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The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ana.23599openalex-snapshot
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination
inferredcites →https://doi.org/10.1002/ana.23815openalex-snapshot
Adoptive regulatory T‐cell therapy protects against cerebral ischemia
inferredcites →https://doi.org/10.1002/glia.23456openalex-snapshot
Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery
inferredcites →https://doi.org/10.1006/nimg.2002.1267openalex-snapshot
Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water
inferredcites →https://doi.org/10.1007/978-3-540-73677-6_8openalex-snapshot
Remyelination in Experimental Models of Toxin-Induced Demyelination
inferredcites →https://doi.org/10.1007/s10519-015-9714-xopenalex-snapshot
IL-4 Knock Out Mice Display Anxiety-Like Behavior
inferredcites →https://doi.org/10.1016/1043-4666(94)90014-0openalex-snapshot
Cytokines in liposomes: Preliminary studies with IL-1, IL-2, IL-6, GM-CSF and interferon-γ
inferredcites →https://doi.org/10.1016/j.bbamcr.2014.04.018openalex-snapshot
Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination
inferredcites →https://doi.org/10.1016/j.brainres.2015.02.019openalex-snapshot
The axon–glia unit in white matter stroke: Mechanisms of damage and recovery
inferredcites →https://doi.org/10.1016/j.chom.2015.11.002openalex-snapshot
Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
inferredcites →https://doi.org/10.1016/j.expneurol.2005.07.014openalex-snapshot
Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and functional recovery following traumatic brain injury
inferredcites →https://doi.org/10.1016/j.expneurol.2015.03.017openalex-snapshot
Demyelination as a rational therapeutic target for ischemic or traumatic brain injury
inferredcites →https://doi.org/10.1016/j.immuni.2010.11.009openalex-snapshot
STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells
inferredcites →https://doi.org/10.1016/j.jconrel.2014.06.053openalex-snapshot
Quantitative analysis of drug delivery to the brain via nasal route
inferredcites →https://doi.org/10.1016/j.neuroscience.2010.04.070openalex-snapshot
Oligodendrocyte degeneration and recovery after focal cerebral ischemia
inferredcites →https://doi.org/10.1016/j.pneurobio.2016.04.005openalex-snapshot
White matter injury in ischemic stroke
inferredcites →https://doi.org/10.1016/j.pneurobio.2017.10.002openalex-snapshot
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
inferredcites →https://doi.org/10.1016/s0165-5728(97)00154-9openalex-snapshot
Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion
inferredcites →https://doi.org/10.1016/s0264-410x(97)00111-4openalex-snapshot
Effect of IL-4 and IL-12 liposomal formulations on the induction of immune response to bovine herpesvirus type-1 glycoprotein D
inferredcites →https://doi.org/10.1038/cddis.2017.256openalex-snapshot
The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke
inferredcites →https://doi.org/10.1038/jcbfm.2010.134openalex-snapshot
Ascl1 Lineage Cells Contribute to Ischemia-Induced Neurogenesis and Oligodendrogenesis
inferredcites →https://doi.org/10.1038/ncomms9518openalex-snapshot
Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors
inferredcites →https://doi.org/10.1038/nm1279openalex-snapshot
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
inferredcites →https://doi.org/10.1038/nn.3469openalex-snapshot
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
inferredcites →https://doi.org/10.1038/nrn.2017.136openalex-snapshot
Regenerating CNS myelin — from mechanisms to experimental medicines
inferredcites →https://doi.org/10.1038/s41593-018-0120-6openalex-snapshot
Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain
inferredcites →https://doi.org/10.1073/pnas.1615322113openalex-snapshot
Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice
inferredcites →https://doi.org/10.1073/pnas.1810693115openalex-snapshot
Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury
inferredcites →https://doi.org/10.1074/jbc.m412170200openalex-snapshot
Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus
inferredcites →https://doi.org/10.1074/jbc.m500403200openalex-snapshot
Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor γ-mediated Adipogenesis through Histone Deacetylase Recruitment
