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Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases
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Outgoing claims: the papers this work cites, builds on, or argues with.
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STUDIES ON ARTHRITIS IN THE ARMY BASED ON FOUR HUNDRED CASES
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Neuroendocrine perturbations as a cause of insulin resistance
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Inadequately low serum levels of steroid hormones in relation to interleukin‐6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis
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Insulin resistance and impaired beta cell function in rheumatoid arthritis
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IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN
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Acute mental stress impairs insulin sensitivity in IDDM patients
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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
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Peripheral glucose metabolism in control subjects and diabetic patients during glucose, glucose-insulin and insulin sensitivity tests
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72-Hour perfusion of the isolated spleen at normothermia
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Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology
inferredcites →https://doi.org/10.1007/s00125-002-1024-1openalex-snapshot
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Hypothesis: muscle insulin resistance is the ("not-so") thrifty genotype
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Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness
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Clinical evaluation of insulin resistance and ?-cell function by the homeostasis model assessment in patients with systemic lupus erythematosus
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Influence of Caregiving on Lifestyle and Psychosocial Risk Factors Among Family Members of Patients Hospitalized with Cardiovascular Disease
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Novel “Thrifty” Models of Increased Eating Behaviour
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Human evolution and insulin-dependent (IDD) and non-insulin dependent diabetes (NIDD)
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Interleukin-6 levels in relation to psychosocial factors: Studies on serum, saliva, and in vitro production by blood mononuclear cells
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Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner
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The Origins and Drivers of Insulin Resistance
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Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
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Innate Immune Receptors: Key Regulators of Metabolic Disease Progression
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Genome-wide association studies of obesity and metabolic syndrome
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The selfish brain: competition for energy resources
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Cardiovascular, Inflammatory, and Metabolic Consequences of Sleep Deprivation
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Insulin resistance syndrome and autonomically mediated physiological responses to experimentally induced mental stress in adolescent boys
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THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS
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Substrate utilization/insulin resistance in sepsis/trauma
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Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet
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A frameshift mutation in human MC4R is associated with a dominant form of obesity
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Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system
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Congenital leptin deficiency is associated with severe early-onset obesity in humans
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Human gut microbes associated with obesity
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Inflammation and metabolic disorders
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Dynamics of fat cell turnover in humans
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Central nervous system control of metabolism
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
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The cellular and signaling networks linking the immune system and metabolism in disease
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Obesity, Inflammation, and Insulin Resistance
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The Treatment of Diabetes Mellitus
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Insulin Resistance and Bronze Diabetes
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Insulin Resistance — Mechanisms, Syndromes, and Implications
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Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus
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Chronic stress and age-related increases in the proinflammatory cytokine IL-6
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Shift Work and Metabolic Syndrome: Respective Impacts of Job Strain, Physical Activity, and Dietary Rhythms
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Prospective Effect of Job Strain on General and Central Obesity in the Whitehall II Study
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Psychosocial Stress and Change in Weight Among US Adults
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Mechanisms in Obesity-related Hypertension: Role of Insulin and Catecholamines
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Life Stress, Mood Disturbance, and Elevated Interleukin-6 in Healthy Older Women
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Caregiving, Metabolic Syndrome Indicators, and 1-year Decline in Walking Speed: Results of Caregiver-SOF
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Stressors Experienced by Relatives of Patients in an Innovative Rehabilitation Program
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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
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Acute Pain Induces Insulin Resistance in Humans
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Job Strain and Incident Metabolic Syndrome Over 5 Years of Follow-Up
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Endocrine Imbalance in Rheumatoid Arthritis and Rheumatoid Spondylitis: Hyperglycemia Unresponsiveness, Insulin Resistance, Increased Gluconeogenesis and Mesenchymal Tissue Degeneration
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Role of the Sympathetic Adrenal System in the Pathogenesis of the Insulin Resistance Syndrome
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The “Thrifty Genotype” in 19981
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Defect in Phosphorylation of Insulin Receptors in Cells from an Insulin-Resistant Patient with Normal Insulin Binding
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Cellular energy utilization and molecular origin of standard metabolic rate in mammals
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Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease
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Dose Effects of Recombinant Human lnterleukin-6 on Pituitary Hormone Secretion and Energy Expenditure
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Differences in Cardiovascular and Hypothalamic-Pituitary-Adrenal Axis Functions between High-Altitude Visitors and Natives during a Trek on the Annapurna Circuit
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Effect of Renal Sympathetic Denervation on Glucose Metabolism in Patients With Resistant Hypertension
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IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN
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Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes
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Insulin sensitivity: modulation by nutrients and inflammation
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Beneficial Antipsychotic Effects of Celecoxib Add-On Therapy Compared to Risperidone Alone in Schizophrenia
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Immediate and Sustained Psychological Impact of an Emerging Infectious Disease Outbreak on Health Care Workers
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Selection of the appropriate method for the assessment of insulin resistance
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Caregiving associated with selected cancer risk behaviors and screening utilization among women: cross-sectional results of the 2009 BRFSS
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Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance
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Stress, Obesity, and the Metabolic Syndrome
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Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis
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Adiposity Signaling and Biological Defense Against Weight Gain: Absence of Protection or Central Hormone Resistance?
