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STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia

https://doi.org/10.1172/jci200113763
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/eji.1830250307openalex-snapshot
Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice
inferredcites →https://doi.org/10.1002/hep.510300615openalex-snapshot
Requirement for interleukin-12 in the pathogenesis of warm hepatic ischemia/reperfusion injury in mice
inferredcites →https://doi.org/10.1002/jlb.64.4.494openalex-snapshot
The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia
inferredcites →https://doi.org/10.1007/s001340050734openalex-snapshot
Nuclear factor kB – a new therapeutic approach?
inferredcites →https://doi.org/10.1007/s004410000274openalex-snapshot
Induction of the synthesis of the C-X-C chemokine interferon-γ-inducible protein-10 in experimental canine endotoxemia
inferredcites →https://doi.org/10.1016/0160-5402(90)90061-oopenalex-snapshot
Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity
inferredcites →https://doi.org/10.1016/s0002-9440(10)64540-3openalex-snapshot
Regulation of Liver Inflammatory Injury by Signal Transducer and Activator of Transcription-6
inferredcites →https://doi.org/10.1016/s0002-9440(10)65208-xopenalex-snapshot
IL-13 Activates STAT6 and Inhibits Liver Injury Induced by Ischemia/Reperfusion
inferredcites →https://doi.org/10.1016/s0171-2985(11)80353-0openalex-snapshot
Response of man to endotoxin
inferredcites →https://doi.org/10.1016/s0898-6568(00)00149-2openalex-snapshot
LPS induction of gene expression in human monocytes
inferredcites →https://doi.org/10.1016/s0923-2494(97)80867-xopenalex-snapshot
“PERFEXT”: a direct method for quantitative assessment of cytokine production in vivo at the local level
inferredcites →https://doi.org/10.1016/s1074-7613(00)80439-2openalex-snapshot
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
inferredcites →https://doi.org/10.1016/s1359-6101(00)00005-8openalex-snapshot
STAT family of transcription factors in cytokine-mediated biological responses
inferredcites →https://doi.org/10.1038/380627a0openalex-snapshot
Essential role of Stat6 in IL-4 signalling
inferredcites →https://doi.org/10.1038/382171a0openalex-snapshot
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
inferredcites →https://doi.org/10.1038/382174a0openalex-snapshot
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
inferredcites →https://doi.org/10.1038/sj.bjp.0701180openalex-snapshot
Effect of calpain inhibitor I, an inhibitor of the proteolysis of IκB, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat
inferredcites →https://doi.org/10.1038/sj.onc.1203239openalex-snapshot
Activators and target genes of Rel/NF-κB transcription factors
inferredcites →https://doi.org/10.1074/jbc.m006227200openalex-snapshot
Interleukin-4/STAT6 Represses STAT1 and NF-κB-dependent Transcription through Distinct Mechanisms
inferredcites →https://doi.org/10.1084/jem.193.6.679openalex-snapshot
Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis
inferredcites →https://doi.org/10.1097/00024382-199711000-00006openalex-snapshot
ANTI-INTERLEUKIN-12 THERAPY PROTECTS MICE IN LETHAL ENDOTOXEMIA BUT IMPAIRS BACTERIAL CLEARANCE IN MURINE ESCHERICHIA COLI PERITONEAL SEPSIS
inferredcites →https://doi.org/10.1097/00024382-200013020-00004openalex-snapshot
COMPARISON OF THE MORTALITY AND INFLAMMATORY RESPONSE OF TWO MODELS OF SEPSIS: LIPOPOLYSACCHARIDE VS. CECAL LIGATION AND PUNCTURE
inferredcites →https://doi.org/10.1146/annurev.immunol.16.1.225openalex-snapshot
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
inferredcites →https://doi.org/10.1172/jci119475openalex-snapshot
MCP-1 protects mice in lethal endotoxemia.
inferredcites →https://doi.org/10.1172/jci119648openalex-snapshot
Role of NFkappaB in the mortality of sepsis.
