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Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice

https://doi.org/10.1210/en.2008-0999
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.291.14.1730openalex-snapshot
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
inferredcites →https://doi.org/10.1002/ptr.1398openalex-snapshot
Antidiabetic herbal drugs officially approved in China
inferredcites →https://doi.org/10.1002/ptr.2332openalex-snapshot
Cardioprotective effects of Astragali Radix against isoproterenol‐induced myocardial injury in rats and its possible mechanism
inferredcites →https://doi.org/10.1016/j.jep.2005.07.025openalex-snapshot
Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats
inferredcites →https://doi.org/10.1016/j.jep.2007.09.027openalex-snapshot
Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk
inferredcites →https://doi.org/10.1016/s0140-6736(02)09335-2openalex-snapshot
Adiponectin and development of type 2 diabetes in the Pima Indian population
inferredcites →https://doi.org/10.1038/90984openalex-snapshot
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
inferredcites →https://doi.org/10.1038/90992openalex-snapshot
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
inferredcites →https://doi.org/10.1038/nm1295openalex-snapshot
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms
inferredcites →https://doi.org/10.1038/nm724openalex-snapshot
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
inferredcites →https://doi.org/10.1038/nm788openalex-snapshot
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
inferredcites →https://doi.org/10.1038/nri1937openalex-snapshot
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
inferredcites →https://doi.org/10.1042/bj20071492openalex-snapshot
Post-translational modifications of adiponectin: mechanisms and functional implications
inferredcites →https://doi.org/10.1042/cs20070347openalex-snapshot
Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention
inferredcites →https://doi.org/10.1053/j.gastro.2007.03.059openalex-snapshot
Obesity, Inflammation, and Insulin Resistance
inferredcites →https://doi.org/10.1073/pnas.222657499openalex-snapshot
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation
inferredcites →https://doi.org/10.1073/pnas.98.4.2005openalex-snapshot
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
inferredcites →https://doi.org/10.1074/jbc.c200251200openalex-snapshot
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
inferredcites →https://doi.org/10.1074/jbc.c200362200openalex-snapshot
Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin
inferredcites →https://doi.org/10.1074/jbc.m200601200openalex-snapshot
Hydroxylation and Glycosylation of the Four Conserved Lysine Residues in the Collagenous Domain of Adiponectin
inferredcites →https://doi.org/10.1074/jbc.m311113200openalex-snapshot
Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity
inferredcites →https://doi.org/10.1074/jbc.m414231200openalex-snapshot
Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes
inferredcites →https://doi.org/10.1074/jbc.m505311200openalex-snapshot
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists
inferredcites →https://doi.org/10.1074/jbc.m505649200openalex-snapshot
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
inferredcites →https://doi.org/10.1128/mcb.00931-06openalex-snapshot
Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Mediated Protein Retention
inferredcites →https://doi.org/10.1128/mcb.02279-06openalex-snapshot
Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα
inferredcites →https://doi.org/10.1152/ajpendo.00187.2006openalex-snapshot
Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1969openalex-snapshot
Adiponectin Modulates the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway and Attenuates Mammary Tumorigenesis of MDA-MB-231 Cells in Nude Mice
inferredcites →https://doi.org/10.1159/000442721openalex-snapshot
European Guidelines for Obesity Management in Adults
inferredcites →https://doi.org/10.1161/01.hyp.0000222368.43759.a1openalex-snapshot
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension
inferredcites →https://doi.org/10.1172/jci17797openalex-snapshot
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
inferredcites →https://doi.org/10.1172/jci29044openalex-snapshot
AMP-activated protein kinase signaling in metabolic regulation
inferredcites →https://doi.org/10.1172/jci29126openalex-snapshot
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
inferredcites →https://doi.org/10.1210/en.2007-0370openalex-snapshot
Activation of Nuclear Factor-κB by High Molecular Weight and Globular Adiponectin
inferredcites →https://doi.org/10.1210/endo.143.3.8662openalex-snapshot
Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization
inferredcites →https://doi.org/10.1210/er.2006-0033openalex-snapshot
Adipose Tissue-Derived Factors: Impact on Health and Disease
inferredcites →https://doi.org/10.2337/db06-0506openalex-snapshot
Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease
inferredcites →https://doi.org/10.2337/db06-1405openalex-snapshot
Globular Adiponectin Activates Nuclear Factor-κB and Activating Protein-1 and Enhances Angiotensin II–Induced Proliferation in Cardiac Fibroblasts
inferredcites →https://doi.org/10.2337/diacare.26.7.2015openalex-snapshot
Decreased Serum Levels of Adiponectin Are a Risk Factor for the Progression to Type 2 Diabetes in the Japanese Population

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Secondary Metabolites of the Genus Astragalus: Structure and Biological‐Activity Update
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Therapeutic Potential of Common Culinary Herbs and Spices of Mauritius
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Modern Phytomedicine in Treating Diabetic Foot Ulcer: Progress and Opportunities
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Pharmacovigilance of Herbal Medicines for Lifestyle Diseases
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Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease
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Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction
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Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks
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Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes
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Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells
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Vascular Actions of Adipokines
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Screening for Adiponectin Secretion Regulators
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Adiponectin-mediated regulation of the adiponectin cascade in cardiovascular disease: Updates
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Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice
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Adiponectin signaling and its role in bone metabolism
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Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids
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Syzygium aqueum leaf extract and its bioactive compounds enhances pre-adipocyte differentiation and 2-NBDG uptake in 3T3-L1 cells
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Effects of Citrus depressa Hayata juice on high-fat diet-induced obesity in HBV transgenic mice
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A novel blood-based bioassay to monitor adiponectin signaling
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Systematic review of the renal protective effect of Astragalus membranaceus (root) on diabetic nephropathy in animal models
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Calycosin protects HUVECs from advanced glycation end products-induced macrophage infiltration
inferred← citeshttps://doi.org/10.1016/j.jep.2012.02.025openalex-snapshot
Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing
inferred← citeshttps://doi.org/10.1016/j.jep.2013.11.024openalex-snapshot
A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice
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Integrative traditional Chinese medicine therapy reduces the risk of diabetic ketoacidosis in patients with type 1 diabetes mellitus
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Yunpi Heluo decoction attenuates insulin resistance by regulating liver miR-29a-3p in Zucker diabetic fatty rats
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Potential antihyperglycaemic effect of myricetin derivatives from Syzygium malaccense
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Effects of delta-tocotrienol on obesity-related adipocyte hypertrophy, inflammation and hepatic steatosis in high-fat-fed mice
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154190openalex-snapshot
A saponin from astragalus promotes pancreatic ductal organoids differentiation into insulin-producing cells
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Molecules and targets of antidiabetic interest
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Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies
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4β-Hydroxywithanolide E isolated from Physalis pruinosa calyx decreases inflammatory responses by inhibiting the NF-κB signaling in diabetic mouse adipose tissue
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Recent discovery of plant-derived anti-diabetic natural products
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Isoastragaloside I suppresses LPS-induced tight junction disruption and monocyte adhesion on bEnd.3 cells via an activating Nrf2 antioxidant defense system
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Dietary methionine restriction improves glucose metabolism in the skeletal muscle of obese mice
inferred← citeshttps://doi.org/10.1055/a-1129-6785openalex-snapshot
Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.1055/s-010-46339openalex-snapshot
inferred← citeshttps://doi.org/10.1073/pnas.1415219111openalex-snapshot
Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin
inferred← citeshttps://doi.org/10.1074/jbc.m109.001107openalex-snapshot
Major Urinary Protein-1 Increases Energy Expenditure and Improves Glucose Intolerance through Enhancing Mitochondrial Function in Skeletal Muscle of Diabetic Mice
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Selected Functional Foods for Potential in Disease Treatment and Their Regulatory Issues
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The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity
inferred← citeshttps://doi.org/10.1111/dme.70162openalex-snapshot
Isoastragaloside I improves hyperglycaemia and increases β‐cell mass in mice
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Adiponectin and cardiovascular health: an update
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Obesity as the common soil of non‐alcoholic fatty liver disease and diabetes: Role of adipokines
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Roles of Adiponectin and Oxidative Stress in the Regulation of Membrane Microviscosity of Red Blood Cells in Hypertensive Men—An Electron Spin Resonance Study
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Recent Advances inAstragalus membranaceusAnti-Diabetic Research: Pharmacological Effects of Its Phytochemical Constituents
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Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity
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Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017
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Pharmacological Network Reveals the Active Mechanism of Qi‐Replenishing, Spleen‐Strengthening, Phlegm‐Dispelling, and Blood‐Nourishing Fufang on Coronary Heart Disease
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Radix Astragali and Its Representative Extracts for Diabetic Nephropathy: Efficacy and Molecular Mechanism
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Natural Triterpenoids for the Treatment of Diabetes Mellitus: A Review
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Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?
