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Fluoxetine: a review on evidence based medicine

https://doi.org/10.1186/1475-2832-3-2
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mortality and Community Mental Health
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Six-Month Prevalence of Psychiatric Disorders in Three Communities
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SSRIs versus tricyclic antidepressants in depressed inpatients: A meta-analysis of efficacy and tolerability
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Antidepressants versus placebo for people with bulimia nervosa
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A meta-analysis of fibromyalgia treatment interventions
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Clomipramine, flouxetine, and behavior therapy in the treatment of obsessive-compulsive disorder: A meta-analysis
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Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publication
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The prevalence of depression in a cohort of the very elderly
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Bulimia nervosa: A meta-analysis of psychosocial and pharmacological treatments
inferredcites →https://doi.org/10.1016/s0149-2918(00)83028-3openalex-snapshot
Adverse events and treatment discontinuations in clinical trials of fluoxetine in major depressive disorder: An updated meta-analysis
inferredcites →https://doi.org/10.1016/s0149-2918(97)80066-5openalex-snapshot
Fluoxetine tenth anniversary update: the progress continues
inferredcites →https://doi.org/10.1016/s0165-0327(00)00254-8openalex-snapshot
Is antidepressant–benzodiazepine combination therapy clinically more useful?
inferredcites →https://doi.org/10.1016/s0165-0327(01)00354-8openalex-snapshot
Suicide risk in patients with anxiety disorders: a meta-analysis of the FDA database
inferredcites →https://doi.org/10.1016/s0193-953x(18)30519-7openalex-snapshot
Late-Onset Depression
inferredcites →https://doi.org/10.1016/s0272-7358(01)00089-7openalex-snapshot
How effective are treatments for child and adolescent depression?
inferredcites →https://doi.org/10.1017/s0033291799001270openalex-snapshot
Safety of fluoxetine during the first trimester of pregnancy: a meta-analytical review of epidemiological studies
inferredcites →https://doi.org/10.1017/s0033291799001324openalex-snapshot
The efficacy of drug treatments for dysthymia: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1034/j.1600-0447.2002.02255.xopenalex-snapshot
SSRIs vs. TCAs in the treatment of panic disorder: a meta‐analysis
inferredcites →https://doi.org/10.1093/bmb/57.1.161openalex-snapshot
Meta-analytical studies on new antidepressants
inferredcites →https://doi.org/10.1093/geront/27.3.281openalex-snapshot
The Epidemiology of Depression in an Elderly Community Population
inferredcites →https://doi.org/10.1097/00004714-199004000-00008openalex-snapshot
Clomipramine versus Fluoxetine in Obsessive-Compulsive Disorder: A Retrospective Comparison of Side Effects and Efficacy
inferredcites →https://doi.org/10.1097/00004850-199206006-00006openalex-snapshot
Fluoxetine and Suicide
inferredcites →https://doi.org/10.1097/00004850-199400940-00003openalex-snapshot
How long to onset of antidepressant action
inferredcites →https://doi.org/10.1097/00004850-200008002-00004openalex-snapshot
The efficacy of the selective serotonin reuptake inhibitors for social anxiety disorder (social phobia): a meta-analysis of randomized controlled trials
inferredcites →https://doi.org/10.1097/00005053-199410000-00003openalex-snapshot
A Meta-Analysis of Fluoxetine Outcome in the Treatment of Depression
inferredcites →https://doi.org/10.1111/j.1532-5415.1986.tb04316.xopenalex-snapshot
Symptomatic Depression in Elderly Medical Outpatients
inferredcites →https://doi.org/10.1111/j.1600-0447.1984.tb02471.xopenalex-snapshot
Mortality among persons with depressive symptoms and among responders and non‐responders in a health check‐up
inferredcites →https://doi.org/10.1136/bmj.303.6804.685openalex-snapshot
Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression.
inferredcites →https://doi.org/10.1192/bjp.176.5.421openalex-snapshot
Meta-analysis of randomised controlled trials of fluoxetine v. placebo and tricyclic antidepressants in the short-term treatment of major depression
inferredcites →https://doi.org/10.1345/1542-6270(2002)036<0713:fittop>2.0.co;2openalex-snapshot
Fluoxetine in the Treatment of Premenstrual Dysphoric Disorder
inferredcites →https://doi.org/10.2105/ajph.84.11.1796openalex-snapshot
The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging.