inferredcites →https://doi.org/10.4049/jimmunol.155.3.1515openalex-snapshot
Macrophage inflammatory protein-1 α mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia
inferredcites →https://doi.org/10.4049/jimmunol.157.8.3220openalex-snapshot
Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
inferredcites →https://doi.org/10.4049/jimmunol.158.6.2898openalex-snapshot
IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production
inferredcites →https://doi.org/10.4049/jimmunol.162.9.5437openalex-snapshot
Multiple Roles for IL-12 in a Model of Acute Septic Peritonitis
inferredcites →https://doi.org/10.4049/jimmunol.164.5.2738openalex-snapshot
Expression and Contribution of Endogenous IL-13 in an Experimental Model of Sepsis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3961380openalex-extracted
The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Rats
inferred← citeshttps://doi.org/10.1002/9783527626151.ch8openalex-snapshot
Inflammatory Mediators
inferred← citeshttps://doi.org/10.1002/jcp.30394openalex-snapshot
Targeting STAT3: A crucial modulator of sepsis
inferred← citeshttps://doi.org/10.1002/mco2.418openalex-snapshot
The pathogenesis and potential therapeutic targets in sepsis
inferred← citeshttps://doi.org/10.1007/978-3-642-18932-6_4openalex-snapshot
Biological Roles of the STAT Family in Cytokine Signaling
inferred← citeshttps://doi.org/10.1007/s10753-015-0135-zopenalex-snapshot
The Specific Roles of JAK/STAT Signaling Pathway in Sepsis
inferred← citeshttps://doi.org/10.1007/s11010-021-04066-9openalex-snapshot
The sepsis induced defective aggravation of immune cells: a translational science underling chemico-biological interactions from altered bioenergetics and/or cellular metabolism to organ dysfunction
inferred← citeshttps://doi.org/10.1007/s12010-025-05201-8openalex-snapshot
Identification of Subtypes and Diagnostic Markers Related to Necroptosis in Sepsis
inferred← citeshttps://doi.org/10.1007/s40123-022-00581-0openalex-snapshot
A Narrative Review of STAT Proteins in Diabetic Retinopathy: From Mechanisms to Therapeutic Prospects
inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.07.019openalex-snapshot
Monoacylglycerol lipase promotes Fcγ receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines
inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149121openalex-snapshot
Comparative analysis of peripheral blood immunoinflammatory landscapes in patients with acute cholangitis and its secondary septic shock using single-cell RNA sequencing
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113648openalex-snapshot
1-Deoxynojirimycin attenuates septic cardiomyopathy by regulating oxidative stress, apoptosis, and inflammation via the JAK2/STAT6 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117179openalex-snapshot
4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.11.007openalex-snapshot
GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism
inferred← citeshttps://doi.org/10.1016/j.humimm.2010.04.004openalex-snapshot
Polymorphisms in innate immunity genes and risk of childhood leukemia
inferred← citeshttps://doi.org/10.1016/j.immuni.2024.01.009openalex-snapshot
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis
inferred← citeshttps://doi.org/10.1016/j.intimp.2009.01.013openalex-snapshot
Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock
inferred← citeshttps://doi.org/10.1016/j.intimp.2015.02.019openalex-snapshot
Selective modulation of microglia polarization to M2 phenotype for stroke treatment
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113715openalex-snapshot
Macrophage polarization in sepsis: Emerging role and clinical application prospect
inferred← citeshttps://doi.org/10.1016/j.jprot.2022.104636openalex-snapshot
MMP-12 polarizes neutrophil signalome towards an apoptotic signature
inferred← citeshttps://doi.org/10.1016/j.jss.2006.07.032openalex-snapshot
The STAT4 and STAT6 Pathways in Pancreatitis-Associated Lung Injury
inferred← citeshttps://doi.org/10.1016/j.micpath.2005.03.003openalex-snapshot
Mycobacterial trehalose 6,6′-dimycolate preferentially induces type 1 helper T cell responses through signal transducer and activator of transcription 4 protein
inferred← citeshttps://doi.org/10.1016/j.molmed.2020.06.007openalex-snapshot
JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis
inferred← citeshttps://doi.org/10.1016/s0092-8674(02)00701-8openalex-snapshot
Cytokine Signaling in 2002
inferred← citeshttps://doi.org/10.1016/s0531-5131(03)00236-xopenalex-snapshot
Regulation of innate immune response by Stat proteins during septic peritonitis
inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00319openalex-snapshot
GPR30 Agonist G1 Mitigates Sepsis-Induced Cardiac Dysfunction by Inhibiting ACE2/c–FOS-Mediated Necroptosis in Female Mice
inferred← citeshttps://doi.org/10.1053/jhep.2003.50066openalex-snapshot
Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection
inferred← citeshttps://doi.org/10.1053/jhep.2003.50075openalex-snapshot
Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury
inferred← citeshttps://doi.org/10.1055/a-2250-3166openalex-snapshot
Glycosaminoglycans: Participants in Microvascular Coagulation of Sepsis
