mesenchymal Stem Cells

inferredcites →https://doi.org/10.1080/03008200390152188openalex-snapshot

Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast Differentiation

inferredcites →https://doi.org/10.1083/jcb.200610046openalex-snapshot

Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development

inferredcites →https://doi.org/10.1083/jcb.200711044openalex-snapshot

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

inferredcites →https://doi.org/10.1086/302622openalex-snapshot

Mutation Analysis of Core Binding Factor A1 in Patients with Cleidocranial Dysplasia

inferredcites →https://doi.org/10.1093/cvr/cvy009openalex-snapshot

Smooth muscle cell and arterial aging: basic and clinical aspects

inferredcites →https://doi.org/10.1093/embo-reports/kvf193openalex-snapshot

Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

inferredcites →https://doi.org/10.1093/emboj/18.9.2551openalex-snapshot

A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator

inferredcites →https://doi.org/10.1093/emboj/20.4.723openalex-snapshot

Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin–proteasome‐mediated degradation

inferredcites →https://doi.org/10.1093/eurheartj/ehu163openalex-snapshot

Medial vascular calcification revisited: review and perspectives

inferredcites →https://doi.org/10.1093/nar/gkh252openalex-snapshot

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

inferredcites →https://doi.org/10.1093/nar/gku712openalex-snapshot

The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter

inferredcites →https://doi.org/10.1093/ndt/gfg414openalex-snapshot

Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality

inferredcites →https://doi.org/10.1096/fj.01-0898hypopenalex-snapshot

Rationale for the role of osteoclast‐like cells in arterial calcification

inferredcites →https://doi.org/10.1097/01.asn.0000145894.57533.c4openalex-snapshot

Vascular Calcification Mechanisms

inferredcites →https://doi.org/10.1101/gad.1119303openalex-snapshot

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

inferredcites →https://doi.org/10.1101/gad.12.9.1260openalex-snapshot

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

inferredcites →https://doi.org/10.1101/gad.13.8.1025openalex-snapshot

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

inferredcites →https://doi.org/10.1111/febs.12887openalex-snapshot

Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation

inferredcites →https://doi.org/10.1126/science.1058714openalex-snapshot

Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

inferredcites →https://doi.org/10.1128/mcb.01771-07openalex-snapshot

Runx2 Represses Myocardin-Mediated Differentiation and Facilitates Osteogenic Conversion of Vascular Smooth Muscle Cells

inferredcites →https://doi.org/10.1128/mcb.14.5.3242openalex-snapshot

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.

inferredcites →https://doi.org/10.1128/mcb.14.5.3242-3252.1994openalex-snapshot

PEBP2αB/Mouse AML1 Consists of Multiple Isoforms That Possess Differential Transactivation Potentials

inferredcites →https://doi.org/10.1128/mcb.15.4.1858openalex-snapshot

Two Distinct Osteoblast-Specific cis-Acting Elements Control Expression of a Mouse Osteocalcin Gene

inferredcites →https://doi.org/10.1128/mcb.16.3.932openalex-snapshot

Drosophila Homologs of the Proto-Oncogene Product PEBP2/CBFβ Regulate the DNA-Binding Properties of Runt

inferredcites →https://doi.org/10.1128/mcb.17.9.5581openalex-snapshot

Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

inferredcites →https://doi.org/10.1128/mcb.18.7.4197openalex-snapshot

Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ

inferredcites →https://doi.org/10.1128/mcb.19.6.4431openalex-snapshot

Collagenase 3 Is a Target of Cbfa1, a Transcription Factor of the runt Gene Family Involved in Bone Formation

inferredcites →https://doi.org/10.1128/mcb.20.23.8783-8792.2000openalex-snapshot

Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12

inferredcites →https://doi.org/10.1128/mcb.22.22.7982-7992.2002openalex-snapshot

Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21 CIP1/WAF1 Promoter

inferredcites →https://doi.org/10.1159/000350089openalex-snapshot

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

inferredcites →https://doi.org/10.1161/01.atv.0000059406.92165.31openalex-snapshot

