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Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
inferredcites →https://doi.org/10.1016/0003-2697(87)90021-2openalex-snapshot
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
inferredcites →https://doi.org/10.1016/0022-2828(90)90117-kopenalex-snapshot
Electrophysiological characterization of cardiac β2-adrenoceptors in sheep Purkinje fibers
inferredcites →https://doi.org/10.1016/0047-6374(82)90004-5openalex-snapshot
Alterations in the properties of β-adrenergic receptors of myocardial membranes in aging: Impairments in agonist—receptor interactions and guanine nucleotide regulation accompany diminished catecholamine-responsiveness of adenylated cyclase
inferredcites →https://doi.org/10.1016/0047-6374(86)90128-4openalex-snapshot
Beta-adrenergic agonist-mediated desensitization in senescent rats
inferredcites →https://doi.org/10.1016/0047-6374(89)90074-2openalex-snapshot
Upregulation of adrenergic beta receptor subtypes in the senescent rat heart
inferredcites →https://doi.org/10.1016/0047-6374(90)90122-vopenalex-snapshot
Forskolin activation of adenylate cyclase in rat myocardium with age: Effects of guanine nucleotide analogs
inferredcites →https://doi.org/10.1016/0047-6374(95)01676-7openalex-snapshot
cAMP signaling mechanisms with aging in rats
inferredcites →https://doi.org/10.1016/s0002-8703(05)80284-4openalex-snapshot
On the physiologic role of beta-2 adrenoceptors in the human heart: In vitro and in vivo studies
inferredcites →https://doi.org/10.1016/s0002-9149(88)80063-8openalex-snapshot
The functional importance of beta1 and beta2 adrenoceptors in the human heart
inferredcites →https://doi.org/10.1016/s0021-9258(17)32287-1openalex-snapshot
Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.
inferredcites →https://doi.org/10.1016/s0021-9258(17)37451-3openalex-snapshot
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
inferredcites →https://doi.org/10.1016/s0021-9258(20)80439-6openalex-snapshot
Structure and mechanism of the G protein-coupled receptor kinases.
inferredcites →https://doi.org/10.1016/s0026-895x(25)08543-8openalex-snapshot
Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.
inferredcites →https://doi.org/10.1073/pnas.93.18.9954openalex-snapshot
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
inferredcites →https://doi.org/10.1074/jbc.270.30.17953openalex-snapshot
Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor
inferredcites →https://doi.org/10.1093/geronj/37.2.156openalex-snapshot
Isoproterenol Responsiveness and Myocardial -Adrenergic Receptors in Young and Old Rats
inferredcites →https://doi.org/10.1096/fasebj.4.11.2165947openalex-snapshot
Turning off the signal: desensitization of β‐adrenergic receptor function
inferredcites →https://doi.org/10.1097/00005344-199202000-00011openalex-snapshot
Spare Receptors for β-Adrenoceptor-Mediated Positive Inotropic Effects of Catecholamines in the Human Heart
inferredcites →https://doi.org/10.1097/00005344-199402000-00003openalex-snapshot
Forskolin Binding Sites and G-Protein Immunoreactivity in Rat Hearts During Aging
inferredcites →https://doi.org/10.1097/00005344-199411000-00003openalex-snapshot
Forskolin Binding Sites and G-Protein Immunoreactivity in Rat Hearts During Aging
inferredcites →https://doi.org/10.1111/j.1476-5381.1995.tb16671.xopenalex-snapshot
β‐Adrenoceptor subtypes in young and old rat ventricular myocytes: a combined patch‐clamp and binding study
inferredcites →https://doi.org/10.1111/j.1532-5415.1988.tb04379.xopenalex-snapshot
Decreased Receptor Activation with Age
inferredcites →https://doi.org/10.1111/j.1749-6632.1992.tb27465.xopenalex-snapshot
Deterioration of β‐Adrenergic Modulation of Cardiovascular Function with Aging
inferredcites →https://doi.org/10.1126/science.2163110openalex-snapshot
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
inferredcites →https://doi.org/10.1126/science.276.5313.800openalex-snapshot
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure
inferredcites →https://doi.org/10.1126/science.7761854openalex-snapshot
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
inferredcites →https://doi.org/10.1146/annurev.bi.60.070191.003253openalex-snapshot
MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS
inferredcites →https://doi.org/10.1152/ajpheart.1992.262.1.h184openalex-snapshot
Contractile response of individual cardiac myocytes to norepinephrine declines with senescence
inferredcites →https://doi.org/10.1152/ajpheart.1993.264.3.h805openalex-snapshot
Effects of exercise on myocardial adenylate cyclase and Gi alpha expression in senescence
inferredcites →https://doi.org/10.1152/ajpheart.1997.272.1.h590openalex-snapshot
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine
inferredcites →https://doi.org/10.1152/ajpheart.1997.273.3.h1611openalex-snapshot
Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling
inferredcites →https://doi.org/10.1152/jappl.1985.59.4.1033openalex-snapshot
Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males
inferredcites →https://doi.org/10.1152/physrev.1993.73.2.413openalex-snapshot
Cardiovascular regulatory mechanisms in advanced age.