inferredcites →https://doi.org/10.1084/jem.20091419openalex-snapshot
Regulation of learning and memory by meningeal immunity: a key role for IL-4
inferredcites →https://doi.org/10.1084/jem.20101880openalex-snapshot
Tissue plasminogen activator prevents white matter damage following stroke
inferredcites →https://doi.org/10.1093/brain/aww254openalex-snapshot
IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation
inferredcites →https://doi.org/10.1097/00004647-200303000-00001openalex-snapshot
Oligodendrocytes and Ischemic Brain Injury
inferredcites →https://doi.org/10.1097/nen.0b013e3181aba2c1openalex-snapshot
Peroxisome Proliferator-Activated Receptor-γ Agonists Promote Differentiation and Antioxidant Defenses of Oligodendrocyte Progenitor Cells
inferredcites →https://doi.org/10.1111/j.1468-1331.2010.03228.xopenalex-snapshot
Functional polymorphisms of interleukin 4 and interleukin 10 may predict evolution and functional outcome of an ischaemic stroke
inferredcites →https://doi.org/10.1111/jnc.13745openalex-snapshot
The oligodendrocyte‐specific antibody ‘ CC 1’ binds Quaking 7
inferredcites →https://doi.org/10.1126/science.1252304openalex-snapshot
Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain
inferredcites →https://doi.org/10.1126/scitranslmed.aao2304openalex-snapshot
Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation
inferredcites →https://doi.org/10.1161/strokeaha.108.521906openalex-snapshot
Clinical Prediction of Functional Outcome After Ischemic Stroke
inferredcites →https://doi.org/10.1161/strokeaha.110.593772openalex-snapshot
Increased Brain Injury and Worsened Neurological Outcome in Interleukin-4 Knockout Mice After Transient Focal Cerebral Ischemia
inferredcites →https://doi.org/10.1161/strokeaha.112.659656openalex-snapshot
Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia
inferredcites →https://doi.org/10.1161/strokeaha.115.010091openalex-snapshot
Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia
inferredcites →https://doi.org/10.1161/strokeaha.115.012079openalex-snapshot
Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia
inferredcites →https://doi.org/10.1172/jci76210openalex-snapshot
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
inferredcites →https://doi.org/10.1172/jci82458openalex-snapshot
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
inferredcites →https://doi.org/10.1172/jci97229openalex-snapshot
Microglia are required for protection against lethal coronavirus encephalitis in mice
inferredcites →https://doi.org/10.1177/0271678x19830791openalex-snapshot
TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia
inferredcites →https://doi.org/10.1186/s13041-017-0307-xopenalex-snapshot
An updated assessment of microglia depletion: current concepts and future directions
inferredcites →https://doi.org/10.1385/jmn:14:3:191openalex-snapshot
Reduced IL-2 But Elevated IL-4, IL-6, and IgE Serum Levels in Patients with Cerebral Infarction During the Acute Stage
inferredcites →https://doi.org/10.1523/jneurosci.1685-15.2015openalex-snapshot
Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage
inferredcites →https://doi.org/10.1523/jneurosci.22-07-02451.2002openalex-snapshot
The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation
inferredcites →https://doi.org/10.1523/jneurosci.2568-14.2015openalex-snapshot
Chronic Oligodendrogenesis and Remyelination after Spinal Cord Injury in Mice and Rats
inferredcites →https://doi.org/10.1523/jneurosci.2615-05.2006openalex-snapshot
Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
inferredcites →https://doi.org/10.1523/jneurosci.3411-10.2010openalex-snapshot
NG2 Glia Generate New Oligodendrocytes But Few Astrocytes in a Murine Experimental Autoimmune Encephalomyelitis Model of Demyelinating Disease
inferredcites →https://doi.org/10.2217/iim.13.49openalex-snapshot
Diffusion tensor MRI as a biomarker in axonal and myelin damage
inferredcites →https://doi.org/10.2741/513openalex-snapshot
Focal cerebral ischemia activates neurovascular restorative dynamics in mouse brain
inferredcites →https://doi.org/10.2741/e513openalex-snapshot
Focal cerebral ischemia activates neurovascular restorative dynamics in mouse brain
inferredcites →https://doi.org/10.4049/jimmunol.1202246openalex-snapshot
