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Trained Immunity and Reactivity of Macrophages and Endothelial Cells

https://doi.org/10.1161/atvbaha.120.315452

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Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

inferredcites →https://doi.org/10.4049/jimmunol.0902458openalex-snapshot

Endothelial Cells Augment the Suppressive Function of CD4+CD25+Foxp3+ Regulatory T Cells: Involvement of Programmed Death-1 and IL-10

inferredcites →https://doi.org/10.4049/jimmunol.175.10.6265openalex-snapshot

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

inferredcites →https://doi.org/10.7554/elife.25217openalex-snapshot

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

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Trained Immunity in sepsis: Exploring the molecular link to long-term cardiometabolic disorders

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Circulating monocyte adhesion repairs endothelium-denuded injury through downstream of kinase 3-mediated endothelialization

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Innate (learned) memory

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Metabolic memory failure and the reprogramming of atherosclerosis in diabetes

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Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers – Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer

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Tanyu Tongzhi decoction ameliorates atherosclerosis by inhibiting trimethylamine N-oxide-induced vascular inflammation via PI3K/Akt/NF-κB pathway regulation

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Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation

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Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis

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A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles

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Redox-signaling in innate immune memory: Similar mechanisms in animals/humans and plants

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Alpha-ketoglutarate accelerates granulocyte-monocyte progenitor differentiation and atherosclerotic plaque inflammation via oxoglutarate receptor 1

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Trained immunity induced by DAMPs and LAMPs in chronic inflammatory diseases

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Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality

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Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory

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Cyanidin-3- O -glucoside promotes late-stage venous thrombus resolution in mice, accompanied by reduced macrophage M1-associated inflammation and attenuated HIF-1α-linked signaling

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Trained immunity in monocytes and macrophages in atherosclerotic cardiovascular disease

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KMT2B drives inflammation in endothelial cells and promotes atherosclerosis via histone H3 lysine 4 trimethylation-mediated autophagy

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Trained immunity in cardiovascular disease

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The role of the immune system in hypertension

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The iterative lipid impact on inflammation in atherosclerosis

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Soluble DNA Concentration in the Perfusate is a Predictor of Posttransplant Renal Function in Hypothermic Machine Perfused Kidney Allografts

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NRF2 pathway activation reverts high-glucose-induced transcriptional memory in endothelial cells

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Deciphering the Pathogenic Landscape of Amyloid Light-Chain Cardiomyopathy

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Endothelial Cells retain inflammatory memory through chromatin remodeling

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Caffeic acid promoted deep vein thrombosis resolution in mice by suppressed macrophage M1 polarization through Keap1/Nrf2 pathway

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Evolution and development of innate immune memory

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The Cellular and Epigenetic Aspects of Trained Immunity and Prospects for Creation of Universal Vaccines on the Eve of More Frequent Pandemics

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The Effect of Mevalonate, Zoledronate, and BCG Induction on the Monocyte/Macrophage Phenotype

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JAKinibs prevent persistent, IFNγ-autonomous endothelial cell inflammation and immunogenicity

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Endothelial cells retain inflammatory memory through chromatin remodeling in a two-hit model of infection-induced inflammation

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Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD

inferred← citeshttps://doi.org/10.1155/2022/1433323openalex-snapshot

29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses

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Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

inferred← citeshttps://doi.org/10.1172/jci192469openalex-snapshot

Maladaptive trained immunity in viral infections

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Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model

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A Unified Model of Cardiovascular Injury: How PANoptosis Connects Atherosclerotic Inflammation to Myocardial Death

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BCG-trained macrophages promote pan-anti-tumor activity through epigenetic rewiring of NOX2-ROS axis

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Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice

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Research Progress on the Related Mechanisms and Treatments of Immune Thrombosis in Sepsis

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The role of trained immunity in broad-spectrum antiviral defense against respiratory viral infections

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Effect of mevalonate, zoledronate and BCG on monocyte/macrophage phenotype

inferred← citeshttps://doi.org/10.20944/preprints202312.0185.v1openalex-snapshot

Antibody Dependent Enhancement (ADE) of Infection into Macrophages Validates the Importance of HERV-K102 Particle Production for Pandemic Preparedness

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mTOR Signaling Pathway in Antiphospholipid Syndrome: Pathogenesis and Potential Therapeutic Targets

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Trained Immunity–Like Memory in Vascular Structural Cells: Metabolic–Epigenetic Reprogramming as a Driving Mechanism of Atherosclerosis and Residual Cardiovascular Risk

inferred← citeshttps://doi.org/10.26508/lsa.202302382openalex-snapshot

Reversal of high-glucose–induced transcriptional and epigenetic memories through NRF2 pathway activation

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Histone Acetylation Contributes to Mitochondrial Dysfunction and Neuroinflammation in Parkinson's disease

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Cellular and Epigenetic Aspects of Trained Immunity and Prospects for Creation of Universal Vaccines in the Face of Increasingly Frequent Pandemics

inferred← citeshttps://doi.org/10.32469/10355/98753openalex-snapshot

A role played by sex in innate immune memory and disease severity

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Editorial: Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity

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Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators

inferred← citeshttps://doi.org/10.3389/fcvm.2021.773473openalex-snapshot

Novel Knowledge-Based Transcriptomic Profiling of Lipid Lysophosphatidylinositol-Induced Endothelial Cell Activation

