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Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use

https://doi.org/10.1177/0091270005282630
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/14651858.cd004295.pub2openalex-snapshot
Dan Shen agents for acute ischaemic stroke
inferredcites →https://doi.org/10.1002/bmc.105openalex-snapshot
Determination of Danshensu, a major active compound of Radix Salvia miltiorrhiza in dog plasma by HPLC with fluorescence detection
inferredcites →https://doi.org/10.1002/jcla.10057openalex-snapshot
Drug–herb interactions: unexpected suppression of free Danshen concentrations by salicylate
inferredcites →https://doi.org/10.1007/bf03190157openalex-snapshot
The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats
inferredcites →https://doi.org/10.1016/0006-2952(93)90624-6openalex-snapshot
Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells
inferredcites →https://doi.org/10.1016/0197-2456(95)00134-4openalex-snapshot
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
inferredcites →https://doi.org/10.1016/j.jchromb.2004.06.028openalex-snapshot
Study of the determination and pharmacokinetics of Compound Danshen Dripping Pills in human serum by column switching liquid chromatography electrospray ion trap mass spectrometry
inferredcites →https://doi.org/10.1016/j.lfs.2003.07.035openalex-snapshot
Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL/6J but not in DBA/2J mice
inferredcites →https://doi.org/10.1016/j.lfs.2004.02.034openalex-snapshot
Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats
inferredcites →https://doi.org/10.1016/j.lfs.2004.06.010openalex-snapshot
Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction
inferredcites →https://doi.org/10.1016/s0003-4975(98)00624-9openalex-snapshot
A taste of Chinese medicine!
inferredcites →https://doi.org/10.1016/s0006-2952(01)00686-4openalex-snapshot
Inhibition of stress-activated protein kinase in the ischemic/reperfused heart: role of magnesium tanshinoate B in preventing apoptosis11Abbreviations: JIP, JNK-interacting protein; MAP, mitogen-activated protein; p38 MAPK, p38 MAP kinase; MTB, magnesium tanshinoate B; PARP, poly(ADP-ribose)…
inferredcites →https://doi.org/10.1016/s0006-2952(02)01250-9openalex-snapshot
Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells
inferredcites →https://doi.org/10.1016/s0024-3205(00)00989-9openalex-snapshot
Magnesium tanshinoate B (MTB) inhibits low density lipoprotein oxidation
inferredcites →https://doi.org/10.1016/s0024-3205(03)00142-5openalex-snapshot
Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes
inferredcites →https://doi.org/10.1023/a:1007081911734openalex-snapshot
Effect of Magnesium tanshinoate B on the production of nitric oxide in endothelial cells
inferredcites →https://doi.org/10.1046/j.1365-2796.1997.134137000.xopenalex-snapshot
Chinese herbs and warfarin potentiation by ‘Danshen’
inferredcites →https://doi.org/10.1055/s-2004-815490openalex-snapshot
Extremely Low Bioavailability of Magnesium Lithospermate B, An Active Component fromSalvia miltiorrhiza,in Rat
inferredcites →https://doi.org/10.1080/10715760000301471openalex-snapshot
Tanshinone II-A inhibits low density lipoprotein oxidationin vitro
inferredcites →https://doi.org/10.1093/chromsci/41.6.327openalex-snapshot
Simultaneous Determination and Pharmacokinetic Studies on (3,4-Dihydroxyphenyl)-Lactic Acid and Protocatechuic Aldehyde in Rat Serum after Oral Administration of Radix Salviae miltiorrhizae Extract
inferredcites →https://doi.org/10.1111/j.1445-5994.1995.tb01540.xopenalex-snapshot
Warfarin interactions with Chinese traditional medicines: danshen and methyl salicylate medicated oil
inferredcites →https://doi.org/10.1111/j.1600-0404.2004.00369.xopenalex-snapshot
Does Danshen improve disability after acute ischaemic stroke?
inferredcites →https://doi.org/10.1111/j.2042-7158.1995.tb05819.xopenalex-snapshot
The Effects of Danshen (Salvia miltiorrhiza) on Warfarin Pharmacodynamics and Pharmacokinetics of Warfarin Enantiomers in Rats
inferredcites →https://doi.org/10.1124/dmd.32.7.752openalex-snapshot
MAGNESIUM LITHOSPERMATE B IS EXCRETED RAPIDLY INTO RAT BILE MOSTLY AS METHYLATED METABOLITES, WHICH ARE POTENT ANTIOXIDANTS
inferredcites →https://doi.org/10.1161/01.atv.18.3.481openalex-snapshot
Increase of Vitamin E Content in LDL and Reduction of Atherosclerosis in Cholesterol-Fed Rabbits by a Water-Soluble Antioxidant-Rich Fraction ofSalvia miltiorrhiza
inferredcites →https://doi.org/10.1211/0022357021602openalex-snapshot
Effects of the aqueous extract from Salvia miltiorrhiza Bge on the pharmacokinetics of diazepam and on liver microsomal cytochrome P450 enzyme activity in rats
inferredcites →https://doi.org/10.1248/bpb.20.285openalex-snapshot
Pharmacokinetics of a Chinese Traditional Medicine, Danshensu (3, 4-Dihydroxyphenyllactic Acid), in Rabbits Using High-Performance Liquid Chromatography.