inferredcites →https://doi.org/10.2165/00003495-200161010-00010openalex-snapshot
Fluoxetine
inferredcites →https://doi.org/10.2165/00019053-199813050-00007openalex-snapshot
Fluoxetine
inferredcites →https://doi.org/10.2165/00023210-200014040-00005openalex-snapshot
Fluoxetine
inferredcites →https://doi.org/10.3102/0013189x005010003openalex-snapshot
Primary, Secondary, and Meta-Analysis of Research
inferredcites →https://doi.org/10.4088/jcp.v61n1003openalex-snapshot
Efficacy, Adverse Events, and Treatment Discontinuations in Fluoxetine Clinical Studies of Major Depression
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Suicide, violent behaviour and fluoxetine

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Antidepressants: A Comprehensive Review of Molecular Mechanisms, US FDA Approvals Till 2025, Synthesis, Pharmacokinetics and Market Trends
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3 d Transition Metal‐Catalyzed Hydrogenation of Nitriles and Alkynes
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Repurposing autophagy regulators in brain tumors
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Fluoxetine‐induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15‐deoxy‐Δ12,14PGJ2
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Genotoxicity and DNA Damage in Long‐Term SSRI Therapy: A Review Across SSRIs With Citalopram as a Case Study
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Optimization of alcohol‐assisted dispersive liquid–liquid microextraction by experimental design for the rapid determination of fluoxetine in biological samples
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Serotonin Reuptake Inhibitors: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, and Sertraline
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Stress and Wound Healing
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Serotonin Reuptake Inhibitors: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, and Sertraline
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Selective Serotonin Reuptake Inhibitors (SSRIs)
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Citalopram versus fluoxetine for the treatment of patients with bulimia nervosa: A single-blind randomized controlled trial
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Hoe zoekt en beoordeelt u medische literatuur?
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Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains
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Inhibitory effects of fluoxetine, an antidepressant drug, on masseter muscle nociception at the trigeminal subnucleus caudalis and upper cervical spinal cord regions in a rat model of psychophysical stress
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Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray
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Changes in Patients’ Beliefs About the Causes of their Depression Following Successful Treatment
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Pre-weaning fluoxetine exposure caused anti-depressant like behavior at adulthood via perturbing tryptophan metabolism in rats
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Immunomodulatory and behavioral effects of ayahuasca and N, N-dimethyltryptamine in a rat model of lipopolysaccharide-induced depression
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Glabridin Improves Depression-Like Behaviors in Mice by Modulating Neuroinflammation via MAPK/NF-κB Signaling Pathway
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Histologic and Biomechanical Evaluation of the Effects of Social Stress and the Antidepressant Fluoxetine on Tendon Healing in Rats
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From In Vitro Genotoxicity Assays to Human Biomarkers: Interpreting DNA Damage Signals in Long-Term SSRI Therapy through a Translational Neurotoxicology Lens
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Sigma-1 Receptor Ligands for CNS Cancer Treatment
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Investigation of effects of fluoxetine on the bronchial smooth muscles by the isolated organ bath system
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Fluoxetine
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ANTIDEPRESSANTS
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Fluoxetine
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Development of a novel mixed hemimicelles dispersive micro solid phase extraction using 1-hexadecyl-3-methylimidazolium bromide coated magnetic graphene for the separation and preconcentration of fluoxetine in different matrices before its determination by fiber optic linear array…
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Ultrasound-assisted electromembrane extraction with supported semi-liquid membrane
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Quantitative structure property relationship study of postpartum depression medications using topological indices and regression models
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Effects of in vitro, acute and chronic treatment with fluoxetine on the sympathetic neurotransmission of rat vas deferens
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Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze
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Beneficial effects of combined administration of fluoxetine and mitochondria-targeted antioxidant at in behavioural and molecular studies in mice model of depression
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The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices
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The Impact of Psychological Stress on Wound Healing
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Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine
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Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer
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The effect of Fluoxetine on lipid profiles in overweight or obese Individuals: A systematic review and meta-analysis of randomized controlled trials
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Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline
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The Impact of Psychological Stress on Wound Healing: Methods and Mechanisms
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An approach to screen susceptible rats and efficacy of an antidepressive treatment after chronic stress
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Fluoxetine attenuates stress-induced depressive-like behavior through modulation of hippocampal GAP43 and neurogenesis in male rats
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Neuroprotective effects of cerium oxide nanoparticles on experimental stress-induced depression in male rats
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Study of the anodic behavior of sertraline and its quantification using carbon electrodes and pulse voltammetry techniques
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Recent advances in decarboxylative trifluoromethyl(thiol)ation of carboxylic acids
