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The therapeutic potential of modulating the ceramide/sphingomyelin pathway

https://doi.org/10.1172/jci16127
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1097-4652(200009)184:3<285::aid-jcp2>3.0.co;2-3openalex-snapshot
Compartmentalization of ceramide signaling: physical foundations and biological effects
inferredcites →https://doi.org/10.1002/j.1460-2075.1995.tb07188.xopenalex-snapshot
PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid.
inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb00760.xopenalex-snapshot
Cathepsin D protease mediates programmed cell death induced by interferon‐gamma, Fas/APO‐1 and TNF‐alpha.
inferredcites →https://doi.org/10.1006/bbrc.2001.5045openalex-snapshot
Molecular Mechanisms of Ceramide-Mediated CD95 Clustering
inferredcites →https://doi.org/10.1006/geno.2002.6686openalex-snapshot
Insertional Mutagenesis of the Mouse Acid Ceramidase Gene Leads to Early Embryonic Lethality in Homozygotes and Progressive Lipid Storage Disease in Heterozygotes
inferredcites →https://doi.org/10.1006/jmbi.2001.5263openalex-snapshot
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of ras (KSR)
inferredcites →https://doi.org/10.1006/mcne.1999.0813openalex-snapshot
Inhibition of PKB/Akt1 by C2-Ceramide Involves Activation of Ceramide-Activated Protein Phosphatase in PC12 Cells
inferredcites →https://doi.org/10.1007/s002800000140openalex-snapshot
Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line
inferredcites →https://doi.org/10.1016/0092-8674(95)90429-8openalex-snapshot
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
inferredcites →https://doi.org/10.1016/0163-7827(91)90005-popenalex-snapshot
Sphingomyelin and derivatives as cellular signals
inferredcites →https://doi.org/10.1016/s0021-9258(17)37526-9openalex-snapshot
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
inferredcites →https://doi.org/10.1016/s0021-9258(18)45447-6openalex-snapshot
1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.
inferredcites →https://doi.org/10.1016/s0021-9258(18)55472-7openalex-snapshot
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
inferredcites →https://doi.org/10.1016/s0021-9258(18)68674-0openalex-snapshot
1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase.
inferredcites →https://doi.org/10.1016/s0021-9258(18)83279-3openalex-snapshot
Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells
inferredcites →https://doi.org/10.1016/s0021-9258(19)47268-2openalex-snapshot
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
inferredcites →https://doi.org/10.1016/s0041-1345(00)02126-6openalex-snapshot
FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression
inferredcites →https://doi.org/10.1016/s0092-8674(00)80183-xopenalex-snapshot
Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase
inferredcites →https://doi.org/10.1021/bi002836kopenalex-snapshot
Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling
inferredcites →https://doi.org/10.1038/365557a0openalex-snapshot
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
inferredcites →https://doi.org/10.1038/381800a0openalex-snapshot
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
inferredcites →https://doi.org/10.1038/80442openalex-snapshot
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy
inferredcites →https://doi.org/10.1038/ng0795-288openalex-snapshot
Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease
inferredcites →https://doi.org/10.1042/bj3350465openalex-snapshot
Signal transduction of stress via ceramide
inferredcites →https://doi.org/10.1073/pnas.93.14.6959openalex-snapshot
Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.
inferredcites →https://doi.org/10.1073/pnas.95.2.681openalex-snapshot
Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
inferredcites →https://doi.org/10.1074/jbc.270.45.27179openalex-snapshot
Compartmentalized Production of Ceramide at the Cell Surface
inferredcites →https://doi.org/10.1074/jbc.272.16.10922openalex-snapshot
Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae
inferredcites →https://doi.org/10.1074/jbc.273.18.11313openalex-snapshot
Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death
inferredcites →https://doi.org/10.1074/jbc.273.29.18250openalex-snapshot
The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene
inferredcites →https://doi.org/10.1074/jbc.273.37.23722openalex-snapshot
Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase
inferredcites →https://doi.org/10.1074/jbc.273.5.2738openalex-snapshot
Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH
inferredcites →https://doi.org/10.1074/jbc.274.25.17908openalex-snapshot
Ataxia Telangiectasia-mutated Gene Product Inhibits DNA Damage-induced Apoptosis via Ceramide Synthase
inferredcites →https://doi.org/10.1074/jbc.274.29.20296openalex-snapshot
Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A
inferredcites →https://doi.org/10.1074/jbc.m002522200openalex-snapshot
Molecular Cloning and Characterization of a Human Mitochondrial Ceramidase
inferredcites →https://doi.org/10.1074/jbc.m002759200openalex-snapshot
Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform
inferredcites →https://doi.org/10.1074/jbc.m010666200openalex-snapshot
Changes in the Lipid Turnover, Composition, and Organization, as Sphingolipid-enriched Membrane Domains, in Rat Cerebellar Granule Cells Developing in Vitro
inferredcites →https://doi.org/10.1074/jbc.m111761200openalex-snapshot
Importance of C1B Domain for Lipid Messenger-induced Targeting of Protein Kinase C
inferredcites →https://doi.org/10.1074/jbc.m112010200openalex-snapshot
De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells
inferredcites →https://doi.org/10.1080/09553009014552281openalex-snapshot
A Comprehensive Study of the Radiobiological Response of the Murine (BDF1) Small Intestine
inferredcites →https://doi.org/10.1093/embo-reports/kvf022openalex-snapshot
An essential role for membrane rafts in the initiation of Fas/CD95‐triggered cell death in mouse thymocytes
inferredcites →https://doi.org/10.1093/emboj/18.19.5252openalex-snapshot
Cathepsin D targeted by acid sphingomyelinase‐derived ceramide
inferredcites →https://doi.org/10.1093/jnci/92.23.1897openalex-snapshot
Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism
inferredcites →https://doi.org/10.1096/fj.00-0370fjeopenalex-snapshot
Ceramide binds to the CaLB domain of cytosolic phospholipase A 2 and facilitates its membrane docking and arachidonic acid release
inferredcites →https://doi.org/10.1097/00004630-199920060-00007openalex-snapshot
THE 1999 MOYER AWARD Burn Injury Induces Skeletal Muscle Apoptosis and the Activation of Caspase Pathways in Rats
inferredcites →https://doi.org/10.1101/gad.12.13.1941openalex-snapshot
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
inferredcites →https://doi.org/10.1126/science.1060191openalex-snapshot
Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice
inferredcites →https://doi.org/10.1126/science.1065323openalex-snapshot
Lysophospholipids--Receptor Revelations
inferredcites →https://doi.org/10.1126/science.1070238openalex-snapshot
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
inferredcites →https://doi.org/10.1126/science.288.5475.2354openalex-snapshot
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
inferredcites →https://doi.org/10.1126/science.290.5497.1721openalex-snapshot
How Cells Handle Cholesterol
inferredcites →https://doi.org/10.1128/mcb.22.1.207-220.2002openalex-snapshot
Molecular Ordering of the Initial Signaling Events of CD95
inferredcites →https://doi.org/10.1152/ajpcell.2001.280.6.c1403openalex-snapshot
Inhibitory actions of ceramide upon PKC-ε/ERK interactions
inferredcites →https://doi.org/10.1161/01.res.87.4.282openalex-snapshot
Ceramide-Coated Balloon Catheters Limit Neointimal Hyperplasia After Stretch Injury in Carotid Arteries
inferredcites →https://doi.org/10.1182/blood.v98.13.3860openalex-snapshot
The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
inferredcites →https://doi.org/10.1242/jcs.114.9.1609openalex-snapshot
KSR: a MAPK scaffold of the Ras pathway?
inferredcites →https://doi.org/10.4049/jimmunol.168.1.298openalex-snapshot
Ceramide-Rich Membrane Rafts Mediate CD40 Clustering

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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(1-Deoxy)Ceramides in Bilayers Containing Sphingomyelin and Cholesterol
inferred← citeshttps://doi.org/10.1002/9780470875780.ch21openalex-snapshot
Mitochondria‐Targeted Pharmaceutical Nanocarriers
inferred← citeshttps://doi.org/10.1002/biof.97openalex-snapshot
Modulation of signal transduction in cancer cells by phytosterols
inferred← citeshttps://doi.org/10.1002/brb3.836openalex-snapshot
Plasma sphingolipids and depressive symptoms in coronary artery disease
inferred← citeshttps://doi.org/10.1002/cmdc.200600099openalex-snapshot
Influence of the Scyphostatin Side Chain on the Mode of Inhibition of Neutral Sphingomyelinase
inferred← citeshttps://doi.org/10.1002/emmm.201202301openalex-snapshot
Systemic ceramide accumulation leads to severe and varied pathological consequences
inferred← citeshttps://doi.org/10.1002/iub.319openalex-snapshot