Osteo/Chondrocytic Transcription Factors and Their Target Genes Exhibit Distinct Patterns of Expression in Human Arterial Calcification

inferredcites →https://doi.org/10.1161/01.atv.0000220441.42041.20openalex-snapshot

Molecular Mechanisms of Vascular Calcification

inferredcites →https://doi.org/10.1161/01.atv.0000236428.91125.e6openalex-snapshot

Osteoprotegerin Inactivation Accelerates Advanced Atherosclerotic Lesion Progression and Calcification in Older ApoE −/− Mice

inferredcites →https://doi.org/10.1161/01.atv.17.4.680openalex-snapshot

Lipid Oxidation Products Have Opposite Effects on Calcifying Vascular Cell and Bone Cell Differentiation

inferredcites →https://doi.org/10.1161/01.cir.0000048894.99865.02openalex-snapshot

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

inferredcites →https://doi.org/10.1161/01.cir.100.21.2168openalex-snapshot

Medial Localization of Mineralization-Regulating Proteins in Association With Monckeberg’s Sclerosis

inferredcites →https://doi.org/10.1161/01.res.00000175571.53833.6copenalex-snapshot

Bone Morphogenetic Proteins in Vascular Calcification

inferredcites →https://doi.org/10.1161/01.res.0000149165.99974.12openalex-snapshot

Regulation of Vascular Calcification by Osteoclast Regulatory Factors RANKL and Osteoprotegerin

inferredcites →https://doi.org/10.1161/01.res.87.7.e10openalex-snapshot

Phosphate Regulation of Vascular Smooth Muscle Cell Calcification

inferredcites →https://doi.org/10.1161/atvbaha.108.180521openalex-snapshot

Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis

inferredcites →https://doi.org/10.1161/atvbaha.110.222547openalex-snapshot

Runx2-Upregulated Receptor Activator of Nuclear Factor κB Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macrophages

inferredcites →https://doi.org/10.1161/atvbaha.114.304786openalex-snapshot

Inhibition of FOXO1/3 Promotes Vascular Calcification

inferredcites →https://doi.org/10.1161/atvbaha.116.306258openalex-snapshot

Arterial Calcification in Diabetes Mellitus

inferredcites →https://doi.org/10.1161/atvbaha.119.312192openalex-snapshot

Metabolic Stress and Cardiovascular Disease in Diabetes Mellitus

inferredcites →https://doi.org/10.1161/atvbaha.120.313131openalex-snapshot

Arterial Stiffness

inferredcites →https://doi.org/10.1161/circresaha.110.236596openalex-snapshot

Activation of Vascular Bone Morphogenetic Protein Signaling in Diabetes Mellitus

inferredcites →https://doi.org/10.1161/circresaha.110.238808openalex-snapshot

Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization

inferredcites →https://doi.org/10.1161/circresaha.112.267237openalex-snapshot

Smooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification

inferredcites →https://doi.org/10.1161/circresaha.112.269811openalex-snapshot

Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo

inferredcites →https://doi.org/10.1161/circresaha.114.302968openalex-snapshot

Activation of AKT by O-Linked N-Acetylglucosamine Induces Vascular Calcification in Diabetes Mellitus

inferredcites →https://doi.org/10.1161/circresaha.116.308301openalex-snapshot

Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo

inferredcites →https://doi.org/10.1161/circresaha.119.314855openalex-snapshot

Recipient c-Kit Lineage Cells Repopulate Smooth Muscle Cells of Transplant Arteriosclerosis in Mouse Models

inferredcites →https://doi.org/10.1161/circresaha.119.315932openalex-snapshot

Mitochondrial Protein Poldip2 (Polymerase Delta Interacting Protein 2) Controls Vascular Smooth Muscle Differentiated Phenotype by O-Linked GlcNAc (N-Acetylglucosamine) Transferase–Dependent Inhibition of a Ubiquitin Proteasome System