inferredcites →https://doi.org/10.1254/jjp.87.289openalex-snapshot
Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
inferredcites →https://doi.org/10.1345/1542-6270(2001)035<0501:ibwads>2.0.co;2openalex-snapshot
Interaction Between Warfarin and Danshen (Salvia miltiorrhiza)
inferredcites →https://doi.org/10.7326/0003-4819-142-12_part_2-200506211-00003openalex-snapshot
Challenges in Systematic Reviews of Complementary and Alternative Medicine Topics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4015439openalex-extracted
inferred← citeshttps://doi.org/10.2139/ssrn.4687382openalex-extracted
inferred← citeshttps://doi.org/10.1002/9781394212767.ch9openalex-snapshot
Synthesis and Functionalization of Natural Products with Light‐Driven Reactions
inferred← citeshttps://doi.org/10.1002/9783527825578.c02-78openalex-snapshot
Salvia Species
inferred← citeshttps://doi.org/10.1002/adem.201800626openalex-snapshot
Preparation of Inorganic‐Organic‐Framework Nanoscale Carries as a Potential Platform for Drug Delivery
inferred← citeshttps://doi.org/10.1002/adfm.202103718openalex-snapshot
Aminoglycoside‐Based Biomaterials: From Material Design to Antibacterial and Gene Delivery Applications
inferred← citeshttps://doi.org/10.1002/adhm.202501456openalex-snapshot
Modified Fish‐Skin‐Collagen‐Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing
inferred← citeshttps://doi.org/10.1002/advs.202206771openalex-snapshot
All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity
inferred← citeshttps://doi.org/10.1002/ange.202402909openalex-snapshot
Synthesis of Tetra‐Substituted 3‐Hydroxyphthalide Esters by Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution
inferred← citeshttps://doi.org/10.1002/anie.202402909openalex-snapshot
Synthesis of Tetra‐Substituted 3‐Hydroxyphthalide Esters by Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution
inferred← citeshttps://doi.org/10.1002/bab.1454openalex-snapshot
Molecular cloning, bioinformatics analysis, and transcriptional profiling of JAZ1 and JAZ2 from Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1002/bdd.2213openalex-snapshot
Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats
inferred← citeshttps://doi.org/10.1002/bio.3776openalex-snapshot
Tunable luminescence of a synthesized furophenanthraquinone derivative: interactions with different solvents
inferred← citeshttps://doi.org/10.1002/bit.24547openalex-snapshot
Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1002/bmc.2851openalex-snapshot
Identification of metabolites in WZS‐miniature pig urine after oral administration of Danshen decoction by HPLC coupled with diode array detection with electrospray ionization tandem ion trap and time‐of‐flight mass spectrometry
inferred← citeshttps://doi.org/10.1002/bmc.3489openalex-snapshot
Identification of chemical constituents and rat metabolites of Kangxianling granule by HPLC‐Q‐TOF‐MS/MS
inferred← citeshttps://doi.org/10.1002/bmc.4869openalex-snapshot
Pharmacokinetic study of tanshinol and ligustrazine in rat plasma after intravenous administration of tanshinol and Danshen Chuanxiongqin Injection
inferred← citeshttps://doi.org/10.1002/bmc.775openalex-snapshot
Analysis of chemical and metabolic components in traditional Chinese medicinal combined prescription containing Radix Salvia miltiorrhiza and Radix Panax notoginseng by LC‐ESI‐MS methods
inferred← citeshttps://doi.org/10.1002/bmc.778openalex-snapshot
Study of tanshinone IIA tissue distribution in rat by liquid chromatography‐tandem mass spectrometry method
inferred← citeshttps://doi.org/10.1002/bmc.968openalex-snapshot
Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography–tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza, PF2401‐SF
inferred← citeshttps://doi.org/10.1002/cbdv.200700441openalex-snapshot
Cultivar Variations of Australian‐Grown Danshen (Salvia miltiorrhiza): Bioactive Markers and Root Yields
inferred← citeshttps://doi.org/10.1002/cbdv.200800090openalex-snapshot
Seasonal Variations in Bioactive Marker Contents in Australian‐Grown Salvia miltiorrhiza Roots
inferred← citeshttps://doi.org/10.1002/cbdv.200800221openalex-snapshot
HPLC Profiles and Biomarker Contents of Australian‐Grown Salvia miltiorrhiza f. alba Roots
inferred← citeshttps://doi.org/10.1002/cbdv.201000192openalex-snapshot
Plant Density‐Dependent Variations in Bioactive Markers and Root Yield in Australian‐Grown Salvia miltiorrhiza Bunge
inferred← citeshttps://doi.org/10.1002/cbic.201200191openalex-snapshot
DYZ‐2‐90, a Novel Neo‐tanshinlactone Ring‐Opened Compound, Induces ERK‐Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells
inferred← citeshttps://doi.org/10.1002/chem.201203506openalex-snapshot
Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface‐Functionalized Gold Nanoparticles
