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Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.20701openalex-snapshot
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
inferredcites →https://doi.org/10.1002/hep.23593openalex-snapshot
Fatty Liver Is Associated With Dyslipidemia and Dysglycemia Independent of Visceral Fat: the Framingham Heart Study
inferredcites →https://doi.org/10.1002/hep.23622openalex-snapshot
Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease†
inferredcites →https://doi.org/10.1002/hep.23768openalex-snapshot
PNPLA3 Variants Specifically Confer Increased Risk for Histologic Nonalcoholic Fatty Liver Disease But Not Metabolic Disease†,‡
inferredcites →https://doi.org/10.1007/978-3-642-95642-3_25openalex-snapshot
The Framingham Offspring Study
inferredcites →https://doi.org/10.1007/pl00000822openalex-snapshot
Neurocan: a brain chondroitin sulfate proteoglycan
inferredcites →https://doi.org/10.1007/s00125-009-1285-zopenalex-snapshot
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
inferredcites →https://doi.org/10.1007/s10557-008-6132-9openalex-snapshot
Phospholipase A2 Biochemistry
inferredcites →https://doi.org/10.1016/j.ajhg.2008.09.012openalex-snapshot
Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes
inferredcites →https://doi.org/10.1016/j.ajhg.2010.02.020openalex-snapshot
Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies
inferredcites →https://doi.org/10.1016/j.cct.2008.09.003openalex-snapshot
Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design
inferredcites →https://doi.org/10.1016/j.cld.2004.06.008openalex-snapshot
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
inferredcites →https://doi.org/10.1016/j.mad.2004.08.027openalex-snapshot
Exploring the genetics of longevity in the Old Order Amish
inferredcites →https://doi.org/10.1016/s0002-9270(01)03229-4openalex-snapshot
Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease
inferredcites →https://doi.org/10.1016/s0002-9343(99)00315-0openalex-snapshot
Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds
inferredcites →https://doi.org/10.1037/e507242006-002openalex-snapshot
Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
inferredcites →https://doi.org/10.1038/nature09270openalex-snapshot
Biological, clinical and population relevance of 95 loci for blood lipids
inferredcites →https://doi.org/10.1038/ng.257openalex-snapshot
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1038/ng.274openalex-snapshot
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
inferredcites →https://doi.org/10.1038/ng.291openalex-snapshot
Common variants at 30 loci contribute to polygenic dyslipidemia
inferredcites →https://doi.org/10.1038/ng.327openalex-snapshot
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
inferredcites →https://doi.org/10.1038/ng.520openalex-snapshot
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
inferredcites →https://doi.org/10.1038/ng.609openalex-snapshot
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
inferredcites →https://doi.org/10.1038/ng.686openalex-snapshot
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
inferredcites →https://doi.org/10.1038/ng.75openalex-snapshot
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
inferredcites →https://doi.org/10.1038/ng.76openalex-snapshot
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
inferredcites →https://doi.org/10.1038/ng1847openalex-snapshot
Principal components analysis corrects for stratification in genome-wide association studies
inferredcites →https://doi.org/10.1042/bj20080595openalex-snapshot
Glucokinase and molecular aspects of liver glycogen metabolism
inferredcites →https://doi.org/10.1053/gast.2002.35354openalex-snapshot
The utility of radiological imaging in nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1053/j.gastro.2009.01.050openalex-snapshot
Heritability of Nonalcoholic Fatty Liver Disease
inferredcites →https://doi.org/10.1056/nejmoa0907295openalex-snapshot
Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
inferredcites →https://doi.org/10.1074/jbc.m109.064501openalex-snapshot
A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
inferredcites →https://doi.org/10.1086/301844openalex-snapshot
Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/aje/kwm021openalex-snapshot
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination
inferredcites →https://doi.org/10.1093/aje/kwn211openalex-snapshot
The Association of Coronary Artery Calcification and Carotid Artery Intima-Media Thickness With Distinct, Traditional Coronary Artery Disease Risk Factors in Asymptomatic Adults
inferredcites →https://doi.org/10.1093/bioinformatics/btm108openalex-snapshot
GenABEL: an R library for genome-wide association analysis
inferredcites →https://doi.org/10.1093/hmg/ddp357openalex-snapshot
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
inferredcites →https://doi.org/10.1093/oxfordjournals.aje.a008709openalex-snapshot
NHLBI Family Heart Study: Objectives and Design
inferredcites →https://doi.org/10.1093/oxfordjournals.aje.a112813openalex-snapshot
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
inferredcites →https://doi.org/10.1097/01.mcg.0000168638.84840.ffopenalex-snapshot
The epidemiology of nonalcoholic fatty liver disease in adults.