IL-4 in the Brain: A Cytokine To Remember
inferredcites →https://doi.org/10.4049/jimmunol.176.7.4385openalex-snapshot
IL-4-Induced Peroxisome Proliferator-Activated Receptor γ Activation Inhibits NF-κB Trans Activation in Central Nervous System (CNS) Glial Cells and Protects Oligodendrocyte Progenitors under Neuroinflammatory Disease Conditions: Implication for CNS-Demyelinating Diseases
inferredcites →https://doi.org/10.4238/2013.may.13.2openalex-snapshot
Association of variable number of tandem repeat polymorphism in the IL-4 gene with ischemic stroke in the Chinese Uyghur population

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The impact of trophic and immunomodulatory factors on oligodendrocyte maturation: Potential treatments for encephalopathy of prematurity
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inferred← citeshttps://doi.org/10.1007/s10571-021-01145-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10616-020-00395-7openalex-snapshot
Interleukin-4 suppresses the proliferation and alters the gene expression in enteroids
inferred← citeshttps://doi.org/10.1007/s12031-021-01851-5openalex-snapshot
Therapeutic Potential of Cytokines in Demyelinating Lesions After Stroke
inferred← citeshttps://doi.org/10.1007/s12035-021-02568-7openalex-snapshot
Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide
inferred← citeshttps://doi.org/10.1007/s12035-026-06003-7openalex-snapshot
IL-4 in Alzheimer’s Disease—Mechanisms and Therapeutic Potential
inferred← citeshttps://doi.org/10.1007/s12264-023-01068-zopenalex-snapshot
Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models
inferred← citeshttps://doi.org/10.1007/s12975-022-01121-5openalex-snapshot
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis
inferred← citeshttps://doi.org/10.1007/s43440-025-00737-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-822522-6.00027-8openalex-snapshot
Quantitative and qualitative analysis of direct nose-to-brain drug delivery
inferred← citeshttps://doi.org/10.1016/j.actbio.2021.04.017openalex-snapshot
Tissue-specific parameters for the design of ECM-mimetic biomaterials
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102866openalex-snapshot
Application of Traditional Chinese Medicine in the different pathological stages of ischemic stroke: Target immune cells
inferred← citeshttps://doi.org/10.1016/j.bbi.2023.09.015openalex-snapshot
Low-dose ionizing radiation promotes motor recovery and brain rewiring by resolving inflammatory response after brain injury and stroke
inferred← citeshttps://doi.org/10.1016/j.bbi.2026.106568openalex-snapshot
IL-4/IL-4Rα signaling activates PPARγ to promote oligodendrocyte differentiation and remyelination
inferred← citeshttps://doi.org/10.1016/j.bbi.2026.107060openalex-snapshot
Anti-inflammatory IL-4 shapes the architecture of presynaptic glutamatergic puncta of human and murine sensory neurons for pain sensitivity
inferred← citeshttps://doi.org/10.1016/j.bbih.2020.100185openalex-snapshot
Early chronic systemic inflammation and associations with cognitive performance after moderate to severe TBI
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.119653openalex-snapshot
Retinoic acid-loaded NFL-lipid nanocapsules promote oligodendrogenesis in focal white matter lesion
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2025.123574openalex-snapshot
Engineered peripheral CD4 T cells delivery across the BBB promote intracerebral Treg conversion unleashes microglial phagocytotic activity for Alzheimer's disease treatment
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114815openalex-snapshot
Alpha-asaronol promoted oligodendrocyte precursor cell differentiation and improved myelination as an activator PPARγ
inferred← citeshttps://doi.org/10.1016/j.brainres.2024.149106openalex-snapshot
Galectin-3 alleviates demyelination by modulating microglial anti-inflammatory polarization through PPARγ-CD36 axis
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2021.12.013openalex-snapshot
Tat-SynGAP improves angiogenesis and post-stroke recovery by inhibiting MST1/JNK signaling
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2024.110912openalex-snapshot
Enriched environment treatment promotes neural functional recovery together with microglia polarization and remyelination after cerebral ischemia in rats