inferred← citeshttps://doi.org/10.1002/cmdc.202400975openalex-snapshot
Signaling Pathways and Promising Small‐Molecule Therapeutic Agents for Ischemic Stroke
inferred← citeshttps://doi.org/10.1002/cmdc.202500280openalex-snapshot
Protocatechuic Acid and its Derivatives: Synthesis, Antioxidant Properties, and Potential In Vivo Wound Healing Applications
inferred← citeshttps://doi.org/10.1002/dta.1750openalex-snapshot
Identification of a major metabolite of danshensu in rat urine and simultaneous determination of danshensu and its metabolite in plasma: application to a pharmacokinetic study in rats
inferred← citeshttps://doi.org/10.1002/dta.1840openalex-snapshot
Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC‐MS/MS and its application to the pharmacokinetic interaction between them
inferred← citeshttps://doi.org/10.1002/fsn3.71436openalex-snapshot
Astragalus membranaceus — Salvia miltiorrhiza Decoction Ameliorates Metabolic Syndrome and Gut Microbiota Dysbiosis Induced by High‐Fat Diet: A Comparative Study
inferred← citeshttps://doi.org/10.1002/fsn3.71755openalex-snapshot
Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care
inferred← citeshttps://doi.org/10.1002/glia.24288openalex-snapshot
RNA regulation of inflammatory responses in glia and its potential as a therapeutic target in central nervous system disorders
inferred← citeshttps://doi.org/10.1002/ijc.25678openalex-snapshot
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice
inferred← citeshttps://doi.org/10.1002/ijch.201800178openalex-snapshot
Natural Product Chemistry for Nitric Oxide Based Therapeutics
inferred← citeshttps://doi.org/10.1002/jcph.209openalex-snapshot
Absence of an effect of T89 on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
inferred← citeshttps://doi.org/10.1002/jsfa.4163openalex-snapshot
Salvianolic acid B inhibits low‐density lipoprotein oxidation and neointimal hyperplasia in endothelium‐denuded hypercholesterolaemic rabbits
inferred← citeshttps://doi.org/10.1002/jssc.200800327openalex-snapshot
Rapid and sensitive analysis of multiple bioactive constituents in Compound Danshen preparations using LC‐ESI‐TOF‐MS
inferred← citeshttps://doi.org/10.1002/jssc.200900398openalex-snapshot
Ionic liquid surfactant‐mediated ultrasonic‐assisted extraction coupled to HPLC: Application to analysis of tanshinones in Salvia miltiorrhiza bunge
inferred← citeshttps://doi.org/10.1002/jssc.201000234openalex-snapshot
Infrared‐assisted extraction coupled with high‐performance liquid chromatography for simultaneous determination of eight active compounds in Radix Salviae miltiorrhizae
inferred← citeshttps://doi.org/10.1002/jssc.201701370openalex-snapshot
Screening and analysis of potentially active components in Shenxiong glucose injection using UHPLC coupled with photodiode array detection and MS/MS
inferred← citeshttps://doi.org/10.1002/lipd.12217openalex-snapshot
Tanshinol A Ameliorates Triton‐1339W‐Induced Hyperlipidemia and Liver Injury in C57BL/6J Mice by Regulating mRNA Expression of Lipemic‐Oxidative Injury Genes
inferred← citeshttps://doi.org/10.1002/mc.21888openalex-snapshot
Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function
inferred← citeshttps://doi.org/10.1002/med.21304openalex-snapshot
The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
inferred← citeshttps://doi.org/10.1002/med.21438openalex-snapshot
Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen
inferred← citeshttps://doi.org/10.1002/med.22102openalex-snapshot
Danshensu Derivatives: A Series of Promising Drugs With Protective Effects Against Cardiocerebrovascular Diseases and Cancers
inferred← citeshttps://doi.org/10.1002/mef2.21openalex-snapshot
Sodium Danshensu mediates human T lymphocyte activation via NF‐κB and MAPK pathway regulation
inferred← citeshttps://doi.org/10.1002/pca.1063openalex-snapshot
Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high‐performance liquid chromatography
inferred← citeshttps://doi.org/10.1002/pca.1330openalex-snapshot
Characterisation of the Degradation of Salvianolic Acid B Using an On‐line Spectroscopic Analysis System and Multivariate Curve Resolution
inferred← citeshttps://doi.org/10.1002/pca.2461openalex-snapshot
Sparse Partial‐least‐squares Discriminant Analysis for Different Geographical Origins of Salvia miltiorrhiza by 1H‐NMR‐based Metabolomics
inferred← citeshttps://doi.org/10.1002/pca.2719openalex-snapshot
Determination of Tanshinones in Danshen (Salvia miltiorrhiza) by High‐Performance Liquid Chromatography with Fluorescence Detection after pre‐Column Derivatisation
inferred← citeshttps://doi.org/10.1002/pfm2.70007openalex-snapshot
Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy
inferred← citeshttps://doi.org/10.1002/pmic.200900178openalex-snapshot
Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells
inferred← citeshttps://doi.org/10.1002/pmic.201000482openalex-snapshot
Clarifying the signal network of salvianolic acid B using proteomic assay and bioinformatic analysis
inferred← citeshttps://doi.org/10.1002/ptr.2615openalex-snapshot
Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice
inferred← citeshttps://doi.org/10.1002/ptr.2654openalex-snapshot
A randomized, multicentre, open‐label, parallel‐group trial to compare the efficacy and safety profile of daming capsule in patients with hypercholesterolemia
inferred← citeshttps://doi.org/10.1002/ptr.2819openalex-snapshot
Danshen extracts decrease blood c reactive protein and prevent ischemic stroke recurrence: a controlled pilot study
inferred← citeshttps://doi.org/10.1002/ptr.3047openalex-snapshot
Effects of the aqueous extract of Salvia Miltiorrhiza (danshen) and its magnesium tanshinoate B‐enriched form on blood pressure
inferred← citeshttps://doi.org/10.1002/ptr.3097openalex-snapshot
Berberine elicits anti‐arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model
inferred← citeshttps://doi.org/10.1002/ptr.3278openalex-snapshot
Regulation of adhesion molecules expression in TNF‐α‐stimulated brain microvascular endothelial cells by tanshinone IIA: involvement of NF‐κB and ROS generation
inferred← citeshttps://doi.org/10.1002/ptr.3548openalex-snapshot
A Randomized, Double‐blind, Placebo‐controlled Study to Evaluate the Efficacy and Tolerability of Fufang Danshen (Salvia miltiorrhiza) as Add‐on Antihypertensive Therapy in Taiwanese Patients with Uncontrolled Hypertension
inferred← citeshttps://doi.org/10.1002/ptr.3616openalex-snapshot
Activation of p53 Signaling and Inhibition of Androgen Receptor Mediate Tanshinone IIA Induced G1 Arrest in LNCaP Prostate Cancer Cells
inferred← citeshttps://doi.org/10.1002/ptr.5015openalex-snapshot
Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM‐5 Leukemia Cells
inferred← citeshttps://doi.org/10.1002/ptr.5777openalex-snapshot
Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats
inferred← citeshttps://doi.org/10.1002/ptr.5877openalex-snapshot
Bioactive Triterpenes from the Root of Salvia miltiorrhiza Bunge
inferred← citeshttps://doi.org/10.1002/ptr.5888openalex-snapshot
Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia
inferred← citeshttps://doi.org/10.1002/ptr.6013openalex-snapshot
Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen)
inferred← citeshttps://doi.org/10.1002/ptr.6880openalex-snapshot
Preventing contrast‐induced nephropathy ( CIN ) with herbal medicines: A review
inferred← citeshttps://doi.org/10.1002/tox.22633openalex-snapshot
Cryptotanshinone (Dsh‐003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2‐induced survival and invasion effects in HA22T hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1002/tpg2.20041openalex-snapshot
A high‐quality reference genome sequence of Salvia miltiorrhiza provides insights into tanshinone synthesis in its red rhizomes
inferred← citeshttps://doi.org/10.1007/978-1-4614-7495-1_217openalex-snapshot
“Danshen” the Night Away
inferred← citeshttps://doi.org/10.1007/978-1-60761-616-0_15openalex-snapshot
The Nitrate–Nitrite–Nitric Oxide Pathway in Traditional Herbal Medicine for Heart Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-24716-4_1openalex-snapshot
Salvia miltiorrhiza: An Economically and Academically Important Medicinal Plant
inferred← citeshttps://doi.org/10.1007/978-3-030-24716-4_13openalex-snapshot
Genetic Transformation of Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/978-3-030-24716-4_3openalex-snapshot
Molecular Maps and Mapping of Genes and QTLs of Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/978-3-030-24716-4_4openalex-snapshot
The Genome of Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/978-3-030-24716-4_5openalex-snapshot
The Chloroplast and Mitochondrial Genomes of Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/978-3-030-24716-4_7openalex-snapshot
Transcriptome Analysis of Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/978-3-030-24716-4_8openalex-snapshot
Gene Expression Regulation in Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/978-3-031-95183-1_7openalex-snapshot
Biosynthesis of Non-ribosomal Peptides in Uncultivated Bacterial Symbionts of Marine Sponges
inferred← citeshttps://doi.org/10.1007/978-3-319-46189-2_19openalex-snapshot
The Nitrate–Nitrite–Nitric Oxide Pathway in Traditional Herbal Medicine and Dietary Supplements with Potential Benefits for Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1007/978-3-319-67903-7_2openalex-snapshot
Rosmarinic Acid and Related Metabolites
inferred← citeshttps://doi.org/10.1007/978-3-319-73900-7_10openalex-snapshot
Genetic Engineering and Manipulation of Metabolite Pathways in Salvia Spp.