inferredcites →https://doi.org/10.1097/01.tp.0000140499.23683.0dopenalex-snapshot
Noninvasive Evaluation of Graft Steatosis in Living Donor Liver Transplantation
inferredcites →https://doi.org/10.1111/j.1440-1746.2005.04058.xopenalex-snapshot
Fatty liver and the metabolic syndrome among Shanghai adults
inferredcites →https://doi.org/10.1111/j.1440-1746.2008.05420.xopenalex-snapshot
Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study
inferredcites →https://doi.org/10.1126/science.1142358openalex-snapshot
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
inferredcites →https://doi.org/10.1148/radiol.2301021176openalex-snapshot
Macrovesicular Hepatic Steatosis in Living Related Liver Donors: Correlation between CT and Histologic Findings
inferredcites →https://doi.org/10.1148/radiol.2341040439openalex-snapshot
Calcified Coronary Artery Plaque Measurement with Cardiac CT in Population-based Studies: Standardized Protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) Study
inferredcites →https://doi.org/10.1159/000353879openalex-snapshot
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
inferredcites →https://doi.org/10.1186/1471-2156-11-40openalex-snapshot
A three-stage approach for genome-wide association studies with family data for quantitative traits
inferredcites →https://doi.org/10.1194/jlr.r800033-jlr200openalex-snapshot
Phospholipase A2 structure/function, mechanism, and signaling
inferredcites →https://doi.org/10.1371/journal.pgen.0030236openalex-snapshot
Discerning the Ancestry of European Americans in Genetic Association Studies
inferredcites →https://doi.org/10.1371/journal.pgen.1000508openalex-snapshot
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
inferredcites →https://doi.org/10.17615/d3bn-7g86openalex-snapshot
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
inferredcites →https://doi.org/10.7326/0003-4819-94-2-286_1openalex-snapshot
The Framingham Study. The Epidemiology of Atherosclerotic Disease.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.3865274openalex-extracted
Electronic Health Record-Based Genome-Wide Meta-Analysis Provides New Insights on the Genetic Architecture of Non-Alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1001/jamapediatrics.2014.2702openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/9780470015902.a0025335openalex-snapshot
Genetics of Non‐alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/9781118512074.ch104openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/9781118556153.ch14openalex-snapshot
Genetic Predisposition to NAFLD and NASH: Implications for Pathogenesis, Diagnosis, Prevention, and Management
inferred← citeshttps://doi.org/10.1002/9781118857991.ch5openalex-snapshot
Aetiology of obesity in children
inferred← citeshttps://doi.org/10.1002/9781118924938.ch11openalex-snapshot
Can genetic influence in non‐alcoholic fatty liver disease be ignored?