inferred← citeshttps://doi.org/10.1016/j.cej.2026.179096openalex-snapshot
Spatiotemporal immune responses and targeted therapeutic strategies in the immune microenvironment of ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112964openalex-snapshot
Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4Rα signaling
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115875openalex-snapshot
Targeting microglial PPARα ameliorates the outcome of ischemic stroke by enhancing interaction with infiltrating peripheral monocytes/macrophages
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.118102openalex-snapshot
Early infiltration of ischemia-conditioned Tregs attenuates BBB damage via suppressing neutrophil extracellular traps in ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176409openalex-snapshot
γ-Glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/β-catenin signalling in mice
inferred← citeshttps://doi.org/10.1016/j.expneurol.2021.113899openalex-snapshot
Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.expneurol.2022.114100openalex-snapshot
Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis after traumatic brain injury in mice by inhibiting cyclooxygenase-2
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Mechanisms and therapeutic potential of microglia-regulated remyelination in chronic cerebral hypoperfusion
inferred← citeshttps://doi.org/10.1016/j.immuni.2021.04.022openalex-snapshot
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.isci.2026.115331openalex-snapshot
Single-cell transcriptomic analyses reveal angiogenic vascular responses to chronic cerebral hypoperfusion
inferred← citeshttps://doi.org/10.1016/j.jep.2021.114358openalex-snapshot
Trillium tschonoskii rhizomes' saponins induces oligodendrogenesis and axonal reorganization for ischemic stroke recovery in rats
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2020.577318openalex-snapshot
Neuroinflammation and fibrosis in stroke: The good, the bad and the ugly
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Initial serum GM-CSF levels are associated with the severity of cerebral small vessel disease in microscopic polyangiitis patients
inferred← citeshttps://doi.org/10.1016/j.jpha.2023.02.007openalex-snapshot
Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1016/j.medj.2024.03.018openalex-snapshot
Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination
inferred← citeshttps://doi.org/10.1016/j.nbd.2023.106063openalex-snapshot
Regulatory T cell expansion promotes white matter repair after stroke
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A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes
inferred← citeshttps://doi.org/10.1016/j.neuroimage.2025.121517openalex-snapshot
Atlas-based analysis of diffusion imaging may predict efficacy of forelimb movement therapy for motor recovery in post-stroke rats
inferred← citeshttps://doi.org/10.1016/j.neuron.2024.05.025openalex-snapshot
Neurodegeneration and demyelination in multiple sclerosis
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A Novel Extract From Ginkgo biloba Inhibits Neuroinflammation and Maintains White Matter Integrity in Experimental Stroke
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.01.021openalex-snapshot
Faecal Microbiota Transplantation Alleviates Ferroptosis after Ischaemic Stroke
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Interleukin-4 as a therapeutic target
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Promoting remyelination in central nervous system diseases: Potentials and prospects of natural products and herbal medicine
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Adiponectin ameliorates hypoperfusive cognitive deficits by boosting a neuroprotective microglial response
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Global Trends and Evolving Frontiers in Intranasal Delivery for CNS Diseases (2000–2025): A Bibliometric Analysis and Systematic Review
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Fingolimod loaded on cerium oxide nanoparticles for enhanced intracerebral hemorrhage therapy targeting white matter injury via STAT3 pathway
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Neuroglia and immune cells play different roles in neuroinflammation and neuroimmune response in post-stroke neural injury and repair
