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Rapamycin extends murine lifespan but has limited effects on aging
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/978-1-59745-471-1_25openalex-snapshot
Systemic First-Line Phenotyping
inferredcites →https://doi.org/10.1007/978-94-017-0673-5_10openalex-snapshot
Aging and the Immune System
inferredcites →https://doi.org/10.1007/bf00537801openalex-snapshot
A rotarod suitable for quantitative measurements of motor incoordination in naive mice
inferredcites →https://doi.org/10.1007/s00262-010-0945-7openalex-snapshot
Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
inferredcites →https://doi.org/10.1007/s003359900551openalex-snapshot
Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment
inferredcites →https://doi.org/10.1016/0006-8993(80)90695-2openalex-snapshot
Mesolimbicocortical dopamine terminal fields are necessary for normal locomotor and investigatory exploration in rats
inferredcites →https://doi.org/10.1016/0047-6374(85)90003-xopenalex-snapshot
Relationship of body temperature stability to mortality in aging mice
inferredcites →https://doi.org/10.1016/j.cmet.2010.05.001openalex-snapshot
With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
inferredcites →https://doi.org/10.1016/j.cub.2004.03.059openalex-snapshot
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
inferredcites →https://doi.org/10.1016/j.cub.2009.09.058openalex-snapshot
An Emerging Role of mTOR in Lipid Biosynthesis
inferredcites →https://doi.org/10.1016/j.neuroscience.2012.06.054openalex-snapshot
Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
inferredcites →https://doi.org/10.1016/j.tcm.2009.12.004openalex-snapshot
Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress
inferredcites →https://doi.org/10.1016/s0009-9120(96)00157-9openalex-snapshot
Distribution of sirolimus in rat tissue
inferredcites →https://doi.org/10.1016/s0167-4943(97)00040-xopenalex-snapshot
The effect of fasting and refeeding on thyroid follicule structure and thyroid hormone levels in young and old rats
inferredcites →https://doi.org/10.1038/426620aopenalex-snapshot
Influence of TOR kinase on lifespan in C. elegans
inferredcites →https://doi.org/10.1038/nature08221openalex-snapshot
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
inferredcites →https://doi.org/10.1038/nprot.2010.22openalex-snapshot
Quantification of steroids in human and mouse plasma using online solid phase extraction coupled to liquid chromatography tandem mass spectrometry
inferredcites →https://doi.org/10.1038/sj.onc.1204091openalex-snapshot
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
inferredcites →https://doi.org/10.1080/019262301753385988openalex-snapshot
Pathology of Aging B6;129 Mice
inferredcites →https://doi.org/10.1093/gerona/glq178openalex-snapshot
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
inferredcites →https://doi.org/10.1093/geronj/31.6.648openalex-snapshot
Gerontological Data of C57BL/6J Mice. II. Changes in Blood Cell Counts in the Course of Natural Aging
inferredcites →https://doi.org/10.1093/jnci/93.20.1517openalex-snapshot
Rapamycin's Resurrection: A New Way to Target the Cancer Cell Cycle
inferredcites →https://doi.org/10.1093/ndt/gfr318openalex-snapshot
mTOR inhibition and erythropoiesis: microcytosis or anaemia?