Mammalian ceramide synthases
inferred← citeshttps://doi.org/10.1002/jcp.21101openalex-snapshot
Ceramide inhibits LPS‐induced production of IL‐5, IL‐10, and IL‐13 from mast cells
inferred← citeshttps://doi.org/10.1002/jcp.22283openalex-snapshot
Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle
inferred← citeshttps://doi.org/10.1002/jnr.20117openalex-snapshot
Cytokine‐induced cell death in human oligodendroglial cell lines. II: Alterations in gene expression induced by interferon‐γ and tumor necrosis factor‐α
inferred← citeshttps://doi.org/10.1002/mnfr.200600164openalex-snapshot
Phytosterols as anticancer compounds
inferred← citeshttps://doi.org/10.1002/mnfr.200700258openalex-snapshot
The potential of sphingomyelin as a chemopreventive agent in AOM‐induced colon cancer model: wild‐type and p53+/– mice
inferred← citeshttps://doi.org/10.1002/nbm.1387openalex-snapshot
Assessment of 31P‐NMR analysis of phospholipid profiles for potential differential diagnosis of human cerebral tumors
inferred← citeshttps://doi.org/10.1002/pros.10350openalex-snapshot
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts
inferred← citeshttps://doi.org/10.1007/0-306-48412-9_19openalex-snapshot
Apoptosis Mechanisms Initiated by Oxidative Stress
inferred← citeshttps://doi.org/10.1007/0-387-34573-6_2openalex-snapshot
FasL-Independent Activation of Fas
inferred← citeshttps://doi.org/10.1007/3-540-27194-5_30openalex-snapshot
Ceramide: Cell Regulation from a Lipid Perspective
inferred← citeshttps://doi.org/10.1007/978-0-387-30378-9_10openalex-snapshot
Functional Dynamics of Myelin Lipids*
inferred← citeshttps://doi.org/10.1007/978-0-387-79208-8openalex-snapshot
Clinical Applications of Immunomics
inferred← citeshttps://doi.org/10.1007/978-0-387-79208-8_11openalex-snapshot
Glycoimmunomics of Human Cancer: Relevance to Monitoring Biomarkers of Early Detection and Therapeutic Response
inferred← citeshttps://doi.org/10.1007/978-1-4020-8831-5_15openalex-snapshot
Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis
inferred← citeshttps://doi.org/10.1007/978-1-4614-0650-1_2openalex-snapshot
Sphingolipids and Cardiovascular Diseases: Lipoprotein Metabolism, Atherosclerosis and Cardiomyopathy
inferred← citeshttps://doi.org/10.1007/978-1-59259-785-7_18openalex-snapshot
Proapoptotic Strategy in Cancer Gene Therapy
inferred← citeshttps://doi.org/10.1007/978-1-60327-538-5_7openalex-snapshot
Lipid Products and Cell Signaling
inferred← citeshttps://doi.org/10.1007/978-3-030-21162-2_6openalex-snapshot
Ceramide Domains in Health and Disease: A Biophysical Perspective
inferred← citeshttps://doi.org/10.1007/978-3-319-55430-3_33openalex-snapshot
Hearing
inferred← citeshttps://doi.org/10.1007/978-3-319-56805-8_9openalex-snapshot
Fas/CD95, Lipid Rafts, and Cancer
inferred← citeshttps://doi.org/10.1007/978-3-7091-1511-4_2openalex-snapshot
Using ASMase Knockout Mice to Model Human Diseases
inferred← citeshttps://doi.org/10.1007/978-94-007-2004-6_5openalex-snapshot
The Role of Proinflammatory Cytokines in Regulation of Cardiac Bioelectrical Activity: Link to Mechanoelectrical Feedback
inferred← citeshttps://doi.org/10.1007/978-94-007-5028-9_16openalex-snapshot
Large Granular Lymphocyte Leukemia – From Molecular Pathogenesis to Targeted Therapy
inferred← citeshttps://doi.org/10.1007/s00018-012-1038-xopenalex-snapshot
Ceramide function in the brain: when a slight tilt is enough
inferred← citeshttps://doi.org/10.1007/s00125-007-0781-2openalex-snapshot
Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00210-006-0036-7openalex-snapshot
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat
inferred← citeshttps://doi.org/10.1007/s00216-012-5843-8openalex-snapshot
Profiling changes triggered during maturation of dendritic cells: a lipidomic approach
inferred← citeshttps://doi.org/10.1007/s00216-018-1313-2openalex-snapshot
Lipidomic differentiation of Graves’ ophthalmopathy in plasma and urine from Graves’ disease patients
inferred← citeshttps://doi.org/10.1007/s00249-009-0562-6openalex-snapshot
Ceramide acyl chain length markedly influences miscibility with palmitoyl sphingomyelin in bilayer membranes
inferred← citeshttps://doi.org/10.1007/s00280-007-0465-0openalex-snapshot
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells
inferred← citeshttps://doi.org/10.1007/s00383-003-1003-8openalex-snapshot
Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model
inferred← citeshttps://doi.org/10.1007/s00432-004-0591-6openalex-snapshot
Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells
inferred← citeshttps://doi.org/10.1007/s00701-004-0286-4openalex-snapshot
Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells
inferred← citeshttps://doi.org/10.1007/s10068-022-01138-4openalex-snapshot
Egg yolk lipids: separation, characterization, and utilization
inferred← citeshttps://doi.org/10.1007/s10337-012-2246-0openalex-snapshot
GC–MS Based Serum Metabolomic Analysis of Isoflurane-Induced Postoperative Cognitive Dysfunctional Rats: Biomarker Screening and Insight into Possible Pathogenesis
inferred← citeshttps://doi.org/10.1007/s10495-007-0721-0openalex-snapshot
Sphingolipids and cell death
inferred← citeshttps://doi.org/10.1007/s10495-015-1104-6openalex-snapshot
Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling
inferred← citeshttps://doi.org/10.1007/s10555-025-10255-5openalex-snapshot
Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings
inferred← citeshttps://doi.org/10.1007/s10616-016-9997-7openalex-snapshot
Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells
inferred← citeshttps://doi.org/10.1007/s10719-014-9541-yopenalex-snapshot
Exploring the link between ceramide and ionizing radiation
inferred← citeshttps://doi.org/10.1007/s10863-008-9156-8openalex-snapshot
All-trans-retinoic acid induces apoptosis in Leydig cells via activation of the mitochondrial death pathway and antioxidant enzyme regulation
inferred← citeshttps://doi.org/10.1007/s11095-008-9614-3openalex-snapshot
Enhancement in Anti-proliferative Effects of Paclitaxel in Aortic Smooth Muscle Cells upon Co-administration with Ceramide using Biodegradable Polymeric Nanoparticles
inferred← citeshttps://doi.org/10.1007/s11745-007-3148-zopenalex-snapshot
Apoptotic Effects of Dietary and Synthetic Sphingolipids in Androgen‐Independent (PC‐3) Prostate Cancer Cells
inferred← citeshttps://doi.org/10.1007/s11886-018-1067-7openalex-snapshot
Tumor Necrosis Factor-α in Heart Failure: an Updated Review
inferred← citeshttps://doi.org/10.1007/s12026-008-8019-zopenalex-snapshot
Statins’ immunomodulatory potential against Th17 cell-mediated autoimmune response
inferred← citeshttps://doi.org/10.1007/s43188-020-00067-wopenalex-snapshot
Differential mechanisms underlying methotrexate-induced cell death and epithelial-mesenchymal transition in A549 cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-394274-6.00008-xopenalex-snapshot
Natural Products as Platforms for the Design of Sphingolipid-Related Anticancer Agents
inferred← citeshttps://doi.org/10.1016/b978-012439510-7/50056-5openalex-snapshot
The Transport, Assembly, and Function of Myelin Lipids
inferred← citeshttps://doi.org/10.1016/j.abb.2009.01.018openalex-snapshot
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
inferred← citeshttps://doi.org/10.1016/j.abb.2011.02.003openalex-snapshot
Involvement of lipid rafts in macrophage apoptosis induced by cationic liposomes
inferred← citeshttps://doi.org/10.1016/j.abb.2011.04.009openalex-snapshot
AP-1 binding transcriptionally regulates human neutral ceramidase
inferred← citeshttps://doi.org/10.1016/j.abb.2011.04.012openalex-snapshot
Transcriptional regulation of the human neutral ceramidase gene
inferred← citeshttps://doi.org/10.1016/j.aca.2009.02.027openalex-snapshot
Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC–oaTOF-MS system
inferred← citeshttps://doi.org/10.1016/j.actbio.2016.07.006openalex-snapshot
Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.addr.2013.09.004openalex-snapshot
Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles
inferred← citeshttps://doi.org/10.1016/j.bbaexp.2006.01.002openalex-snapshot
KLF6 is one transcription factor involved in regulating acid ceramidase gene expression
inferred← citeshttps://doi.org/10.1016/j.bbagen.2007.08.014openalex-snapshot
Sphingolipid therapy in myocardial ischemia–reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.bbagen.2007.08.015openalex-snapshot
Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends
inferred← citeshttps://doi.org/10.1016/j.bbalip.2007.05.007openalex-snapshot
Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization
inferred← citeshttps://doi.org/10.1016/j.bbalip.2013.03.001openalex-snapshot
Emerging roles of lipids in BCL-2 family-regulated apoptosis
inferred← citeshttps://doi.org/10.1016/j.bbalip.2013.06.005openalex-snapshot
Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors
inferred← citeshttps://doi.org/10.1016/j.bbamem.2006.08.019openalex-snapshot
Acid ceramidase and human disease
inferred← citeshttps://doi.org/10.1016/j.bbamem.2014.05.024openalex-snapshot
Ceramide–lipid interactions studied by MD simulations and solid-state NMR