inferred← citeshttps://doi.org/10.1038/s41467-024-53613-7openalex-snapshot
Human iPSC-derived neural stem cells displaying radial glia signature exhibit long-term safety in mice
inferred← citeshttps://doi.org/10.1038/s41467-025-58254-yopenalex-snapshot
Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery
inferred← citeshttps://doi.org/10.1038/s43587-023-00373-6openalex-snapshot
Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
inferred← citeshttps://doi.org/10.1073/pnas.2018497117openalex-snapshot
IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
inferred← citeshttps://doi.org/10.1080/01616412.2025.2559306openalex-snapshot
Electroacupuncture promotes myelin repair in the corpus callosum region of cerebral ischemic rats by modulating microglia activation and polarization
inferred← citeshttps://doi.org/10.1084/jem.20241830openalex-snapshot
Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production
inferred← citeshttps://doi.org/10.1084/jem.20242025openalex-snapshot
Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke
inferred← citeshttps://doi.org/10.1093/brain/awae378openalex-snapshot
Nuclear receptor PPARγ targets GPNMB to promote oligodendrocyte development and remyelination
inferred← citeshttps://doi.org/10.1097/wnr.0000000000002026openalex-snapshot
Electroacupuncture reduces oxidative stress response and improves secondary injury of intracerebral hemorrhage in rats by activating the peroxisome proliferator-activated receptor-γ/nuclear factor erythroid2-related factor 2/γ-glutamylcysteine synthetase pathway
inferred← citeshttps://doi.org/10.1101/2023.08.04.551937openalex-snapshot
Human iPSC-derived neural stem cells display a radial glia-like signature in vitro and favorable long-term safety in transplanted mice
inferred← citeshttps://doi.org/10.1101/2023.12.05.570057openalex-snapshot
IL-4 shaping glutamatergic synapse like structures for more mature iPSC derived neuron phenotypes
inferred← citeshttps://doi.org/10.1111/acel.14476openalex-snapshot
Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice
inferred← citeshttps://doi.org/10.1111/bph.17475openalex-snapshot
TREM2 activation reduces white matter injury via PI3K/Akt/GSK‐3β signalling after intracerebral haemorrhage
inferred← citeshttps://doi.org/10.1111/cns.13260openalex-snapshot
Rosiglitazone ameliorates tissue plasminogen activator‐induced brain hemorrhage after stroke
inferred← citeshttps://doi.org/10.1111/cns.13291openalex-snapshot
Potential microglia‐based interventions for stroke
inferred← citeshttps://doi.org/10.1111/cns.13497openalex-snapshot
Demyelinating processes in aging and stroke in the central nervous system and the prospect of treatment strategy
inferred← citeshttps://doi.org/10.1111/cns.14518openalex-snapshot
Novel subsets of peripheral immune cells associated with promoting stroke recovery in mice
inferred← citeshttps://doi.org/10.1111/cns.14652openalex-snapshot
Unraveling the complex pathophysiology of white matter hemorrhage in intracerebral stroke: A single‐cell RNA sequencing approach
inferred← citeshttps://doi.org/10.1111/cns.14747openalex-snapshot
Perioperative stroke deteriorates white matter integrity by enhancing cytotoxic CD8 + T‐cell activation
inferred← citeshttps://doi.org/10.1111/ejn.70328openalex-snapshot
Development of a Human Preclinical Platform for the Identification of Neuroprotective Compounds
inferred← citeshttps://doi.org/10.1111/imm.13757openalex-snapshot
Anti‐ and pro‐inflammatory milieu differentially regulate differentiation and immune functions of oligodendrocyte progenitor cells
inferred← citeshttps://doi.org/10.1111/jnc.15849openalex-snapshot
Bioinformatics‐based analysis of mechanistic differences in vascular endothelial injury ischemic stroke induced by atrial fibrillation and atherosclerosis
inferred← citeshttps://doi.org/10.1111/jnc.16084openalex-snapshot
Muscle‐building supplement β‐hydroxy β‐methylbutyrate stimulates the maturation of oligodendroglial progenitor cells to oligodendrocytes
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The emerging neuroimmune hypothesis of bipolar disorder: An updated overview of neuroimmune and microglial findings
inferred← citeshttps://doi.org/10.1111/jns.12561openalex-snapshot