inferredcites →https://doi.org/10.1097/00029330-200603020-00013openalex-snapshot
Expression of tissue inhibitor of matrix metalloproteinase-1 in aging of transgenic mouse liver
inferredcites →https://doi.org/10.1097/01.jgp.0000209405.27548.7bopenalex-snapshot
Investigation of Age-Related Cognitive Decline Using Mice as a Model System: Behavioral Correlates
inferredcites →https://doi.org/10.1097/01.tp.0000229384.22217.15openalex-snapshot
Tacrolimus and Sirolimus Cause Insulin Resistance in Normal Sprague Dawley Rats
inferredcites →https://doi.org/10.1101/gad.1381406openalex-snapshot
Extension of chronological life span in yeast by decreased TOR pathway signaling
inferredcites →https://doi.org/10.1111/j.1474-9726.2011.00791.xopenalex-snapshot
Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling
inferredcites →https://doi.org/10.1111/j.1474-9726.2012.00832.xopenalex-snapshot
Rapamycin slows aging in mice
inferredcites →https://doi.org/10.1111/j.1476-5381.2011.01716.xopenalex-snapshot
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
inferredcites →https://doi.org/10.1126/science.1115535openalex-snapshot
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
inferredcites →https://doi.org/10.1126/science.1177221openalex-snapshot
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
inferredcites →https://doi.org/10.1126/scisignal.2000559openalex-snapshot
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
inferredcites →https://doi.org/10.1152/ajpendo.1982.243.3.e257openalex-snapshot
Luteinizing hormone and testosterone secretion in young and old male mice
inferredcites →https://doi.org/10.1152/ajpheart.00241.2007openalex-snapshot
Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging
inferredcites →https://doi.org/10.1155/2012/467251openalex-snapshot
Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3524openalex-snapshot
Pten Loss in the Mouse Thyroid Causes Goiter and Follicular Adenomas: Insights into Thyroid Function and Cowden Disease Pathogenesis
inferredcites →https://doi.org/10.1158/1055-9965.epi-07-0045openalex-snapshot
The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention
inferredcites →https://doi.org/10.1158/1940-6207.capr-09-0199openalex-snapshot
Loss of Inhibitory Insulin Receptor Substrate-1 Phosphorylation Is an Early Event in Mammalian Target of Rapamycin–Dependent Endometrial Hyperplasia and Carcinoma
inferredcites →https://doi.org/10.1161/01.cir.58.6.1072openalex-snapshot
Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.
inferredcites →https://doi.org/10.1167/iovs.04-0541openalex-snapshot
Rapid Quantification of Adult and Developing Mouse Spatial Vision Using a Virtual Optomotor System
inferredcites →https://doi.org/10.1177/019262339502300503openalex-snapshot
Longevity, Body Weight, and Neoplasia in Ad Libitum-Fed and Diet-Restricted C57BL6 Mice Fed NIH-31 Open Formula Diet
inferredcites →https://doi.org/10.1182/blood-2010-05-287821openalex-snapshot
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
inferredcites →https://doi.org/10.1242/dev.01255openalex-snapshot
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
inferredcites →https://doi.org/10.1258/la.2007.06001eopenalex-snapshot
Echocardiographic assessment of global left ventricular function in mice
inferredcites →https://doi.org/10.1371/journal.pone.0007507openalex-snapshot
Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography
inferredcites →https://doi.org/10.1523/jneurosci.18-09-03206.1998openalex-snapshot
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
inferredcites →https://doi.org/10.18632/aging.100190openalex-snapshot
Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis
inferredcites →https://doi.org/10.18632/aging.100498openalex-snapshot
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
inferredcites →https://doi.org/10.2144/000112257openalex-snapshot
CellProfiler™: Free, Versatile Software for Automated Biological Image Analysis
inferredcites →https://doi.org/10.2337/db09-1324openalex-snapshot
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
inferredcites →https://doi.org/10.2353/ajpath.2010.091050openalex-snapshot
Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
inferredcites →https://doi.org/10.4161/cc.10.24.18486openalex-snapshot
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.3897/pharmacia.71.e124801zenodo-depositor-declared
Canagliflozin exerts anti-inflammatory and antioxidant effects in the heart and skin tissues: Biochemical and histopathological assessment in a model of accelerated aging induced by D-galactose in mice
inferred← citeshttps://doi.org/10.1002/adfm.202315317openalex-snapshot