inferredcites →https://doi.org/10.1161/01.cir.87.2.454openalex-snapshot
Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.
inferredcites →https://doi.org/10.1161/01.cir.90.3.1225openalex-snapshot
Age-related changes in beta-adrenergic neuroeffector systems in the human heart.
inferredcites →https://doi.org/10.1161/01.cir.92.6.1612openalex-snapshot
Response of Failing Canine and Human Heart Cells to β 2 -Adrenergic Stimulation
inferredcites →https://doi.org/10.1161/01.hyp.21.4.498openalex-snapshot
Age and gender influence muscle sympathetic nerve activity at rest in healthy humans.
inferredcites →https://doi.org/10.1161/01.res.36.2.262openalex-snapshot
Diminished inotropic response of aged myocardium to catecholamines.
inferredcites →https://doi.org/10.1161/01.res.59.3.297openalex-snapshot
Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.
inferredcites →https://doi.org/10.1161/01.res.70.4.688openalex-snapshot
Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.
inferredcites →https://doi.org/10.1161/01.res.73.2.286openalex-snapshot
Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.
inferredcites →https://doi.org/10.1161/01.res.76.1.40openalex-snapshot
β2-Adrenergic Receptor Actions in Neonatal and Adult Rat Ventricular Myocytes
inferredcites →https://doi.org/10.1161/01.res.79.3.455openalex-snapshot
Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia
inferredcites →https://doi.org/10.1172/jci116312openalex-snapshot
Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.
inferredcites →https://doi.org/10.1172/jci116891openalex-snapshot
Reduced beta 1 receptor messenger RNA abundance in the failing human heart.
inferredcites →https://doi.org/10.1172/jci117559openalex-snapshot
Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Loss Of Beta2-Adrenoceptor Triggers Ca v1.2-CaNKII-Dependent Inflammation and Fibrosis in the Heart
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β-Blockade in Noncardiac Surgery
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Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure
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Potential Myocardial Protection of 3,4‐ seco ‐Lupane Triterpenoids from Acanthopanax sessiliflorus Leaves
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Cardiac Physiology of Aging: Extracellular Considerations
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Beta2‐adrenergic agonist clenbuterol increases energy expenditure and fat oxidation, and induces mTOR phosphorylation in skeletal muscle of young healthy men
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Cardiac Physiology of Aging: Extracellular Considerations
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Vascular β -Adrenergic Receptor Adenylyl Cyclase System in Maturation and Aging
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β -Adrenergic Cardiac Hypertrophy is Mediated Primarily by the β1-Subtype in the Rat Heart
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Dilated Cardiomyopathy in Two Transgenic Mouse Lines Expressing Activated G Protein αq: Lack of Correlation Between Phospholipase C Activation and the Phenotype
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Zelluläre und molekulare Mechanismen des Alterungsprozesses an Herz und Gefäßen
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Cholinergic and Adrenergic Modulation of Cardiac K+Channels
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Changes in the Heart That Accompany Advancing Age: Humans to Molecules
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Aging and the Cardiovascular System
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Senescence and Arrhythmogenesis
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Cerebral Aging: Implications for the Heart Autonomic Nervous System Regulation
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NOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes
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The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population: the copenhagen city heart study
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Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress
inferred← citeshttps://doi.org/10.1007/s10741-010-9167-5openalex-snapshot
Modulation of sarcoplasmic reticulum Ca2+ cycling in systolic and diastolic heart failure associated with aging
inferred← citeshttps://doi.org/10.1007/s10741-010-9183-5openalex-snapshot