Macrophages influence Schwann cell myelin autophagy after nerve injury and in a model of Charcot‐Marie‐Tooth disease
inferred← citeshttps://doi.org/10.1155/2022/1274550openalex-snapshot
Mechanism of Ferroptosis and Its Relationships with Other Types of Programmed Cell Death: Insights for Potential Therapeutic Benefits in Traumatic Brain Injury
inferred← citeshttps://doi.org/10.1161/strokeaha.120.032444openalex-snapshot
IL33 (Interleukin 33)/ST2 (Interleukin 1 Receptor-Like 1) Axis Drives Protective Microglial Responses and Promotes White Matter Integrity After Stroke
inferred← citeshttps://doi.org/10.1161/strokeaha.126.055924openalex-snapshot
Adiponectin Fortifies White Matter After Chronic Hypoperfusion–Induced Vascular Dementia
inferred← citeshttps://doi.org/10.1172/jci.insight.131355openalex-snapshot
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice
inferred← citeshttps://doi.org/10.1172/jci.insight.168919openalex-snapshot
HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury
inferred← citeshttps://doi.org/10.1177/0271678x20902542openalex-snapshot
Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery
inferred← citeshttps://doi.org/10.1177/0271678x20941393openalex-snapshot
Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ
inferred← citeshttps://doi.org/10.1177/0271678x211028680openalex-snapshot
Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury
inferred← citeshttps://doi.org/10.1177/0271678x241260100openalex-snapshot
Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke
inferred← citeshttps://doi.org/10.1177/0271678x251414082openalex-snapshot
Monocyte-derived macrophages and their roles in ischemic stroke
inferred← citeshttps://doi.org/10.1177/15230864251401591openalex-snapshot
Cytokine–Microglia Interactions in Neuroinflammation: Mechanisms, Disease Dynamics, and Therapeutic Strategies
inferred← citeshttps://doi.org/10.1186/s11671-022-03668-6openalex-snapshot
Nanoscale Drug Delivery Systems in Glioblastoma
inferred← citeshttps://doi.org/10.1186/s12967-026-08523-1openalex-snapshot
CTSS regulates macrophage lipid metabolic reprogramming and white matter repair after intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1186/s12974-021-02101-6openalex-snapshot
Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination
inferred← citeshttps://doi.org/10.1186/s12974-022-02471-5openalex-snapshot
Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3
inferred← citeshttps://doi.org/10.1186/s12974-022-02563-2openalex-snapshot
Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
inferred← citeshttps://doi.org/10.1186/s12974-023-02741-wopenalex-snapshot
TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair
inferred← citeshttps://doi.org/10.1186/s12974-023-02780-3openalex-snapshot
Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia
inferred← citeshttps://doi.org/10.1186/s12974-024-03142-3openalex-snapshot
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling
inferred← citeshttps://doi.org/10.1186/s12974-025-03463-xopenalex-snapshot
RiboTag-based RNA profiling uncovers oligodendroglial lineage-specific inflammation in autoimmune encephalomyelitis: implications for pathogenesis
inferred← citeshttps://doi.org/10.1186/s12974-025-03483-7openalex-snapshot
Pro-repair macrophages driven by CGRP rescue white matter integrity following intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1186/s12974-025-03510-7openalex-snapshot
Dihydroartemisinin enhances remyelination by switching microglia to the reparative phenotype
inferred← citeshttps://doi.org/10.1186/s12987-026-00794-6openalex-snapshot
Endothelial cells temporally orchestrate lymphocyte dynamics and functional outcomes after ischemic stroke
inferred← citeshttps://doi.org/10.1186/s13024-024-00742-8openalex-snapshot
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
inferred← citeshttps://doi.org/10.1186/s13054-025-05477-6openalex-snapshot
Extracellular vesicles as biomarkers in traumatic brain injury: a systematic review of animal and clinical studies
inferred← citeshttps://doi.org/10.1186/s40478-026-02229-7openalex-snapshot
Neurons differentially upregulate type 2 immune cytokines and interleukin-4 receptor subtypes during neuroinflammation
inferred← citeshttps://doi.org/10.1186/s40659-024-00486-1openalex-snapshot
Glial-restricted progenitor cells: a cure for diseased brain?