Plaque‐Specific Adhesive Balloons Coated with Calcium Phosphate Nanoparticles Loaded with Rapamycin for Atherosclerosis Therapy
inferred← citeshttps://doi.org/10.1002/adhm.202302972openalex-snapshot
Elimination of Senescent Osteocytes by Bone‐Targeting Delivery of β‐Galactose‐Modified Maytansinoid Prevents Age‐Related Bone Loss
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Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster
inferred← citeshttps://doi.org/10.1002/bjs.10053openalex-snapshot
Molecular and biological hallmarks of ageing
inferred← citeshttps://doi.org/10.1002/cyto.a.22452openalex-snapshot
In search of antiaging modalities: Evaluation of mTOR‐ and ROS/DNA damage‐signaling by cytometry
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Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs
inferred← citeshttps://doi.org/10.1002/jbm4.10486openalex-snapshot
Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 ( mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice
inferred← citeshttps://doi.org/10.1002/jcsm.12505openalex-snapshot
mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice
inferred← citeshttps://doi.org/10.1002/mc.22539openalex-snapshot
Emerging links among Chromosome Instability (CIN), cancer, and aging
inferred← citeshttps://doi.org/10.1002/wrna.1325openalex-snapshot
The role of the ribosome in the regulation of longevity and lifespan extension
inferred← citeshttps://doi.org/10.1007/112_2013_17openalex-snapshot
The Role of mTORC1 in Regulating Protein Synthesis and Skeletal Muscle Mass in Response to Various Mechanical Stimuli
inferred← citeshttps://doi.org/10.1007/164_2021_553openalex-snapshot
Mechanistic Target of Rapamycin (mTOR) Inhibitors
inferred← citeshttps://doi.org/10.1007/978-2-8178-0492-7_13openalex-snapshot
mTOR, Aging, and Cancer: A Dangerous Link
inferred← citeshttps://doi.org/10.1007/978-3-030-24970-0_5openalex-snapshot
Epigenomic, Transcriptome and Image-Based Biomarkers of Aging
inferred← citeshttps://doi.org/10.1007/978-3-030-83017-5_25openalex-snapshot
Calorie Restriction Mimetics and Adult Stem Cells
inferred← citeshttps://doi.org/10.1007/978-3-319-14830-4_10openalex-snapshot
Calorie Restriction Mimetics: Progress and Potential
inferred← citeshttps://doi.org/10.1007/978-3-319-23246-1_1openalex-snapshot
The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
inferred← citeshttps://doi.org/10.1007/978-3-319-23246-1_5openalex-snapshot
Cardiovascular Disease and Aging
inferred← citeshttps://doi.org/10.1007/978-3-7091-1232-8_16openalex-snapshot
Closing the Circle: Stem Cell Rejuvenation and Longevity
inferred← citeshttps://doi.org/10.1007/978-4-431-55763-0_1openalex-snapshot
The Biological Mechanisms of Aging: A Historical and Critical Overview
inferred← citeshttps://doi.org/10.1007/978-981-13-3540-2_10openalex-snapshot
Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes
inferred← citeshttps://doi.org/10.1007/978-981-16-7977-3_1openalex-snapshot
An Unsolved Problem in Gerontology Yet: Molecular Mechanisms of Biological Aging—A Historical and Critical Overview
inferred← citeshttps://doi.org/10.1007/s00018-014-1677-1openalex-snapshot
Longevity, aging and rapamycin
inferred← citeshttps://doi.org/10.1007/s00277-024-06090-3openalex-snapshot
mTOR inhibitors potentially preserve fertility in female patients with haematopoietic malignancies: a narrative review
inferred← citeshttps://doi.org/10.1007/s00335-016-9638-7openalex-snapshot
The dog aging project: translational geroscience in companion animals
inferred← citeshttps://doi.org/10.1007/s00335-016-9642-yopenalex-snapshot
INFRAFRONTIER: a European resource for studying the functional basis of human disease
inferred← citeshttps://doi.org/10.1007/s00335-016-9647-6openalex-snapshot
Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s10522-021-09910-5openalex-snapshot
Aging and age‐related diseases: from mechanisms to therapeutic strategies
inferred← citeshttps://doi.org/10.1007/s10838-026-09775-7openalex-snapshot
The Measurement of Human Ageing for the Development of Anti-ageing Medicines: An Epistemic and Practical Discussion
inferred← citeshttps://doi.org/10.1007/s11357-017-9972-zopenalex-snapshot
A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
inferred← citeshttps://doi.org/10.1007/s11357-017-9988-4openalex-snapshot
A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1007/s11357-017-9994-6openalex-snapshot
Rapamycin treatment attenuates age-associated periodontitis in mice
inferred← citeshttps://doi.org/10.1007/s11357-018-0036-9openalex-snapshot
How healthy is the healthspan concept?