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Sixty Years after Hench—Corticosteroids and Chronic Inflammatory Disease
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Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence
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STUDIES ON OBESITY I. THE INSULIN-GLUCOSE TOLERANCE CURVE
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Effects of Inhibition of Interleukin-6 Signalling on Insulin Sensitivity and Lipoprotein (A) Levels in Human Subjects with Rheumatoid Diseases
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Somatic Symptoms Evoked by Exam Stress in University Students: The Role of Alexithymia, Neuroticism, Anxiety and Depression
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Therapeutic Approaches to Target Inflammation in Type 2 Diabetes
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From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
inferredcites →https://doi.org/10.2337/dc06-1519openalex-snapshot
Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
inferredcites →https://doi.org/10.2337/dc07-1338openalex-snapshot
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
inferredcites →https://doi.org/10.2337/diab.35.3.258openalex-snapshot
Insulin Induces Progressive Insulin Resistance in Cultured Rat Adipocytes: Sequential Effects at Receptor and Multiple Postreceptor Sites
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Role of Insulin Resistance in Human Disease
inferredcites →https://doi.org/10.2337/diab.37.6.667openalex-snapshot
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
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Role of Cytokines in Inducing Hyperlipidemia
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Metabolic Syndrome and Robustness Tradeoffs
inferredcites →https://doi.org/10.2337/diacare.26.3.719openalex-snapshot
Work Stress and Low Sense of Coherence Is Associated With Type 2 Diabetes in Middle-Aged Swedish Women
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Role of Glucose Transport in the Postreceptor Defect of Non-insulin-dependent Diabetes Mellitus
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How the selfish brain organizes its supply and demand
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Neuroendocrine regulation of appetitive ingestive behavior
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The early programming of metabolic health: is epigenetic setting the missing link?
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Cutting Edge: Back to “One-Way” Germinal Centers
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Work stress in the etiology of coronary heart disease—a meta-analysis
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Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women
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INSULIN RESISTANCE IN SCHIZOPHRENIA
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Energy metabolism in animals and man
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The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Rehabilitation muskulärer, skelettaler und neurologischer Funktionsstörungen
inferred← citeshttps://doi.org/10.1016/b978-3-437-45422-6.00005-9openalex-snapshot
Rehabilitation muskulärer, skelettaler und neurologischer Funktionsstörungen
inferred← citeshttps://doi.org/10.1016/bs.apha.2015.03.005openalex-snapshot
Role of Cytochrome P450s in Inflammation
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.06.002openalex-snapshot
IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.ibmb.2019.04.005openalex-snapshot
Molecular regulations of metabolism during immune response in insects
inferred← citeshttps://doi.org/10.1016/j.metabol.2015.09.006openalex-snapshot
Short comment on “A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus”, by Yoona Kim, Jennifer Keogh, Peter Clifton
inferred← citeshttps://doi.org/10.1016/j.molmet.2026.102335openalex-snapshot
Interplay between obesity-associated insulin resistance and immune system through the lens of evolutionary medicine