inferred← citeshttps://doi.org/10.1186/s40824-022-00311-4openalex-snapshot
Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages
inferred← citeshttps://doi.org/10.1186/s41232-022-00193-yopenalex-snapshot
Central nervous system regeneration: the roles of glial cells in the potential molecular mechanism underlying remyelination
inferred← citeshttps://doi.org/10.1186/s43556-026-00483-8openalex-snapshot
Exercise mimetics: molecular mechanisms, biological and therapeutic effects
inferred← citeshttps://doi.org/10.14336/ad.2023.1010openalex-snapshot
Role of Crosstalk between Glial Cells and Immune Cells in Blood-Brain Barrier Damage and Protection after Acute Ischemic Stroke
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3908681/v1openalex-snapshot
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling
inferred← citeshttps://doi.org/10.2147/jir.s448620openalex-snapshot
Quercetin Protects Against Global Cerebral ischemia‒reperfusion Injury by Inhibiting Microglial Activation and Polarization
inferred← citeshttps://doi.org/10.2147/ndt.s498660openalex-snapshot
White Matter Injury in Central Nervous System Disorders
inferred← citeshttps://doi.org/10.2174/1570159x19666210610093658openalex-snapshot
Pathways Involved in Remyelination after Cerebral Ischemia
inferred← citeshttps://doi.org/10.31083/jin53774openalex-snapshot
LRP1 in Ischemic Stroke: From CNS Homeostasis to Ischemic Injury and Repair
inferred← citeshttps://doi.org/10.3233/jad-200757openalex-snapshot
Lentivirus-Mediated Expression of Human Secreted Amyloid Precursor Protein-Alpha Promotes Long-Term Induction of Neuroprotective Genes and Pathways in a Mouse Model of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00294openalex-snapshot
Glial Cells: Role of the Immune Response in Ischemic Stroke
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1013311openalex-snapshot
Microglia autophagy in ischemic stroke: A double-edged sword
inferred← citeshttps://doi.org/10.3389/fimmu.2022.828447openalex-snapshot
Interleukins and Ischemic Stroke
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1512634openalex-snapshot
CD4+ T cells in ischemic stroke: effects and therapeutic targets
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1691335openalex-snapshot
The role of interleukins in peripheral nerve injury and the current status of treatment
inferred← citeshttps://doi.org/10.3389/fmicb.2024.1398618openalex-snapshot
Role of inflammatory cytokines and the gut microbiome in vascular dementia: insights from Mendelian randomization analysis
inferred← citeshttps://doi.org/10.3389/fncel.2022.1013905openalex-snapshot
Roles of peripheral immune cells in the recovery of neurological function after ischemic stroke
inferred← citeshttps://doi.org/10.3389/fncel.2023.1266019openalex-snapshot
Nanomaterial payload delivery to central nervous system glia for neural protection and repair
inferred← citeshttps://doi.org/10.3389/fncel.2025.1549433openalex-snapshot
A dual role for pleiotrophin in modulating inflammation and myelination in the presence of chondroitin sulfate proteoglycans after nervous system injury
inferred← citeshttps://doi.org/10.3389/fncel.2025.1550139openalex-snapshot
Intrinsic retinoic acid synthesis is required for oligodendrocyte progenitor expansion during CNS remyelination
inferred← citeshttps://doi.org/10.3389/fnmol.2020.554547openalex-snapshot
Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
inferred← citeshttps://doi.org/10.3389/fphar.2021.763181openalex-snapshot
Effect of Neurorepair for Motor Functional Recovery Enhanced by Total Saponins From Trillium tschonoskii Maxim. Treatment in a Rat Model of Focal Ischemia
inferred← citeshttps://doi.org/10.3390/antiox14050515openalex-snapshot
Argan Oil: A Natural Bioactive Lipid Modulating Oxidative Stress and Inflammation
inferred← citeshttps://doi.org/10.3390/biom11091301openalex-snapshot
Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries
inferred← citeshttps://doi.org/10.3390/cells14221756openalex-snapshot