inferred← citeshttps://doi.org/10.1007/s11357-019-00088-wopenalex-snapshot
Validation of a geropathology grading system for aging mouse studies
inferred← citeshttps://doi.org/10.1007/s11357-020-00274-1openalex-snapshot
Effect of rapamycin on aging and age-related diseases—past and future
inferred← citeshttps://doi.org/10.1007/s11357-020-00317-7openalex-snapshot
Fasting and fasting-mimicking diets for chemotherapy augmentation
inferred← citeshttps://doi.org/10.1007/s11357-021-00349-7openalex-snapshot
Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age
inferred← citeshttps://doi.org/10.1007/s11357-023-00818-1openalex-snapshot
Evaluation of off-label rapamycin use to promote healthspan in 333 adults
inferred← citeshttps://doi.org/10.1007/s11357-024-01200-5openalex-snapshot
Quantification of healthspan in aging mice: introducing FAMY and GRAIL
inferred← citeshttps://doi.org/10.1007/s11357-026-02294-9openalex-snapshot
Regulation of survival, growth, and metabolism by neuronal mTOR
inferred← citeshttps://doi.org/10.1007/s11357-026-02306-8openalex-snapshot
Bench to bedside: is rapamycin headed for the docTOR?
inferred← citeshttps://doi.org/10.1007/s11357-026-02372-yopenalex-snapshot
Diet-dependent, beneficial and adverse effects of rapamycin on life span of Drosophila melanogaster
inferred← citeshttps://doi.org/10.1007/s13670-013-0064-3openalex-snapshot
Cardiac Hegemony of Senescence
inferred← citeshttps://doi.org/10.1007/s40495-015-0039-5openalex-snapshot
When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?
inferred← citeshttps://doi.org/10.1007/s40572-017-0131-6openalex-snapshot
Environmental Chemicals and Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-397920-9.00003-2openalex-snapshot
Mouse Models and Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-410490-7.00016-5openalex-snapshot
Analysis of Phenotype
inferred← citeshttps://doi.org/10.1016/b978-0-12-411596-5.00001-0openalex-snapshot
Longevity as a Complex Genetic Trait
inferred← citeshttps://doi.org/10.1016/b978-0-12-411596-5.00002-2openalex-snapshot
The mTOR Pathway and Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-411596-5.00010-1openalex-snapshot
NIA Interventions Testing Program
inferred← citeshttps://doi.org/10.1016/b978-0-12-802167-5.00014-1openalex-snapshot
Regulation of Macroautophagy by Nutrients and Metabolites
inferred← citeshttps://doi.org/10.1016/b978-0-12-811353-0.00016-6openalex-snapshot
Determining Cause of Death and Contributing Causes of Death in Rodent Aging Studies
inferred← citeshttps://doi.org/10.1016/b978-0-12-811353-0.00018-xopenalex-snapshot
Life Extension in Dwarf Mice
inferred← citeshttps://doi.org/10.1016/b978-0-12-811353-0.00019-1openalex-snapshot
Extension of Life Span in Laboratory Mice
inferred← citeshttps://doi.org/10.1016/b978-0-12-814118-2.00012-4openalex-snapshot
Sirtuins in mechanistic target of rapamycin complex 1 signaling
inferred← citeshttps://doi.org/10.1016/b978-0-12-815962-0.00001-9openalex-snapshot
Longevity as a complex genetic trait
inferred← citeshttps://doi.org/10.1016/b978-0-12-815962-0.00010-xopenalex-snapshot
NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-823679-6.00002-3openalex-snapshot
Rapamycin and rapalogs
inferred← citeshttps://doi.org/10.1016/b978-0-12-823761-8.00016-1openalex-snapshot
Disrupted cellular quality control mechanisms in aging
inferred← citeshttps://doi.org/10.1016/b978-0-443-30060-8.00008-xopenalex-snapshot
Cellular autophagy and aging: role in intermittent fasting-induced health benefits
inferred← citeshttps://doi.org/10.1016/j.arr.2014.11.005openalex-snapshot
Calorie restriction mimetics: Can you have your cake and eat it, too?