inferred← citeshttps://doi.org/10.1007/978-3-319-73900-7_5openalex-snapshot
Anticancer Activity of Salvia miltiorrhiza and Its Secondary Metabolites
inferred← citeshttps://doi.org/10.1007/978-3-540-73042-2_44openalex-snapshot
Traditionelle chinesische Medizin in der Prävention kardiovaskulärer Erkrankungen — Grundprinzipien, Anwendungshäufigkeit und Wirksamkeit der chinesischen Kräutermedizin
inferred← citeshttps://doi.org/10.1007/978-3-7091-0442-2_9openalex-snapshot
Chinese Herbal Medicines for Neuroprotection in Ischemic Stroke: Promise and Reality
inferred← citeshttps://doi.org/10.1007/978-3-7091-0763-8_74openalex-snapshot
Radix et Rhizoma Salviae miltiorrhizae Danshen
inferred← citeshttps://doi.org/10.1007/978-94-007-1983-5_15openalex-snapshot
Evidence-based Materia Medica for Cancer Chemoprevention
inferred← citeshttps://doi.org/10.1007/978-94-007-1983-5_16openalex-snapshot
Pharmacokinetics of Anticancer Materia Medica in Humans
inferred← citeshttps://doi.org/10.1007/978-94-007-4945-0_9openalex-snapshot
Molecular Mechanism and Regulation on Biosynthesis of Active Ingredients of Medicinal Plants
inferred← citeshttps://doi.org/10.1007/978-981-10-1085-9_8openalex-snapshot
Salvia miltiorrhiza: A Medicinal Herb from Metabolites to Pathway Engineering
inferred← citeshttps://doi.org/10.1007/978-981-13-0289-3_15openalex-snapshot
Neuropharmacology of Salvia miltiorrhiza Bunge (Danshen)
inferred← citeshttps://doi.org/10.1007/978-981-15-1067-0_10openalex-snapshot
Metabolic and Enzyme Engineering for the Microbial Production of Anticancer Terpenoids
inferred← citeshttps://doi.org/10.1007/978-981-15-2874-3_2openalex-snapshot
Advanced Approaches for Biofortification
inferred← citeshttps://doi.org/10.1007/978-981-16-4779-6_4openalex-snapshot
Role of Plant Secondary Metabolites as Anticancer and Chemopreventive Agents
inferred← citeshttps://doi.org/10.1007/978-981-32-9034-1_8openalex-snapshot
Molecular Mechanisms and Gene Regulation for Biosynthesis of Medicinal Plant Active Ingredients
inferred← citeshttps://doi.org/10.1007/978-981-99-7652-2_13openalex-snapshot
Therapeutic Significance of Tanshinone
inferred← citeshttps://doi.org/10.1007/bf02974077openalex-snapshot
Natural compounds from danshen suppress the activity of hepatic stellate cells
inferred← citeshttps://doi.org/10.1007/bf02980766openalex-snapshot
Note: Occurrence and distribution ofCucumber mosaic virus infecting danshen (Salvia miltiorrhiza) in China
inferred← citeshttps://doi.org/10.1007/bf03191013openalex-snapshot
Determination and pharmacokinetics of danshensu in rat plasma after oral administration of danshen extract using liquid chromatography/tandem mass spectrometry
inferred← citeshttps://doi.org/10.1007/s00011-009-0152-1openalex-snapshot
Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis
inferred← citeshttps://doi.org/10.1007/s00210-015-1154-xopenalex-snapshot
Effects of Tanshinone IIA on osteogenic differentiation of mouse bone marrow mesenchymal stem cells
inferred← citeshttps://doi.org/10.1007/s00210-018-1585-2openalex-snapshot
Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion
inferred← citeshttps://doi.org/10.1007/s00210-026-05423-5openalex-snapshot
Comparative extracellular and intracellular anti-Mycobacterium tuberculosis activity of three tanshinones from Salvia miltiorrhiza and oral cryptotanshinone efficacy in mice
inferred← citeshttps://doi.org/10.1007/s00216-012-6078-4openalex-snapshot
Rational design of core–shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge
inferred← citeshttps://doi.org/10.1007/s00216-014-8396-1openalex-snapshot
Effervescent-salt-assisted dispersive micro-solid-phase extraction using mesoporous hybrid materials coupled with ultra-performance liquid chromatography for the determination of trace-level compounds in complicated plant preparations
inferred← citeshttps://doi.org/10.1007/s00248-023-02295-7openalex-snapshot
Genotype-Controlled Vertical Transmission Exerts Selective Pressure on Community Assembly of Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s00253-010-2797-7openalex-snapshot
Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures
inferred← citeshttps://doi.org/10.1007/s00253-014-5890-5openalex-snapshot
Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1007/s00253-017-8351-0openalex-snapshot
New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii
inferred← citeshttps://doi.org/10.1007/s00277-010-0996-zopenalex-snapshot
Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro
inferred← citeshttps://doi.org/10.1007/s00280-010-1440-8openalex-snapshot
Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity
inferred← citeshttps://doi.org/10.1007/s00280-016-3034-6openalex-snapshot
Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers
inferred← citeshttps://doi.org/10.1007/s00299-012-1334-9openalex-snapshot
Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s00299-014-1592-9openalex-snapshot
Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway
inferred← citeshttps://doi.org/10.1007/s00299-017-2154-8openalex-snapshot
Overexpression of SmMYB9b enhances tanshinone concentration in Salvia miltiorrhiza hairy roots
inferred← citeshttps://doi.org/10.1007/s00299-020-02562-8openalex-snapshot
smi-miR396b targeted SmGRFs, SmHDT1, and SmMYB37/4 synergistically regulates cell growth and active ingredient accumulation in Salvia miltiorrhiza hairy roots
inferred← citeshttps://doi.org/10.1007/s00403-013-1428-4openalex-snapshot
Phytotherapy in the management of psoriasis: a review of the efficacy and safety of oral interventions and the pharmacological actions of the main plants
inferred← citeshttps://doi.org/10.1007/s10068-010-0069-zopenalex-snapshot
Large scale isolation and purification of salvianolic acid b in high purity from roots of dansham (Salvia miltiorrhiza bunge)
inferred← citeshttps://doi.org/10.1007/s10142-014-0385-0openalex-snapshot
Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and 1-deoxy-d-xylulose 5-phosphate reductoisomerase
inferred← citeshttps://doi.org/10.1007/s10265-010-0350-5openalex-snapshot
RNAi-mediated suppression of the phenylalanine ammonia-lyase gene in Salvia miltiorrhiza causes abnormal phenotypes and a reduction in rosmarinic acid biosynthesis
inferred← citeshttps://doi.org/10.1007/s10295-013-1399-7openalex-snapshot
Preparation of przewalskinic acid A from salvianolic acid B using a crude enzyme from an Aspergillus oryzae strain
inferred← citeshttps://doi.org/10.1007/s10404-009-0554-yopenalex-snapshot
Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid–liquid interface area
inferred← citeshttps://doi.org/10.1007/s10528-013-9600-2openalex-snapshot
Diversity Evaluation of Salvia miltiorrhiza Using ISSR Markers
inferred← citeshttps://doi.org/10.1007/s10529-013-1358-4openalex-snapshot
RNA interference-mediated repression of SmCPS (copalyldiphosphate synthase) expression in hairy roots of Salvia miltiorrhiza causes a decrease of tanshinones and sheds light on the functional role of SmCPS
inferred← citeshttps://doi.org/10.1007/s10620-007-9863-8openalex-snapshot
Tanshinone IIA Ameliorates Trinitrobenzene Sulfonic Acid (TNBS)-Induced Murine Colitis
inferred← citeshttps://doi.org/10.1007/s10719-016-9712-0openalex-snapshot
Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan
inferred← citeshttps://doi.org/10.1007/s10753-010-9214-3openalex-snapshot
Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways
inferred← citeshttps://doi.org/10.1007/s10753-017-0603-8openalex-snapshot
Tanshinone IIA Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice Infected with Porphyromonas gingivalis
inferred← citeshttps://doi.org/10.1007/s10875-008-9206-3openalex-snapshot
Sodium Tanshinone IIA Sulfonate Protects Mice From ConA-Induced Hepatitis via Inhibiting NF-κB and IFN-γ/STAT1 Pathways
inferred← citeshttps://doi.org/10.1007/s11010-015-2424-0openalex-snapshot
Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro
inferred← citeshttps://doi.org/10.1007/s11010-021-04257-4openalex-snapshot
Tanshinone I restrains osteosarcoma progression by regulating circ_0000376/miR-432-5p/BCL2 axis
inferred← citeshttps://doi.org/10.1007/s11030-025-11128-3openalex-snapshot
Computational exploration in search for novel natural product-derived EZH2 inhibitors for advancing anti-cancer therapy
inferred← citeshttps://doi.org/10.1007/s11033-008-9413-2openalex-snapshot
Characterization and expression profiling of 4-hydroxyphenylpyruvate dioxygenase gene (Smhppd) from Salvia miltiorrhiza hairy root cultures
inferred← citeshttps://doi.org/10.1007/s11033-011-1388-8openalex-snapshot
Molecular cloning and characterization of the promoter of SmGGPPs and its expression pattern in Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s11033-012-1477-3openalex-snapshot
Tanshinone IIA protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway
inferred← citeshttps://doi.org/10.1007/s11033-012-2419-9openalex-snapshot
Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-α levels, and IL-10 mRNA, TNF-α mRNA expression levels, cerebral TGF-β1 positive expression level and its neuroprotective mechanisms in CIR rats
inferred← citeshttps://doi.org/10.1007/s11064-009-0011-zopenalex-snapshot
Targeting BuChE-inflammatory Pathway by SK0506 to Manage Type 2 Diabetes and Alzheimer Disease
inferred← citeshttps://doi.org/10.1007/s11064-010-0151-1openalex-snapshot
Anti-inflammatory Activity of Salvianolic Acid B in Microglia Contributes to its Neuroprotective Effect
inferred← citeshttps://doi.org/10.1007/s11095-009-9899-xopenalex-snapshot
Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of Bidirectional Effect of Danshensu on Plasma Homocysteine in Rats
inferred← citeshttps://doi.org/10.1007/s11095-012-0670-3openalex-snapshot
Tanshinones from Chinese Medicinal Herb Danshen (Salvia miltiorrhiza Bunge) Suppress Prostate Cancer Growth and Androgen Receptor Signaling
