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2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
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Glucagon-related peptides in the human gastrointestinal mucosa
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Circulating glucagon after total pancreatectomy in man
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Peptide YY release after intraduodenal, intraileal, and intracolonic administration of nutrients in rats
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Characterization of N‐acylphosphatidylethanolamine and acylphosphatidylglycerol in oats
inferredcites →https://doi.org/10.1016/0006-2952(95)00109-dopenalex-snapshot
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
inferredcites →https://doi.org/10.1016/0163-7827(90)90004-5openalex-snapshot
N-Acylated glycerophospholipids and their derivatives
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Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man
inferredcites →https://doi.org/10.1016/j.bbalip.2005.12.011openalex-snapshot
Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors
inferredcites →https://doi.org/10.1016/j.bbalip.2008.01.006openalex-snapshot
Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine
inferredcites →https://doi.org/10.1016/j.bbrc.2004.11.120openalex-snapshot
Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor
inferredcites →https://doi.org/10.1016/j.bbrc.2005.01.139openalex-snapshot
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
inferredcites →https://doi.org/10.1016/j.bcp.2009.04.024openalex-snapshot
N-acylethanolamines, anandamide and food intake
inferredcites →https://doi.org/10.1016/j.cmet.2006.02.004openalex-snapshot
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
inferredcites →https://doi.org/10.1016/j.cmet.2008.08.005openalex-snapshot
The Lipid Messenger OEA Links Dietary Fat Intake to Satiety
inferredcites →https://doi.org/10.1016/j.cmet.2010.04.014openalex-snapshot
Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses
inferredcites →https://doi.org/10.1016/j.cmet.2010.05.008openalex-snapshot
An Enteroendocrine Full Package Solution
inferredcites →https://doi.org/10.1016/j.metabol.2009.07.039openalex-snapshot
Effects of meal size and composition on incretin, α-cell, and β-cell responses
inferredcites →https://doi.org/10.1016/j.phrs.2003.12.006openalex-snapshot
Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration
inferredcites →https://doi.org/10.1016/j.phrs.2003.12.022openalex-snapshot
Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration
inferredcites →https://doi.org/10.1016/j.physbeh.2004.07.031openalex-snapshot
Fat in the intestine as a regulator of appetite—role of CCK
inferredcites →https://doi.org/10.1016/j.plipres.2004.03.002openalex-snapshot
Occurrence, metabolism, and prospective functions of N-acylethanolamines in plants
inferredcites →https://doi.org/10.1016/j.pneurobio.2010.07.003openalex-snapshot
Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
inferredcites →https://doi.org/10.1016/s0009-3084(02)00068-3openalex-snapshot
Chemical stability of 2-arachidonylglycerol under biological conditions
inferredcites →https://doi.org/10.1016/s0021-9258(18)46908-6openalex-snapshot
Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.