inferred← citeshttps://doi.org/10.1002/9781119436812.ch41openalex-snapshot
Clinical Genomics of NAFLD
inferred← citeshttps://doi.org/10.1002/cphy.c220028openalex-snapshot
Gallstone and Gallbladder Disease: Biliary Tract and Cholangiopathies
inferred← citeshttps://doi.org/10.1002/cpt.629openalex-snapshot
Genome‐Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy
inferred← citeshttps://doi.org/10.1002/edm2.177openalex-snapshot
Diagnostic and interventional circulating biomarkers in nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.1002/edm2.179openalex-snapshot
Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum
inferred← citeshttps://doi.org/10.1002/emmm.201100671openalex-snapshot
Balancing the fat: lipid droplets and human disease
inferred← citeshttps://doi.org/10.1002/hep.24350openalex-snapshot
Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C
inferred← citeshttps://doi.org/10.1002/hep.24483openalex-snapshot
Role of ethnicity in overweight and obese patients with nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.1002/hep.24793openalex-snapshot
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1002/hep.24806openalex-snapshot
Variant in the glucokinase regulatory protein ( GCKR ) gene is associated with fatty liver in obese children and adolescents
inferred← citeshttps://doi.org/10.1002/hep.25506openalex-snapshot
I148M PNPLA3 Variant and Progressive Liver Disease: A New Paradigm in Hepatology
inferred← citeshttps://doi.org/10.1002/hep.25617openalex-snapshot
Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphisms
inferred← citeshttps://doi.org/10.1002/hep.26052openalex-snapshot
Solute Carrier Family 2 Member 1 Is Involved in the Development of Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/hep.26184openalex-snapshot
Association Between Liver-Specific Gene Polymorphisms and Their Expression Levels With Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/hep.26440openalex-snapshot
Characterization of European Ancestry Nonalcoholic Fatty Liver Disease-Associated Variants in Individuals of African And Hispanic Descent
inferred← citeshttps://doi.org/10.1002/hep.26551openalex-snapshot
Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis
inferred← citeshttps://doi.org/10.1002/hep.27242openalex-snapshot
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
inferred← citeshttps://doi.org/10.1002/hep.27490openalex-snapshot
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
inferred← citeshttps://doi.org/10.1002/hep.27556openalex-snapshot
Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity
inferred← citeshttps://doi.org/10.1002/hep.28142openalex-snapshot
The dual and opposite role of the TM6SF2‐rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta‐analysis
inferred← citeshttps://doi.org/10.1002/hep.28283openalex-snapshot
Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study
inferred← citeshttps://doi.org/10.1002/hep.28390openalex-snapshot
Noninvasive fatty liver markers predict liver disease mortality in the U.S. population
inferred← citeshttps://doi.org/10.1002/hep.28392openalex-snapshot
Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice
inferred← citeshttps://doi.org/10.1002/hep.28475openalex-snapshot
Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes
inferred← citeshttps://doi.org/10.1002/hep.28495openalex-snapshot
Genome‐wide association study in mice identifies loci affecting liver‐related phenotypes including Sel1l influencing serum bile acids
inferred← citeshttps://doi.org/10.1002/hep.28674openalex-snapshot
Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study
inferred← citeshttps://doi.org/10.1002/hep.29347openalex-snapshot
Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents
inferred← citeshttps://doi.org/10.1002/hep.29522openalex-snapshot
Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1002/hep.29739openalex-snapshot
Thwart your destiny; effect of nonacoholic fatty liver disease genes on steatosis, liver injury and cirrhosis varies by body mass index
inferred← citeshttps://doi.org/10.1002/hep.29751openalex-snapshot
Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride
inferred← citeshttps://doi.org/10.1002/hep.29892openalex-snapshot
Link between gut‐microbiome derived metabolite and shared gene‐effects with hepatic steatosis and fibrosis in NAFLD
inferred← citeshttps://doi.org/10.1002/hep.30113openalex-snapshot
The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice
inferred← citeshttps://doi.org/10.1002/hep.30350openalex-snapshot
17‐Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/hep.30610openalex-snapshot
Collagen Formation Assessed by N‐Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography
inferred← citeshttps://doi.org/10.1002/hep.30799openalex-snapshot
High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase–Lowering Effect of a HSD17B13 Variant
inferred← citeshttps://doi.org/10.1002/hep.31229openalex-snapshot
Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology
inferred← citeshttps://doi.org/10.1002/hep.31238openalex-snapshot
Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population
inferred← citeshttps://doi.org/10.1002/hep.31897openalex-snapshot
A Systematic Review of Animal Models of NAFLD Finds High‐Fat, High‐Fructose Diets Most Closely Resemble Human NAFLD
inferred← citeshttps://doi.org/10.1002/hep.32183openalex-snapshot
Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study
inferred← citeshttps://doi.org/10.1002/hep4.1171openalex-snapshot
Coding variants in PNPLA3 and TM6SF2 are risk factors for hepatic steatosis and elevated serum alanine aminotransferases caused by a glucagon receptor antagonist
inferred← citeshttps://doi.org/10.1002/hep4.1183openalex-snapshot
Patatin‐like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events
inferred← citeshttps://doi.org/10.1002/hep4.1192openalex-snapshot
Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1002/hep4.1227openalex-snapshot
Whole‐Exome Sequencing Study of Extreme Phenotypes of NAFLD
inferred← citeshttps://doi.org/10.1002/hep4.1235openalex-snapshot
A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.1002/hep4.1319openalex-snapshot
Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease
inferred← citeshttps://doi.org/10.1002/hep4.1353openalex-snapshot
Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes
inferred← citeshttps://doi.org/10.1002/hep4.1382openalex-snapshot
Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug‐Induced Liver Injury
inferred← citeshttps://doi.org/10.1002/hep4.1391openalex-snapshot
Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis
inferred← citeshttps://doi.org/10.1002/hep4.1529openalex-snapshot
Genome‐Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus
inferred← citeshttps://doi.org/10.1002/hep4.1533openalex-snapshot
Genome‐Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study
inferred← citeshttps://doi.org/10.1002/hep4.1630openalex-snapshot
Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition
inferred← citeshttps://doi.org/10.1002/hep4.1668openalex-snapshot
Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD
inferred← citeshttps://doi.org/10.1002/hep4.1751openalex-snapshot
Association of Genetic Risk Score With NAFLD in An Ethnically Diverse Cohort
inferred← citeshttps://doi.org/10.1002/hep4.1805openalex-snapshot
Genome‐Wide Association Study of NAFLD Using Electronic Health Records
inferred← citeshttps://doi.org/10.1002/hep4.1822openalex-snapshot
TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease
inferred← citeshttps://doi.org/10.1002/hep4.1955openalex-snapshot
Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17‐beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms
inferred← citeshttps://doi.org/10.1002/hep4.2066openalex-snapshot
Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2023.tb00275.xopenalex-snapshot
Gallstone and Gallbladder Disease: Biliary Tract and Cholangiopathies
inferred← citeshttps://doi.org/10.1002/jgh3.70043openalex-snapshot
An epidemiological study on the factors including genetic polymorphism influencing ALT > 30 U /L and liver fibrosis progression in metabolic dysfunction‐associated steatotic liver disease among the general population
inferred← citeshttps://doi.org/10.1002/jgm.3160openalex-snapshot
Association of metabolic syndrome and patatin‐like phospholipase 3 – rs738409 gene variant in non‐alcoholic fatty liver disease among a Chennai‐based south Indian population
inferred← citeshttps://doi.org/10.1002/jgm.3439openalex-snapshot
Downregulation of indolethylamine N‐methyltransferase is an early event in the rat hepatocarcinogenesis and is associated with poor prognosis in hepatocellular carcinoma patients
inferred← citeshttps://doi.org/10.1002/jpn3.12346openalex-snapshot
Environmental toxicants modulate disease severity in pediatric metabolic dysfunction‐associated steatohepatitis
inferred← citeshttps://doi.org/10.1002/jpn3.70490openalex-snapshot
European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) steatotic liver disease special interest group position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction‐associated steatotic liver disease
inferred← citeshttps://doi.org/10.1002/mgg3.168openalex-snapshot
Genetic analysis of nonalcoholic fatty liver disease within a Caribbean–Hispanic population