inferred← citeshttps://doi.org/10.1055/s-014-59841openalex-snapshot
inferred← citeshttps://doi.org/10.1080/01902140490517791openalex-snapshot
EFFECTS OF INTRATRACHEAL TUMOR NECROSIS FACTOR-ALPHA PLASMID VECTOR ON LIPOPOLYSACCHARIDE LETHALITY AND LUNG INJURY IN MICE
inferred← citeshttps://doi.org/10.1089/1043034041361244openalex-snapshot
Interleukin 13 Gene Transfer in Liver Ischemia and Reperfusion Injury: Role of Stat6 and TLR4 Pathways in Cytoprotection
inferred← citeshttps://doi.org/10.1089/aid.2018.0132openalex-snapshot
Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection
inferred← citeshttps://doi.org/10.1097/01.ta.0000028970.50515.a0openalex-snapshot
Differential Local and Systemic Tumor Necrosis Factor-?? Responses to a Second Hit of Lipopolysaccharide after Hemorrhagic Shock
inferred← citeshttps://doi.org/10.1097/shk.0000000000002683openalex-snapshot
Macrophages in Septic Cardiomyopathy: Heterogeneity, Function, and Therapy
inferred← citeshttps://doi.org/10.1111/apt.14866openalex-snapshot
A STAT 4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B
inferred← citeshttps://doi.org/10.1111/j.0105-2896.2004.00211.xopenalex-snapshot
Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4
inferred← citeshttps://doi.org/10.1111/j.1365-2222.2006.02370.xopenalex-snapshot
Signal transducer and activator of transcription 6 down‐regulates toll‐like receptor‐4 expression of a monocytic cell line
inferred← citeshttps://doi.org/10.1111/j.1365-2222.2006.02425.xopenalex-snapshot
The innate and adaptive immune systems in allergy: a two‐way street
inferred← citeshttps://doi.org/10.1111/j.1365-2249.2011.04437.xopenalex-snapshot
Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Th1) and Th17 nephritogenic immunity in experimental crescentic glomerulonephritis
inferred← citeshttps://doi.org/10.1111/jfbc.12449openalex-snapshot
Phenethyl isothiocyanate decreases thymic stromal lymphopoietin-induced inflammatory reactions in mast cells
inferred← citeshttps://doi.org/10.1152/ajpcell.00032.2008openalex-snapshot
Activation of hepatocytes by extracellular heat shock protein 72
inferred← citeshttps://doi.org/10.1152/ajpendo.00133.2005openalex-snapshot
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome
inferred← citeshttps://doi.org/10.1152/ajpgi.00428.2010openalex-snapshot
Establishment of tolerance to commensal bacteria requires a complex microbiota and is accompanied by decreased intestinal chemokine expression
inferred← citeshttps://doi.org/10.1172/jci45556openalex-snapshot
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
inferred← citeshttps://doi.org/10.1186/s10020-026-01522-4openalex-snapshot
Formyl peptide receptor 1 agonism selectively suppresses mitochondria-driven neutrophil extracellular trap formation while preserving antibacterial immunity
inferred← citeshttps://doi.org/10.13130/masciocchi-daniela_phd2012-02-13openalex-snapshot
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENTIAL STAT3 INHIBITORS AS ANTICANCER AGENTS
inferred← citeshttps://doi.org/10.1385/ir:31:3:231openalex-snapshot
STAT4: A Critical Regulator of Inflammation In Vivo
inferred← citeshttps://doi.org/10.18297/etd/4066openalex-snapshot
Soluble epoxide hydrolase inhibition: a novel therapeutic strategy for alcohol-associated liver disease.
inferred← citeshttps://doi.org/10.2741/3886openalex-snapshot
JAK-STAT signaling in hepatic fibrosis
inferred← citeshttps://doi.org/10.3389/fimmu.2022.820685openalex-snapshot
The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1238972openalex-snapshot
Advances in Mesenchymal stem cells regulating macrophage polarization and treatment of sepsis-induced liver injury
inferred← citeshttps://doi.org/10.3390/biom12030447openalex-snapshot
Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute Inflammation in Mice
inferred← citeshttps://doi.org/10.3390/jcm13082385openalex-snapshot
Influence of STAT4 Genetic Variants and Serum Levels on Multiple Sclerosis Occurrence in the Lithuanian Population
inferred← citeshttps://doi.org/10.3390/pathogens14040324openalex-snapshot
The Dual-Edged Sword: Risks and Benefits of JAK Inhibitors in Infections
inferred← citeshttps://doi.org/10.4049/jimmunol.171.4.2035openalex-snapshot
Helicobacter pylori Infection Interferes with Epithelial Stat6-Mediated Interleukin-4 Signal Transduction Independent of cagA , cagE , or VacA
inferred← citeshttps://doi.org/10.4049/jimmunol.171.6.3233openalex-snapshot
Crucial Role of IL-4/STAT6 in T Cell-Mediated Hepatitis: Up-Regulating Eotaxins and IL-5 and Recruiting Leukocytes
inferred← citeshttps://doi.org/10.4081/reumatismo.2015.851openalex-snapshot
The signal transducer and activator of transcription factors lodge in immunopathogenesis of rheumatoid arthritis
inferred← citeshttps://doi.org/10.4314/tjpr.v15i2.7openalex-snapshot
A Study on Expression and Tyrosine 705 phosphorylation of STAT3 in Focal Cerebral Ischemia-Reperfusion Rat Model and its Role in Neuronal Apoptosis
inferred← citeshttps://doi.org/10.70675/a65a57a6ze1d1z47baz8fa5zabef17722df4openalex-snapshot
Effet de l'inhibition ciblée des interférons de type I sur l'endothélium vasculaire au cours du sepsis
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