Modulation of β-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5
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cAMP signaling affects age-associated deterioration of pacemaker beating interval dynamics
inferred← citeshttps://doi.org/10.1007/s11897-011-0064-6openalex-snapshot
Beta-3 Adrenoceptors as New Therapeutic Targets for Cardiovascular Pathologies
inferred← citeshttps://doi.org/10.1007/s12012-018-9461-3openalex-snapshot
The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice
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Molecular aspects of the cardioprotective effect of exercise in the elderly
inferred← citeshttps://doi.org/10.1016/b978-0-12-394803-8.00004-8openalex-snapshot
Cholinergic Signaling and Muscle Contraction
inferred← citeshttps://doi.org/10.1016/b978-0-323-99570-2.00011-4openalex-snapshot
Neurohormones in cardiac remodeling and function
inferred← citeshttps://doi.org/10.1016/b978-012656975-9/50044-4openalex-snapshot
Aging of the Cardiovascular System
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MiRNA Deregulation in Cardiac Aging and Associated Disorders
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Pharmacodynamics in Older Adults: A Review
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Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
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Ageing is the main determinant of haemodynamics and autonomic cardiac changes observed in post-menopausal female rats
inferred← citeshttps://doi.org/10.1016/j.bbrc.2012.10.077openalex-snapshot
GRK5 ablation contributes to insulin resistance
inferred← citeshttps://doi.org/10.1016/j.cardfail.2005.11.020openalex-snapshot
Section 15: Management of Heart Failure in Special Populations
inferred← citeshttps://doi.org/10.1016/j.cardfail.2010.05.024openalex-snapshot
Section 15: Management of Heart Failure in Special Populations
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Cross-talk of opioid peptide receptor and ?-adrenergic receptor signalling in the heart
inferred← citeshttps://doi.org/10.1016/j.cardiores.2004.12.020openalex-snapshot
Protection in the aged heart: preventing the heart-break of old age?
inferred← citeshttps://doi.org/10.1016/j.cger.2009.07.004openalex-snapshot
Effects of Physical Activity on Cardiovascular and Noncardiovascular Outcomes in Older Adults
inferred← citeshttps://doi.org/10.1016/j.cophys.2023.100722openalex-snapshot
Adrenergic signaling in cardiovascular aging
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Cardiology in the ageing heart: Models
inferred← citeshttps://doi.org/10.1016/j.echo.2006.08.011openalex-snapshot
Arginine 16 Glycine β2-Adrenoceptor Polymorphism and Cardiovascular Structure and Function in Patients with Heart Failure
inferred← citeshttps://doi.org/10.1016/j.ejphar.2004.07.022openalex-snapshot
Autonomic receptor systems in the failing and aging human heart: similarities and differences
inferred← citeshttps://doi.org/10.1016/j.ejphar.2005.02.020openalex-snapshot
Heterogenic contractile response of rat left ventricular myocytes to β1-adrenoceptor stimulation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2016.02.065openalex-snapshot
Differential regulation of the β-adrenoceptor density and cyclic AMP level with age and sex in turkey cardiac chambers
inferred← citeshttps://doi.org/10.1016/j.exger.2021.111339openalex-snapshot
Reduced cardiac response to the adrenergic system is a key limiting factor for physical capacity in old age
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Brown adipose tissue and aging: A potential role for exercise
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Inhibitory G-protein–mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart
inferred← citeshttps://doi.org/10.1016/j.ijcard.2005.04.009openalex-snapshot
Left ventricular morphology, global and longitudinal function in normal older individuals: A cardiac magnetic resonance study
inferred← citeshttps://doi.org/10.1016/j.ijcard.2007.12.001openalex-snapshot
Coexistent chronic obstructive pulmonary disease and heart failure in the elderly
inferred← citeshttps://doi.org/10.1016/j.ijcard.2015.11.040openalex-snapshot
Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism
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Therapeutic synergy and complementarity for ischemia/reperfusion injury: β1-adrenergic blockade and phosphodiesterase-3 inhibition
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The age-related decrease in catecholamine sensitivity is mediated by ß1-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats
inferred← citeshttps://doi.org/10.1016/j.nuclcard.2005.09.008openalex-snapshot
Cardiac receptor physiology and imaging: An update
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Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling
inferred← citeshttps://doi.org/10.1016/j.tem.2013.06.001openalex-snapshot
Age-related changes of myocardial ATP supply and demand mechanisms
inferred← citeshttps://doi.org/10.1016/j.tips.2004.05.007openalex-snapshot
Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications
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Subtype-specific α1- and β-adrenoceptor signaling in the heart
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Na+/Ca2+ exchange linking β2-adrenergic Gi signaling to heart failure: associated defect of adrenergic contractile support
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Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCε phosphorylation
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2015.02.025openalex-snapshot
Heart failure with preserved ejection fraction in the elderly: scope of the problem
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β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573
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Gi-Dependent Localization of β2-Adrenergic Receptor Signaling to L-Type Ca2+ Channels
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Relationships between β- and α2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide
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Modulation of the pacemaker current If by β-adrenoceptor subtypes in ventricular myocytes isolated from hypertensive and normotensive rats
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Adrenergic regulation of myocardial apoptosis
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Alterations in G-Proteins and β-Adrenergic Responsive Adenylyl Cyclase in Rat Urinary Bladder during Aging
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Spontaneous β2-Adrenergic Signaling Fails To Modulate L-Type Ca2+ Current in Mouse Ventricular Myocytes
inferred← citeshttps://doi.org/10.1016/s0031-6997(24)01425-xopenalex-snapshot
Adrenergic and Muscarinic Receptors in the Human Heart
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Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging
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Use of cardiovascular medications in the elderly
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Influence of age on circadian rhythms of adrenoceptors in brain cortex, heart and submandibular glands of BALB/c mice: when circadian studies are not only useful but necessary
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Aging of the vascular-wall and atherosclerosis
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G protein-dependent signalling and ageing☆
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G protein-coupled receptor kinases: gotta real kure for heart failure?∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
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Unchanged G-protein-coupled receptor kinase activity in the aging human heart
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CARDIOVASCULAR AGING IN HEALTH
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Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color doppler tissue imaging
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β-adrenergic mechanisms in cardiac diseases:
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Perspectives on mammalian cardiovascular aging: humans to molecules
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Calcium cycling in the aged heart
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Myocardial Beta-1 Adrenoceptor Down-Regulation in Aging and Heart Failure: Implications for Beta-Blocker use in Older Adults with Heart Failure
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Cardiac and thoracic vascular surgery
inferred← citeshttps://doi.org/10.1016/s1568-1637(02)00063-6openalex-snapshot
Age-related changes in vascular adrenergic signaling: clinical and mechanistic implications
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Cardiovascular Aging in Health
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Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons
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Monitoring of end‐tidal carbon dioxide partial pressure changes during infrarenal aortic cross‐clamping: a non‐invasive method to predict unclamping hypotension
inferred← citeshttps://doi.org/10.1038/s41467-024-47847-8openalex-snapshot
BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts
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Beta2-adrenergic receptor activation increases susceptibility to arrhythmogenesis in aging heart by impairing repolarization reserve via Giβγ–PLC signaling pathway
inferred← citeshttps://doi.org/10.1046/j.1444-2892.2002.00126.xopenalex-snapshot
Cardiovascular ageing in health sets the stage for cardiovascular disease
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Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
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Cardiac-specific Overexpression of the α1 Subunit of the L-type Voltage-dependent Ca2+ Channel in Transgenic Mice
inferred← citeshttps://doi.org/10.1074/jbc.m203640200openalex-snapshot
Age Increases Cardiac Gαi2 Expression, Resulting in Enhanced Coupling to G Protein-coupled Receptors
inferred← citeshttps://doi.org/10.1074/jbc.m909484199openalex-snapshot
Inhibition of Spontaneous β2-Adrenergic Activation Rescues β1-Adrenergic Contractile Response in Cardiomyocytes Overexpressing β2-Adrenoceptor
inferred← citeshttps://doi.org/10.1080/10253890600771858openalex-snapshot
Stress and cardiac beta adrenoceptors
inferred← citeshttps://doi.org/10.1080/17425255.2017.1325873openalex-snapshot
Pharmacokinetic and pharmacodynamic alterations in older people with dementia
inferred← citeshttps://doi.org/10.1093/ageing/afi043openalex-snapshot
Longitudinal myocardial dysfunction in healthy older subjects as a manifestation of cardiac ageing
inferred← citeshttps://doi.org/10.1093/cvr/cvy306openalex-snapshot
Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction
inferred← citeshttps://doi.org/10.1093/gerona/glv217openalex-snapshot
Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model
inferred← citeshttps://doi.org/10.1097/00000441-200408000-00006openalex-snapshot
Use of Beta-Blockers in Older Adults with Chronic Heart Failure
inferred← citeshttps://doi.org/10.1097/00000542-200611000-00017openalex-snapshot
Effects of Desflurane in Senescent Rat Myocardium
inferred← citeshttps://doi.org/10.1097/00005344-200303000-00001openalex-snapshot
Cardiac β-Adrenoceptor Changes in Monocrotaline-Treated Rats: Differences Between Membrane Preparations From Whole Ventricles and Isolated Ventricular Cardiomyocytes
inferred← citeshttps://doi.org/10.1097/00005344-200311000-00013openalex-snapshot
Age Increases Expression and Receptor-Mediated Activation of Gαi in Human Atria
inferred← citeshttps://doi.org/10.1097/01.ccm.0000124871.58281.d1openalex-snapshot
Renal, but not systemic, hemodynamic effects of dopamine are influenced by the severity of congestive heart failure*
inferred← citeshttps://doi.org/10.1097/01.fjc.0000246405.89380.48openalex-snapshot
Normal Aging Impairs Upregulation of the Beta-adrenergic but not the Alpha-Adrenergic Response: Aging and Adrenergic Upregulation
inferred← citeshttps://doi.org/10.1097/01.hco.0000231411.15049.20openalex-snapshot
Drug therapy of chronic heart failure in the elderly: the current state of clinical-trial evidence
inferred← citeshttps://doi.org/10.1097/01.psy.0000132876.95620.04openalex-snapshot
Hostility Is Related to Blunted β-Adrenergic Receptor Responsiveness Among Middle-Aged Women
inferred← citeshttps://doi.org/10.1097/aln.0000000000000526openalex-snapshot
Overexpression of Cyclic Adenosine Monophosphate Effluent Protein MRP4 Induces an Altered Response to β-Adrenergic Stimulation in the Senescent Rat Heart
inferred← citeshttps://doi.org/10.1097/aln.0b013e31818d7e5aopenalex-snapshot
Involvement of β3-Adrenoceptor in Altered β-Adrenergic Response in Senescent Heart
inferred← citeshttps://doi.org/10.1097/fjc.0000000000001119openalex-snapshot
Protopanaxadiol and Protopanaxatriol Ginsenosides Can Protect Against Aconitine-induced Injury in H9c2 Cells by Maintaining Calcium Homeostasis and Activating the AKT Pathway
inferred← citeshttps://doi.org/10.1111/1440-1681.12622openalex-snapshot
Exacerbated cardiac fibrosis induced by β‐adrenergic activation in old mice due to decreased AMPK activity
inferred← citeshttps://doi.org/10.1111/acel.12011openalex-snapshot
Common genetic variants of the β2‐adrenergic receptor affect its translational efficiency and are associated with human longevity