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2016.11.010openalex-snapshot
Selfish brain and selfish immune system interplay: A theoretical framework for metabolic comorbidities of mood disorders
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.08.006openalex-snapshot
The immunological influence of physical exercise on TBI-induced pathophysiology: Crosstalk between the spleen, gut, and brain
inferred← citeshttps://doi.org/10.1016/j.obmed.2024.100561openalex-snapshot
The evolution of obesity and the origin of adipose tissue
inferred← citeshttps://doi.org/10.1016/j.plipres.2020.101049openalex-snapshot
The memory of the fatty acid system
inferred← citeshttps://doi.org/10.1016/j.redox.2016.10.007openalex-snapshot
Prevailing vitamin D status influences mitochondrial and glycolytic bioenergetics in peripheral blood mononuclear cells obtained from adults
inferred← citeshttps://doi.org/10.1016/j.tibs.2025.06.001openalex-snapshot
SAM cycle and adenosine at the heart of immune conversations
inferred← citeshttps://doi.org/10.1016/j.tibs.2026.02.007openalex-snapshot
Adenosine signals an imbalance between activity and supply in privileged cells
inferred← citeshttps://doi.org/10.1038/nrrheum.2017.172openalex-snapshot
The brain and immune system prompt energy shortage in chronic inflammation and ageing
inferred← citeshttps://doi.org/10.1038/s41584-024-01178-6openalex-snapshot
Rheumatic diseases and metabolism: where centre and periphery meet
inferred← citeshttps://doi.org/10.1038/s41598-025-28102-6openalex-snapshot
Association between triglyceride-glucose index and depression in middle-aged and older adults with hypertension: insights from the CHARLS study
inferred← citeshttps://doi.org/10.1055/a-1322-9936openalex-snapshot
Wechselwirkungen zwischen neuroendokrinem System und Immunsystem bei chronisch-entzündlichen Systemerkrankungen
inferred← citeshttps://doi.org/10.1055/a-1718-7573openalex-snapshot
Die Bedeutung von Lactoferrin im Sport – am Beispiel von Amateurfußballern
inferred← citeshttps://doi.org/10.1093/cvr/cvx227openalex-snapshot
Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice
inferred← citeshttps://doi.org/10.1093/emph/eow001openalex-snapshot
Chronic inflammatory systemic diseases – an evolutionary trade-off between acutely beneficial but chronically harmful programs
inferred← citeshttps://doi.org/10.1093/oso/9780198814153.003.0012openalex-snapshot
The Role of the Immune System from an Evolutionary Perspective
inferred← citeshttps://doi.org/10.1097/shk.0000000000000512openalex-snapshot
OBESITY AND CRITICAL ILLNESS
inferred← citeshttps://doi.org/10.1098/rsif.2022.0206openalex-snapshot
The transition between acute and chronic infections in light of energy control: a mathematical model of energy flow in response to infection
inferred← citeshttps://doi.org/10.1101/2020.09.24.311670openalex-snapshot
Macrophage-derived insulin/IGF antagonist ImpL2 regulates systemic metabolism for mounting an effective acute immune response in Drosophila
inferred← citeshttps://doi.org/10.1111/jch.14767openalex-snapshot
Association between triglyceride glucose index and depression in hypertensive population
inferred← citeshttps://doi.org/10.1136/annrheumdis-2015-eular.6376openalex-snapshot
AB0352 Diabetes Mellitus in Patients with Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.1155/2018/6712901openalex-snapshot
Favorable Effect of Anti-TNF Therapy on Insulin Sensitivity in Nonobese, Nondiabetic Patients with Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1159/000539531openalex-snapshot
Endocrine Aspects of Pain Pathophysiology: Focus on Adipose Tissue
inferred← citeshttps://doi.org/10.1159/000540959openalex-snapshot
A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases
inferred← citeshttps://doi.org/10.11606/t.59.2023.tde-01122023-152146openalex-snapshot
Tratamento sistêmico com canabidiol em ratos das linhagens Cariocas de alto e baixo congelamento no modelo de dor crônica: avaliação da dor, da ansiedade e da expressão de BDNF em áreas encefálicas
inferred← citeshttps://doi.org/10.1163/23524588-00001211openalex-snapshot