inferred← citeshttps://doi.org/10.1016/j.bbcan.2007.11.002openalex-snapshot
Dissecting lipid raft facilitated cell signaling pathways in cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.02.070openalex-snapshot
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation
inferred← citeshttps://doi.org/10.1016/j.biocel.2008.10.021openalex-snapshot
De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2007.09.037openalex-snapshot
Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2011.01.006openalex-snapshot
A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.01.068openalex-snapshot
Phytosterols as a natural anticancer agent: Current status and future perspective
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111610openalex-snapshot
Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase
inferred← citeshttps://doi.org/10.1016/j.canlet.2003.08.034openalex-snapshot
Ceramide synthesis and metabolism as a target for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.canlet.2014.03.003openalex-snapshot
Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells
inferred← citeshttps://doi.org/10.1016/j.cca.2011.12.014openalex-snapshot
Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS
inferred← citeshttps://doi.org/10.1016/j.ccr.2007.04.011openalex-snapshot
Regulators of Mitotic Arrest and Ceramide Metabolism Are Determinants of Sensitivity to Paclitaxel and Other Chemotherapeutic Drugs
inferred← citeshttps://doi.org/10.1016/j.ccr.2007.05.003openalex-snapshot
A CERTain Role for Ceramide in Taxane-Induced Cell Death
inferred← citeshttps://doi.org/10.1016/j.chembiol.2005.04.019openalex-snapshot
S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate
inferred← citeshttps://doi.org/10.1016/j.chemphyslip.2016.04.002openalex-snapshot
Cholesterol interactions with ceramide and sphingomyelin
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2010.04.072openalex-snapshot
Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.ebiom.2019.03.087openalex-snapshot
Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2016.06.025openalex-snapshot
The ceramide inhibitor fumonisin B1 mitigates the pulmonary effects of low-dose diesel exhaust inhalation in mice
inferred← citeshttps://doi.org/10.1016/j.ejbas.2018.10.003openalex-snapshot
Ceramide pathway: A novel approach to cancer chemotherapy
inferred← citeshttps://doi.org/10.1016/j.ejpb.2019.02.019openalex-snapshot
Liposome-targeted recombinant human acid sphingomyelinase: Production, formulation, and in vitro evaluation
inferred← citeshttps://doi.org/10.1016/j.expneurol.2008.07.026openalex-snapshot
Neuropathology of the acid sphingomyelinase knockout mouse model of Niemann-Pick A disease including structure–function studies associated with cerebellar Purkinje cell degeneration
inferred← citeshttps://doi.org/10.1016/j.febslet.2006.08.052openalex-snapshot
Sphingolipids in cancer: Regulation of pathogenesis and therapy
inferred← citeshttps://doi.org/10.1016/j.febslet.2010.02.026openalex-snapshot
Ceramide‐rich platforms in transmembrane signaling
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2011.01.026openalex-snapshot
Roles of reactive oxygen and nitrogen species in pain
inferred← citeshttps://doi.org/10.1016/j.gene.2006.12.011openalex-snapshot
The role of sphingosine 1-phosphate in the TNF-α induction of IL-8 gene expression in lung epithelial cells
inferred← citeshttps://doi.org/10.1016/j.heares.2014.03.003openalex-snapshot
Mechanisms of radiation-induced sensorineural hearing loss and radioprotection
inferred← citeshttps://doi.org/10.1016/j.idairyj.2007.10.014openalex-snapshot
Nutritional and technological aspects of milk fat globule membrane material
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2010.05.048openalex-snapshot
Effect of Irradiation on Microvascular Endothelial Cells of Parotid Glands in the Miniature Pig
inferred← citeshttps://doi.org/10.1016/j.immuni.2012.08.018openalex-snapshot
The Receptor LMIR3 Negatively Regulates Mast Cell Activation and Allergic Responses by Binding to Extracellular Ceramide
inferred← citeshttps://doi.org/10.1016/j.it.2007.01.007openalex-snapshot
Tipping the gatekeeper: S1P regulation of endothelial barrier function
inferred← citeshttps://doi.org/10.1016/j.jchromb.2009.02.048openalex-snapshot
Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization
inferred← citeshttps://doi.org/10.1016/j.jchromb.2015.12.004openalex-snapshot
Serum metabolomics strategy for understanding pharmacological effects of ShenQi pill acting on kidney yang deficiency syndrome
inferred← citeshttps://doi.org/10.1016/j.jep.2015.05.019openalex-snapshot