inferredcites →https://doi.org/10.1161/hh2401.101070openalex-snapshot

Smooth Muscle Cell Phenotypic Transition Associated With Calcification

inferredcites →https://doi.org/10.1172/jci200524140openalex-snapshot

Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals

inferredcites →https://doi.org/10.1172/jci42285openalex-snapshot

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

inferredcites →https://doi.org/10.1172/jci43802openalex-snapshot

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

inferredcites →https://doi.org/10.1172/jci59041openalex-snapshot

MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice

inferredcites →https://doi.org/10.1186/1756-0500-2-59openalex-snapshot

The evolution of Runx genes II. The C-terminal Groucho recruitment motif is present in both eumetazoans and homoscleromorphs but absent in a haplosclerid demosponge

inferredcites →https://doi.org/10.1186/s12933-018-0714-zopenalex-snapshot

Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study

inferredcites →https://doi.org/10.1196/annals.1402.075openalex-snapshot

Vascular Bmp–Msx2–Wnt Signaling and Oxidative Stress in Arterial Calcification

inferredcites →https://doi.org/10.1210/me.2008-0217openalex-snapshot

Runx2 Recruits p300 to Mediate Parathyroid Hormone’s Effects on Histone Acetylation and Transcriptional Activation of the Matrix Metalloproteinase-13 Gene

inferredcites →https://doi.org/10.1210/me.2010-0029openalex-snapshot

Runx2Trans-Activation Mediated by the Msx2-Interacting Nuclear Target Requires Homeodomain Interacting Protein Kinase-3

inferredcites →https://doi.org/10.1242/jcs.053678openalex-snapshot

The intersections betweenO-GlcNAcylation and phosphorylation: implications for multiple signaling pathways

inferredcites →https://doi.org/10.1242/jcs.114.17.3093openalex-snapshot

A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene

inferredcites →https://doi.org/10.1359/jbmr.2000.15.8.1477openalex-snapshot

Identification and Characterization of the New Osteoclast Progenitor with Macrophage Phenotypes Being Able to Differentiate into Mature Osteoclasts

inferredcites →https://doi.org/10.1359/jbmr.2003.18.2.213openalex-snapshot

Changes in Runx2/Cbfa1 Expression and Activity During Osteoblastic Differentiation of Human Bone Marrow Stromal Cells

inferredcites →https://doi.org/10.1371/journal.pone.0000837openalex-snapshot

GSK-3β Controls Osteogenesis through Regulating Runx2 Activity

inferredcites →https://doi.org/10.1371/journal.pone.0027324openalex-snapshot

Twist Controls Skeletal Development and Dorsoventral Patterning by Regulating Runx2 in Zebrafish

inferredcites →https://doi.org/10.1615/critreveukargeneexpr.v10.i2.40openalex-snapshot

Regulatory Mechanisms in Vascular Calcification

inferredcites →https://doi.org/10.2353/ajpath.2009.080957openalex-snapshot

Inhibition of Receptor Activator of NF-κB Ligand by Denosumab Attenuates Vascular Calcium Deposition in Mice

inferredcites →https://doi.org/10.3389/fendo.2018.00599openalex-snapshot

O-GlcNAc as an Integrator of Signaling Pathways

inferredcites →https://doi.org/10.5551/jat.23044openalex-snapshot

Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Virgin and Photo-Degraded Microplastics Induce the Activation of Vascular Smooth Muscle Cells

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Prosthetic vascular grafts engineered to combat calcification: Progress and future directions

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High glucose promotes osteogenic differentiation of human lens epithelial cells through hypoxia‐inducible factor (HIF) activation

inferred← citeshttps://doi.org/10.1007/s00125-022-05733-2openalex-snapshot

A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease

inferred← citeshttps://doi.org/10.1007/s00395-025-01113-0openalex-snapshot

A new mechanism of high-altitude adaptation reducing myocardium infarction: inhibiting inflammation-induced ubiquitin degradation of BKCa to enhance coronary vasodilation

inferred← citeshttps://doi.org/10.1007/s11302-024-10045-8openalex-snapshot

Regulation of transcription factor function by purinergic signalling in cardiovascular diseases

inferred← citeshttps://doi.org/10.1016/b978-0-12-822224-9.00006-2openalex-snapshot