inferred← citeshttps://doi.org/10.1111/j.1076-7460.2000.80047.xopenalex-snapshot
Research Agenda for Cardiovascular Aging: Humans to Molecules
inferred← citeshttps://doi.org/10.1111/j.1076-7460.2001.00800.xopenalex-snapshot
Exercise in Patients With Hypertension
inferred← citeshttps://doi.org/10.1111/j.1076-7460.2001.00833.xopenalex-snapshot
Aging‐Associated Changes in Vascular Activity: A Potential Link to Geriatric Cardiovascular Disease
inferred← citeshttps://doi.org/10.1111/j.1440-1681.2009.05276.xopenalex-snapshot
Effect of age on cardiac excitation–contraction coupling
inferred← citeshttps://doi.org/10.1111/j.1532-5415.1999.tb02579.xopenalex-snapshot
Cardiovascular Aging Research: The Next Horizons
inferred← citeshttps://doi.org/10.1111/nyas.15298openalex-snapshot
Age‐dependent reduction in voltage‐gated inward sodium current and Scn8a gene expression in murine stellate ganglia
inferred← citeshttps://doi.org/10.1113/jp276396openalex-snapshot
Age‐related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation
inferred← citeshttps://doi.org/10.1113/jphysiol.2003.056770openalex-snapshot
β2‐Agonist administration reverses muscle wasting and improves muscle function in aged rats
inferred← citeshttps://doi.org/10.1124/mol.56.3.485openalex-snapshot
Spontaneous β2-Adrenergic Signaling Fails To Modulate L-Type Ca2+Current in Mouse Ventricular Myocytes
inferred← citeshttps://doi.org/10.1134/s2079057016040044openalex-snapshot
Changes in the hormonal status of cardiovascular and the thyroid systems in rats with 18-month type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1152/ajpheart.00086.2003openalex-snapshot
Impact of aging on myocardial metabolic response to dobutamine
inferred← citeshttps://doi.org/10.1152/ajpheart.00308.2007openalex-snapshot
Exercise training and β-blocker treatment ameliorate age-dependent impairment of β-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation
inferred← citeshttps://doi.org/10.1152/ajpheart.00591.2005openalex-snapshot
Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes
inferred← citeshttps://doi.org/10.1152/ajpheart.00993.2007openalex-snapshot
Dopamine increases L-type calcium current more in newborn than adult rabbit cardiomyocytes via D1 and β2 receptors
inferred← citeshttps://doi.org/10.1152/ajpheart.01018.2002openalex-snapshot
Age-related functional effects linked to phosphatase activity in ventricular myocytes
inferred← citeshttps://doi.org/10.1152/ajpheart.01254.2004openalex-snapshot
Chronic β-agonist administration affects cardiac function of adult but not old rats, independent of β-adrenoceptor density
inferred← citeshttps://doi.org/10.1152/ajpheart.2001.280.3.h1129openalex-snapshot
Vascular β-adrenergic receptor system is dysfunctional after myocardial infarction
inferred← citeshttps://doi.org/10.1152/ajpregu.00372.2017openalex-snapshot
Altered expression of hepatic β-adrenergic receptors in aging rats: implications for age-related metabolic dysfunction in liver
inferred← citeshttps://doi.org/10.1152/ajpregu.00756.2010openalex-snapshot
Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat
inferred← citeshttps://doi.org/10.1152/ajpregu.2001.280.3.r897openalex-snapshot
Upregulation of G protein-linked receptor kinases with advancing age in rat aorta
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00076.2003openalex-snapshot
Molecular mechanisms of reduced β-adrenergic signaling in the aged heart as revealed by genomic profiling
inferred← citeshttps://doi.org/10.1152/physrev.00024.2019openalex-snapshot
Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
inferred← citeshttps://doi.org/10.1155/2021/8876792openalex-snapshot
Melatonin to Rescue the Aged Heart: Antiarrhythmic and Antioxidant Benefits
inferred← citeshttps://doi.org/10.1155/2022/6454467openalex-snapshot
The Importance of Cardiac Troponin Metabolism in the Laboratory Diagnosis of Myocardial Infarction (Comprehensive Review)
inferred← citeshttps://doi.org/10.1159/000022034openalex-snapshot
Mechanisms of Aging of the Extracellular Matrix: Role of the Elastin-Laminin Receptor
inferred← citeshttps://doi.org/10.1159/000358903openalex-snapshot
Aging of Cell Communication: Loss of Receptor Function
inferred← citeshttps://doi.org/10.11606/d.82.2016.tde-29032016-113506openalex-snapshot
Análise de existência de máxima fase estável de lactato em exercício resistido em população jovem e idosa
inferred← citeshttps://doi.org/10.1161/01.cir.0000048894.99865.02openalex-snapshot
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