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Editorial: Highlights for Cardiovascular Therapeutics in 2021 – Trained Immunity, Immunometabolism, Gender Differences of Cardiovascular Diseases, and Novel Targets of Cardiovascular Therapeutics

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Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis

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inferred← citeshttps://doi.org/10.3389/fcvm.2023.1184030openalex-snapshot

Editorial: Insights in cardiovascular therapeutics 2022—cardiovascular innate immunity

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Editorial: Debates in cardiovascular pharmacology and drug discovery: 2022

inferred← citeshttps://doi.org/10.3389/fcvm.2024.1500775openalex-snapshot

Perspective: Pathological transdifferentiation—a novel therapeutic target for cardiovascular diseases and chronic inflammation

inferred← citeshttps://doi.org/10.3389/fcvm.2026.1782258openalex-snapshot

Reduced R-loop abundance at proinflammatory loci: a shared epigenetic mechanism in inflammatory and metabolic diseases

inferred← citeshttps://doi.org/10.3389/fgene.2024.1382502openalex-snapshot

Causal role of gut microbiota, serum metabolites, immunophenotypes in myocarditis: a mendelian randomization study

inferred← citeshttps://doi.org/10.3389/fimmu.2021.653110openalex-snapshot

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

inferred← citeshttps://doi.org/10.3389/fimmu.2021.757393openalex-snapshot

Transcriptomic Remodelling of Fetal Endothelial Cells During Establishment of Inflammatory Memory

inferred← citeshttps://doi.org/10.3389/fimmu.2022.1035497openalex-snapshot

Editorial: Endothelial cells as innate immune cells

inferred← citeshttps://doi.org/10.3389/fimmu.2022.858256openalex-snapshot

Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans-Differentiation—Early Secretomes may Serve as Drivers for Trained Immunity

inferred← citeshttps://doi.org/10.3389/fimmu.2022.951614openalex-snapshot

Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1052925openalex-snapshot

Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1113883openalex-snapshot

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1243220openalex-snapshot

Isolation, culture, and delivery considerations for the use of mesenchymal stem cells in potential therapies for acute liver failure

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1268916openalex-snapshot

ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1348238openalex-snapshot

Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1819744openalex-snapshot

Trained immunity in lung injury and repair

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1918068openalex-snapshot

The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications

inferred← citeshttps://doi.org/10.3389/fmed.2022.1000324openalex-snapshot

Single-cell RNA-seq reveals the communications between extracellular matrix-related components and Schwann cells contributing to the earlobe keloid formation

inferred← citeshttps://doi.org/10.3389/fmed.2026.1721780openalex-snapshot

Chronic obstructive pulmonary disease reprograms the lung into an immune organ through trained immunity, cell death networks, and immune checkpoint dysregulation

inferred← citeshttps://doi.org/10.3389/fnmol.2025.1605012openalex-snapshot

Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

inferred← citeshttps://doi.org/10.3390/biomedicines11020451openalex-snapshot

Immune Response and Molecular Mechanisms of Cardiovascular Adverse Effects of Spike Proteins from SARS-CoV-2 and mRNA Vaccines

inferred← citeshttps://doi.org/10.3390/cells11182810openalex-snapshot

Cigarette Smoke and Morphine Promote Treg Plasticity to Th17 via Enhancing Trained Immunity

inferred← citeshttps://doi.org/10.3390/cells11233935openalex-snapshot

Cross-Generational Impact of Innate Immune Memory Following Pregnancy Complications

inferred← citeshttps://doi.org/10.3390/cells12111482openalex-snapshot

Chronic Kidney Disease Transdifferentiates Veins into a Specialized Immune–Endocrine Organ with Increased MYCN-AP1 Signaling

inferred← citeshttps://doi.org/10.3390/cimb48060642openalex-snapshot

Metformin as an Innate Immune Modulator: Metabolic and Epigenetic Reprogramming of Innate Immune Cells and Therapeutic Implications

inferred← citeshttps://doi.org/10.3390/ijms222011241openalex-snapshot

Autoinflammatory Diseases and Cytokine Storms—Imbalances of Innate and Adaptative Immunity

inferred← citeshttps://doi.org/10.3390/ijms241210308openalex-snapshot

Target and Cell Therapy for Atherosclerosis and CVD

inferred← citeshttps://doi.org/10.3390/vaccines10050721openalex-snapshot

BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus

inferred← citeshttps://doi.org/10.3390/vaccines10111932openalex-snapshot

Trained Immunity as a Prospective Tool against Emerging Respiratory Pathogens

inferred← citeshttps://doi.org/10.3390/vaccines13070768openalex-snapshot

Immunization with Complete Freund’s Adjuvant Reveals Trained Immunity-like Features in A/J Mice

inferred← citeshttps://doi.org/10.3990/1.9789036557245openalex-snapshot

"Microfluidic vessels-on-chips for vascular disease modelling"

inferred← citeshttps://doi.org/10.4239/wjd.v14.i10.1478openalex-snapshot

Role of glycolysis in diabetic atherosclerosis

inferred← citeshttps://doi.org/10.5005/jp-journals-11002-0058openalex-snapshot

Innate Immune Memory in Macrophages

inferred← citeshttps://doi.org/10.53941/ijddp.2024.100022openalex-snapshot

Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4+Foxp3+ Regulatory T Cell Immunosuppression

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.