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Proteomic Analysis of Plasma in the Polycystic Ovary Syndrome Identifies Novel Markers Involved in Iron Metabolism, Acute-Phase Response, and Inflammation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archinte.166.19.2081openalex-snapshot
Prevalence and Characteristics of the Polycystic Ovary Syndrome in Overweight and Obese Women
inferredcites →https://doi.org/10.1002/elps.1150080203openalex-snapshot
Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels
inferredcites →https://doi.org/10.1002/pmic.200300681openalex-snapshot
Determining a significant change in protein expression with DeCyder™ during a pair‐wise comparison using two‐dimensional difference gel electrophoresis
inferredcites →https://doi.org/10.1002/pmic.200300830openalex-snapshot
SWISS‐2DPAGE, ten years later
inferredcites →https://doi.org/10.1007/s00216-005-3126-3openalex-snapshot
The development of the DIGE system: 2D fluorescence difference gel analysis technology
inferredcites →https://doi.org/10.1016/j.fertnstert.2003.10.004openalex-snapshot
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
inferredcites →https://doi.org/10.1016/j.fertnstert.2008.06.035openalex-snapshot
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
inferredcites →https://doi.org/10.1016/s0009-9120(01)00245-4openalex-snapshot
Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease☆
inferredcites →https://doi.org/10.1016/s0025-7125(16)31585-1openalex-snapshot
Disorders of Iron Metabolism
inferredcites →https://doi.org/10.1021/ac9806005openalex-snapshot
Modification of Cysteine Residues by Alkylation. A Tool in Peptide Mapping and Protein Identification
inferredcites →https://doi.org/10.1021/pr070124bopenalex-snapshot
Characterization of Biomarkers in Polycystic Ovary Syndrome (PCOS) Using Multiple Distinct Proteomic Platforms
inferredcites →https://doi.org/10.1056/nejm199912233412607openalex-snapshot
Disorders of Iron Metabolism
inferredcites →https://doi.org/10.1067/mob.2002.119180openalex-snapshot
Polycystic ovary syndrome: A risk for coronary artery disease?
inferredcites →https://doi.org/10.1093/brain/awl279openalex-snapshot
Proteome-based plasma biomarkers for Alzheimer's disease
inferredcites →https://doi.org/10.1093/humrep/deh098openalex-snapshot
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
inferredcites →https://doi.org/10.1093/humrep/dem380openalex-snapshot
Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry
inferredcites →https://doi.org/10.1093/humupd/dmn024openalex-snapshot
Functional genetic polymorphisms and female reproductive disorders: Part I: polycystic ovary syndrome and ovarian response
inferredcites →https://doi.org/10.1111/j.1471-0528.2008.02041.xopenalex-snapshot
Proteomic biomarkers for the diagnosis and risk stratification of polycystic ovary syndrome: a systematic review
inferredcites →https://doi.org/10.1172/jci200420945openalex-snapshot
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
inferredcites →https://doi.org/10.1210/er.2002-0010openalex-snapshot
Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
inferredcites →https://doi.org/10.1210/er.2003-0004openalex-snapshot
Polycystic Ovary Syndrome and Cardiovascular Disease: A Premature Association?