inferredcites →https://doi.org/10.1016/s0022-2275(20)31496-6openalex-snapshot
Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal
inferredcites →https://doi.org/10.1016/s0163-7827(03)00050-xopenalex-snapshot
The digestion of dietary triacylglycerols
inferredcites →https://doi.org/10.1016/s0167-0115(03)00111-3openalex-snapshot
Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
inferredcites →https://doi.org/10.1016/s0167-0115(03)00125-3openalex-snapshot
GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
inferredcites →https://doi.org/10.1017/s0954422409369267openalex-snapshot
Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats: an overview and implications for cardiovascular disease
inferredcites →https://doi.org/10.1017/s146239940900132xopenalex-snapshot
Molecular mechanisms underlying nutrient-stimulated incretin secretion
inferredcites →https://doi.org/10.1038/284033a0openalex-snapshot
Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK
inferredcites →https://doi.org/10.1038/nm.1937openalex-snapshot
Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding
inferredcites →https://doi.org/10.1038/nm1168openalex-snapshot
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
inferredcites →https://doi.org/10.1039/c000237bopenalex-snapshot
Characterization of mice lacking candidate N -acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo
inferredcites →https://doi.org/10.1073/pnas.061029898openalex-snapshot
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB 1 receptor
inferredcites →https://doi.org/10.1074/jbc.274.5.2794openalex-snapshot
Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor
inferredcites →https://doi.org/10.1074/jbc.m601203200openalex-snapshot
Prohormone Convertase 1/3 Is Essential for Processing of the Glucose-dependent Insulinotropic Polypeptide Precursor
inferredcites →https://doi.org/10.1074/jbc.m707807200openalex-snapshot
Anandamide Biosynthesis Catalyzed by the Phosphodiesterase GDE1 and Detection of Glycerophospho-N-acyl Ethanolamine Precursors in Mouse Brain
inferredcites →https://doi.org/10.1079/nrr19880008openalex-snapshot
Nutrient Regulation of the Enteroinsular Axis And Insulin Secretion
inferredcites →https://doi.org/10.1080/00365521.1979.12562648openalex-snapshot
Peptidergic and Adrenergic Innervation of Pancreatic Ganglia
inferredcites →https://doi.org/10.1093/clinchem/44.5.991openalex-snapshot
Accurate measurement of cholecystokinin in plasma
inferredcites →https://doi.org/10.1096/fj.10-166595openalex-snapshot
Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor
inferredcites →https://doi.org/10.1124/mol.109.055244openalex-snapshot
Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients
inferredcites →https://doi.org/10.1124/pr.110.003004openalex-snapshot
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
inferredcites →https://doi.org/10.1126/science.1470919openalex-snapshot
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
inferredcites →https://doi.org/10.1146/annurev.nutr.012809.104701openalex-snapshot
The Endocannabinoid System and Its Relevance for Nutrition
inferredcites →https://doi.org/10.1152/ajpendo.90233.2008openalex-snapshot
Incretin and islet hormonal responses to fat and protein ingestion in healthy men
inferredcites →https://doi.org/10.1152/physrev.00034.2006openalex-snapshot
The Physiology of Glucagon-like Peptide 1
inferredcites →https://doi.org/10.1172/jci115012openalex-snapshot
Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.
inferredcites →https://doi.org/10.1172/jci116186openalex-snapshot
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.
inferredcites →https://doi.org/10.1177/153537020322800301openalex-snapshot
Recent Developments in Our Understanding of the Physiological Role of PP-Fold Peptide Receptor Subtypes
inferredcites →https://doi.org/10.1189/jlb.0508330openalex-snapshot
OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca2+ entry
inferredcites →https://doi.org/10.1194/jlr.c300008-jlr200openalex-snapshot
Food intake is inhibited by oral oleoylethanolamide
inferredcites →https://doi.org/10.1210/en.133.1.233openalex-snapshot
Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop
inferredcites →https://doi.org/10.1210/en.2006-1403openalex-snapshot
Protein Kinase Cζ Is Required for Oleic Acid-Induced Secretion of Glucagon-Like Peptide-1 by Intestinal Endocrine L Cells
inferredcites →https://doi.org/10.1210/en.2006-1608openalex-snapshot
A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release