Urine and plasma metabonomics coupled with UHPLC-QTOF/MS and multivariate data analysis on potential biomarkers in anemia and hematinic effects of herb pair Gui-Hong
inferred← citeshttps://doi.org/10.1016/j.jhep.2014.09.023openalex-snapshot
Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2005.04.004openalex-snapshot
β-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells
inferred← citeshttps://doi.org/10.1016/j.lfs.2005.05.015openalex-snapshot
Cannabinoids and ceramide: Two lipids acting hand-by-hand
inferred← citeshttps://doi.org/10.1016/j.lfs.2014.05.009openalex-snapshot
Propofol prevents lung injury after intestinal ischemia–reperfusion by inhibiting the interaction between mast cell activation and oxidative stress
inferred← citeshttps://doi.org/10.1016/j.matpr.2021.02.482openalex-snapshot
Hydrolysis of sphingomyelin in supported raft bilayers and relative structural changes studied by fluorescence microscopy
inferred← citeshttps://doi.org/10.1016/j.mce.2006.12.016openalex-snapshot
Steroidogenic factor-1 is a sphingolipid binding protein
inferred← citeshttps://doi.org/10.1016/j.mib.2006.06.003openalex-snapshot
Lipid signaling in pathogenic fungi
inferred← citeshttps://doi.org/10.1016/j.neulet.2009.07.051openalex-snapshot
Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance
inferred← citeshttps://doi.org/10.1016/j.neulet.2011.10.044openalex-snapshot
Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative model
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2007.01.011openalex-snapshot
Cellular metabolic responses of PET radiotracers to 188Re radiation in an MCF7 cell line containing dominant-negative mutant p53
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2014.11.012openalex-snapshot
Cardioprotective potential of annexin-A1 mimetics in myocardial infarction
inferred← citeshttps://doi.org/10.1016/j.plipres.2007.11.001openalex-snapshot
The multi-functional role of sphingosylphosphorylcholine
inferred← citeshttps://doi.org/10.1016/j.plipres.2010.02.004openalex-snapshot
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease
inferred← citeshttps://doi.org/10.1016/j.pupt.2008.12.003openalex-snapshot
Lipid metabolites as regulators of airway smooth muscle function
inferred← citeshttps://doi.org/10.1016/j.steroids.2010.01.020openalex-snapshot
The interplay between bioactive sphingolipids and steroid hormones
inferred← citeshttps://doi.org/10.1016/j.survophthal.2013.02.005openalex-snapshot
Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders
inferred← citeshttps://doi.org/10.1016/j.tips.2012.12.001openalex-snapshot
Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain
inferred← citeshttps://doi.org/10.1016/j.tips.2020.09.006openalex-snapshot
Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics
inferred← citeshttps://doi.org/10.1016/j.ultrasmedbio.2013.01.012openalex-snapshot
Effects of Biophysical Parameters in Enhancing Radiation Responses of Prostate Tumors with Ultrasound-Stimulated Microbubbles
inferred← citeshttps://doi.org/10.1016/j.yexcr.2003.10.001openalex-snapshot
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells
inferred← citeshttps://doi.org/10.1016/j.yexcr.2006.08.017openalex-snapshot
The murine TRAIL receptor signals caspase-independent cell death through ceramide
inferred← citeshttps://doi.org/10.1016/j.ygyno.2017.07.143openalex-snapshot
Plasma and ovarian tissue sphingolipids profiling in patients with advanced ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.ymgme.2007.11.011openalex-snapshot
Glucosylceramide accumulation is not confined to the lysosome in fibroblasts from patients with Gaucher disease
inferred← citeshttps://doi.org/10.1016/j.ymgme.2014.07.005openalex-snapshot
Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency: The utility of animal models of disease in the toxicological evaluation of potential therapeutics
inferred← citeshttps://doi.org/10.1016/j.zemedi.2023.04.007openalex-snapshot
Radiation combined with ultrasound and microbubbles: A potential novel strategy for cancer treatment
inferred← citeshttps://doi.org/10.1016/s0003-2697(03)00388-9openalex-snapshot
A specific ceramide kinase assay to measure cellular levels of ceramide
inferred← citeshttps://doi.org/10.1016/s0006-291x(03)00449-2openalex-snapshot
Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell
inferred← citeshttps://doi.org/10.1016/s0014-5793(02)03248-9openalex-snapshot
Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?
inferred← citeshttps://doi.org/10.1016/s0014-5793(02)03489-0openalex-snapshot
Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?