Transcriptomic response of Hermetia illucens L. (Diptera: Stratiomyidae) to wounding and Gram-negative bacterial infection
inferred← citeshttps://doi.org/10.1186/s12883-021-02198-5openalex-snapshot
The possible role of Interleukin-6 as a regulator of insulin sensitivity in patients with neuromyelitis optica spectrum disorder
inferred← citeshttps://doi.org/10.1186/s12888-018-1827-3openalex-snapshot
Hyperprolactinemia and insulin resistance in drug naive patients with early onset first episode psychosis
inferred← citeshttps://doi.org/10.1186/s12964-024-01575-0openalex-snapshot
JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
inferred← citeshttps://doi.org/10.1186/s13063-021-05146-3openalex-snapshot
A study protocol for a randomized controlled trial of an anti-inflammatory nutritional intervention in patients with fibromyalgia
inferred← citeshttps://doi.org/10.1186/s43166-025-00339-zopenalex-snapshot
Insulin resistance in non-diabetic premenopausal female patients with fibromyalgia: relation to disease characteristics
inferred← citeshttps://doi.org/10.12688/f1000research.12724.1openalex-snapshot
The sedentary (r)evolution: Have we lost our metabolic flexibility?
inferred← citeshttps://doi.org/10.12688/f1000research.12724.2openalex-snapshot
The sedentary (r)evolution: Have we lost our metabolic flexibility?
inferred← citeshttps://doi.org/10.1371/journal.pbio.1002135openalex-snapshot
Extracellular Adenosine Mediates a Systemic Metabolic Switch during Immune Response
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1010445openalex-snapshot
Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution
inferred← citeshttps://doi.org/10.1371/journal.ppat.1007022openalex-snapshot
Extracellular adenosine modulates host-pathogen interactions through regulation of systemic metabolism during immune response in Drosophila
inferred← citeshttps://doi.org/10.17116/kurort202410105166openalex-snapshot
«Selfish brain» theory: modern concept and practical use. (Literature review)
inferred← citeshttps://doi.org/10.18632/oncotarget.4685openalex-snapshot
Adenosine: a selfish-immunity signal?
inferred← citeshttps://doi.org/10.20524/aog.2016.0077openalex-snapshot
Adipokines and the role of visceral adipose tissue in inflammatory bowel disease
inferred← citeshttps://doi.org/10.21518/2079-701x-2022-16-10-84-95openalex-snapshot
Influence of gut microbiota on the development of insulin resistance
inferred← citeshttps://doi.org/10.2337/dc15-1585openalex-snapshot
The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell–Centric Classification Schema
inferred← citeshttps://doi.org/10.26481/dis.20231213xzopenalex-snapshot
Interplay of methylglyoxal and immune cells
inferred← citeshttps://doi.org/10.3389/fcell.2021.629238openalex-snapshot
Polarization of Macrophages in Insects: Opening Gates for Immuno-Metabolic Research
inferred← citeshttps://doi.org/10.3389/fendo.2018.00097openalex-snapshot
Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study
inferred← citeshttps://doi.org/10.3389/fendo.2019.00940openalex-snapshot
Why and How Imprinted Genes Drive Fetal Programming
inferred← citeshttps://doi.org/10.3389/fimmu.2023.905467openalex-snapshot
Immunometabolic regulation during the presence of microorganisms and parasitoids in insects
inferred← citeshttps://doi.org/10.3389/fnut.2026.1791821openalex-snapshot
Uncovering non-linear dietary predictors of cardiovascular disease risk in older adults with periodontitis: a cross-sectional analysis
inferred← citeshttps://doi.org/10.3389/fphys.2018.00224openalex-snapshot
Dai-Zong-Fang, A Traditional Chinese Herbal Formula, Ameliorates Insulin Resistance in db/db Mice
inferred← citeshttps://doi.org/10.3389/fpsyt.2020.00775openalex-snapshot
Glucose Metabolism, Thyroid Function, and Prolactin Level in Adolescent Patients With First Episode of Schizophrenia and Affective Disorders
inferred← citeshttps://doi.org/10.3389/fpsyt.2022.992988openalex-snapshot
Association of higher plasma leptin levels with HOMA-IR index, high sensitivity C-reactive protein and glycolipid metabolism in patients with chronic schizophrenia: A multi-center cross-sectional study