inferredcites →https://doi.org/10.1210/er.2004-0004openalex-snapshot
The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome
inferredcites →https://doi.org/10.1210/jc.2003-032046openalex-snapshot
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
inferredcites →https://doi.org/10.1210/jc.2005-2153openalex-snapshot
Diagnosis of Polycystic Ovarian Syndrome: The Rotterdam Criteria Are Premature
inferredcites →https://doi.org/10.1210/jc.2005-2501openalex-snapshot
Diagnosis of Polycystic Ovarian Syndrome: In Defense of the Rotterdam Criteria
inferredcites →https://doi.org/10.1210/jc.2006-0178openalex-snapshot
Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline
inferredcites →https://doi.org/10.1210/jc.2007-2053openalex-snapshot
A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia among Women Presenting with Hyperandrogenic Symptoms and Signs
inferredcites →https://doi.org/10.1210/jc.84.1.165openalex-snapshot
Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women
inferredcites →https://doi.org/10.1210/jc.84.11.4006openalex-snapshot
A Survey of the Polycystic Ovary Syndrome in the Greek Island of Lesbos: Hormonal and Metabolic Profile
inferredcites →https://doi.org/10.1210/jc.85.7.2434openalex-snapshot
A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain
inferredcites →https://doi.org/10.1210/jcem.84.1.5393openalex-snapshot
Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women1
inferredcites →https://doi.org/10.1210/jcem.85.7.6682openalex-snapshot
A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain1
inferredcites →https://doi.org/10.1371/journal.pone.0005606openalex-snapshot
Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women
inferredcites →https://doi.org/10.1385/1-59745-026-x:71openalex-snapshot
Two-Dimensional Difference Gel Electrophoresis
inferredcites →https://doi.org/10.2337/dc09-0420openalex-snapshot
Body Iron Stores and Glucose Intolerance in Premenopausal Women
inferredcites →https://doi.org/10.2337/diabetes.51.8.2348openalex-snapshot
Cross-Talk Between Iron Metabolism and Diabetes
inferredcites →https://doi.org/10.2337/diacare.22.1.141openalex-snapshot
Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
inferredcites →https://doi.org/10.2337/diacare.22.9.1462openalex-snapshot
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
inferredcites →https://doi.org/10.2337/diacare.28.8.2042openalex-snapshot
Body Iron Stores Are Increased in Overweight and Obese Women With Polycystic Ovary Syndrome

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4975832openalex-extracted
Discovery of Novel Protein Biomarkers for the Detection of Polycystic Ovary Syndrome
inferred← citeshttps://doi.org/10.1002/mas.21484openalex-snapshot
A mass spectrometric insight into the origins of benign gynecological disorders
inferred← citeshttps://doi.org/10.1007/978-1-4614-8394-6_11openalex-snapshot
Role of Statins in PCOS Management
inferred← citeshttps://doi.org/10.1007/978-3-030-92589-5_13openalex-snapshot
Role of Statins and Resveratrol in PCOS Management
inferred← citeshttps://doi.org/10.1007/978-981-99-2193-5_9openalex-snapshot
Polycystic Ovary Syndrome (PCOS): Clinical Features, Risk Factors, Biomarkers, Treatment, and Therapeutic Strategies
inferred← citeshttps://doi.org/10.1007/s10142-023-01053-9openalex-snapshot
Multi-omics insights and therapeutic implications in polycystic ovary syndrome: a review
inferred← citeshttps://doi.org/10.1007/s10815-017-1030-3openalex-snapshot
Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1007/s11306-014-0726-yopenalex-snapshot
Lipidomic analysis of plasma samples from women with polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1007/s11886-024-02050-5openalex-snapshot
Polycystic Ovary Syndrome, Insulin Resistance, and Cardiovascular Disease
inferred← citeshttps://doi.org/10.1007/s12020-023-03487-4openalex-snapshot
Effects and plasma proteomic analysis of GLP-1RA versus CPA/EE, in combination with metformin, on overweight PCOS women: a randomized controlled trial
inferred← citeshttps://doi.org/10.1007/s40618-017-0632-zopenalex-snapshot
Evaluation of serum hepcidin and iron levels in patients with PCOS: a case-control study
inferred← citeshttps://doi.org/10.1007/s43032-022-00863-9openalex-snapshot
Multiomics Analysis–Based Biomarkers in Diagnosis of Polycystic Ovary Syndrome
inferred← citeshttps://doi.org/10.1016/bs.acc.2019.04.005openalex-snapshot
Proteomics of reproduction: Prospects and perspectives
inferred← citeshttps://doi.org/10.1016/j.bbapap.2012.10.004openalex-snapshot
Proteomics in reproductive biology: Beacon for unraveling the molecular complexities
inferred← citeshttps://doi.org/10.1016/j.biochi.2025.09.015openalex-snapshot
Altered hemostatic dynamics and its regulation in follicular microenvironment of women with polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1016/j.fertnstert.2011.11.023openalex-snapshot
Is PCOS an inflammatory process?