inferred← citeshttps://doi.org/10.1007/s11095-014-1437-9openalex-snapshot
Cumulative Organic Anion Transporter-Mediated Drug-Drug Interaction Potential of Multiple Components in Salvia Miltiorrhiza (Danshen) Preparations
inferred← citeshttps://doi.org/10.1007/s11101-019-09633-zopenalex-snapshot
Quinone diterpenes from Salvia species: chemistry, botany, and biological activity
inferred← citeshttps://doi.org/10.1007/s11101-024-09987-zopenalex-snapshot
Exploring Lamiaceae-derived bioactive compounds as nature’s arsenal for sustainable pest management
inferred← citeshttps://doi.org/10.1007/s11105-008-0065-0openalex-snapshot
Conserved Region Amplification Polymorphism (CoRAP), a Novel Marker Technique for Plant Genotyping in Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s11239-019-01945-3openalex-snapshot
Interactions between clopidogrel and traditional Chinese medicine
inferred← citeshttps://doi.org/10.1007/s11240-006-9187-yopenalex-snapshot
Genetic transformation of the medicinal plant Salvia miltiorrhiza by Agrobacterium tumefaciens-mediated method
inferred← citeshttps://doi.org/10.1007/s11240-016-1040-3openalex-snapshot
Regulation of folic acid on phenolic acids production in Salvia miltiorrhiza hairy roots
inferred← citeshttps://doi.org/10.1007/s11240-021-02141-zopenalex-snapshot
Elicitation of solid callus cultures of Salvia miltiorrhiza Bunge with salicylic acid and a synthetic auxin (1-naphthaleneacetic acid)
inferred← citeshttps://doi.org/10.1007/s11373-006-9110-xopenalex-snapshot
Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro
inferred← citeshttps://doi.org/10.1007/s11418-011-0576-0openalex-snapshot
Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells
inferred← citeshttps://doi.org/10.1007/s11418-019-01379-4openalex-snapshot
Danshen formula granule and salvianic acid A alleviate ethanol-induced neurotoxicity
inferred← citeshttps://doi.org/10.1007/s11427-010-0005-8openalex-snapshot
Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s11427-010-3106-5openalex-snapshot
Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice
inferred← citeshttps://doi.org/10.1007/s11434-015-0929-2openalex-snapshot
Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants
inferred← citeshttps://doi.org/10.1007/s11434-016-1046-6openalex-snapshot
Liposome intracellular delivery of Salvia miltiorrhiza Bge. deprivative DS-201 improves its BKCa channel-activating and vasorelaxing effects
inferred← citeshttps://doi.org/10.1007/s11481-025-10228-zopenalex-snapshot
Enhancing Neuroprotection Through Exercise: The Synergistic Effects of Bioactive Plant Compounds Via the CREB-BDNF Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s11655-012-1213-9openalex-snapshot
Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity
inferred← citeshttps://doi.org/10.1007/s11655-016-2508-zopenalex-snapshot
Huoxue Anxin Recipe (活血安心方) promotes myocardium angiogenesis of acute myocardial infarction rats by up-regulating miR-210 and vascular endothelial growth factor
inferred← citeshttps://doi.org/10.1007/s11655-017-2801-5openalex-snapshot
Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge.
inferred← citeshttps://doi.org/10.1007/s11655-019-3040-8openalex-snapshot
Danqi Tablet (丹七片) Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway
inferred← citeshttps://doi.org/10.1007/s11738-009-0320-5openalex-snapshot
Molecular characterization and expression of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) gene from Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s11738-010-0627-2openalex-snapshot
Molecular cloning and expression analysis of a new putative gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase from Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s11738-012-0940-zopenalex-snapshot
Molecular mechanism of elicitor-induced tanshinone accumulation in Salvia miltiorrhiza hairy root cultures
inferred← citeshttps://doi.org/10.1007/s11738-012-0948-4openalex-snapshot
An integrated analysis of the rosmarinic acid-biosynthetic genes to uncover the regulation of rosmarinic acid pathway in Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s11738-014-1484-1openalex-snapshot
Effect and mechanism of endophytic bacteria on growth and secondary metabolite synthesis in Salvia miltiorrhiza hairy roots
inferred← citeshttps://doi.org/10.1007/s12010-014-0876-4openalex-snapshot
Effects of Streptomyces pactum Act12 on Salvia miltiorrhiza Hairy Root Growth and Tanshinone Synthesis and Its Mechanisms
inferred← citeshttps://doi.org/10.1007/s12011-021-02806-yopenalex-snapshot
Analysis and Health Risk Assessment of Potentially Toxic Elements in Three Codonopsis Radix Varieties in China
inferred← citeshttps://doi.org/10.1007/s12013-013-9806-2openalex-snapshot
Magnesium Lithospermate B Reduces Inflammatory Response in a Mouse Model of Hepatic Ischemia–Reperfusion Injury
inferred← citeshttps://doi.org/10.1007/s12013-025-01932-xopenalex-snapshot