inferredcites →https://doi.org/10.1210/en.2007-0966openalex-snapshot
A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release
inferredcites →https://doi.org/10.1210/en.2008-1162openalex-snapshot
Coingestion of Acylglycerols Differentially Affects Glucose-Induced Insulin Secretion via Glucose-Dependent Insulinotropic Polypeptide in C57BL/6J Mice
inferredcites →https://doi.org/10.1210/jc.2009-1062openalex-snapshot
Role of Fat Hydrolysis in Regulating Glucagon-Like Peptide-1 Secretion
inferredcites →https://doi.org/10.1210/jc.85.10.3575openalex-snapshot
Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide
inferredcites →https://doi.org/10.1210/jc.87.3.1239openalex-snapshot
Effects of Glucagon-Like Peptide 1 on Counterregulatory Hormone Responses, Cognitive Functions, and Insulin Secretion during Hyperinsulinemic, Stepped Hypoglycemic Clamp Experiments in Healthy Volunteers
inferredcites →https://doi.org/10.1210/jcem-65-3-395openalex-snapshot
Physiological Concentrations of Cholecystokinin Stimulate Amino Acid-Induced Insulin Release in Humans*
inferredcites →https://doi.org/10.1210/jcem-70-5-1312openalex-snapshot
Regulation of Pancreatic Endocrine Function by Cholecystokinin: Studies with MK-329, a Nonpeptide Cholecystokinin Receptor Antagonist*
inferredcites →https://doi.org/10.1210/jcem.85.10.6855openalex-snapshot
Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide1
inferredcites →https://doi.org/10.1210/me.2009-0239openalex-snapshot
N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119
inferredcites →https://doi.org/10.1515/cclm.1988.26.11.783openalex-snapshot
A General Regression Procedure for Method Transformation. Application of Linear Regression Procedures for Method Comparison Studies in Clinical Chemistry, Part III
inferredcites →https://doi.org/10.2214/ajr.145.5.1009openalex-snapshot
Sonographic measurement of gallbladder volume
inferredcites →https://doi.org/10.2337/db08-1237openalex-snapshot
GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell
inferredcites →https://doi.org/10.2337/diab.43.4.535openalex-snapshot
Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans
inferredcites →https://doi.org/10.31579/2834-8761/cemopenalex-snapshot
Clinical Endocrinology and Metabolism
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Enhanced Monoacylglycerol Lipolysis by ABHD6 Promotes NSCLC Pathophysiology
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inferred← citeshttps://doi.org/10.1002/biof.1189openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/biof.1303openalex-snapshot
Oral 2‐oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor
inferred← citeshttps://doi.org/10.1002/cphy.c170044openalex-snapshot
Interactions of Gut Endocrine Cells with Epithelium and Neurons
inferred← citeshttps://doi.org/10.1002/cphy.c170047openalex-snapshot
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract
inferred← citeshttps://doi.org/10.1002/cphy.c180013openalex-snapshot
Physiology of the Incretin Hormones, GIP and GLP ‐1—Regulation of Release and Posttranslational Modifications
inferred← citeshttps://doi.org/10.1002/ejlt.201400004openalex-snapshot
Scalable synthesis of highly pure 2‐monoolein by enzymatic ethanolysis
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2018.tb00035.xopenalex-snapshot
Interactions of Gut Endocrine Cells with Epithelium and Neurons
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2018.tb00048.xopenalex-snapshot
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2019.tb00092.xopenalex-snapshot
Physiology of the Incretin Hormones, GIP and GLP ‐1—Regulation of Release and Posttranslational Modifications
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2‐Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC ‐1 cells via cannabinoid receptor CB1
inferred← citeshttps://doi.org/10.1002/lipd.12341openalex-snapshot
2‐Arachidonoyl glycerol suppresses gastric emptying via the cannabinoid receptor 1‐cholecystokinin signaling pathway in mice
inferred← citeshttps://doi.org/10.1002/mnfr.202200192openalex-snapshot
Colonic Delivery of Nutrients for Sustained and Prolonged Release of Gut Peptides: A Novel Strategy for Appetite Management
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Endocannabinoids and related lipids in serum from patients with amyotrophic lateral sclerosis
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Involvement of the vagus nerve in the anorectic effect of monoacylglycerol acyltransferase 2 inhibition in mice