Vascular Pathobiology: Atherosclerosis and Large Vessel Disease

inferred← citeshttps://doi.org/10.1016/j.arr.2022.101649openalex-snapshot

Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies

inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.152263openalex-snapshot

Transcription factor RUNX2 participates in astrocyte-mediated neuropathic pain via transcriptional activation of Ccl2

inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112598openalex-snapshot

Predicting sulforaphane-induced adverse effects in colon cancer patients via in silico investigation

inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115469openalex-snapshot

Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease

inferred← citeshttps://doi.org/10.1016/j.bone.2025.117719openalex-snapshot

A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density

inferred← citeshttps://doi.org/10.1016/j.cej.2024.150549openalex-snapshot

Therapeutic strategies for small-diameter vascular graft calcification

inferred← citeshttps://doi.org/10.1016/j.diff.2024.100803openalex-snapshot

RUNX2 regulation in osteoblast differentiation: A possible therapeutic function of the lncRNA and miRNA-mediated network

inferred← citeshttps://doi.org/10.1016/j.jmccpl.2025.100487openalex-snapshot

YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs

inferred← citeshttps://doi.org/10.1016/j.kint.2022.04.027openalex-snapshot

Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease

inferred← citeshttps://doi.org/10.1016/j.lfs.2023.122309openalex-snapshot

Vascular calcification and cellular signaling pathways as potential therapeutic targets

inferred← citeshttps://doi.org/10.1016/j.mad.2026.112215openalex-snapshot

PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts

inferred← citeshttps://doi.org/10.1016/j.redox.2023.102720openalex-snapshot

Impaired intracellular calcium homeostasis enhances protein O-GlcNAcylation and promotes vascular calcification and stiffness in diabetes

inferred← citeshttps://doi.org/10.1016/j.trsl.2023.09.004openalex-snapshot

Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification

inferred← citeshttps://doi.org/10.1016/j.vph.2023.107167openalex-snapshot

Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2023.12.005openalex-snapshot

Substrate stiffness promotes vascular smooth muscle cell calcification by reducing the levels of nuclear actin monomers

inferred← citeshttps://doi.org/10.1038/s41392-025-02540-0openalex-snapshot

MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysm

inferred← citeshttps://doi.org/10.1038/s41392-026-02884-1openalex-snapshot

Vascular calcification: pathogenic mechanisms, signaling crosstalk and translational therapeutics

inferred← citeshttps://doi.org/10.1038/s41419-023-05642-1openalex-snapshot

Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis

inferred← citeshttps://doi.org/10.1038/s41598-025-89006-zopenalex-snapshot

Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells

inferred← citeshttps://doi.org/10.1038/s42003-025-07972-6openalex-snapshot

METTL3 obstructs vascular smooth muscle cells osteogenic reprogramming by methylating Runx2 in chronic kidney disease

inferred← citeshttps://doi.org/10.1080/0886022x.2025.2488876openalex-snapshot

The m6A reader YTHDF2 protects vascular smooth muscle cells against the osteogenic differentiation through targeting Runx2

inferred← citeshttps://doi.org/10.1080/09205063.2023.2170675openalex-snapshot

Design and development of biodegradable POSS-PCL-Zeolite (β) nano-scaffold for potential applications in bone regeneration

inferred← citeshttps://doi.org/10.1080/15592294.2026.2653962openalex-snapshot

M6A-dependent regulation of microRNAs from CKD stage 5 patients: insights from epigenetic modification analysis

inferred← citeshttps://doi.org/10.1088/1758-5090/ace000openalex-snapshot

Scaffold-free human vascular calcification model using a bio-three-dimensional printer

inferred← citeshttps://doi.org/10.1093/eurheartj/ehaf341openalex-snapshot

Medial arterial calcification in ageing and disease: current evidence and knowledge gaps