inferred← citeshttps://doi.org/10.1016/j.arr.2016.06.005openalex-snapshot
A synopsis on aging—Theories, mechanisms and future prospects
inferred← citeshttps://doi.org/10.1016/j.arr.2016.08.004openalex-snapshot
Anti-aging pharmacology: Promises and pitfalls
inferred← citeshttps://doi.org/10.1016/j.arr.2021.101376openalex-snapshot
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102224openalex-snapshot
Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102857openalex-snapshot
Beyond the 900-day rule: Reclaiming healthspan as geroscience’s primary goal
inferred← citeshttps://doi.org/10.1016/j.bbadis.2015.11.010openalex-snapshot
Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.bbadis.2018.12.008openalex-snapshot
Mitochondrial regulation of cardiac aging
inferred← citeshttps://doi.org/10.1016/j.bbadva.2022.100066openalex-snapshot
mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.01.003openalex-snapshot
mTOR, cardiomyocytes and inflammation in cardiac hypertrophy
inferred← citeshttps://doi.org/10.1016/j.bbcan.2014.10.007openalex-snapshot
mTOR signaling in tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.bbr.2015.06.028openalex-snapshot
Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways
inferred← citeshttps://doi.org/10.1016/j.bcmd.2015.08.001openalex-snapshot
Rapamycin increases fetal hemoglobin and ameliorates the nociception phenotype in sickle cell mice
inferred← citeshttps://doi.org/10.1016/j.beem.2017.02.005openalex-snapshot
GH and ageing: Pitfalls and new insights
inferred← citeshttps://doi.org/10.1016/j.cell.2014.08.041openalex-snapshot
Aging Research—Where Do We Stand and Where Are We Going?
inferred← citeshttps://doi.org/10.1016/j.cell.2014.12.016openalex-snapshot
Reduced Expression of MYC Increases Longevity and Enhances Healthspan
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.05.035openalex-snapshot
V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.10.040openalex-snapshot
Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.05.001openalex-snapshot
Selenium Deficiency Is Associated with Pro-longevity Mechanisms
inferred← citeshttps://doi.org/10.1016/j.cmet.2013.09.010openalex-snapshot
Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
inferred← citeshttps://doi.org/10.1016/j.cmet.2014.01.001openalex-snapshot
Rapamycin: One Drug, Many Effects
inferred← citeshttps://doi.org/10.1016/j.cmet.2014.05.001openalex-snapshot
Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.11.013openalex-snapshot
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
inferred← citeshttps://doi.org/10.1016/j.cmet.2025.03.001openalex-snapshot
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin
inferred← citeshttps://doi.org/10.1016/j.cois.2016.05.003openalex-snapshot
A critical look at proximate causes of social insect senescence: damage accumulation or hyperfunction?
inferred← citeshttps://doi.org/10.1016/j.cub.2020.05.020openalex-snapshot
GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production
inferred← citeshttps://doi.org/10.1016/j.ddmod.2017.07.005openalex-snapshot
Modelling ageing and age-related disease
inferred← citeshttps://doi.org/10.1016/j.ddmod.2019.01.002openalex-snapshot
A primer on ageing studies in mice: Considerations, opportunities and limitations
inferred← citeshttps://doi.org/10.1016/j.devcel.2020.06.011openalex-snapshot
Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
inferred← citeshttps://doi.org/10.1016/j.exger.2013.10.014openalex-snapshot
Caloric restriction and aging stem cells: The stick and the carrot?
inferred← citeshttps://doi.org/10.1016/j.exger.2014.12.002openalex-snapshot
How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story
inferred← citeshttps://doi.org/10.1016/j.exger.2015.08.008openalex-snapshot
Why is the dog an ideal model for aging research?