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Druggable Lipid GPCRs: Past, Present, and Prospects
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The Endocannabinoid System: A Dynamic Signalling System at the Crossroads Between Metabolism and Disease
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Low-temperature synthesis of di- and monoolein by enzymatic hydrolysis in a biphasic system using cutinase from Fusarium graminearum
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Fatty acid composition in 2-monoacylglycerol modulates GLP-1 secretion
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Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
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From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
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Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans
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G-Protein-Coupled Receptors in Intestinal Chemosensation
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Molecular mechanisms of incretin hormone secretion
inferred← citeshttps://doi.org/10.1016/j.coph.2013.09.008openalex-snapshot
Gut microbiota, enteroendocrine functions and metabolism
inferred← citeshttps://doi.org/10.1016/j.coph.2016.08.010openalex-snapshot
Neuroendocrine peptide mechanisms controlling intestinal epithelial function
inferred← citeshttps://doi.org/10.1016/j.coph.2022.102189openalex-snapshot
GLP-1 – Incretin and pleiotropic hormone with pharmacotherapy potential. Increasing secretion of endogenous GLP-1 for diabetes and obesity therapy
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.07.009openalex-snapshot
Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy
inferred← citeshttps://doi.org/10.1016/j.ebiom.2020.102696openalex-snapshot
Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115584openalex-snapshot
Discovery of orally active sulfonylphenyl thieno[3,2-d]pyrimidine derivatives as GPR119 agonists
inferred← citeshttps://doi.org/10.1016/j.ejphar.2015.06.031openalex-snapshot
Sustained wash-resistant receptor activation responses of GPR119 agonists
inferred← citeshttps://doi.org/10.1016/j.ejphar.2015.08.051openalex-snapshot
Fatty acids, endocannabinoids and inflammation
inferred← citeshttps://doi.org/10.1016/j.foodchem.2019.125218openalex-snapshot
Food database of N-acyl-phosphatidylethanolamines, N-acylethanolamines and endocannabinoids and daily intake from a Western, a Mediterranean and a vegetarian diet
inferred← citeshttps://doi.org/10.1016/j.foodchem.2025.146247openalex-snapshot
Effects of fermentation, ripening and storage on endocannabinoids and endocannabinoid-like compounds in different cheeses
inferred← citeshttps://doi.org/10.1016/j.foodres.2025.116926openalex-snapshot
Formation of endocannabinoids and endocannabinoid-like compounds in sausages: Effect of fermentation, heat treatment and storage
inferred← citeshttps://doi.org/10.1016/j.gastha.2024.07.006openalex-snapshot
Cannabinoids Block Fat-induced Incretin Release via CB1-dependent and CB1-independent Pathways in Intestinal Epithelium
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114660openalex-snapshot
Oleoylethanolamide ameliorates collagen-induced rheumatoid arthritis via activation of GPR119
inferred← citeshttps://doi.org/10.1016/j.jare.2026.01.083openalex-snapshot
Human milk fat substitutes improve obesity-related NAFLD by enriching LPC 18:2 to activate hepatic GPR119–AMPK signaling
inferred← citeshttps://doi.org/10.1016/j.jff.2019.103656openalex-snapshot
Characterization of seaweed hypoglycemic property with integration of virtual screening for identification of bioactive compounds
inferred← citeshttps://doi.org/10.1016/j.jlr.2025.100754openalex-snapshot
Deleting adipose FXR exacerbates metabolic defects and induces endocannabinoid lipid, 2-oleoyl glycerol, in obesity
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2013.05.005openalex-snapshot
The modulatory role of high fat feeding on gastrointestinal signals in obesity
inferred← citeshttps://doi.org/10.1016/j.jpain.2014.09.006openalex-snapshot
Mechanisms of Exercise-Induced Hypoalgesia
inferred← citeshttps://doi.org/10.1016/j.mam.2018.01.002openalex-snapshot
The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite
inferred← citeshttps://doi.org/10.1016/j.metabol.2012.06.010openalex-snapshot
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function
inferred← citeshttps://doi.org/10.1016/j.micres.2026.128749openalex-snapshot