inferred← citeshttps://doi.org/10.1002/mp.13675openalex-snapshot
Fully automatic liver attenuation estimation combing CNN segmentation and morphological operations
inferred← citeshttps://doi.org/10.1002/oby.20174openalex-snapshot
Nonalcoholic fatty liver disease in severely obese adolescent and adult patients
inferred← citeshttps://doi.org/10.1002/oby.20228openalex-snapshot
Acquired liver fat is a key determinant of serum lipid alterations in healthy monozygotic twins
inferred← citeshttps://doi.org/10.1002/oby.20366openalex-snapshot
A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population
inferred← citeshttps://doi.org/10.1002/oby.20523openalex-snapshot
Genetic and clinical markers of elevated liver fat content in overweight and obese hispanic children
inferred← citeshttps://doi.org/10.1002/oby.22527openalex-snapshot
Genome‐Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium
inferred← citeshttps://doi.org/10.1002/stem.2454openalex-snapshot
Concise Review: Current Status and Future Directions on Research Related to Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/ygh2.354openalex-snapshot
A narrative review of factors associated with the development and progression if non‐alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1007/164_2019_239openalex-snapshot
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology
inferred← citeshttps://doi.org/10.1007/164_2020_352openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/16833_2022_87openalex-snapshot
The Role of Senescence in NASH-Related HCC
inferred← citeshttps://doi.org/10.1007/978-1-4471-4715-2_9openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-1-4614-8642-8_6openalex-snapshot
Genetic Pleiotropies of Obesity
inferred← citeshttps://doi.org/10.1007/978-3-030-37173-9_3openalex-snapshot
Genes and NAFLD/NASH Progression
inferred← citeshttps://doi.org/10.1007/978-3-030-80068-0_69openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-98808-1_10openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-3-031-33548-8_3openalex-snapshot
Natural History of Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-17169-2_66openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-20538-0_4openalex-snapshot
Pathogenesis of NAFLD and NASH
inferred← citeshttps://doi.org/10.1007/978-3-319-20538-0_7openalex-snapshot
Genetic Basis of Alcoholic and Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-25065-6_7openalex-snapshot
Role of Lipogenesis and Lipid Desaturases in Non-alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-30103-7_14openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-73344-9_7openalex-snapshot
Mitochondria in Liver Diseases
inferred← citeshttps://doi.org/10.1007/978-3-319-75856-5_21openalex-snapshot
Clinical Manifestations of Liver Disease in Diabetes Mellitus
inferred← citeshttps://doi.org/10.1007/978-3-319-95828-6_7openalex-snapshot
The Natural History of NAFLD: Environmental vs. Genetic Risk Factors
inferred← citeshttps://doi.org/10.1007/978-3-319-98890-0_12openalex-snapshot
Genetic Aspects of Non-alcoholic Fatty Liver Disease (NAFLD)
inferred← citeshttps://doi.org/10.1007/978-3-662-62484-5_8openalex-snapshot
Pathophysiologie: Genetik
inferred← citeshttps://doi.org/10.1007/978-94-007-5881-0_5openalex-snapshot
Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-94-007-7742-2_28-1openalex-snapshot
PNPLA3 Polymorphism and Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-981-10-8684-7_2openalex-snapshot
Epidemiology and Etiologic Associations of Non-alcoholic Fatty Liver Disease and Associated HCC
inferred← citeshttps://doi.org/10.1007/978-981-13-1465-0_7openalex-snapshot
Diabetes in Liver Disease
inferred← citeshttps://doi.org/10.1007/978-981-19-5642-3_13openalex-snapshot
Genome Editing and Fatty Liver
inferred← citeshttps://doi.org/10.1007/s00018-012-1037-yopenalex-snapshot
Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology
inferred← citeshttps://doi.org/10.1007/s00018-016-2161-xopenalex-snapshot
Pathogenesis of nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.1007/s00018-019-03348-2openalex-snapshot
Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1007/s00018-019-03390-0openalex-snapshot
Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis
inferred← citeshttps://doi.org/10.1007/s00109-011-0803-xopenalex-snapshot
Genetic variants in candidate genes influencing NAFLD progression
inferred← citeshttps://doi.org/10.1007/s00109-019-01780-2openalex-snapshot
Circadian rhythms: a possible new player in non-alcoholic fatty liver disease pathophysiology
inferred← citeshttps://doi.org/10.1007/s00125-012-2478-4openalex-snapshot
Is FTO a type 2 diabetes susceptibility gene?