inferred← citeshttps://doi.org/10.1161/01.cir.0000087595.17277.73openalex-snapshot
Enhanced G i Signaling Selectively Negates β 2 -Adrenergic Receptor (AR)– but Not β 1 -AR–Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts
inferred← citeshttps://doi.org/10.1161/01.cir.98.17.1783openalex-snapshot
Reciprocal In Vivo Regulation of Myocardial G Protein–Coupled Receptor Kinase Expression by β-Adrenergic Receptor Stimulation and Blockade
inferred← citeshttps://doi.org/10.1161/01.hyp.0000175842.19266.95openalex-snapshot
Interactive Effects of Common β 2 -Adrenoceptor Haplotypes and Age on Susceptibility to Hypertension and Receptor Function
inferred← citeshttps://doi.org/10.1161/01.hyp.33.1.402openalex-snapshot
The Myocardial β-Adrenergic System in Spontaneously Hypertensive Heart Failure (SHHF) Rats
inferred← citeshttps://doi.org/10.1161/01.res.0000191541.06788.bbopenalex-snapshot
Ischemic Neoangiogenesis Enhanced by β2-Adrenergic Receptor Overexpression
inferred← citeshttps://doi.org/10.1161/01.res.84.1.43openalex-snapshot
Coupling of β2-Adrenoceptor to GiProteins and Its Physiological Relevance in Murine Cardiac Myocytes
inferred← citeshttps://doi.org/10.1161/01.res.85.11.1092openalex-snapshot
Recent Advances in Cardiac β2-Adrenergic Signal Transduction
inferred← citeshttps://doi.org/10.1161/01.res.86.10.1085openalex-snapshot
Contribution of Caveolin Protein Abundance to Augmented Nitric Oxide Signaling in Conscious Dogs With Pacing-Induced Heart Failure
inferred← citeshttps://doi.org/10.1161/circresaha.107.151449openalex-snapshot
The Young Mouse Heart Is Composed of Myocytes Heterogeneous in Age and Function
inferred← citeshttps://doi.org/10.1161/circresaha.115.305250openalex-snapshot
The Role of Exercise in Cardiac Aging
inferred← citeshttps://doi.org/10.1172/jci200420149openalex-snapshot
Direct evidence for a β1-adrenergic receptor–directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy
inferred← citeshttps://doi.org/10.1186/1742-4933-10-10openalex-snapshot
Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes
inferred← citeshttps://doi.org/10.1186/s12871-023-02244-4openalex-snapshot
Hemodynamic impact of ephedrine on hypotension during general anesthesia: a prospective cohort study on middle-aged and older patients
inferred← citeshttps://doi.org/10.1186/s12871-024-02456-2openalex-snapshot
Influence of a chronic beta-blocker therapy on perioperative opioid consumption – a post hoc secondary analysis
inferred← citeshttps://doi.org/10.1186/s12899-017-0030-yopenalex-snapshot
Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age
inferred← citeshttps://doi.org/10.1249/01.mss.0000218144.02831.f6openalex-snapshot
Genotype Related Differences in β2 Adrenergic Receptor Density and Cardiac Function
inferred← citeshttps://doi.org/10.1254/jphs.crj06001xopenalex-snapshot
Cardiac Adrenoceptors: Physiological and Pathophysiological Relevance
inferred← citeshttps://doi.org/10.1371/journal.pone.0068747openalex-snapshot
Relationship between the Autoantibody and Expression of β3-Adrenoceptor in Lung and Heart
inferred← citeshttps://doi.org/10.1371/journal.pone.0153632openalex-snapshot
Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging
inferred← citeshttps://doi.org/10.1385/endo:26:2:127openalex-snapshot
Views From Within and Beyond: Narratives of Cardiac Contractile Dysfunction Under Senescence
inferred← citeshttps://doi.org/10.14740/cr1351openalex-snapshot
The Metabolic Pathway of Cardiac Troponins Release: Mechanisms and Diagnostic Role
inferred← citeshttps://doi.org/10.14814/phy2.13485openalex-snapshot
Linking metabolic and contractile dysfunction in aged cardiac myocytes
inferred← citeshttps://doi.org/10.1530/joe-11-0406openalex-snapshot
Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging
inferred← citeshttps://doi.org/10.1590/s0066-782x1999000200009openalex-snapshot
The role of G-proteins in the pathophysiology of the cardiovascular diseases
inferred← citeshttps://doi.org/10.1631/jzus.b0820213openalex-snapshot
Expressions of cardiac sympathetic norepinephrine transporter and β1-adrenergic receptor decreased in aged rats
inferred← citeshttps://doi.org/10.17802/2306-1278-2019-8-4-103-115openalex-snapshot
Metabolism of cardiac troponins (literature review)
inferred← citeshttps://doi.org/10.18297/etd/3812openalex-snapshot
Adipose-derived stromal vascular fraction therapy improves age-related adrenergic mediated microvascular dysfunction and increases revascularization potential following injury.