The gut–pancreas axis in chronic pancreatitis: Microbiota–endogenous GLP-1 interactions and candidate repair pathways
inferred← citeshttps://doi.org/10.1016/j.molcatb.2014.11.014openalex-snapshot
Effective and highly selective lipase-mediated synthesis of 2-monoolein and 1,2-diolein in a two-phase system
inferred← citeshttps://doi.org/10.1016/j.molmed.2012.07.009openalex-snapshot
The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity
inferred← citeshttps://doi.org/10.1016/j.molmed.2019.07.003openalex-snapshot
Targeting GPCRs Activated by Fatty Acid-Derived Lipids in Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2011.11.065openalex-snapshot
Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol
inferred← citeshttps://doi.org/10.1016/j.peptides.2015.06.012openalex-snapshot
Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells
inferred← citeshttps://doi.org/10.1016/j.peptides.2015.08.001openalex-snapshot
Regulation of gut hormone secretion. Studies using isolated perfused intestines
inferred← citeshttps://doi.org/10.1016/j.pharmr.2025.100070openalex-snapshot
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2017.02.033openalex-snapshot
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2022.108238openalex-snapshot
Bile acid metabolism and signaling, the microbiota, and metabolic disease
inferred← citeshttps://doi.org/10.1016/j.phrs.2014.03.006openalex-snapshot
Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.04.015openalex-snapshot
Where’s my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.04.020openalex-snapshot
Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain
inferred← citeshttps://doi.org/10.1016/j.phrs.2018.09.025openalex-snapshot
Multiple target tissue effects of GLP-1 analogues on non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105822openalex-snapshot
Pharmacological and structure-activity relationship studies of oleoyl-lysophosphatidylinositol synthetic mimetics
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106237openalex-snapshot
Revisiting the concept of incretin and enteroendocrine L-cells as type 2 diabetes mellitus treatment
inferred← citeshttps://doi.org/10.1016/j.physbeh.2011.12.001openalex-snapshot
Nutrient detection by incretin hormone secreting cells
inferred← citeshttps://doi.org/10.1016/j.physbeh.2021.113315openalex-snapshot
Post-oral fat-induced satiation is mediated by endogenous CCK and GLP-1 in a fat self-administration mouse model
inferred← citeshttps://doi.org/10.1016/j.physbeh.2025.114929openalex-snapshot
The endocannabinoid and paracannabinoid systems in natural reward processes: possible pharmacological targets?
inferred← citeshttps://doi.org/10.1016/j.plipres.2016.02.002openalex-snapshot
Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders
inferred← citeshttps://doi.org/10.1016/j.plipres.2016.08.004openalex-snapshot
Evolution of the diacylglycerol lipases
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2015.07.001openalex-snapshot
Therapeutic potential of cannabis-related drugs
inferred← citeshttps://doi.org/10.1016/j.tem.2012.11.006openalex-snapshot
Nutrient sensing in the gut: new roads to therapeutics?
inferred← citeshttps://doi.org/10.1016/j.ygeno.2025.111006openalex-snapshot
Multiple omics analysis reveals the regulation of SIRT4 on lipid deposition and metabolism during the differentiation of bovine preadipocytes
inferred← citeshttps://doi.org/10.1016/s2213-8587(21)00113-3openalex-snapshot
Treatment of type 2 diabetes: challenges, hopes, and anticipated successes
inferred← citeshttps://doi.org/10.1017/s0007114513002286openalex-snapshot
Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing
inferred← citeshttps://doi.org/10.1017/s0029665112000110openalex-snapshot
Nutrient sensing and signalling by the gut
inferred← citeshttps://doi.org/10.1017/s0029665112000705openalex-snapshot
The gut endocrine system as a coordinator of postprandial nutrient homoeostasis
inferred← citeshttps://doi.org/10.1017/s1751731119001861openalex-snapshot
Link between intestinal immunity and practical approaches to swine nutrition
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.6b00871openalex-snapshot
A Mechanistic Study on Nanoparticle-Mediated Glucagon-Like Peptide-1 (GLP-1) Secretion from Enteroendocrine L Cells
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.3c00263openalex-snapshot
Lysophosphatidylcholines Enriched with cis and trans Palmitoleic Acid Regulate Insulin Secretion via GPR119 Receptor
inferred← citeshttps://doi.org/10.1021/jm301626popenalex-snapshot
Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119
inferred← citeshttps://doi.org/10.1038/ijo.2014.10openalex-snapshot
Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes
inferred← citeshttps://doi.org/10.1038/ijo.2015.172openalex-snapshot
Intestinal GLP-1 and satiation: from man to rodents and back
inferred← citeshttps://doi.org/10.1038/ijo.2016.199openalex-snapshot
Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet
inferred← citeshttps://doi.org/10.1038/ijosup.2016.6openalex-snapshot
Interactions between gut microbes and host cells control gut barrier and metabolism
inferred← citeshttps://doi.org/10.1038/nature23874openalex-snapshot
Commensal bacteria make GPCR ligands that mimic human signalling molecules
inferred← citeshttps://doi.org/10.1038/ncomms6648openalex-snapshot
Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
inferred← citeshttps://doi.org/10.1038/nrd.2015.4openalex-snapshot
G protein-coupled receptors as targets for anti-diabetic therapeutics
inferred← citeshttps://doi.org/10.1038/nrgastro.2012.185openalex-snapshot
Ghrelin, the proglucagon-derived peptides and peptide YY in nutrient homeostasis
inferred← citeshttps://doi.org/10.1038/s12276-021-00677-wopenalex-snapshot
Role of the gut–brain axis in energy and glucose metabolism
inferred← citeshttps://doi.org/10.1038/s41387-017-0011-zopenalex-snapshot
Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes
inferred← citeshttps://doi.org/10.1038/s41401-023-01215-2openalex-snapshot
GPCRs involved in metabolic diseases: pharmacotherapeutic development updates
inferred← citeshttps://doi.org/10.1038/s41467-022-34696-6openalex-snapshot
Activation and signaling mechanism revealed by GPR119-Gs complex structures
inferred← citeshttps://doi.org/10.1038/s41467-023-35861-1openalex-snapshot
Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol
inferred← citeshttps://doi.org/10.1038/s41574-026-01278-1openalex-snapshot
Lipid sensing and brain hormone receptors in food intake and glucose regulation
inferred← citeshttps://doi.org/10.1038/s41574-026-01289-yopenalex-snapshot
Endocannabinoids and related lipids in host metabolism–gut microbiome signalling
inferred← citeshttps://doi.org/10.1038/s42004-025-01589-wopenalex-snapshot
Chemoproteomics identifies protein ligands for monoacylglycerol lipids
inferred← citeshttps://doi.org/10.1038/s42255-020-00327-xopenalex-snapshot
Metabolic Messengers: glucagon-like peptide 1
inferred← citeshttps://doi.org/10.1039/9781788016070-00241openalex-snapshot
Cannabinoids as a Therapeutic Approach in Multiple Sclerosis
inferred← citeshttps://doi.org/10.1039/c4fo00032copenalex-snapshot
Dietary sweet potato ( Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1)
inferred← citeshttps://doi.org/10.1039/c7fo01772copenalex-snapshot
Salivary endocannabinoids and N -acylethanolamines upon mastication of a semisolid food: implications in fat taste, appetite and food liking
inferred← citeshttps://doi.org/10.1039/c9fo02205hopenalex-snapshot
N -Acylphosphatidylethanolamines and N -acylethanolamines increase in saliva upon food mastication: the influence of the individual nutritional status and fat type in food
inferred← citeshttps://doi.org/10.1039/d5fo03328dopenalex-snapshot
Dietary N -acylethanolamines are bioaccessible in the small intestine and modulate postprandial hormonal responses: a randomized crossover trial in subjects with ileostomy
inferred← citeshttps://doi.org/10.1042/cs20150154openalex-snapshot
The regulation of function, growth and survival of GLP-1-producing L-cells
inferred← citeshttps://doi.org/10.1073/pnas.1219451110openalex-snapshot
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
inferred← citeshttps://doi.org/10.1074/jbc.m113.473579openalex-snapshot
Liver Fatty Acid-binding Protein Binds Monoacylglycerol in Vitro and in Mouse Liver Cytosol
inferred← citeshttps://doi.org/10.1080/10408398.2022.2045894openalex-snapshot
Akkermansia muciniphila : from its critical role in human health to strategies for promoting its abundance in human gut microbiome
inferred← citeshttps://doi.org/10.1080/10409238.2020.1768207openalex-snapshot
Retinol-binding protein 2 (RBP2): biology and pathobiology
inferred← citeshttps://doi.org/10.1093/ajcn/nqz272openalex-snapshot
Intestinal sensing and handling of dietary lipids in gastric bypass–operated patients and matched controls
inferred← citeshttps://doi.org/10.1093/ecco-jcc/jjy185openalex-snapshot
Cannabis, Cannabinoids, and the Endocannabinoid System—Is there Therapeutic Potential for Inflammatory Bowel Disease?