inferred← citeshttps://doi.org/10.1007/s00125-013-2880-6openalex-snapshot
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
inferred← citeshttps://doi.org/10.1007/s00125-015-3801-7openalex-snapshot
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans
inferred← citeshttps://doi.org/10.1007/s00125-022-05848-6openalex-snapshot
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
inferred← citeshttps://doi.org/10.1007/s00125-026-06759-6openalex-snapshot
Genetics of MASLD: a diabetes perspective
inferred← citeshttps://doi.org/10.1007/s00198-023-06996-0openalex-snapshot
Association between fatty liver index and controlled attenuation parameters as markers of metabolic dysfunction-associated fatty liver disease and bone mineral density: observational and two-sample Mendelian randomization studies
inferred← citeshttps://doi.org/10.1007/s00210-026-05810-yopenalex-snapshot
Exploring the role of inflammatory cytokines in obesity-mediated MASLD development and drug target identification
inferred← citeshttps://doi.org/10.1007/s00330-022-08904-2openalex-snapshot
Plaque progression at coronary CT angiography links non-alcoholic fatty liver disease and cardiovascular events: a prospective single-center study
inferred← citeshttps://doi.org/10.1007/s00428-012-1216-0openalex-snapshot
Keratin 8 variants are associated with cryptogenic hepatitis
inferred← citeshttps://doi.org/10.1007/s00438-015-1037-3openalex-snapshot
Transcriptional networks implicated in human nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1007/s00439-013-1294-3openalex-snapshot
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
inferred← citeshttps://doi.org/10.1007/s00508-023-02196-2openalex-snapshot
No association of NAFLD-related polymorphisms in PNPLA3 and TM6SF2 with all-cause and cardiovascular mortality in an Austrian population study
inferred← citeshttps://doi.org/10.1007/s00535-012-0527-xopenalex-snapshot
Inflammation and fibrogenesis in steatohepatitis
inferred← citeshttps://doi.org/10.1007/s00535-013-0850-xopenalex-snapshot
Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene
inferred← citeshttps://doi.org/10.1007/s00535-017-1372-8openalex-snapshot
Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1007/s00535-018-01533-xopenalex-snapshot
Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s00592-014-0654-3openalex-snapshot
Genome-wide analysis of hepatic lipid content in extreme obesity
inferred← citeshttps://doi.org/10.1007/s00592-015-0766-4openalex-snapshot
GCKR polymorphism influences liver fat content in patients with type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s10620-014-3279-zopenalex-snapshot
Role of the PNPLA3 I148M Polymorphism in Nonalcoholic Fatty Liver Disease and Fibrosis in Korea
inferred← citeshttps://doi.org/10.1007/s10620-018-5278-yopenalex-snapshot
PNPLA3 Gene Polymorphisms in HCV/HIV-Coinfected Individuals
inferred← citeshttps://doi.org/10.1007/s10620-023-07980-8openalex-snapshot
Low LDL Cholesterol Is Not an Independent Risk Factor for Hepatic Steatosis
inferred← citeshttps://doi.org/10.1007/s11033-016-4058-zopenalex-snapshot
Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults
inferred← citeshttps://doi.org/10.1007/s11154-014-9293-9openalex-snapshot
Genetics of metabolic syndrome
inferred← citeshttps://doi.org/10.1007/s11377-013-0752-8openalex-snapshot
Genetik der Fettlebererkrankung
inferred← citeshttps://doi.org/10.1007/s11428-020-00647-2openalex-snapshot
Genetisches Risiko bei metabolischer Fettlebererkrankung
inferred← citeshttps://doi.org/10.1007/s11745-016-4155-8openalex-snapshot
Fatty Acid Binding Protein‐1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias
inferred← citeshttps://doi.org/10.1007/s11892-015-0648-8openalex-snapshot
Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
inferred← citeshttps://doi.org/10.1007/s11892-015-0674-6openalex-snapshot
Epidemiology of NAFLD and Type 2 Diabetes: Health Disparities Among Persons of Hispanic Origin
inferred← citeshttps://doi.org/10.1007/s11892-021-01377-5openalex-snapshot
Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications
inferred← citeshttps://doi.org/10.1007/s11901-014-0222-xopenalex-snapshot
Genetic and Epigenetic Associations with NAFLD: Focus on Clinical Decision Making and Novel Concepts in Disease Pathogenesis
inferred← citeshttps://doi.org/10.1007/s11901-014-0224-8openalex-snapshot
Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.1007/s11901-017-0372-8openalex-snapshot
Genetic and Epigenetic Associations of NAFLD: Focus on Clinical Decision Making
inferred← citeshttps://doi.org/10.1007/s11901-020-00539-5openalex-snapshot
High-Risk Groups for Non-alcoholic Fatty Liver and Non-alcoholic Steatohepatitis Development and Progression
inferred← citeshttps://doi.org/10.1007/s11901-025-00707-5openalex-snapshot
Hepatocellular Carcinoma in the Setting of Metabolic Dysfunction Associated Steatotic Liver Disease
inferred← citeshttps://doi.org/10.1007/s11904-018-0392-1openalex-snapshot
NAFLD and HIV: Do Sex, Race, and Ethnicity Explain HIV-Related Risk?