inferred← citeshttps://doi.org/10.1016/j.fertnstert.2012.08.002openalex-snapshot
Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration
inferred← citeshttps://doi.org/10.1016/j.fertnstert.2012.10.050openalex-snapshot
Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring
inferred← citeshttps://doi.org/10.1016/j.mam.2020.100851openalex-snapshot
Haptoglobin: From hemoglobin scavenging to human health
inferred← citeshttps://doi.org/10.1016/j.mce.2012.07.001openalex-snapshot
A nontargeted proteomic approach to the study of visceral and subcutaneous adipose tissue in human obesity
inferred← citeshttps://doi.org/10.1016/j.mce.2013.02.009openalex-snapshot
Proteomic and metabolomic approaches to the study of polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1016/j.metabol.2017.03.002openalex-snapshot
Combining a nontargeted and targeted metabolomics approach to identify metabolic pathways significantly altered in polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1016/j.rbmo.2018.04.043openalex-snapshot
Distinct changes in the proteome profile of endometrial tissues in polycystic ovary syndrome compared with healthy fertile women
inferred← citeshttps://doi.org/10.1016/j.tem.2012.04.003openalex-snapshot
Iron metabolism and the polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1016/j.theriogenology.2023.09.012openalex-snapshot
Prolonged follicular dominance is associated with dysregulated proteomic profile of the follicular fluid in Bos indicus cows
inferred← citeshttps://doi.org/10.1021/acs.jproteome.9b00528openalex-snapshot
Glycoprotein A and B Height-to-Width Ratios as Obesity-Independent Novel Biomarkers of Low-Grade Chronic Inflammation in Women with Polycystic Ovary Syndrome (PCOS)
inferred← citeshttps://doi.org/10.1021/pr3000317openalex-snapshot
Metabonomics Reveals Plasma Metabolic Changes and Inflammatory Marker in Polycystic Ovary Syndrome Patients
inferred← citeshttps://doi.org/10.1038/pr.2012.182openalex-snapshot
Intestinal proteome changes during infant necrotizing enterocolitis
inferred← citeshttps://doi.org/10.1038/s41598-019-54067-4openalex-snapshot
Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics
inferred← citeshttps://doi.org/10.1039/c1mb05107eopenalex-snapshot
A proteomic approach to identify plasma proteins in patients with abdominal aortic aneurysm
inferred← citeshttps://doi.org/10.1042/bsr20212234openalex-snapshot
Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues
inferred← citeshttps://doi.org/10.1093/hropen/hoag080openalex-snapshot
Multi-omics factor analysis v2 (MOFA+) reveals specific co-variation patterns in women with PMOS that are strongly influenced by obesity
inferred← citeshttps://doi.org/10.1093/molehr/gas029openalex-snapshot
Metabolomic biomarkers in women with polycystic ovary syndrome: a pilot study
inferred← citeshttps://doi.org/10.1097/gco.0000000000000619openalex-snapshot
Mitochondrial function in women with polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1111/aji.13644openalex-snapshot
Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial
inferred← citeshttps://doi.org/10.1186/s12902-019-0486-9openalex-snapshot
PCOS without hyperandrogenism is associated with higher plasma Trimethylamine N-oxide levels
inferred← citeshttps://doi.org/10.1186/s12902-025-02113-wopenalex-snapshot
Dysregulated iron metabolism related to ferroptosis in polycystic ovary syndrome: a meta-analysis and a case-control study in pregnant women
inferred← citeshttps://doi.org/10.1186/s12958-016-0173-xopenalex-snapshot
Genetic, hormonal and metabolic aspects of PCOS: an update
inferred← citeshttps://doi.org/10.1186/s13048-024-01562-6openalex-snapshot
Link between iron-mediated lipid peroxidation and polycystic ovary syndrome (PCOS): exploring the genes underlying iron regulatory mechanism
inferred← citeshttps://doi.org/10.1186/s13048-025-01698-zopenalex-snapshot
a1-antitrypsin, a new biomarker of polycystic ovary syndrome by changing its expression and rhythm
inferred← citeshttps://doi.org/10.1186/s13048-025-01703-5openalex-snapshot
Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women
inferred← citeshttps://doi.org/10.1186/s13048-025-01711-5openalex-snapshot
Fatty acid metabolism of granulose cells and follicular fluid and their associations with embryo quality in normal-weight women with PCOS
inferred← citeshttps://doi.org/10.1210/jc.2012-3438openalex-snapshot
A Nontargeted Proteomic Study of the Influence of Androgen Excess on Human Visceral and Subcutaneous Adipose Tissue Proteomes