inferred← citeshttps://doi.org/10.1016/s0014-5793(03)00570-2openalex-snapshot
Annexin A1 processing is associated with caspase‐dependent apoptosis in BZR cells
inferred← citeshttps://doi.org/10.1016/s0028-3908(03)00284-3openalex-snapshot
Inhibition of rat sympathetic neuron apoptosis by ceramide. Role of p75NTR in ceramide generation
inferred← citeshttps://doi.org/10.1016/s0065-7743(08)00013-4openalex-snapshot
Oncology Drug Targets in the Sphingomyelin-Signaling Pathway
inferred← citeshttps://doi.org/10.1016/s1043-6618(03)00048-3openalex-snapshot
Sphingolipids as therapeutics
inferred← citeshttps://doi.org/10.1016/s1043-6618(03)00050-1openalex-snapshot
Intracellular signal transduction pathways activated by ceramide and its metabolites
inferred← citeshttps://doi.org/10.1016/s1043-6618(03)00051-3openalex-snapshot
Sphingolipids and the immune system
inferred← citeshttps://doi.org/10.1016/s1367-5931(03)00085-1openalex-snapshot
Sphingosine 1-phosphate pathway therapeutics: a lipid ligand–receptor paradigm
inferred← citeshttps://doi.org/10.1016/s1567-7443(07)10005-3openalex-snapshot
Interleukin-1β Signal Transduction via the Sphingomyelin Pathway in Brain Cells
inferred← citeshttps://doi.org/10.1017/s1462399409001070openalex-snapshot
RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance
inferred← citeshttps://doi.org/10.1021/ac501937dopenalex-snapshot
On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00964openalex-snapshot
Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain
inferred← citeshttps://doi.org/10.1021/acsnano.7b00186openalex-snapshot
Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues To Regulate Skeletal Muscle Maturation and Vascularization
inferred← citeshttps://doi.org/10.1021/jm070524aopenalex-snapshot
Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model
inferred← citeshttps://doi.org/10.1021/jp212325eopenalex-snapshot
Mixing Properties of Sphingomyelin Ceramide Bilayers: A Simulation Study
inferred← citeshttps://doi.org/10.1021/la401826bopenalex-snapshot
Tunable Nucleation Time of Functional Sphingomyelinase–Lipid Features Studied by Membrane Array Statistic Tool
inferred← citeshttps://doi.org/10.1021/nl801908yopenalex-snapshot
Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo
inferred← citeshttps://doi.org/10.1021/pr800370nopenalex-snapshot
Proteome Analysis of Bronchoalveolar Lavage in Individuals from Metsovo, Nonoccupationally Exposed to Asbestos
inferred← citeshttps://doi.org/10.1023/b:glyc.0000016741.88476.8bopenalex-snapshot
Glycosphingolipids and cell death
inferred← citeshttps://doi.org/10.1023/b:glyc.0000024254.64450.8bopenalex-snapshot
Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP
inferred← citeshttps://doi.org/10.1034/j.1600-065x.2003.00068.xopenalex-snapshot
Egress: a receptor‐regulated step in lymphocyte trafficking
inferred← citeshttps://doi.org/10.1038/mt.2008.281openalex-snapshot
Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer
inferred← citeshttps://doi.org/10.1038/mtna.2015.8openalex-snapshot
MicroRNA-423-5p Promotes Autophagy in Cancer Cells and Is Increased in Serum From Hepatocarcinoma Patients Treated With Sorafenib
inferred← citeshttps://doi.org/10.1038/nm0505-471openalex-snapshot
Lipid let loose in pulmonary emphysema
inferred← citeshttps://doi.org/10.1038/nm1238openalex-snapshot
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
inferred← citeshttps://doi.org/10.1038/nrc1188openalex-snapshot
Cannabinoids: potential anticancer agents
inferred← citeshttps://doi.org/10.1038/nrc3398openalex-snapshot
Ceramide-orchestrated signalling in cancer cells
inferred← citeshttps://doi.org/10.1038/nrc992openalex-snapshot
The role of p53 in determining sensitivity to radiotherapy
inferred← citeshttps://doi.org/10.1038/nri11308openalex-snapshot
Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
inferred← citeshttps://doi.org/10.1038/nrm1103openalex-snapshot
Sphingosine-1-phosphate: an enigmatic signalling lipid
inferred← citeshttps://doi.org/10.1038/s41423-020-0388-9openalex-snapshot
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases
inferred← citeshttps://doi.org/10.1038/s41556-022-00934-8openalex-snapshot
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation
inferred← citeshttps://doi.org/10.1038/s41598-018-25905-8openalex-snapshot
Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells
inferred← citeshttps://doi.org/10.1038/s41598-020-62823-0openalex-snapshot
Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)
inferred← citeshttps://doi.org/10.1038/s41598-020-71008-8openalex-snapshot
C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes
inferred← citeshttps://doi.org/10.1038/s41598-020-77639-1openalex-snapshot
Secreted sphingomyelins modulate low mammary cancer incidence observed in certain mammals
inferred← citeshttps://doi.org/10.1038/s41598-024-53860-0openalex-snapshot
ReTimeML: a retention time predictor that supports the LC–MS/MS analysis of sphingolipids