inferred← citeshttps://doi.org/10.1007/s12029-017-9961-6openalex-snapshot
Is That Possible to Stop or Cease the NASH to Turn into HCC?
inferred← citeshttps://doi.org/10.1007/s12041-019-1071-8openalex-snapshot
Genetics of nonalcoholic fatty liver disease in Asian populations
inferred← citeshttps://doi.org/10.1007/s12041-019-1075-4openalex-snapshot
A small supernumerary marker chromosome resulting in mosaic partial tetrasomy 4q26-q31.21 in a foetus with multiple congenital malformations
inferred← citeshttps://doi.org/10.1007/s12072-015-9689-yopenalex-snapshot
Genetic and epigenetic mechanisms of NASH
inferred← citeshttps://doi.org/10.1007/s12072-022-10371-2openalex-snapshot
The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease
inferred← citeshttps://doi.org/10.1007/s12072-022-10443-3openalex-snapshot
Diet-derived antioxidants and nonalcoholic fatty liver disease: a Mendelian randomization study
inferred← citeshttps://doi.org/10.1007/s12072-023-10486-0openalex-snapshot
Association of MAFLD with end-stage kidney disease: a prospective study of 337,783 UK Biobank participants
inferred← citeshttps://doi.org/10.1007/s12072-024-10667-5openalex-snapshot
The contribution of genetics and epigenetics to MAFLD susceptibility
inferred← citeshttps://doi.org/10.1007/s12263-014-0388-4openalex-snapshot
The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
inferred← citeshttps://doi.org/10.1007/s12328-018-0841-9openalex-snapshot
The genetic backgrounds in nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1007/s12519-013-0438-9openalex-snapshot
Type 2 diabetes mellitus in pediatrics: a new challenge
inferred← citeshttps://doi.org/10.1007/s13353-025-01015-wopenalex-snapshot
Genetic variations and functions of KLF14 in gene expression and metabolic disease development
inferred← citeshttps://doi.org/10.1007/s13668-014-0085-3openalex-snapshot
The Genetics of Nonalcoholic Fatty Liver Disease: Role of Diet as a Modifying Factor
inferred← citeshttps://doi.org/10.1007/s42000-022-00391-wopenalex-snapshot
Detangling the interrelations between MAFLD, insulin resistance, and key hormones
inferred← citeshttps://doi.org/10.1007/s42452-025-07243-3openalex-snapshot
Hepatic steatosis: associated rs2954029 and rs2605100 genetic factors in an Indian population
inferred← citeshttps://doi.org/10.1016/b978-0-08-097086-8.64026-6openalex-snapshot
Obesity: Cultural and Biological Factors
inferred← citeshttps://doi.org/10.1016/b978-0-12-386456-7.04207-6openalex-snapshot
Fatty Liver, NASH, and Alcoholic Liver Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11596-xopenalex-snapshot
Genetics of Polygenic Metabolic Liver Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-811297-7.00018-4openalex-snapshot
The Neurocan-cartilage Intermediate Layer Protein 2 (NCAN-CILP2) Region and Plasma Lipid Levels
inferred← citeshttps://doi.org/10.1016/b978-0-12-814466-4.00020-3openalex-snapshot
Critical Role of Hepatic Fatty-Acyl Phospholipid Remodeling in Obese and Nonobese Fatty Liver Mouse Models
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00265-0openalex-snapshot
Non-Alcoholic Fatty Liver Disease and Steatohepatitis
inferred← citeshttps://doi.org/10.1016/b978-0-12-823809-7.00010-4openalex-snapshot
IPSC-derived 3D human fatty liver models
inferred← citeshttps://doi.org/10.1016/b978-0-323-42873-6.00012-3openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1016/b978-0-323-55138-0.00011-5openalex-snapshot
Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-323-99649-5.00006-6openalex-snapshot
Pathogenesis of NAFLD/NASH
inferred← citeshttps://doi.org/10.1016/b978-0-443-33590-7.00012-5openalex-snapshot
Genetic and epigenetic landscape of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/bs.acr.2022.03.004openalex-snapshot
Understanding the genetic basis for cholangiocarcinoma