inferred← citeshttps://doi.org/10.1016/j.exger.2016.04.004openalex-snapshot
Nutrition and energetics in rodent longevity research
inferred← citeshttps://doi.org/10.1016/j.exger.2016.05.012openalex-snapshot
Energetic interventions for healthspan and resiliency with aging
inferred← citeshttps://doi.org/10.1016/j.exger.2016.08.002openalex-snapshot
Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice
inferred← citeshttps://doi.org/10.1016/j.exger.2019.01.030openalex-snapshot
Coupling lifespan and aging? The age at onset of body mass decline associates positively with sex-specific lifespan but negatively with environment-specific lifespan
inferred← citeshttps://doi.org/10.1016/j.exger.2023.112166openalex-snapshot
Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update
inferred← citeshttps://doi.org/10.1016/j.gde.2014.05.004openalex-snapshot
Alive and well? Exploring disease by studying lifespan
inferred← citeshttps://doi.org/10.1016/j.gene.2019.144191openalex-snapshot
MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages
inferred← citeshttps://doi.org/10.1016/j.genrep.2025.102401openalex-snapshot
Mechanistic basis of NMN and rapamycin in aging biology: Independent and intersecting pathways
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.125914openalex-snapshot
R-phycocyanin from porphyra haitanensis influences drosophila melanogaster lifespan in a sex-specific manner
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2016.07.026openalex-snapshot
Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104021openalex-snapshot
Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes
inferred← citeshttps://doi.org/10.1016/j.jeoa.2022.100423openalex-snapshot
Therapeutic approaches to treat and prevent age-related diseases through understanding the underlying biological drivers of ageing
inferred← citeshttps://doi.org/10.1016/j.jff.2019.03.045openalex-snapshot
Coeloglossum viride var. bracteatum extract improves learning and memory of chemically-induced aging mice through upregulating neurotrophins BDNF and FGF2 and sequestering neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.jgg.2014.06.002openalex-snapshot
Lifespan Modulation in Mice and the Confounding Effects of Genetic Background
inferred← citeshttps://doi.org/10.1016/j.jgg.2014.06.009openalex-snapshot
Rapamycin and Ageing: When, for How Long, and How Much?
inferred← citeshttps://doi.org/10.1016/j.mad.2014.06.002openalex-snapshot
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D
inferred← citeshttps://doi.org/10.1016/j.mad.2015.12.004openalex-snapshot
Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR
inferred← citeshttps://doi.org/10.1016/j.mad.2016.09.009openalex-snapshot
Interventions for age-related diseases: Shifting the paradigm
inferred← citeshttps://doi.org/10.1016/j.mad.2017.03.005openalex-snapshot
The role of the TOR pathway in mediating the link between nutrition and longevity
inferred← citeshttps://doi.org/10.1016/j.mad.2019.03.002openalex-snapshot
Geroprotectors: A role in the treatment of frailty
inferred← citeshttps://doi.org/10.1016/j.mad.2020.111391openalex-snapshot
The use of geroprotectors to prevent multimorbidity: Opportunities and challenges
inferred← citeshttps://doi.org/10.1016/j.mad.2021.111584openalex-snapshot
Rodent diet aids and the fallacy of caloric restriction
inferred← citeshttps://doi.org/10.1016/j.mad.2023.111837openalex-snapshot
Aging – What it is and how to measure it
inferred← citeshttps://doi.org/10.1016/j.mad.2023.111852openalex-snapshot
Ageing-associated phenotypes in mice
inferred← citeshttps://doi.org/10.1016/j.mad.2024.111918openalex-snapshot
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice
inferred← citeshttps://doi.org/10.1016/j.mce.2016.11.014openalex-snapshot
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
inferred← citeshttps://doi.org/10.1016/j.molmed.2014.05.001openalex-snapshot
Caloric restriction and cancer: molecular mechanisms and clinical implications
inferred← citeshttps://doi.org/10.1016/j.molmet.2014.06.004openalex-snapshot
Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
inferred← citeshttps://doi.org/10.1016/j.molmet.2024.101902openalex-snapshot
Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension
inferred← citeshttps://doi.org/10.1016/j.neulet.2022.136493openalex-snapshot
Rapamycin ameliorates age-related hearing loss in C57BL/6J mice by enhancing autophagy in the SGNs
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.05.015openalex-snapshot
Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction
inferred← citeshttps://doi.org/10.1016/j.semcdb.2015.03.005openalex-snapshot
Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation
inferred← citeshttps://doi.org/10.1016/j.stem.2014.06.012openalex-snapshot
Stem Cells on Alert: Priming Quiescent Stem Cells after Remote Injury
inferred← citeshttps://doi.org/10.1016/j.tcb.2016.05.002openalex-snapshot
Does Longer Lifespan Mean Longer Healthspan?