inferred← citeshttps://doi.org/10.1093/eurheartj/ehag756openalex-snapshot

Transcription factor TBX2 is a key regulator of vascular calcification

inferred← citeshttps://doi.org/10.1093/ndt/gfae091openalex-snapshot

FHL2 in arterial medial calcification in chronic kidney disease

inferred← citeshttps://doi.org/10.1096/fj.202200727rropenalex-snapshot

Degeneration of biological heart valve grafts in a rat model of superoxide dismutase‐3 deficiency

inferred← citeshttps://doi.org/10.1097/fjc.0000000000001752openalex-snapshot

Integration of Vascular Smooth Muscle Cell Phenotypic Switching and Senescence

inferred← citeshttps://doi.org/10.1101/2023.06.18.545506openalex-snapshot

Extracellular Matrix Stiffness Promotes Vascular Smooth Muscle Cell Calcification By Reducing The Levels Of Nuclear Actin Monomers

inferred← citeshttps://doi.org/10.1111/iwj.13972openalex-snapshot

Calciphylaxis and its co‐occurrence with connective tissue diseases

inferred← citeshttps://doi.org/10.1159/000541280openalex-snapshot

The Bone-Vascular Axis: A Key Player in Chronic Kidney Disease Associated Vascular Calcification

inferred← citeshttps://doi.org/10.1161/atvbaha.121.315836openalex-snapshot

DNA Damage Response, Runx2 (Runt-Related Transcription Factor 2), and Vascular Calcification

inferred← citeshttps://doi.org/10.1161/atvbaha.122.317332openalex-snapshot

Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification

inferred← citeshttps://doi.org/10.1161/atvbaha.123.319198openalex-snapshot

Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications

inferred← citeshttps://doi.org/10.1161/atvbaha.123.320330openalex-snapshot

Spatial Transcriptomic Approach to Understanding Coronary Atherosclerotic Plaque Stability

inferred← citeshttps://doi.org/10.1161/atvbaha.125.322138openalex-snapshot

Peripheral Vascular Calcification

inferred← citeshttps://doi.org/10.1161/atvbaha.126.324359openalex-snapshot

When the Clock Breaks Character: Bmal1 as a Driver of Vascular Calcification in Diabetes

inferred← citeshttps://doi.org/10.1161/circulationaha.121.057868openalex-snapshot

Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification

inferred← citeshttps://doi.org/10.1161/circulationaha.122.059812openalex-snapshot

Expanding the Therapeutic World of Tryptophan Metabolism

inferred← citeshttps://doi.org/10.1161/circulationaha.123.063760openalex-snapshot

INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10

inferred← citeshttps://doi.org/10.1161/circulationaha.123.065830openalex-snapshot

Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification

inferred← citeshttps://doi.org/10.1167/iovs.66.2.40openalex-snapshot

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

inferred← citeshttps://doi.org/10.1172/jci.insight.153769openalex-snapshot

Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury

inferred← citeshttps://doi.org/10.1172/jci186673openalex-snapshot

TET2 suppresses vascular calcification by forming an inhibitory complex with HDAC1/2 and SNIP1 independent of demethylation

inferred← citeshttps://doi.org/10.1186/s12931-022-01933-xopenalex-snapshot

Epithelial microRNA-30a-3p targets RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma

inferred← citeshttps://doi.org/10.1186/s12964-022-00993-2openalex-snapshot

How vascular smooth muscle cell phenotype switching contributes to vascular disease

inferred← citeshttps://doi.org/10.1186/s13018-025-05669-4openalex-snapshot

Synergistic influences of BMP9 and NGF on the osteogenic differentiation of C3H10T1/2 mesenchymal stem cells

inferred← citeshttps://doi.org/10.1186/s40824-023-00379-6openalex-snapshot

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

inferred← citeshttps://doi.org/10.26538/tjnpr/v8i3.19openalex-snapshot

An Immunoinformatic of Epigallocatechin-3-O-gallate as Adjuvant Therapy of Periodontitis: An in-silico Study