inferred← citeshttps://doi.org/10.1371/journal.pone.0044929openalex-snapshot
Antibiotics Increase Gut Metabolism and Antioxidant Proteins and Decrease Acute Phase Response and Necrotizing Enterocolitis in Preterm Neonates
inferred← citeshttps://doi.org/10.1371/journal.pone.0053801openalex-snapshot
Proteomic Biomarkers of Preterm Birth Risk in Women with Polycystic Ovary Syndrome (PCOS): A Systematic Review and Biomarker Database Integration
inferred← citeshttps://doi.org/10.1371/journal.pone.0100902openalex-snapshot
Identification of Reduced Circulating Haptoglobin Concentration as a Biomarker of the Severity of Pulmonary Embolism: A Nontargeted Proteomic Study
inferred← citeshttps://doi.org/10.1373/clinchem.2011.176396openalex-snapshot
Metabolic Heterogeneity in Polycystic Ovary Syndrome Is Determined by Obesity: Plasma Metabolomic Approach Using GC-MS
inferred← citeshttps://doi.org/10.1515/tjb-2018-0088openalex-snapshot
Association of oxidative stress marker ischemia modified albumin and polycystic ovary syndrome in adolescent and young girls
inferred← citeshttps://doi.org/10.1530/eje-12-0718openalex-snapshot
MECHANISMS IN ENDOCRINOLOGY: Proteomic biomarkers of type 2 diabetes mellitus risk in women with polycystic ovary syndrome
inferred← citeshttps://doi.org/10.15380/2277-5706.jcsr.12.002openalex-snapshot
Body iron status and association with hyperinsulinaemia and hyperandrogenism in non-obese Indian women with polycystic ovarian syndrome
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Therapeutic potentials of the caffeine in polycystic ovary syndrome in a rat model
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Proteomics and polycystic ovary syndrome
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3667534/v1openalex-snapshot
Causal association of metabolites and polycystic ovarian syndrome: A Mendelian randomization study
inferred← citeshttps://doi.org/10.2169/internalmedicine.55.6265openalex-snapshot
Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance
inferred← citeshttps://doi.org/10.23736/s2724-6507.20.03199-5openalex-snapshot
Untargeted metabolomics analysis of serum and follicular fluid samples from women with polycystic ovary syndrome
inferred← citeshttps://doi.org/10.2478/enr-2018-0026openalex-snapshot
Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review
inferred← citeshttps://doi.org/10.25207/1608-6228-2019-26-2-162-172openalex-snapshot
PATHOGENETIC ASPECTS OF METABOLIC SYNDROME IN WOMEN OF REPRODUCTIVE AGE (A LITERATURE REVIEW)
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Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration
inferred← citeshttps://doi.org/10.3109/09513590.2013.871520openalex-snapshot
Validation of proteomic biomarkers previously found to be differentially expressed in women with Polycystic Ovary Syndrome: a cross-sectional study
inferred← citeshttps://doi.org/10.3275/8108openalex-snapshot
Application of proteomics to the study of polycystic ovary syndrome.
inferred← citeshttps://doi.org/10.3389/fendo.2019.00821openalex-snapshot
TMT Based Proteomic Analysis of Human Follicular Fluid From Overweight/Obese and Normal-Weight Patients With Polycystic Ovary Syndrome
inferred← citeshttps://doi.org/10.3389/fendo.2025.1652178openalex-snapshot
Shared senescence-associated gene networks in PCOS and T2DM: biomarker identification and functional validation
inferred← citeshttps://doi.org/10.3390/jcm10173879openalex-snapshot
Remission of Diabetes Following Bariatric Surgery: Plasma Proteomic Profiles
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Biomarker-Guided Dietary Supplementation: A Narrative Review of Precision in Personalized Nutrition
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Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome.
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Apolipoprotein A1 as a novel anti-implantation biomarker in polycystic ovary syndrome: A case-control study
inferred← citeshttps://doi.org/10.4103/2305-0500.298775openalex-snapshot
Overexpression of tyrosine phosphorylated proteins in reproductive tissues of polycystic ovary syndrome rats induced by letrozole
inferred← citeshttps://doi.org/10.60037/edu.v1i15.1202openalex-snapshot
Assessment of Erythropoietin, Testosterone, hepcidin and many hematological parameters in polycystic ovary women in Kirkuk city
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