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Nonclinical Safety Assessment of the Histone Deacetylase Inhibitor Vorinostat
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague‐Dawley rats and Dutch Belted rabbits
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Assessment of female and male fertility in Sprague–Dawley rats administered vorinostat, a histone deacetylase inhibitor
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Revised methods for the Salmonella mutagenicity test
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Report from working group on in vitro tests for chromosomal aberrations
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Micronuclei and 3AB index in human and canine lymphocytes after in vitro X-irradiation
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Mutagenicity of platinum coordination complexes in Salmonella typhimurium
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Development of vorinostat: Current applications and future perspectives for cancer therapy
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5-Fluorouracil forward mutation assay in Salmonella: Determination of mutational target and spontaneous mutational spectra
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Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests
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DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens
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Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing
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Rapid method for improving slide quality in the bone marrow micronucleus assay; an adapted cellulose column procedure
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HDAC inhibitors overcome first hurdle
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Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
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Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas
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Cancer biology: mechanism of antitumour action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor
inferredcites →https://doi.org/10.1038/sj.onc.1206502openalex-snapshot
Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation
inferredcites →https://doi.org/10.1038/sj.onc.1210779openalex-snapshot
Histone deacetylase inhibitors induce mitotic slippage
inferredcites →https://doi.org/10.1042/bj20021321openalex-snapshot
Histone deacetylases (HDACs): characterization of the classical HDAC family
inferredcites →https://doi.org/10.1073/pnas.180316197openalex-snapshot
Histone deacetylase inhibitor selectively induces p21 WAF1 expression and gene-associated histone acetylation
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Cell line-specific differences in the control of cell cycle progression in the absence of mitosis.
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Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family
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Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen
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Comparative Mutagenicity of Apicidin and Apicidin Derivatives (SD-0203 and SD-2007), Histone Deacetylase Inhibitors
inferredcites →https://doi.org/10.1091/mbc.11.6.2069openalex-snapshot
Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells
inferredcites →https://doi.org/10.1091/mbc.e03-01-0860openalex-snapshot
Histone Hyperacetylation in Mitosis Prevents Sister Chromatid Separation and Produces Chromosome Segregation Defects
inferredcites →https://doi.org/10.1093/toxsci/kfl068openalex-snapshot
The Histone Deacetylase Inhibitor Trichostatin A Has Genotoxic Effects in Human Lymphoblasts In Vitro
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Flunarizine is a Highly Potent Inhibitor of Cardiac hERG Potassium Current
inferredcites →https://doi.org/10.1101/sqb.1991.056.01.049openalex-snapshot
Differences in Mitotic Control among Mammalian Cells
inferredcites →https://doi.org/10.1111/j.0954-6820.1920.tb18266.xopenalex-snapshot
Die Systolendauer im Elektrokardiogramm bei normalen Menschen und bei Herzkranken
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Novel, Potent Inhibitors of Human Kv1.5 K+ Channels and Ultrarapidly Activating Delayed Rectifier Potassium Current
inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-2689openalex-snapshot
Cardiotoxicity of Histone Deacetylase Inhibitor Depsipeptide in Patients with Metastatic Neuroendocrine Tumors
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-0511openalex-snapshot
A Phase I Study of Intravenous LBH589, a Novel Cinnamic Hydroxamic Acid Analogue Histone Deacetylase Inhibitor, in Patients with Refractory Hematologic Malignancies
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-2672openalex-snapshot
Vorinostat for Treatment of Cutaneous Manifestations of Advanced Primary Cutaneous T-Cell Lymphoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-09-1214openalex-snapshot
A Single Supratherapeutic Dose of Vorinostat Does Not Prolong the QTc Interval in Patients with Advanced Cancer
inferredcites →https://doi.org/10.1200/jco.2005.14.167openalex-snapshot
Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer
inferredcites →https://doi.org/10.1200/jco.2005.23.16_suppl.3131openalex-snapshot
Cardiac monitoring in phase I trials of a novel histone deacetylase (HDAC) inhibitor LAQ824 in patients with advanced solid tumors and hematologic malignancies
inferredcites →https://doi.org/10.2174/187231207780363642openalex-snapshot
Disposition of Vorinostat, A Novel Histone Deacetylase Inhibitor and Anticancer Agent, in Preclinical Species
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Exploration of 2-Mercaptoquinazolin-4(3H)-one Based N-Hydroxyheptanamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Anticancer Bioevaluation
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inferred← citeshttps://doi.org/10.1016/j.bone.2011.01.007openalex-snapshot
Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts
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Reply to vorinostat induced bone loss in mice
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Histone Deacetylase Inhibitors in Multiple Myeloma: Rationale and Evidence for Their Use in Combination Therapy
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Vorinostat is genotoxic and epigenotoxic in the mouse bone marrow cells at the human equivalent doses
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