inferred← citeshttps://doi.org/10.3389/fcell.2025.1520850openalex-snapshot

Cardiovascular diseases in the elderly: possibilities for modulating autophagy using non-coding RNAs

inferred← citeshttps://doi.org/10.3389/fcvm.2021.670222openalex-snapshot

AMPK: Potential Therapeutic Target for Vascular Calcification

inferred← citeshttps://doi.org/10.3389/fcvm.2021.708470openalex-snapshot

Wnt Signaling in Vascular Calcification

inferred← citeshttps://doi.org/10.3389/fendo.2025.1589160openalex-snapshot

Regulation of osteogenic differentiation in vascular smooth muscle cells under high-glucose condition

inferred← citeshttps://doi.org/10.3389/fimmu.2021.701924openalex-snapshot

Runx Transcription Factors in T Cells—What Is Beyond Thymic Development?

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1844567openalex-snapshot

VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair

inferred← citeshttps://doi.org/10.3389/fnagi.2022.848495openalex-snapshot

The Interplay Between Brain Vascular Calcification and Microglia

inferred← citeshttps://doi.org/10.3389/fnagi.2023.1131548openalex-snapshot

Comparative analysis of calcified soft tissues revealed shared deregulated pathways

inferred← citeshttps://doi.org/10.3389/fphys.2024.1416967openalex-snapshot

The role of O-GlcNAcylation in bone metabolic diseases

inferred← citeshttps://doi.org/10.3390/biom10121648openalex-snapshot

Tissue-Nonspecific Alkaline Phosphatase—A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease

inferred← citeshttps://doi.org/10.3390/cells15181625openalex-snapshot

Smooth Muscle Cell MAPK14 Promotes Vascular Calcification During Hyperlipidemic Aging

inferred← citeshttps://doi.org/10.3390/ijms24043132openalex-snapshot

Inflammatory, Metabolic, and Coagulation Effects on Medial Arterial Calcification in Patients with Peripheral Arterial Disease

inferred← citeshttps://doi.org/10.3390/ijms24097910openalex-snapshot

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

inferred← citeshttps://doi.org/10.3390/ijms241511963openalex-snapshot

The Relationship between Renin–Angiotensin–Aldosterone System (RAAS) Activity, Osteoporosis and Estrogen Deficiency in Type 2 Diabetes

inferred← citeshttps://doi.org/10.3390/ijms25136933openalex-snapshot

Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases

inferred← citeshttps://doi.org/10.3390/ijms252413292openalex-snapshot

Unravelling the Mechanisms of Oxidised Low-Density Lipoprotein in Cardiovascular Health: Current Evidence from In Vitro and In Vivo Studies

inferred← citeshttps://doi.org/10.3390/ijms252413667openalex-snapshot

CCAAT/Enhancer-Binding Protein β (C/EBPβ) Regulates Calcium Deposition in Smooth Muscle Cells

inferred← citeshttps://doi.org/10.3390/ijms26094220openalex-snapshot

Biodentine Stimulates Calcium-Dependent Osteogenic Differentiation of Mesenchymal Stromal Cells from Periapical Lesions

inferred← citeshttps://doi.org/10.3390/ijms27031138openalex-snapshot

High-Phosphate-Induced Hypertension: The Pathogenic Role of Fibroblast Growth Factor 23 (FGF23) Signaling in Sympathetic Nervous System Activation

inferred← citeshttps://doi.org/10.3390/ijms27104599openalex-snapshot

DPP-Mediated Interaction of TAZ/β-Catenin Promotes the Differentiation of DPSCs into Odontoblasts

inferred← citeshttps://doi.org/10.3390/ph15050493openalex-snapshot

Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells

inferred← citeshttps://doi.org/10.4252/wjsc.v16.i3.228openalex-snapshot

O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells

inferred← citeshttps://doi.org/10.7554/elife.85464openalex-snapshot

O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors

inferred← citeshttps://doi.org/10.7717/peerj.18063openalex-snapshot

Key regulators of vascular calcification in chronic kidney disease: Hyperphosphatemia, BMP2, and RUNX2

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