Interleukin-4-Enhanced Oligodendrocyte Differentiation Depends on Extracellular Zinc Uptake via ZIP11
inferred← citeshttps://doi.org/10.3390/ijms23147787openalex-snapshot
Conditioned Medium of Human Pluripotent Stem Cell-Derived Neural Precursor Cells Exerts Neurorestorative Effects against Ischemic Stroke Model
inferred← citeshttps://doi.org/10.3390/ijms24098240openalex-snapshot
Intrathecal Injection of Autologous Mesenchymal Stem-Cell-Derived Extracellular Vesicles in Spinal Cord Injury: A Feasibility Study in Pigs
inferred← citeshttps://doi.org/10.3390/ijms241310802openalex-snapshot
Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review
inferred← citeshttps://doi.org/10.3390/jcm12041680openalex-snapshot
Supplementary Pharmacotherapy for the Behavioral Abnormalities Caused by Stressors in Humans, Focused on Post-Traumatic Stress Disorder (PTSD)
inferred← citeshttps://doi.org/10.3390/jcm12052049openalex-snapshot
Cure of Alzheimer’s Dementia Requires Addressing All of the Affected Brain Cell Types
inferred← citeshttps://doi.org/10.3390/medicina59071317openalex-snapshot
Regulatory T Cells Secrete IL10 to Suppress Neuroinflammation in Early Stage after Subarachnoid Hemorrhage
inferred← citeshttps://doi.org/10.3390/pharmaceutics17111447openalex-snapshot
Nanoparticle-Mediated Nose-to-Brain Delivery for Ischemic Stroke Therapy: Preclinical Insights
inferred← citeshttps://doi.org/10.34133/research.0287openalex-snapshot
Age-Related Alterations in Peripheral Immune Landscape with Magnified Impact on Post-Stroke Brain
inferred← citeshttps://doi.org/10.4049/jimmunol.1900909openalex-snapshot
IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury
inferred← citeshttps://doi.org/10.4103/1673-5374.355759openalex-snapshot
Blocking postsynaptic density-93 binding to C-X3-C motif chemokine ligand 1 promotes microglial phenotypic transformation during acute ischemic stroke
inferred← citeshttps://doi.org/10.4103/1673-5374.371365openalex-snapshot
A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke
inferred← citeshttps://doi.org/10.4103/1673-5374.392854openalex-snapshot
Oligodendrocytes in central nervous system diseases: the effect of cytokine regulation
inferred← citeshttps://doi.org/10.6084/m9.figshare.14037355openalex-snapshot
Additional file 1 of Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination
inferred← citeshttps://doi.org/10.6084/m9.figshare.19777974openalex-snapshot
Additional file 1 of Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3
inferred← citeshttps://doi.org/10.6084/m9.figshare.20445408openalex-snapshot
Additional file 1 of Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
inferred← citeshttps://doi.org/10.6084/m9.figshare.20445411openalex-snapshot
Additional file 2 of Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
inferred← citeshttps://doi.org/10.6084/m9.figshare.21629275openalex-snapshot
Additional file 1 of Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages
inferred← citeshttps://doi.org/10.6084/m9.figshare.25951842openalex-snapshot
Additional file 1 of Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling
inferred← citeshttps://doi.org/10.6084/m9.figshare.26571397openalex-snapshot
Additional file 1 of TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair
inferred← citeshttps://doi.org/10.6084/m9.figshare.26586462openalex-snapshot
Additional file 1 of Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia
inferred← citeshttps://doi.org/10.64898/2026.05.07.723637openalex-snapshot
Discovery and Characterization of Interleukin-4-Specific Affibodies for Affinity-Controlled Protein Release and Macrophage Polarization
inferred← citeshttps://doi.org/10.7554/elife.66706openalex-snapshot
Sensing the world and its dangers: An evolutionary perspective in neuroimmunology
inferred← citeshttps://doi.org/10.7759/cureus.32042openalex-snapshot
Meteorin-Like Protein Levels Decrease in Patients With Acute Ischaemic Stroke
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