inferred← citeshttps://doi.org/10.1038/sj.bjp.0705934openalex-snapshot
Cardiovascular effects of sphingosine‐1‐phosphate and other sphingomyelin metabolites
inferred← citeshttps://doi.org/10.1038/sj.bjp.0706173openalex-snapshot
Ceramide alters endothelial cell permeability by a nonapoptotic mechanism
inferred← citeshttps://doi.org/10.1038/sj.leu.2404023openalex-snapshot
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1
inferred← citeshttps://doi.org/10.1038/sj.leu.2404084openalex-snapshot
Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs
inferred← citeshttps://doi.org/10.1038/sj.onc.1209834openalex-snapshot
Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo
inferred← citeshttps://doi.org/10.1039/c5ra05142hopenalex-snapshot
Ceramide increases free volume voids in DPPC membranes
inferred← citeshttps://doi.org/10.1042/bj20031287openalex-snapshot
Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes
inferred← citeshttps://doi.org/10.1046/j.1523-1747.2003.12116.xopenalex-snapshot
Paradoxical Effects of Sphingosine-1-Phosphate
inferred← citeshttps://doi.org/10.1073/pnas.0406536101openalex-snapshot
Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert
inferred← citeshttps://doi.org/10.1073/pnas.0408340102openalex-snapshot
γ-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis
inferred← citeshttps://doi.org/10.1073/pnas.0808720105openalex-snapshot
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity
inferred← citeshttps://doi.org/10.1073/pnas.2220269120openalex-snapshot
Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands
inferred← citeshttps://doi.org/10.1074/jbc.m111.257519openalex-snapshot
Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage
inferred← citeshttps://doi.org/10.1074/jbc.m111.280271openalex-snapshot
Acyl Chain Specificity of Ceramide Synthases Is Determined within a Region of 150 Residues in the Tram-Lag-CLN8 (TLC) Domain
inferred← citeshttps://doi.org/10.1074/jbc.m209713200openalex-snapshot
Inactivation of Kex2p Diminishes the Virulence of Candida albicans
inferred← citeshttps://doi.org/10.1074/jbc.m209962200openalex-snapshot
Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis
inferred← citeshttps://doi.org/10.1074/jbc.m300212200openalex-snapshot
Glucosylceramide and Glucosylsphingosine Modulate Calcium Mobilization from Brain Microsomes via Different Mechanisms
inferred← citeshttps://doi.org/10.1074/jbc.m300932200openalex-snapshot
Purification, Characterization, and Identification of a Sphingomyelin Synthase from Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1074/jbc.m301579200openalex-snapshot
Novel Localization of the DNA-PK Complex in Lipid Rafts
inferred← citeshttps://doi.org/10.1074/jbc.m302548200openalex-snapshot
Palmitate Inhibition of Insulin Gene Expression Is Mediated at the Transcriptional Level via Ceramide Synthesis
inferred← citeshttps://doi.org/10.1074/jbc.m303206200openalex-snapshot
Sphingomyelinase Activity Causes Transbilayer Lipid Translocation in Model and Cell Membranes
inferred← citeshttps://doi.org/10.1074/jbc.m305294200openalex-snapshot
Sphingosine-dependent Protein Kinase-1, Directed to 14-3-3, Is Identified as the Kinase Domain of Protein Kinase Cδ
inferred← citeshttps://doi.org/10.1074/jbc.m306088200openalex-snapshot
Oxidized Phospholipids in Minimally Modified Low Density Lipoprotein Induce Apoptotic Signaling via Activation of Acid Sphingomyelinase in Arterial Smooth Muscle Cells
inferred← citeshttps://doi.org/10.1074/jbc.m311096200openalex-snapshot
Stimulus-specific Differences in Protein Kinase Cδ Localization and Activation Mechanisms in Cardiomyocytes
inferred← citeshttps://doi.org/10.1074/jbc.m313561200openalex-snapshot
Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1
inferred← citeshttps://doi.org/10.1074/jbc.m404466200openalex-snapshot
Inhibition of Glucosylceramide Synthase Does Not Reverse Drug Resistance in Cancer Cells
inferred← citeshttps://doi.org/10.1074/jbc.m502849200openalex-snapshot
Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition
inferred← citeshttps://doi.org/10.1074/jbc.m503002200openalex-snapshot
Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α
inferred← citeshttps://doi.org/10.1074/jbc.m608137200openalex-snapshot
Protein Kinase C-induced Activation of a Ceramide/Protein Phosphatase 1 Pathway Leading to Dephosphorylation of p38 MAPK
inferred← citeshttps://doi.org/10.1074/jbc.m700082200openalex-snapshot
Ceramide Recruits and Activates Protein Kinase C ζ (PKCζ) within Structured Membrane Microdomains
inferred← citeshttps://doi.org/10.1074/jbc.m805920200openalex-snapshot
Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy
inferred← citeshttps://doi.org/10.1074/jbc.r600010200openalex-snapshot
When Do Lasses (Longevity Assurance Genes) Become CerS (Ceramide Synthases)?
inferred← citeshttps://doi.org/10.1080/07328303.2022.2063308openalex-snapshot
The structural diversity of natural glycosphingolipids (GSLs)
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