inferred← citeshttps://doi.org/10.18632/aging.102069openalex-snapshot
Enhanced beta-1 adrenergic receptor responsiveness in coronary arterioles following intravenous stromal vascular fraction therapy in aged rats
inferred← citeshttps://doi.org/10.20517/jca.2022.01openalex-snapshot
Mechanisms and implications of sex differences in cardiac aging
inferred← citeshttps://doi.org/10.20517/jca.2024.22openalex-snapshot
Aging diastole - root cause for atrial fibrillation and heart failure with preserved ejection fraction
inferred← citeshttps://doi.org/10.20517/jca.2025.14openalex-snapshot
Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions
inferred← citeshttps://doi.org/10.2147/vhrm.s335851openalex-snapshot
Metabolic Pathway of Cardiac Troponins and Its Diagnostic Value
inferred← citeshttps://doi.org/10.2165/00002512-199813020-00007openalex-snapshot
Age-Associated Alterations in Calcium Current and its Modulation in Cardiac Myocytes
inferred← citeshttps://doi.org/10.2165/00002512-200825050-00005openalex-snapshot
Potential Adverse Effects of Bronchodilators in the Treatment of Airways Obstruction in Older People
inferred← citeshttps://doi.org/10.2165/00003495-200565120-00001openalex-snapshot
Inhaled ??2-Adrenoceptor Agonists
inferred← citeshttps://doi.org/10.2174/092986710790416326openalex-snapshot
Age-Related Pharmacokinetic and Pharmacodynamic Changes and Related Risk of Adverse Drug Reactions
inferred← citeshttps://doi.org/10.2174/0929867329666220610200409openalex-snapshot
Current Understanding of Cardiac Troponins Metabolism: A Narrative Review
inferred← citeshttps://doi.org/10.2174/1570161120666220107105840openalex-snapshot
Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing
inferred← citeshttps://doi.org/10.2337/db11-1027openalex-snapshot
Age-Related Impairment in Insulin Release
inferred← citeshttps://doi.org/10.23860/thesis-agostinucci-kevin-2017openalex-snapshot
The Physiological Glucagon Receptor in Rat Heart
inferred← citeshttps://doi.org/10.3109/07435800.2010.539993openalex-snapshot
β-Adrenergic Responsive Induction of Insulin Resistance in Liver of Aging Rats
inferred← citeshttps://doi.org/10.3109/10799891003801918openalex-snapshot
Age-related up-regulation of β3-adrenergic receptor in heart-failure rats
inferred← citeshttps://doi.org/10.33678/cor.2022.044openalex-snapshot
(Modern ideas about the mechanisms of cardiac troponin release and their diagnostic role)
inferred← citeshttps://doi.org/10.3389/fcell.2022.1031007openalex-snapshot
Plasma membrane and brain dysfunction of the old: Do we age from our membranes?
inferred← citeshttps://doi.org/10.3389/fcvm.2021.732708openalex-snapshot
Oxidative Stress in Takotsubo Syndrome—Is It Essential for an Acute Attack? Indirect Evidences Support Multisite Impact Including the Calcium Overload—Energy Failure Hypothesis
inferred← citeshttps://doi.org/10.3389/fmolb.2022.841277openalex-snapshot
Metabolic Pathway of Cardiospecific Troponins: From Fundamental Aspects to Diagnostic Role (Comprehensive Review)
inferred← citeshttps://doi.org/10.3389/fphar.2018.00904openalex-snapshot
New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging
inferred← citeshttps://doi.org/10.3389/fphys.2013.00348openalex-snapshot
Effects of exercise training on cardiovascular adrenergic system
inferred← citeshttps://doi.org/10.3389/fphys.2013.00396openalex-snapshot
β-adrenergic receptor responsiveness in aging heart and clinical implications
inferred← citeshttps://doi.org/10.3389/fphys.2021.810408openalex-snapshot
Nanoscale Organization, Regulation, and Dynamic Reorganization of Cardiac Calcium Channels
inferred← citeshttps://doi.org/10.3389/fragi.2021.727604openalex-snapshot
Vascular Aging in Rodent Models: Contrasting Mechanisms Driving the Female and Male Vascular Senescence
inferred← citeshttps://doi.org/10.3390/biology11030429openalex-snapshot
Biology of Cardiac Troponins: Emphasis on Metabolism
inferred← citeshttps://doi.org/10.3390/cimb44030092openalex-snapshot
Features of the Metabolisms of Cardiac Troponin Molecules—Part 1: The Main Stages of Metabolism, Release Stage
inferred← citeshttps://doi.org/10.3390/ijms20102386openalex-snapshot
Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart
inferred← citeshttps://doi.org/10.3390/ijms222010928openalex-snapshot
Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review)
inferred← citeshttps://doi.org/10.3390/ijms26167989openalex-snapshot
Altered β-Adrenergic System, Cardiac Dysfunction, and Lethal Arrhythmia in a Rat Model of Metabolic Syndrome
inferred← citeshttps://doi.org/10.34883/pi.2022.11.1.018openalex-snapshot
Analytical Review of Modern Information on the Physiological and Pathochemical Mechanisms of the Release of Cardiospecific Proteins from Muscle Tissue, Methodology and Technologies of Their Research, Interpretation of the Results
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