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Synthesis/characterization of molecular imprinted polymer based on magnetic chitosan/graphene oxide for selective separation/preconcentration of fluoxetine from environmental and biological samples
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Assessing adult zebrafish despair-like behaviors in the small vertical cylinder immobility test (VCIT)
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Real-world and clinical trial efficacy of selective serotonin-reuptake inhibitors in the treatment of obsessive-compulsive disorder measured by survey and meta-analysis
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Three-phase, liquid-phase microextraction combined with high performance liquid chromatography-fluorescence detection for the simultaneous determination of fluoxetine and norfluoxetine in human plasma
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Simultaneous determination of fluoxetine, venlafaxine, vortioxetine and their active metabolites in human plasma by LC–MS/MS using one-step sample preparation procedure
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A novel self-supportive thin film based on graphene oxide reinforced chitosan nano-biocomposite for thin film microextraction of fluoxetine in biological and environmental samples
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Fluoxetine and nortriptyline affect NTPDase and 5′-nucleotidase activities in rat blood serum
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Antidepressants as new endocrine disruptors? – transcriptomic profiling in gonads of Mytilus trossulus exposed to norfluoxetine
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Anatase-rutile-brookite: Structural and photocatalytic properties of TiO2 modified with different boron concentrations
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An innovative combination of molecular modeling and green analysis approaches for the enantioseparation and quantitation of certain CNS acting drugs using HPLC
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Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques
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A novel behavioral paradigm to measure anxiety-like behaviors in zebrafish by the concomitant assessment of geotaxis and scototaxis
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Tianeptine, olanzapine and fluoxetine show similar restoring effects on stress induced molecular changes in mice brain: An FT-IR study
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Recent advancement of carbon nanomaterials engrained molecular imprinted polymer for environmental matrix
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Impact of Extensive Plasma Protein Binding on the In Situ Hepatic Uptake and Clearance of Perampanel and Fluoxetine in Sprague Dawley Rats
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Role of 5-HT1A receptors in fluoxetine-induced lordosis inhibition
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Psychiatric Treatment Preferences for the Management of Postconcussion Symptoms
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Acute fluoxetine modulates emotional processing in young adult volunteers
inferred← citeshttps://doi.org/10.1017/s0033291722001805openalex-snapshot
Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
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Sequential Ring-Opening and Ring-Closing Reactions for Converting para-Substituted Pyridines into meta-Substituted Anilines
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The combined effects of memantine and fluoxetine on an animal model of obsessive compulsive disorder.
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Corticostriatal circuit defects in Hoxb8 mutant mice
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A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
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Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine
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A simple and automated online SPE-LC-MS/MS method for simultaneous determination of olanzapine, fluoxetine and norfluoxetine in human plasma and its application in therapeutic drug monitoring
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Fluoxetine during pregnancy: impact on fetal development
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Strategies for the detection, removal and elimination of antidepressants
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Sex-specific effects of psychoactive pollution on behavioral individuality and plasticity in fish
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The Distribution of Fluoxetine in Human Fluids and Tissues
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Fluoxetine Enhances Cutaneous Wound Healing in Chronically Stressed Wistar Rats
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Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting
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Acute Urinary Retention Developing After Fluoxetine Treatment
inferred← citeshttps://doi.org/10.1101/2025.10.25.684561openalex-snapshot
Is poor dose selection undermining the translational validity of antidepressant research involving animal models?
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Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility1
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Fluoxetine and Cocaine Induce the Epigenetic Factors MeCP2 and MBD1 in Adult Rat Brain
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Identification of the subventricular tegmental nucleus as brainstem reward center
inferred← citeshttps://doi.org/10.1126/scisignal.abc9089openalex-snapshot
Fluoxetine restrains allergic inflammation by targeting an FcɛRI-ATP positive feedback loop in mast cells
inferred← citeshttps://doi.org/10.1139/cjpp-2018-0390openalex-snapshot
Fluoxetine oral treatment discloses 5-HT1D receptor as vagoinhibitor of the cardiac cholinergic neurotransmission in rat
inferred← citeshttps://doi.org/10.1155/2019/4315038openalex-snapshot
Fluoxetine Attenuated Anxiety-Like Behaviors in Streptozotocin-Induced Diabetic Mice by Mitigating the Inflammation
inferred← citeshttps://doi.org/10.1176/appi.ajp.2018.17111282openalex-snapshot
Clinical Implementation of Pharmacogenetic Decision Support Tools for Antidepressant Drug Prescribing
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Chapter 4. Combined CBT and Psychopharmacology
inferred← citeshttps://doi.org/10.1177/2045125313490305openalex-snapshot
A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series
inferred← citeshttps://doi.org/10.1186/s12888-025-07441-8openalex-snapshot
The impact of fluoxetine on obesity and diabetes-related biomarkers in overweight and obese individuals: a systematic review and meta-analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.1186/s13256-022-03652-9openalex-snapshot
Fluoxetine for the treatment of onychotillomania associated with obsessive–compulsive disorder: a case report
inferred← citeshttps://doi.org/10.1186/s43088-021-00118-7openalex-snapshot
Antagonization of monoamine reuptake transporters by agmatine improves anxiolytic and locomotive behaviors commensurate with fluoxetine and methylphenidate
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Parotid salivary parameters in bulimic patients – a controlled clinical trial.