inferred← citeshttps://doi.org/10.1093/ibd/izz217openalex-snapshot
Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases
inferred← citeshttps://doi.org/10.1096/fj.201801203ropenalex-snapshot
Monoacylglycerol lipase deficiency affects diet‐induced obesity, fat absorption, and feeding behavior in CB 1 cannabinoid receptor–deficient mice
inferred← citeshttps://doi.org/10.1097/in9.0000000000000087openalex-snapshot
Tissue-specific roles of monoacylglycerol (MAG) in metabolic diseases
inferred← citeshttps://doi.org/10.1097/mco.0000000000000027openalex-snapshot
The endocannabinoid system
inferred← citeshttps://doi.org/10.1097/mco.0b013e32834f4598openalex-snapshot
G-protein-coupled receptors as fat sensors
inferred← citeshttps://doi.org/10.1097/med.0000000000000614openalex-snapshot
Chemosensing in enteroendocrine cells: mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.1099/jmm.0.001435openalex-snapshot
The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis
inferred← citeshttps://doi.org/10.1101/2021.07.09.451829openalex-snapshot
Monoacylglycerol disrupts Golgi structure and perilipin 2 association with lipid droplets
inferred← citeshttps://doi.org/10.1101/2023.01.30.526249openalex-snapshot
Plasma and Liver Lipids are Differentially Regulated After Cannabinoid Treatments in Male and Female Mice
inferred← citeshttps://doi.org/10.1101/2024.12.22.629584openalex-snapshot
Chemical Proteomics Identifies Protein Ligands for Monoacylglycerol Lipids
inferred← citeshttps://doi.org/10.1111/1750-3841.13246openalex-snapshot
Valorization of Olive Pomace Oil with Enzymatic Synthesis of 2‐Monoacylglycerol
inferred← citeshttps://doi.org/10.1111/1753-0407.12439openalex-snapshot
The incretin hormone GLP‐1 and mechanisms underlying its secretion
inferred← citeshttps://doi.org/10.1111/bph.14175openalex-snapshot
Non‐endocannabinoid N‐acylethanolamines and 2‐monoacylglycerols in the intestine
inferred← citeshttps://doi.org/10.1111/bph.15603openalex-snapshot
Reappraising the role of the vagus nerve in GLP‐1‐mediated regulation of eating
inferred← citeshttps://doi.org/10.1111/dom.13008openalex-snapshot
Monoacylglycerol signalling and ABHD6 in health and disease
inferred← citeshttps://doi.org/10.1111/dom.13062openalex-snapshot
Therapeutic application of GPR119 ligands in metabolic disorders
inferred← citeshttps://doi.org/10.1111/febs.12152openalex-snapshot
Metabolism of endocannabinoids and related N ‐acylethanolamines: Canonical and alternative pathways
inferred← citeshttps://doi.org/10.1111/ijfs.14247openalex-snapshot
Effect of food ingredients on glucagon‐like peptide‐1 secretion in STC‐1 and HuTu‐80 cells
inferred← citeshttps://doi.org/10.1111/j.1476-5381.2012.01951.xopenalex-snapshot
Peripheral neural targets in obesity
inferred← citeshttps://doi.org/10.1111/jam.14911openalex-snapshot
A review of a potential and promising probiotic candidate— Akkermansia muciniphila
inferred← citeshttps://doi.org/10.1111/joim.13433openalex-snapshot
Glucagon‐like peptide‐1: Are its roles as endogenous hormone and therapeutic wizard congruent?