inferred← citeshttps://doi.org/10.1016/j.ajhg.2016.04.013openalex-snapshot
Imputing Phenotypes for Genome-wide Association Studies
inferred← citeshttps://doi.org/10.1016/j.ajhg.2017.12.005openalex-snapshot
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects
inferred← citeshttps://doi.org/10.1016/j.ajhg.2018.01.015openalex-snapshot
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
inferred← citeshttps://doi.org/10.1016/j.ajhg.2018.02.017openalex-snapshot
PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger
inferred← citeshttps://doi.org/10.1016/j.ajhg.2020.03.011openalex-snapshot
Pleiotropy-Based Decomposition of Genetic Risk Scores: Association and Interaction Analysis for Type 2 Diabetes and CAD
inferred← citeshttps://doi.org/10.1016/j.annepidem.2012.08.003openalex-snapshot
Alanine transaminase has opposite associations with death from diabetes and ischemic heart disease in NHANES III
inferred← citeshttps://doi.org/10.1016/j.aohep.2023.101120openalex-snapshot
Examining genetic associations with hepatic steatosis in Mexican-origin adults
inferred← citeshttps://doi.org/10.1016/j.arcmed.2024.103128openalex-snapshot
Genetic Risk Phenotypes for Type 2 Diabetes Differ with Ancestry in US Adults with Diabetes and Overweight/Obesity
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2013.01.038openalex-snapshot
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2015.01.001openalex-snapshot
A concise review of non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2015.01.039openalex-snapshot
New insights into the pathophysiology of dyslipidemia in type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2016.12.018openalex-snapshot
Non-alcoholic fatty liver disease and subclinical atherosclerosis: A comparison of metabolically- versus genetically-driven excess fat hepatic storage
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2019.01.029openalex-snapshot
Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps
inferred← citeshttps://doi.org/10.1016/j.athplu.2024.12.003openalex-snapshot
Impact of NAFLD-related SNPs on the carotid atherosclerosis development; a five-year prospective observational study
inferred← citeshttps://doi.org/10.1016/j.avdiab.2011.11.004openalex-snapshot
Genetics of non-alcoholic fatty liver disease and associated metabolic disorders
inferred← citeshttps://doi.org/10.1016/j.bbadis.2011.07.017openalex-snapshot
Genetic modifiers of non-alcoholic fatty liver disease progression
inferred← citeshttps://doi.org/10.1016/j.bbadis.2015.12.003openalex-snapshot
Role of Tribbles Pseudokinase 1 (TRIB1) in human hepatocyte metabolism
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.07.019openalex-snapshot
Lipid droplet proteins and metabolic diseases
inferred← citeshttps://doi.org/10.1016/j.bbalip.2016.02.004openalex-snapshot
iPLA2β deficiency attenuates obesity and hepatic steatosis in ob / ob mice through hepatic fatty-acyl phospholipid remodeling
inferred← citeshttps://doi.org/10.1016/j.bbalip.2019.01.012openalex-snapshot
Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling
inferred← citeshttps://doi.org/10.1016/j.bbalip.2022.159153openalex-snapshot
Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2013.10.001openalex-snapshot
ERK1/2 regulates hepatocyte Trib1 in response to mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.09.019openalex-snapshot
High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.114173openalex-snapshot
From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease
inferred← citeshttps://doi.org/10.1016/j.beem.2013.02.002openalex-snapshot
Gastrointestinal complications of obesity: Non-alcoholic fatty liver disease (NAFLD) and its sequelae
inferred← citeshttps://doi.org/10.1016/j.bpg.2026.102150openalex-snapshot
Insulin resistance and hepatic steatosis
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