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Repinotan, a Selective 5-HT1A-R-Agonist, Antagonizes Morphine-Induced Ventilatory Depression in Anesthetized Rats

https://doi.org/10.1213/ane.0b013e3181eac011

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What this work says

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Serotonin, the periaqueductal gray and panic

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Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT

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In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia

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The effect of 5-HT1A receptor stimulation on nociceptive dorsal horn neurones in rats

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5-HT1A Agonists Induce Central Cholinergic Antinociception

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The BRAINS Study: Safety, Tolerability, and Dose-finding of Repinotan in Acute Stroke

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The Partial 5-Hydroxytryptamine1A Receptor Agonist Buspirone does not Antagonize Morphine-induced Respiratory Depression in Humans

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Neuroprotective Efficacy of Repinotan HCl, a 5-HT1A Receptor Agonist, in Animal Models of Stroke and Traumatic Brain Injury

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Intrathecal Amitriptyline

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High-Efficacy 5-Hydroxytryptamine 1A Receptor Activation Counteracts Opioid Hyperallodynia and Affective Conditioning

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Buspirone Treatment for Apneustic Breathing in Brain Stem Infarct

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Sources of Inspiration: A Neurophysiologic Framework for Understanding Anesthetic Effects on Ventilatory Control

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Selective 5-HT1A-R-agonist Repinotan Prevents Remifentanil-induced Ventilatory Depression and Prolongs Antinociception

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Advances in attenuating opioid-induced respiratory depression: A narrative review

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