inferred← citeshttps://doi.org/10.3390/antiox14101189openalex-snapshot
fliC Mediates Pseudomonas plecoglossicida’s Hijack of Inflammatory Immunity and Glucose Metabolism in the Large Yellow Croaker
inferred← citeshttps://doi.org/10.3390/diseases11040164openalex-snapshot
Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.3390/ijms242316904openalex-snapshot
Energy Regulation in Inflammatory Sarcopenia by the Purinergic System
inferred← citeshttps://doi.org/10.3390/ijms26115206openalex-snapshot
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications
inferred← citeshttps://doi.org/10.3390/jcm14124021openalex-snapshot
Recognizing the Role of Insulin Resistance in Polycystic Ovary Syndrome: A Paradigm Shift from a Glucose-Centric Approach to an Insulin-Centric Model
inferred← citeshttps://doi.org/10.36076/ppj.2021.24.175-184openalex-snapshot
Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia
inferred← citeshttps://doi.org/10.4081/cc.2026.15921openalex-snapshot
To feed or to fast? Nutritional triggers in migraine: a narrative review
inferred← citeshttps://doi.org/10.4155/fsoa-2017-0015openalex-snapshot
Catabolic and Anabolic Faces of Insulin Resistance and their Disorders: A New Insight into Circadian Control of Metabolic Disorders Leading to Diabetes
inferred← citeshttps://doi.org/10.4236/fns.2019.101006openalex-snapshot
Energy Metabolism and Allocation in Selfish Immune System and Brain: A Beneficial Role of Insulin Resistance in Aging
inferred← citeshttps://doi.org/10.4239/wjd.v12.i3.238openalex-snapshot
Anti- and non-tumor necrosis factor-α-targeted therapies effects on insulin resistance in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
inferred← citeshttps://doi.org/10.5114/ceji.2017.67317openalex-snapshot
Differentiated all-trans retinoic acid response of naive CD4+CD25– cells isolated from rats with collagen-induced arthritis and healthy ones under in vitro conditions
inferred← citeshttps://doi.org/10.6084/m9.figshare.14190356openalex-snapshot
Additional file 1 of A study protocol for a randomized controlled trial of an anti-inflammatory nutritional intervention in patients with fibromyalgia
inferred← citeshttps://doi.org/10.6084/m9.figshare.14190359openalex-snapshot
Additional file 2 of A study protocol for a randomized controlled trial of an anti-inflammatory nutritional intervention in patients with fibromyalgia
inferred← citeshttps://doi.org/10.6084/m9.figshare.14190362openalex-snapshot
Additional file 3 of A study protocol for a randomized controlled trial of an anti-inflammatory nutritional intervention in patients with fibromyalgia
inferred← citeshttps://doi.org/10.6084/m9.figshare.14190365openalex-snapshot
Additional file 4 of A study protocol for a randomized controlled trial of an anti-inflammatory nutritional intervention in patients with fibromyalgia
inferred← citeshttps://doi.org/10.6084/m9.figshare.14456981openalex-snapshot
Additional file 1 of The possible role of Interleukin-6 as a regulator of insulin sensitivity in patients with neuromyelitis optica spectrum disorder
inferred← citeshttps://doi.org/10.6084/m9.figshare.25530154openalex-snapshot
Additional file 1 of JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
inferred← citeshttps://doi.org/10.6084/m9.figshare.25530364openalex-snapshot
Additional file 2 of JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
inferred← citeshttps://doi.org/10.7554/elife.105039openalex-snapshot
SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response
inferred← citeshttps://doi.org/10.7554/elife.105039.1openalex-snapshot
SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response
inferred← citeshttps://doi.org/10.7554/elife.105039.2openalex-snapshot
SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response
inferred← citeshttps://doi.org/10.7554/elife.105039.3openalex-snapshot
SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response
inferred← citeshttps://doi.org/10.7554/elife.50414openalex-snapshot
Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense
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