inferred← citeshttps://doi.org/10.1016/j.tdr.2025.100034openalex-snapshot
Senescence and oral cancer: From mechanisms to therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.tig.2014.04.007openalex-snapshot
Sirtuins: guardians of mammalian healthspan
inferred← citeshttps://doi.org/10.1016/j.tips.2018.10.005openalex-snapshot
Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1016/j.tiv.2019.03.025openalex-snapshot
Rapamycin-induced autophagy decreases Myf5 and MyoD proteins in C2C12 myoblast cells
inferred← citeshttps://doi.org/10.1016/j.tma.2017.09.004openalex-snapshot
Translational geroscience: A new paradigm for 21st century medicine
inferred← citeshttps://doi.org/10.1016/j.ymeth.2020.04.005openalex-snapshot
Hutchinson-Gilford progeria syndrome: Rejuvenating old drugs to fight accelerated ageing
inferred← citeshttps://doi.org/10.1016/s2666-7568(20)30068-4openalex-snapshot
The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19
inferred← citeshttps://doi.org/10.1017/erm.2023.18openalex-snapshot
Toxicology of pharmaceutical and nutritional longevity compounds
inferred← citeshttps://doi.org/10.1017/s0029665113003832openalex-snapshot
Dietary restriction and the pursuit of effective mimetics
inferred← citeshttps://doi.org/10.1038/celldisc.2017.39openalex-snapshot
Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins
inferred← citeshttps://doi.org/10.1038/mp.2017.53openalex-snapshot
A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice
inferred← citeshttps://doi.org/10.1038/nrd4391openalex-snapshot
Caloric restriction mimetics: towards a molecular definition
inferred← citeshttps://doi.org/10.1038/s41380-022-01680-xopenalex-snapshot
Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?
inferred← citeshttps://doi.org/10.1038/s41392-023-01343-5openalex-snapshot
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
inferred← citeshttps://doi.org/10.1038/s41422-022-00718-7openalex-snapshot
Unraveling female reproductive senescence to enhance healthy longevity
inferred← citeshttps://doi.org/10.1038/s41467-017-00178-3openalex-snapshot
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
inferred← citeshttps://doi.org/10.1038/s41467-018-06203-3openalex-snapshot
Temporal genetic association and temporal genetic causality methods for dissecting complex networks
inferred← citeshttps://doi.org/10.1038/s41467-020-18140-1openalex-snapshot
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
inferred← citeshttps://doi.org/10.1038/s41467-022-34515-yopenalex-snapshot
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
inferred← citeshttps://doi.org/10.1038/s41514-024-00170-4openalex-snapshot
Cell senescence in cardiometabolic diseases
inferred← citeshttps://doi.org/10.1038/s41556-018-0206-0openalex-snapshot
Turning back time with emerging rejuvenation strategies
inferred← citeshttps://doi.org/10.1038/s41573-020-0067-7openalex-snapshot
The quest to slow ageing through drug discovery
inferred← citeshttps://doi.org/10.1038/s41573-026-01449-9openalex-snapshot
Autophagy modulation in cancer
inferred← citeshttps://doi.org/10.1038/s41576-022-00477-6openalex-snapshot
Making sense of the ageing methylome
inferred← citeshttps://doi.org/10.1038/s41591-022-01923-yopenalex-snapshot
Cellular senescence and senolytics: the path to the clinic
inferred← citeshttps://doi.org/10.1038/s41596-019-0256-1openalex-snapshot
A toolbox for the longitudinal assessment of healthspan in aging mice
inferred← citeshttps://doi.org/10.1038/s41598-017-03158-1openalex-snapshot
High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
inferred← citeshttps://doi.org/10.1038/s41598-019-53098-1openalex-snapshot
PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells
inferred← citeshttps://doi.org/10.1038/s41598-026-68622-3openalex-snapshot
The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets
inferred← citeshttps://doi.org/10.1038/s42003-025-08178-6openalex-snapshot
Systematic transcriptomics analysis of calorie restriction and rapamycin unveils their synergistic interaction in prolonging cellular lifespan
inferred← citeshttps://doi.org/10.1038/s42255-023-00815-wopenalex-snapshot
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome
inferred← citeshttps://doi.org/10.1038/s43587-020-00010-6openalex-snapshot
Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging
inferred← citeshttps://doi.org/10.1038/s43587-023-00416-yopenalex-snapshot
Targeting the biology of aging with mTOR inhibitors
inferred← citeshttps://doi.org/10.1038/s43587-024-00802-0openalex-snapshot
Ginkgolide B increases healthspan and lifespan of female mice
inferred← citeshttps://doi.org/10.1039/9781788016506-00230openalex-snapshot