Theranekron D6 Shows Selective Effects on HEL299, A549, and Hep3B cells, Indicating Potential in the Fight Against Cancer
inferred← citeshttps://doi.org/10.1007/s12031-013-0083-8openalex-snapshot
The Protective Effect of Salvianolic Acid B on Blood–Spinal Cord Barrier After Compression Spinal Cord Injury in Rats
inferred← citeshttps://doi.org/10.1007/s12035-023-03487-5openalex-snapshot
Role of Non-Receptor-Type Tyrosine Phosphatases in Brain-Related Diseases
inferred← citeshttps://doi.org/10.1007/s12035-024-04626-2openalex-snapshot
Sodium Danshensu Inhibits Macrophage Inflammation in Atherosclerosis via the miR-200a-3p/MEKK3/NF-κB Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s12041-016-0621-6openalex-snapshot
Expression profiles of genes involved in tanshinone biosynthesis of two Salvia miltiorrhiza genotypes with different tanshinone contents
inferred← citeshttps://doi.org/10.1007/s12257-020-0270-8openalex-snapshot
Efficient Production of Phenyllactic Acid by Whole-cell Biocatalysis with Cofactor Regeneration System
inferred← citeshttps://doi.org/10.1007/s12272-011-0317-7openalex-snapshot
Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β
inferred← citeshttps://doi.org/10.1007/s12272-012-0311-8openalex-snapshot
Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge
inferred← citeshttps://doi.org/10.1007/s12272-014-0425-2openalex-snapshot
Anti-fibrotic effect of PF2401-SF, a standardized fraction of Salvia miltiorrhiza, in thioacetamide-induced experimental rats liver fibrosis
inferred← citeshttps://doi.org/10.1007/s12539-011-0077-6openalex-snapshot
QSAR study for cytotoxicity of diterpenoid tanshinones
inferred← citeshttps://doi.org/10.1007/s12539-019-00342-xopenalex-snapshot
Computer-Aided Saturation Mutagenesis of Arabidopsis thaliana Ent-Copalyl Diphosphate Synthase
inferred← citeshttps://doi.org/10.1007/s13213-013-0614-0openalex-snapshot
Isolation and identification of endophytic bacteria from root tissues of Salvia miltiorrhiza Bge. and determination of their bioactivities
inferred← citeshttps://doi.org/10.1007/s13238-021-00836-9openalex-snapshot
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
inferred← citeshttps://doi.org/10.1007/s13258-022-01251-yopenalex-snapshot
SmGDB: genome database of Salvia miltiorrhiza, an important TCM Plant
inferred← citeshttps://doi.org/10.1007/s13318-011-0048-7openalex-snapshot
The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats
inferred← citeshttps://doi.org/10.1007/s13562-017-0434-6openalex-snapshot
Isolation and characterization of a 3-hydroxy-3-methylglutaryl coenzyme A reductase 2 promoter from Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1007/s13659-021-00317-wopenalex-snapshot
Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2
inferred← citeshttps://doi.org/10.1007/s42452-019-0368-9openalex-snapshot
Development of a high resolution mass spectrometry method for the determination of danshensu and salvianolic acid B
inferred← citeshttps://doi.org/10.1007/s43450-023-00421-7openalex-snapshot
Pharmacological Actions of Tanshinone IIA with Special Focus on Nrf-2 Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s44337-025-00279-9openalex-snapshot
Complementary therapies for stroke towards neurorecovery
inferred← citeshttps://doi.org/10.1016/b978-0-12-801816-3.00047-9openalex-snapshot
Potential of Asian Natural Products for Health in Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-809593-5.00002-1openalex-snapshot
Natural Phytoestrogens
inferred← citeshttps://doi.org/10.1016/b978-0-12-824044-1.00003-9openalex-snapshot
Valuable bioactives from vegetable wastes
inferred← citeshttps://doi.org/10.1016/b978-0-12-824385-5.00007-8openalex-snapshot
Herbal bioactives for pulmonary drug delivery systems
inferred← citeshttps://doi.org/10.1016/b978-0-323-95702-1.00490-5openalex-snapshot
Herbs Acting in the CNS
inferred← citeshttps://doi.org/10.1016/b978-008045382-8.00654-7openalex-snapshot
Chinese Traditional Medicine
inferred← citeshttps://doi.org/10.1016/bs.irn.2017.02.013openalex-snapshot
Chinese Herbal Medicine for the Treatment of Drug Addiction
inferred← citeshttps://doi.org/10.1016/j.abb.2023.109655openalex-snapshot
Tanshinone IIA inhibits endometrial carcinoma growth through the MAPK/ERK/TRIB3 pathway
inferred← citeshttps://doi.org/10.1016/j.aca.2007.03.005openalex-snapshot
Coupling continuous ultrasound-assisted extraction with ultrasonic probe, solid-phase extraction and high-performance liquid chromatography for the determination of sodium Danshensu and four tanshinones in Salvia miltiorrhiza bunge
inferred← citeshttps://doi.org/10.1016/j.acthis.2021.151735openalex-snapshot
Inhibitory effect of Salvia coccinea on inflammatory responses through NF-κB signaling pathways in THP-1 cells and acute rat diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.ajps.2016.08.004openalex-snapshot
Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones
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