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Modeling of the Temporal Patterns of Fluoxetine Prescriptions and Suicide Rates in the United States
inferred← citeshttps://doi.org/10.1381/0960892055002301openalex-snapshot
Daily High Doses of Fluoxetine for Weight Loss and Improvement in Lifestyle before Bariatric Surgery
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Efficacy and safety of fluoxetine monotherapy in bipolar depression: a systematic review
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Testosterone boosters: a report of a supplement’s misleading labelling claims
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Pre-clinical assessment of genetic and neurobiochemical markers for depressive behavior and antidepressant response
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Investigation of the Genotoxic Effect of Fluoxetine Hydrochloride in Drosophila melanogaster
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Identification and Validation of Antidepressant Small Molecules Using Bioinformatics and Mouse Depression Models
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The Safety of Newer Antidepressants in Pregnancy and Breastfeeding
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Antidepressants and Antipsychotic Agents as Repurposable Oncological Drug Candidates
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Flow rates and inorganic composition of whole saliva in purging bulimic patients treated with a fluoxetine
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Parotid gland flow activity and inorganic composition in purging bulimic patients treated with fluoxetine
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Update on binge eating disorder: What general practitioners should know
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Acute Exposure to Fluoxetine Alters Aggressive Behavior of Zebrafish and Expression of Genes Involved in Serotonergic System Regulation
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Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice
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Emotional Blunting in Patients With Major Depressive Disorder: A Brief Non-systematic Review of Current Research
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Short-term outcomes associated with fluoxetine, low-frequency rTMS, and their combination in first-onset adolescent OCD: a single-center retrospective cohort
inferred← citeshttps://doi.org/10.3390/cells10040738openalex-snapshot
Antidepressant Screening Demonstrated Non-Monotonic Responses to Amitriptyline, Amoxapine and Sertraline in Locomotor Activity Assay in Larval Zebrafish
inferred← citeshttps://doi.org/10.3390/cells11193031openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/children9121878openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ddc3040037openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms20030757openalex-snapshot
Fluoxetine Induces Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits ERK/NF-κB-Modulated Anti-Apoptotic and Invasive Potential in Hepatocellular Carcinoma Cells In Vitro
inferred← citeshttps://doi.org/10.3390/ijms23105736openalex-snapshot
Fluoxetine Treatment Decreases Cardiac Vagal Input and Alters the Serotonergic Modulation of the Parasympathetic Outflow in Diabetic Rats
inferred← citeshttps://doi.org/10.3390/ijms25126542openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/neurolint13030038openalex-snapshot
Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review
inferred← citeshttps://doi.org/10.34248/bsengineering.1458736openalex-snapshot
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inferred← citeshttps://doi.org/10.37349/ent.2022.00023openalex-snapshot
The glymphatic system and subarachnoid hemorrhage: disruption and recovery
inferred← citeshttps://doi.org/10.4103/1673-5374.301031openalex-snapshot
Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke
inferred← citeshttps://doi.org/10.4103/cjp.cjp_39_21openalex-snapshot
Exercise-Induced Increases of Corticosterone Contribute to Exercise-Enhanced Adult Hippocampal Neurogenesis in Mice
inferred← citeshttps://doi.org/10.4103/ijaim.ijaim_29_24openalex-snapshot
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inferred← citeshttps://doi.org/10.4103/indianjpsychiatry_94_25openalex-snapshot
Fluoxetine induced cirrhosis of liver: A case report from India
inferred← citeshttps://doi.org/10.47134/scpr.v2i4.5268openalex-snapshot
Aktivitas Ekstrak Etanol 95% dari Daun Teh Putih (Camellia sinensis) Sebagai Antidepresan Pada Mencit Jantan
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inferred← citeshttps://doi.org/10.7759/cureus.116516openalex-snapshot
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