inferred← citeshttps://doi.org/10.1113/jphysiol.2014.285635openalex-snapshot
Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2‐monoacylglycerol
inferred← citeshttps://doi.org/10.1124/jpet.118.250019openalex-snapshot
DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats
inferred← citeshttps://doi.org/10.1124/pr.112.007179openalex-snapshot
International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands
inferred← citeshttps://doi.org/10.1126/sciadv.aay8937openalex-snapshot
Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight
inferred← citeshttps://doi.org/10.1128/mbio.02032-23openalex-snapshot
Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases
inferred← citeshttps://doi.org/10.1134/s1068162025602502openalex-snapshot
Nonclassical Cannabinoid Receptors: Modern Concepts of Signal Transmission Functions and Mechanisms
inferred← citeshttps://doi.org/10.1134/s1990750814030093openalex-snapshot
Pathogenesis of insulin resistance in metabolic obesity
inferred← citeshttps://doi.org/10.1136/gutjnl-2023-330301openalex-snapshot
Human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice
inferred← citeshttps://doi.org/10.1146/annurev-nutr-043020-090216openalex-snapshot
Roles of Endocannabinoids and Endocannabinoid-Like Molecules in Energy Homeostasis and Metabolic Regulation: A Nutritional Perspective
inferred← citeshttps://doi.org/10.1146/annurev-nutr-062320-113625openalex-snapshot
Glucose-Dependent Insulinotropic Polypeptide—A Postprandial Hormone with Unharnessed Metabolic Potential
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010818-021441openalex-snapshot
Beyond THC and Endocannabinoids
inferred← citeshttps://doi.org/10.1152/ajpendo.00116.2012openalex-snapshot
Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells
inferred← citeshttps://doi.org/10.1152/ajpendo.00269.2012openalex-snapshot
Regulation of GPR119 receptor activity with endocannabinoid-like lipids
inferred← citeshttps://doi.org/10.1152/ajpgi.00075.2015openalex-snapshot
The role of apolipoprotein A-IV in regulating glucagon-like peptide-1 secretion
inferred← citeshttps://doi.org/10.1152/ajpgi.00275.2020openalex-snapshot
GPCRs get fatty: the role of G protein-coupled receptor signaling in the development and progression of nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1152/ajpgi.00457.2011openalex-snapshot
Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents
inferred← citeshttps://doi.org/10.1152/ajpheart.00641.2012openalex-snapshot
Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease
inferred← citeshttps://doi.org/10.1152/ajpregu.00106.2021openalex-snapshot
Acyloxyacyl hydrolase is a host determinant of gut microbiome-mediated pelvic pain
inferred← citeshttps://doi.org/10.1152/physrev.00057.2024openalex-snapshot
Proglucagon-derived peptides: human physiology and therapeutic potential
inferred← citeshttps://doi.org/10.1155/2012/379024openalex-snapshot
Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions
inferred← citeshttps://doi.org/10.1155/2015/651757openalex-snapshot
Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1
inferred← citeshttps://doi.org/10.1155/jfq/4997835openalex-snapshot
Marine‐Derived Antioxidants for Sesame Oil: Investigating the Functional Benefits of Sargassum bovianum Extract
inferred← citeshttps://doi.org/10.1159/000475736openalex-snapshot
Enteroendocrine Cells: Metabolic Relays between Microbes and Their Host
inferred← citeshttps://doi.org/10.1159/000513376openalex-snapshot
1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats
inferred← citeshttps://doi.org/10.1172/jci76302openalex-snapshot
Intestinal lipid–derived signals that sense dietary fat
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