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The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity
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Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice
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Tissue-specific role and associated downstream signaling pathways of adiponectin
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Antioxidant, Antidiabetic and Chemical Composition of Syzygium Aqueum Leaf Extracts
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Calycosin Promotes Angiogenesis Involving Estrogen Receptor and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Zebrafish and HUVEC
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Insights into the Molecular Mechanisms of the Anti-Atherogenic Actions of Flavonoids in Normal and Obese Mice
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Characterisation of the relationship between Heme-oxygenase-1 and adiponectin
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Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications
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Botanical remedy for diabetes mellitus: Roadmap of last 10 years
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Dual PPAR-α/γ Activation by Algal Fiber-Rich NBF2 Formula Reverses Dyslipidemia and Hyperglycemia In Vivo
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Adiponectin as a potential biomarker of vascular disease
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Adiponectin, the Controversial Hormone
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Case Report of Type-1 Diabetes Mellitus with Uncontrolled Blood Sugar Improved by Complex Korean Medicine Treatment
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Astragale : Astragalus membranaceus Bunge (Fabaceae)
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Buyang Huanwu decoction affects gut microbiota and lipid metabolism in a ZDF rat model of co-morbid type 2 diabetes mellitus and obesity: An integrated metabolomics analysis
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Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases
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Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases
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Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito
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Herbal Medicine Ninjin'yoeito in the Treatment of Sarcopenia and Frailty
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Evaluation of Effect of Ninjin'yoeito on Regional Brain Glucose Metabolism by 18F-FDG Autoradiography With Insulin Loading in Aged Mice
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Yiqi Huoxue recipe ameliorates diabetic nephropathy by mediating VAPB–PTPIP51 complex to activate autophagy and regulate MAM contact
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Indapamide Increases IRS1 Expression and Modifies Adiponectin/NLRP3/PPARγ Crosstalk in Type 2 Diabetic Rats
inferred← citeshttps://doi.org/10.3390/biom15040533openalex-snapshot
The Flavonoids and Monoterpenes from Citrus unshiu Peel Contained in Ninjinyoeito Synergistically Activate Orexin 1 Receptor: A Possible Mechanism of the Orexigenic Effects of Ninjinyoeito
inferred← citeshttps://doi.org/10.3390/ijms18061321openalex-snapshot
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
inferred← citeshttps://doi.org/10.3390/ijms21093247openalex-snapshot
Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials
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Analysis of the Effects of Ninjin’yoeito on Physical Frailty in Mice
inferred← citeshttps://doi.org/10.3390/ijms251910828openalex-snapshot
NBF2, an Algal Fiber-Rich Formula, Reverses Diabetic Dyslipidemia and Hyperglycemia In Vivo
inferred← citeshttps://doi.org/10.3390/md15020032openalex-snapshot
Uncovering Adiponectin Replenishing Property of Sujiaonori Algal Biomaterial in Humans
inferred← citeshttps://doi.org/10.3390/molecules27051713openalex-snapshot
The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review
inferred← citeshttps://doi.org/10.3390/molecules30183721openalex-snapshot
Research Progress on Chemical Components of Astragalus membranaceus and Treatment of Metabolic Syndrome
inferred← citeshttps://doi.org/10.3390/ph19030352openalex-snapshot
Cycloartane-Type Saponins, Phytochemical-Rich Extracts, and Sub-Extracts from Astragalus noeanus Boiss. Exhibit In Vitro and In Silico Effects on Glucose Metabolism
inferred← citeshttps://doi.org/10.35248/2155-6156.19.10.824openalex-snapshot
Herbal Anti-Hyperglycemic Compound Increases Expression of Glucose Transporter Molecules in Diabetic Rats
inferred← citeshttps://doi.org/10.3831/kpi.2022.25.2.130openalex-snapshot
Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice
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Pollen Typhae total flavone improves insulin-induced glucose uptake through the β-arrestin-2-mediated signaling in C2C12 myotubes
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Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway
inferred← citeshttps://doi.org/10.3892/ijmm.2017.3114openalex-snapshot
Isoastragaloside I inhibits NF-κB activation and inflammatory responses in BV-2 microglial cells stimulated with lipopolysaccharide
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Network pharmacology-based study of the active constituents of Chinese medicinal formulae for antitumor mechanism
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Adiponectin serum level in chronic hepatitis C infection and therapeutic profile
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Ursolic acid and rosiglitazone combination prevent low-grade inflammation and hepatic insulin resistance by modulating cytokine expression in mice fed a high-fat diet
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