Eating Habits and Their Impact on Aging and Cancer
inferred← citeshttps://doi.org/10.1039/d1fo01579fopenalex-snapshot
Aspartame and sucralose extend the lifespan and improve the health status of C. elegans
inferred← citeshttps://doi.org/10.1042/bst20170141openalex-snapshot
Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome
inferred← citeshttps://doi.org/10.1053/j.ackd.2015.11.005openalex-snapshot
Aging Biology in the Kidney
inferred← citeshttps://doi.org/10.1073/pnas.1707337115openalex-snapshot
Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice
inferred← citeshttps://doi.org/10.1074/jbc.m115.681445openalex-snapshot
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
inferred← citeshttps://doi.org/10.1080/15384101.2018.1554781openalex-snapshot
Rapamycin, proliferation and geroconversion to senescence
inferred← citeshttps://doi.org/10.1080/15548627.2016.1263776openalex-snapshot
Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L
inferred← citeshttps://doi.org/10.1080/15548627.2018.1530929openalex-snapshot
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
inferred← citeshttps://doi.org/10.1080/17460441.2017.1349750openalex-snapshot
Novel strategies for anti-aging drug discovery
inferred← citeshttps://doi.org/10.1080/19491034.2015.1128610openalex-snapshot
Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production
inferred← citeshttps://doi.org/10.1084/jem.20191212openalex-snapshot
Endothelial mTOR maintains hematopoiesis during aging
inferred← citeshttps://doi.org/10.1089/ten.teb.2023.0136openalex-snapshot
Cellular Senescence in Craniofacial Tissue Regeneration: Inducers, Biomarkers, and Interventions
inferred← citeshttps://doi.org/10.1093/gerona/glac221openalex-snapshot
Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice
inferred← citeshttps://doi.org/10.1093/gerona/glae135openalex-snapshot
Animal Models Relevant for Geroscience: Current Trends and Future Perspectives in Biomarkers, and Measures of Biological Aging
inferred← citeshttps://doi.org/10.1093/gerona/glae196openalex-snapshot
Characterization of Effects of mTOR Inhibitors on Aging in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1093/gerona/glu053openalex-snapshot
Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver
inferred← citeshttps://doi.org/10.1093/gerona/glu058openalex-snapshot
Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span
inferred← citeshttps://doi.org/10.1093/gerona/glu101openalex-snapshot
Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset
inferred← citeshttps://doi.org/10.1093/gerona/glu238openalex-snapshot
Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life
inferred← citeshttps://doi.org/10.1093/gerona/glv080openalex-snapshot
Measures of Healthspan as Indices of Aging in Mice—A Recommendation
inferred← citeshttps://doi.org/10.1093/gerona/glv164openalex-snapshot
Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society
inferred← citeshttps://doi.org/10.1093/gerona/glv170openalex-snapshot
Rapamycin Increases Mortality indb/dbMice, a Mouse Model of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1093/gerona/glv307openalex-snapshot
Rapamycin Attenuates Age-associated Changes in Tibialis Anterior Tendon Viscoelastic Properties
inferred← citeshttps://doi.org/10.1093/gerona/glw064openalex-snapshot
Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice
inferred← citeshttps://doi.org/10.1093/gerona/glw090openalex-snapshot
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island
inferred← citeshttps://doi.org/10.1093/gerona/glw153openalex-snapshot
Meta-Analysis of 29 Experiments Evaluating the Effects of Rapamycin on Life Span in the Laboratory Mouse
inferred← citeshttps://doi.org/10.1093/gerona/glx090openalex-snapshot
The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop
inferred← citeshttps://doi.org/10.1093/gerona/glz056openalex-snapshot
Next Generation Strategies for Geroprotection via mTORC1 Inhibition
inferred← citeshttps://doi.org/10.1093/gerona/glz069openalex-snapshot
Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin
inferred← citeshttps://doi.org/10.1093/gerona/glz239openalex-snapshot
NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity
inferred← citeshttps://doi.org/10.1093/hmg/ddv087openalex-snapshot
Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments
inferred← citeshttps://doi.org/10.1093/oxfordhb/9780190686307.013.18openalex-snapshot
Dysregulation of Neuronal Protein Synthesis in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1097/mph.0000000000001898openalex-snapshot
Increased Malignancy Rate in Children With IgE Deficiency: A Single-center Experience
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